Category Archives: Stem Cell Clinic

Clinical trial of stem cell therapy for traumatic spinal …

April 27, 2018

Mayo Clinic is enrolling patients in a phase 1 clinical trial of adipose stem cell treatment for spinal cord injury caused by trauma. The researchers already have approval from the Food and Drug Administration for subsequent phase 2A and 2B randomized control crossover trials.

Participants in the phase 1 clinical trial must have experienced a trauma-related spinal cord injury from two weeks to one year prior to enrollment. They will receive intrathecal injections of adipose-derived mesenchymal stem cells. No surgery or implantable medical device is required.

"That is the most encouraging part of this study," says Mohamad Bydon, M.D., a consultant in Neurosurgery specializing in spinal surgery at Mayo Clinic in Rochester, Minnesota, and the study's director. "Intrathecal injection is a well-tolerated and common procedure. Stem cells can be delivered with an implantable device, but that would require surgery for implantation and additional surgeries to maintain the device. If intrathecal treatment is successful, it could impact patients' lives without having them undergo additional surgery or maintain permanently implantable devices for the rest of their lives."

To qualify for the trial, patients must have a spinal cord injury of grade A or B on the American Spinal Injury Association (ASIA) Impairment Scale. After evaluation at Mayo Clinic, eligible patients who enroll will have adipose tissue extracted from their abdomens or thighs. The tissue will be processed in the Human Cellular Therapies Laboratories, which are co-directed by Allan B. Dietz, Ph.D., to isolate and expand stem cells.

Four to six weeks after the tissue extraction, patients will return to Mayo Clinic for intrathecal injection of the stem cells. The trial participants will then be evaluated periodically for 96 weeks.

Mayo Clinic has already demonstrated the safety of intrathecal autologous adipose-derived stem cells for neurodegenerative disease. In a previous phase 1 clinical trial, with results published in the Nov. 22, 2016, issue of Neurology, Mayo Clinic researchers found that therapy was safe for people with amyotrophic lateral sclerosis (ALS). The therapy, developed in the Regenerative Neurobiology Laboratory under the direction of Anthony J. Windebank, M.D., is moving into phase 2 clinical trials.

Dr. Windebank is also involved in the new clinical trial for people with traumatic spinal cord injuries. "We have demonstrated that stem cell therapy is safe in people with ALS. That allows us to study this novel therapy in a different population of patients," he says. "Spinal cord injury is devastating, and it generally affects people in their 20s or 30s. We hope eventually that this novel therapy will reduce inflammation and also promote some regeneration of nerve fibers in the spinal cord to improve function."

Mayo Clinic's extensive experience with stem cell research provides important guidance for the new trial. "We know from prior studies that stem cell treatment can be effective in aiding with regeneration after spinal cord injury, but many questions remain unanswered," Dr. Bydon says. "Timing of treatment, frequency of treatment, mode of delivery, and number and type of stem cells are all open questions. Our hope is that this study can help answer some of these questions."

In addition to experience, Mayo Clinic brings to this clinical trial the strength of its multidisciplinary focus. The principal investigator, Wenchun Qu, M.D., M.S., Ph.D., is a consultant in Physical Medicine and Rehabilitation at Mayo Clinic's Minnesota campus, as is another of the trial's investigators, Ronald K. Reeves, M.D. Dr. Dietz, the study's sponsor, is a transfusion medicine specialist. Also involved is Nicolas N. Madigan, M.B., B.Ch., BAO, Ph.D., a consultant in Neurology at Mayo Clinic's Minnesota campus.

The study team is in discussions with U.S. military medical centers to enroll patients, and discussing additional collaboration with international sites, potentially in Israel or Europe, for future phases of the study.

"At Mayo Clinic, we have a high-volume, patient-centered multidisciplinary practice," Dr. Bydon says. "That allows us to do the most rigorous scientific trial that is in the best interests of our patients."

Mayo Clinic. Adipose Stem Cells for Traumatic Spinal Cord Injury (CELLTOP). ClinicalTrials.gov.

Staff NP, et al. Safety of intrathecal autologous adipose-derived mesenchymal stromal cells in patients with ALS. Neurology. 2016;87:2230.

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Autologous stem cell transplant – Type – Mayo Clinic

Autologous stem cell transplant

An autologous stem cell transplant uses healthy blood stem cells from your own body to replace your diseased or damaged bone marrow. An autologous stem cell transplant is also called an autologous bone marrow transplant.

Using cells from your own body during your stem cell transplant offers some advantages over stem cells from a donor. For example, you won't need to worry about incompatibility between the donor's cells and your own cells if you have an autologous stem cell transplant.

An autologous stem cell transplant might be an option if your body is producing enough healthy bone marrow cells. Those cells can be collected, frozen and stored for later use.

Autologous stem cell transplants are typically used in people who need to undergo high doses of chemotherapy and radiation to cure their diseases. These treatments are likely to damage the bone marrow. An autologous stem cell transplant helps to replace the damaged bone marrow.

An autologous stem cell transplant is most often used to treat:

Undergoing an autologous stem cell transplant involves:

Filtering stem cells from your blood (apheresis). In order to collect your stem cells, a needle is inserted into a vein in your arm to draw out your blood. A machine filters out the stem cells and the rest of your blood is returned to your body.

A preservative is added to your stem cells and then they're frozen and stored for later use.

Undergoing high doses of cancer treatment (conditioning). During the conditioning process, you'll receive high doses of chemotherapy or radiation therapy or sometimes both treatments to kill your cancer cells. What treatment you undergo depends on your disease and your particular situation.

The cancer treatments used during the conditioning process carry a risk of side effects. Talk with your doctor about what you can expect from your treatment.

After your autologous stem cell transplant, you'll remain under close medical care. You'll meet with your care team frequently to watch for side effects and to monitor your body's response to the transplant.

Jan. 24, 2019

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Stem cell therapy for hip | Mayo Clinic Connect

@kdukes52, there are several discussions about stem cell therapy in the Bones, Joints & Muscles group. Here are a few you may wish to review:

Stem Cell Therapy for Rotator Cuff Tears https://connect.mayoclinic.org/discussion/stem-cell-therapy-for-rotator-cuff-tears/ Stem Cell Therapy for Arthritic Knees https://connect.mayoclinic.org/discussion/stem-cell-therapy-for-arthritic-knees/ Has anyone used PRP or Stem Cell Therapy to fix cervical discs https://connect.mayoclinic.org/discussion/has-anyone-used-prp-or-stem-cell-therapy-to-fix-cervical-discs/

While these discussions are not specific to regenerative medicine for the hip, I think you'll find a lot of relevant and related information. I'm also tagging fellow members @gailb @cobweb and @winning to join this discussion.

It is so important to do your homework and due diligence when researching new treatment options. Stem cells offer a lot of hope. But where these is hope, there is hype and charlatans as this FDA warning illustrates: FDA acts to remove unproven, potentially harmful treatment used in stem cell centers targeting vulnerable patients https://www.fda.gov/newsevents/newsroom/pressannouncements/ucm573427.htm

You can read more about stem cells on the FDAs website here: https://www.fda.gov/AboutFDA/Transparency/Basics/ucm194655.htm

Another service I encourage you to take advantage of is Mayo Clinics Regenerative Medicine free Consult Service. If you call them, you will talk to a live person who will provide more information, research, and advice on seeking stem cell therapy from reputable providers, even if that provider is not Mayo Clinic. Their primary goal is to educate and help you find effective treatment.

Furthermore, you can add your name to a database to be notified when additional studies and information become available. Heres more information about the stem cell Consult Service http://www.mayo.edu/research/centers-programs/center-regenerative-medicine/patient-care/clinical-services/regenerative-medicine-consult-service. Or simply call 1-844-276-2003 to speak with one of our experts.

Phew, that's a long-winded response to your simple question Kdukes. Are you considering a hip replacement?

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Stem cell therapy for hip | Mayo Clinic Connect

Next Generation Stem Cell – Professional medical clinic

Questions & Facts

Questions to Ask and Facts to Know

About Stem Cell Before Deciding on Treatment.

Time is of the essence! The longer you wait to treat your condition, the more it will worsen.

Call321-877-1855 to make an appointment with Dr. Kobobel TODAY to start your journey to a stronger, healthier, happier you!

Dr. KobobelPublic Advocacy For Stem Cells. Living with Pain? Listen to Our Patients. Learn about STEM CELL treatments at the SEMINAR. Explore Your Treatment Options. Research shows that your own body produces the cells it needs to regenerate, repair & restore damaged or missing tissue.

Osteoarthritis is caused by the degeneration of the cartilage of the joints. There have been a range of treatments including diet and exercise, rest, joint care, various long term medications and in more serious cases, complete joint replacement. Now in many cases osteoarthritis can be reversed with regenerative medicine.

COPD clinical studies are being evaluated to determine stem cells role in improving COPD complications to perhaps help patients who do not respond to conventional drug treatment.

Diseases such as Multiple Sclerosis, Lupus, Chrohns, Type 1 Diabetes, Rheumatoid Arthritis, Alopecia Areata, Autoimmue Hepatitis, Celiac, Graves Disease, Hashimotos Disease, Psoriasis can now be treated with stem cell regenerative medicine.

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Next Generation Stem Cell - Professional medical clinic

N.Y. Attorney General Sues Manhattan Stem Cell Clinic …

Defendants claim that they can treat a variety of serious medical conditions, including but not limited to, urologic diseases and erectile dysfunction, neurology diseases, cardiac/pulmonary disease, autoimmune diseases, and orthopedic conditions, even through there is currently no adequate scientific substantiation that these treatments will be effective; in fact, they could be harmful, according to the lawsuit.

On its website, the clinic promotes what it describes as personal cell therapy to use your own cells to start or enhance your own healing process. The site goes on to promise you will lead a life that is more meaningful and pain-free with services that will change your life and lifestyle.

It lists what it claims is scientific literature suggesting these cells may represent a medical breakthrough in the treatment of many chronic medical conditions.

Patients would pay $3,995 or more for a stem cell procedure, according to the lawsuit. Many people thought they were part of a patient-funded research study, and regulators accused the clinic of giving patients the false impression that the treatments were part of a study approved by the F.D.A.

The clinic emphasized its research, including a long list of reference articles and studies, according to the lawsuit. Such claims overstate the scientific legitimacy of the clinics treatments, the regulators said.

Regulators also say Dr. Singer is operating a GoFundMe fund-raising campaign to perform stem cell treatments for free. Not only chronic pain, but other ailments such as post traumatic brain syndrome, autoimmune diseases, orthopedic injuries and other ailments can be helped by this amazing procedure, the campaign promises. So far, Dr. Singer appears not to have raised any money.

Since being contacted by state regulators, the clinic has revised its website and added numerous disclaimers, but state officials say consumers had a net impression that stem cells were an effective treatment for these various conditions. The website also appears to have been further changed to solely emphasize orthopedic conditions like arthritis or joint disease.

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N.Y. Attorney General Sues Manhattan Stem Cell Clinic ...

ThriveMD | Colorado’s Experts in Stem Cells & Regenerative …

Zvezdomir Zamfirov

03:55 14 Nov 16

I am a pain management physician myself. I am 52, and physically very active. I still play soccer competitively. Six months ago I suffered a hip injury with a labrum tear. Due to the pre-existing wear and tear, the only conventional treatment, which was offered to me was total hip replacement. I wanted to remain physically active and continue to play sports, so I decided that this is not the best option for me. I choose instead to try stem-cell therapy. Ten days ago I had my procedure done by Dr. Brandt, and since then I have nothing but positive things to say about him and his practice. Everyone in his office was extremely welcoming and put me at ease and comfort about my procedure. The procedure went very smooth. And I did not have ANY post procedure pain or discomfort. I had no need for any pain medication. I was back to work seeing patients on the 2nd day after the procedure. My hip already feels noticeably better. I have the second procedure scheduled in four weeks, and I am confident that in another 3-4 weeks I'll be back playing soccer again. Thank you, Dr. Brandt and team for taking such excellent care of me.

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ThriveMD | Colorado's Experts in Stem Cells & Regenerative ...

Top Rated Stem Cell Therapy Clinic in Denver & Vail …

Do you have an idea of the natural healing potential that is available in your body?

Read on to find out where your body stores these powerful stem cells.

Adult stem cells are found in the highest concentration in adipose (fat) tissue. In smaller concentrations, they are additionally found in your bone marrow. Beyond what is used for harvesting, stem cells are also found in blood, skin, muscles, and organs.

Adipose tissue provides the largest volume of adult stem cells (1,000 to 2,000 times the number of cells per volume found in bone marrow). Bone marrow provides some stem cells but more importantly provides a large volume of growth factors to aid in the repair process. In addition to adult stem cells, fat tissue also contains numerous other regenerative cells that are important to the healing process.

Stem cells derived from adipose fat tissue have been shown to be a much better source for the repair of cartilage degeneration and recent studies have demonstrated its superior ability to differentiate into cartilage.

There are some myths and misconceptions about stem cells and where the cells come from. Dr. Brandt has dedicated a blog post to the important topic.

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Top Rated Stem Cell Therapy Clinic in Denver & Vail ...

South Florida Stem Cell Center | Regenerative Therapy Clinic

Cardiac-Pulmonary Conditions

Led by Melvin M. Propis, M.D., South Florida Stem Cell Center is one of theleading Stem Cell Regenerative Therapy Clinics in South Florida. Dr. Propis is a seasoned M.D. and surgeon who has had solid success rates.

Stem Cell Regenerative Therapy is a breakthrough in medical science that treats and prevents conditions and diseases using stem cells. This is accomplished by harvesting cells and then concentrating those cells in a lab before precisely re-injecting them. This greatly increases your bodys own natural repair cells and promotes healing.

South Florida Stem Cell Center is made up of research scientists and experts in Stem Cell Therapy.Our passion and belief is that our treatments truly helpthose that are suffering and need our help.

I injured both of my knees. After confirming that the cartilage was still in the joint, Dr. Propis injected my knees with a mixture of stem cells and PRP 4 months ago. Today I walk comfortably, No pain in those joints. I have noticed significant improvement in my balance and no longer need a walker or narcotics for pain.

I have had Crohns disease for most of my short life which has led me to miss out on many teenage activities. After seeing other patients improve from having stem cells injected, I (and my mother) decided to try it. It was a wonderful thing to gradually be able to discontinue giving myself Humara shots routinely. I can actually have an active social life without worrying and even married the love of my life last year. Thanking my doctor, mom, God, and the many people who believe in stem cells for my happy ending!

I flew to the US in hopes of getting help for my diabetes. Having tried medicine & diets with no results, I was ready to try stem cells. After 1 treatment (and a six month period) I am off all meds and not considered diabetic anymore. To me, life changing! Especially after a relatively simple procedure. Thank you to the office of Dr. Propis and staff.

A chronic inflammatory bowel disease that affects the lining of the digestive tract.

Widespread muscle pain and tenderness.

A chronic inflammatory disorder affecting many joints, including those in the hands and feet.

An inflammatory disease caused when the immune system attacks its own tissues.

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A congenital disorder of movement, muscle tone, or posture.

Damage to the brain from interruption of its blood supply.

A progressive disease that destroys memory and other important mental functions.

A disease in which the immune system eats away at the protective covering of nerves.

A disorder of the central nervous system that affects movement, often including tremors.

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Damage to any part of the spinal cord or nerves at the end of the spinal canal.

A chronic condition that affects the way the body processes blood sugar (glucose).

Kidney Failure (Renal Failure)

A condition in which the kidneys lose the ability to remove waste and balance fluids.

A type of arthritis that occurs when flexible tissue at the ends of bones wears down.

Occurs when a man can't get or keep an erection firm enough for sexual intercourse.

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Mayo Clinic Q and A: Stem cell therapy for arthritis …

DEAR MAYO CLINIC: Whats the latest information on using stem cell therapy to treat an arthritic shoulder that causes excessive pain?

ANSWER: New efforts in regenerative medicine, including stem cell therapy, could dramatically affect orthopedic surgery over the coming years. Much of this hope is pinned on using stem cells to treat degenerative conditions such as shoulder arthritis. Although it shows promise, stem cell treatment for arthritis isnt widely available at this time, as its still being researched.

Stem cells are the basic building blocks of all human tissue. Stem cells hold potential as treatment, in part, because they can communicate valuable information about tissue growth and healing to other cells in the body. Arthritis involves joint degeneration due to loss of the cartilage that cushions bones. Recently researchers have begun to look to stem cells for orthopedic conditions such as shoulder arthritis. Progress using stem cells to treat arthritis already has been reported, with the ultimate goal of using stem cells to regrow cartilage.

When discussing stem cell therapy, its important to understand that pure stem cells are not currently available to U.S. patients outside of a clinical research study. A handful of clinical research trials, monitored by the U.S. Food and Drug Administration (FDA), are ongoing at this time to study stem cell treatment for arthritis. The early findings from these trials are encouraging.

Unfortunately, the excitement surrounding emerging stem cell therapy has led some patients and health care providers to overlook the lack of scientific evidence to support its use at this time. Stem cell therapies currently used outside clinical studies do not contain pure stem cells. Instead, they are a mix of a variety of cells, of which only a very small percentage are stem cells. It is possible that many of these treatments do not contain enough stem cells to help.

It is also important to recognize that many stem cell therapies now marketed directly to patients are conducted without the required biologics license from the FDA. Also, some forms of mislabeled stem cell therapies do not contain any living stem cells. Such practices are cause for concern, as these treatments can mislead patients and the public, and delay the scientific progress needed to turn stem cell therapies into cures.

What the research into stem cells and arthritis shows is that there are opportunities for stem cell treatment to be used as injection therapy alone and in addition to orthopedic surgical procedures. Successful stem cell therapies thus far have resulted mostly in pain relief and improvement in function or quality of life. Only a few limited early studies have demonstrated improvement in new cartilage or bone formation needed to cure arthritis. Exactly how that cartilage regrowth occurs, or even how pain relief is achieved, is still unknown. That means if you have a stem cell procedure, it will be used to treat the symptoms of arthritis only. The ability to cure the disease entirely is not yet available.

No major research studies have specifically investigated stem cell treatment for shoulder arthritis. Much of what is known about stem cells in arthritis comes from research into knee degeneration. Its not known if the successes treating knee arthritis will prove to be similarly beneficial when used for the shoulder. Therefore, current recommendations to treat shoulder arthritis remain the judicious use of gentle pain relievers, exercise and occasional steroid injections. In severe cases, shoulder replacement can provide long-lasting pain relief.

With demonstrable safety and mounting evidence of the effectiveness of stem cell therapy for some orthopedic conditions, potentially all orthopedic disease could be treated with stem cell therapy in the future. But, first, doctors and patients will have to wait until the scientific evidence catches up to the excitement around this promising option. Dr. Shane Shapiro, Orthopedic Surgery and Center for Regenerative Medicine, Mayo Clinic, Jacksonville, Florida

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Mayo Clinic Q and A: Stem cell therapy for arthritis ...

COPD and stem cell treatment | Mayo Clinic Connect

I have been trying to find some actual people who have tried any of the Stem Cell treatments being offered. Especially interested in the Cellular Therapy being offered at many clinics in the USA. Not knowing who or what to believe is very difficult. I have also heard that Aloe Vera is an effective treatment that can help immensely I don't know how much of this is true either. I am on oxygen therapy 24/7 and my nose runs so much that I am desperate. I have tried Saline Solution, Sesame seed oil, Aloe Vera from the plant inside my nose. I have a humidity container on my oxygen consentrator and also a humidifier in my bedroom. I have been trying to take off the oxygen for an hour or so every few hours but my oxygen gets low and I go into A-fib. Nothing has worked to stop my runny nose. It truly makes me want to just give up. I am also in remission for stage 3B lung cancer since August 2018.

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Hi @justapril, I moved your message to this existing discussion about COPD and stem cell therapy in the Lung Health group. I recommend reading through the past messages in this discussion as well as these:

Stem Cells / Regeneration https://connect.mayoclinic.org/discussion/stem-cells-regeneration/

Regenerative medicine for COPD is still in the research phase. Do use caution about promises made by some clinics.

To help people learn more about the proven therapies and the promise of developing therapies, Mayo Clinic offers a free telephone consult service. When you call the consult service, they will tell you about the availability of approved stem cell therapy at Mayo Clinic and elsewhere, and for what conditions. You can learn more about the Consult Service here http://www.mayo.edu/research/centers-programs/center-regenerative-medicine/patient-care/clinical-services/regenerative-medicine-consult-service. Or call 1-844-276-2003 to speak with one of our experts.

@justapril you may also wish to join the Lung Cancer group here: https://connect.mayoclinic.org/group/lung-cancer/

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COPD and stem cell treatment | Mayo Clinic Connect