Platelet-Rich Plasma Injections for knee osteoarthritis …

Marc Darrow MD, JD. Thank you for reading my article. You can ask me your questions using the contact form below.

While we do offer stem cell therapy for knee osteoarthritis, the focus of this article will be onPlatelet-Rich Plasma Therapy. We receive many emails which ask which is the better treatment for me, stem cells or PRP? That answer comes best after a physical examination and when we have the opportunity to sit down together and discuss what are your goals of treatment. Goals of treatment would be different for a mountain climber than a stair climber at home.

In the same regard, we get many emails that ask us if PRP is better thanhyaluronic acid injections or cortisone injection. Many of these people already had cortisone andhyaluronic acid injections. They are somewhat skeptical because these treatments did not help them as much as they thought they would.

In our experience, we have found PRP injections to be the superior treatment. In fact we have submitted our findings for peer-review and upcoming medical journal publication. Supporting our view most recently is a2019 study in the medical journalOrthopade(1) which found thatIntra-articular PRP injections into the knee for symptomatic early stages of knee osteoarthritis are a valid treatment option. The clinical efficacy of Intra-articular PRP injections is comparable to that of the Intra-articular-hyaluronic acid injections and Intra-articular cortisone after 3 months, HOWEVER, the long-term effectiveness of PRP injections is superior to hyaluronic acid and cortisone.

In this article we will discuss research on grade 1 to 3 knee osteoarthritis and PRP treatments. When a new patient comes into our office for a consultation for their knee osteoarthritis, we do a careful assessment of the patient and then make recommendations. Sometimes, the lack of range of motion in this patients knee and other factors lead us to a recommendation of stem cell injections. This recommendation is based on a realistic expectation of what both treatments may offer. For some, having the PRP only may not offer the healing that they hope to achieve.

Doctors at the worlds leading medical universities and hospitals are showing that PRP can regenerate damaged knee cartilage and meniscus in patients suffering from knee osteoarthritis and PRP can also enhance healing after knee ligament reconstruction.

An October 2018 study in the journal Current reviews in musculoskeletal medicine(2) says this:

Recent research into the applications ofPRPfor knee osteoarthritis has further indicated both the efficacy and safety ofPRPtreatment. Although research has shown a tendency toward better efficacy at earlier stages ofosteoarthritis, evidence exists to indicate positive effects at all stages of osteoarthritis. In summary, since knee osteoarthritis is an extremely prevalent condition that can be a challenge to treat, it is imperative that safe and effective nonoperative treatment methods be available to individuals that are suffering from this condition.

In July 2018, medical university researchers in Ireland lead a multi-national European research team to conclude in their research:

Platelet-rich plasma therapy is a simple, low-cost and minimally invasive intervention which is feasible to deliver in primary care to treat degenerative lesions of articular cartilage of the knee. This therapy appears to have minimal associated adverse events and may have beneficial effects in terms of pain, health utility, patient satisfaction and goal-orientated outcomes.(3)

What is interesting about this study is who the PRP helped:

Even a single injection of PRP provided benefit.

In the video below (there is no sound), I demonstrate how why administer PRP. In this case the patient has problems of meniscus degeneration. We apply multiply injections to support regeneration of the whole knee. Below the video is research that showed positive results of even a single PRP injection against a single placebo injection.

In November 2017, researchers reported on the benefits of PRP compared to placebo injection in patients who had osteoarthritis in both knees.Published in the American journal of physical medicine & rehabilitation, the study showedPRP treatment significantly improves pain, stiffness, and disability in patients with knee osteoarthritis compared to normal saline (placebo) treatment.(4)

Also in November 2017, in the International journal of rheumatic diseases, researchers reported a summary of the most recent findings on the benefits of PRP for knee osteoarthritis.

In the medical journal Arthroscopy, a journal devoted to obviously arthroscopy, surgeons are told thatPlatelet Rich Plasma injections(PRP),offers better symptomatic relief to patients with early knee degenerative changes (than hyaluronic acid or placebo), and its use should be considered in patients with kneeosteoarthritis.(6)

This is a verification of early research from the Mayo Clinic which came to the same conclusion PRPshowed better improvement than hyaluronic acid injection and placebo in reducing symptoms and improving function and quality of life. Especially in in younger, active patients with low-grade osteoarthritis.(7)

This is from the Mayo Clinic research:

Intraarticular platelet-rich plasma (PRP) injection has emerged as a promising treatment forkneeosteoarthritis. Studies to date, including multiple randomized controlled trials, have shown thatPRPis a safe and effective treatment option forkneeosteoarthritis. IntraarticularPRPis similar in efficacy to hyaluronic acid, and seems to be more effective than hyaluronic acid in younger, active patients with low-grade osteoarthritis. Treatment benefits seem to wane after 6-9 mos. There are numerousPRPtreatment variables that may be of importance, and the optimalPRPprotocol remains unclear.

At the end of that paragraph the Mayo team points out that benefits may only last 6 9 months and that there is much variation in the way PRP is delivered so it is difficult to understand why PRP may not work.

When we see a new patient with degenerative knee disease who had failed PRP treatments at other clinics, we ask them how many treatments did they have? More often than not they say one injection. For some with minor osteoarthritis, as pointed out by the medical studies highlighted in this article, one injection provides benefit.

But one injection may not be sufficient for someone who has a more active lifestyle than others.

Here is a recent study where the patients received two PRP injections as the complete PRP treatment program. This treatment group was considered to be active. This research was published in the journal Sports Health.(8)

A paper published in the Journal of physical therapy science.(9) It comes from doctors working in medical university hospitals in Turkey.


Below is what doctors are saying to each other about athletes who want to stay active. It was published in the medical journal Cartilage: As a result of the complexity of the arthritic knee, athletes, particularly those with a history of knee injury, have an earlier onset and higher prevalence of osteoarthritis. This can present a clinical dilemma to the physician managing the patient who, despite the presence of radiologically confirmed disease, has few symptoms and wishes to maintain an active lifestyle.(10)

The difficulty or challenge is in the prevention of advancing of knee osteoarthritis. Here the typical recommendations of anti-inflammatory medications, knee braces, and ice, those that the athlete can impose upon themselves, will lead to further knee deterioration. It is a challenge to convince an athlete of this when it may get them on the course, track of field this weekend.

In a recentstudy, researchers at Hospital for Special Surgery gavepatients with early osteoarthritis an injection of PRP (6-mL), and then monitored them for one year. At baseline and then one year after the PRP injection, physicians evaluated the knee cartilage with magnetic resonance imaging (MRI). While previous studies have shown that patients with osteoarthritis can lose roughly five percent of knee cartilage per year, the Hospital for Special Surgeryinvestigators found that a large majority of patients in their study had no further cartilage loss. At minimum PRP prevented further knee deterioration.

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1 Huang Y, Liu X, Xu X, Liu J. Intra-articular injections of platelet-rich plasma, hyaluronic acid or corticosteroids for knee osteoarthritis. Der Orthopde. 2019 Jan 8:1-8. 2 Cook CS, Smith PA. Clinical Update: Why PRP Should Be Your First Choice for Injection Therapy inTreating Osteoarthritis of the Knee.Curr Rev Musculoskelet Med. 2018 Oct 22. doi: 10.1007/s12178-018-9524-x. 3 Glynn LG, Mustafa A, Casey M, et al. Platelet-rich plasma (PRP) therapy for knee arthritis: a feasibility study in primary care.Pilot Feasibility Stud. 2018;4:93. Published 2018 Jul 4. doi:10.1186/s40814-018-0288-2 4 Wu YT, Hsu KC, Li TY, Chang CK, Chen LC. Effects of platelet-rich plasma on pain and muscle strength in patients with knee osteoarthritis. American journal of physical medicine & rehabilitation. 2017 Nov. 5 Xing D, Wang B, Zhang W, Yang Z, Hou Y, Chen Y, Lin J. Intraarticular plateletrich plasma injections for knee osteoarthritis: An overview of systematic reviews and risk of bias considerations. International journal of rheumatic diseases. 2017 Dec 5. 6 Campbell KA, Saltzman BM, Mascarenhas R, Khair MM, Verma NN, Bach BR Jr, Cole BJ.A Systematic Review of Overlapping Meta-analyses.Arthroscopy. 2015 Nov;31(11):2213-21. doi: 10.1016/j.arthro.2015.03.041. Epub 2015 May 29. 7 Pourcho AM, Smith J, Wisniewski SJ, Sellon JL.Intraarticular platelet-rich plasma injection in the treatment of knee osteoarthritis: review and recommendations. Am J Phys Med Rehabil. 2014 Nov;93(11 Suppl 3):S108-21. doi: 10.1097/PHM.0000000000000115. 8 Gobbi A, Karnatzikos G, Mahajan V, Malchira S. Platelet-rich plasma treatment in symptomatic patients with knee osteoarthritis: preliminary results in a group of active patients.Sports Health. 2012;4(2):162-72. 9 Kavadar G, Demircioglu DT, Celik MY, Emre TY.Effectiveness of platelet-rich plasma in the treatment of moderate knee osteoarthritis: a randomized prospective study.J Phys Ther Sci. 2015 Dec;27(12):3863-7. doi: 10.1589/jpts.27.3863. Epub 2015 Dec 28. 10 Kirkendall DT. Management of the Retired Athlete with Osteoarthritis of the Knee. Cartilage January 2012 vol. 3 no. 1 suppl 69S-76S 11 Wang-Saegusa A, Cugat R, Ares O, et al. Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life. Arch Orthop Trauma Surg. 2011 Mar;131(3):311-7. Epub 2010 Aug 17. 12 Injection of platelet-rich plasma in patients with primary and secondary knee osteoarthritis: a pilot study.Sampson S, Reed M, Silvers H, ey al. Injection of platelet-rich plasma in patients with primary and secondary knee osteoarthritis: a pilot study.Am J Phys Med Rehabil. 2010 Dec;89(12):961-9.1537-2290

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