Category Archives: Platelet Rich Plasma Injections

Vampire Facial 2021: My Before and After Pics of PRP Microneedling – Cosmopolitan

Listen, I'm not one to be ~easily influenced~ into trying something just because a celebrity or influencer posts about it. ...Well, okay, except for that one time I tried the viral Hanacure face mask. Or, fine, that other time I ordered Curology (but it really works! Sue me!). Or, ugh, that time I triedand surprisingly lovedsoap brows. But! I can say that I did hold out on trying one incredibly popular trend for years: PRP microneedlingaka the vampire facial. Yup, despite the fact that Kim Kardashian posted a viral selfie of her own vampire facial in 2013, I saw that bloodied towel next to her and decided I'd sit that trend out.

But it's been eight years, and the popularity of vampire facials has yet to die downand for good reason: They're said to help boost collagen production (for tighter, smoother, newer-looking skin) and improve everything from hyperpigmentation to acne scars, so I decided it might be one worth finally trying it for myself and paid a visit to board-certified dermatologist Jordan Carqueville, MD. Never say never, kids. Below, a breakdown of the bloody beauty treatment and a review of my experience trying it for the first time.

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To put it simply, a vampire facial stimulates collagen production in your skin through a combination of microneedling with platelet-rich plasma (PRP). Stay with me. Microneedling, as you probably already know, is a treatment that involves poking your skin with itty-bitty needles to create "micro-injuries." Sounds barbaric, but these little injuries actually trigger your body's wound-healing process to encourage new collagen production (aka the essence of good skin).

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The only difference with a vampire facial is instead of puncturing your skin with bare needles (like with microneedling), it's punctured with your own blood platelets. Yup. Basically, some blood is drawn from your arm, then spun with a centrifuge to separate the plasma and platelets that contain your own growth factorsi.e., platelet-rich plasma (PRP). That PRP is then "microneedled" into the skin and applied on top of the micro-wounds to help stimulate your collagen even more.

It all sounds incredibly ~extra~, but vampire facials (or PRP microneedling, if we're being specific) can help boost collagen production, brighten your overall skin tone, get rid of minor acne scars, fade hyperpigmentation, and tighten your skin.

A vampire facial is microneedlingbut better. Microneedling works great to stimulate collagen on its own, but Dr. Carqueville says that PRP serves as one of the best ways to really boost your collagen by using those concentrated platelets and growth factors in addition to the basic microneedling.

After you heal (which can take up to a week), your skin will look and feel brighter, dewier, more supple, and refreshedbut don't expect those results overnight. Immediately after my treatment, my face was comically red and flushed, and it only softened to a bright-pink (!) for the rest of the day. It also felt tight, tender, and dry, like I'd been swimming in the salty ocean aaaand also got a sunburn. By the next morning, I felt totally normal again, and the redness had significantly improved, but I still had lil red splotches all over my face that took a few days to fade.

According to Dr. Carqueville, how long a vampire facial takes to heal depends on the needle length and the amount of pressure applied. With the stronger treatments, the healing period could last five to seven days, and for a light refresher, two to three days. Since I was in the hands of a physician I trusted, I felt comfortable with a stronger, more aggressive treatment in hopes that I would see some serious results even faster. So needless to say, my face needed the maximum amount of time to heal: one full week.

After your skin heals, you can expect to have a nice, dewy glow for a few weeks, but know that your results will just get better with time. Basically, a vampire facial is an investment toward your future skinit's not an immediate fix. "Collagen stimulation, that tightening and remodeling of your collagen, happens over the course of six months to a year after a procedure like this," Dr. Carqueville explains. I mean, you're quite literally tricking your body into speeding up its natural regenerative process, and that's gonna take some time.

With vampire facials or PRP microneedling, a light refresher once a quarter or even once a year might be enough for someone younger without major acne scarring. But if you're trying to treat deeper acne scars, you might need a series of three sessions spaced four to six weeks apart. "Theres no right or wrong answer, but generally, the cumulative results will be more noticeable with the more treatments you get," Dr. Carqueville says. Your dermatologist will be able to tell you during your consultation how many treatments they think you'll need, so don't stress.

The first few days after your treatment, keep it simple. You've just created wounds that need to heal, so any harsh ingredients like exfoliating acids are a definite no. For the first 48 hours, Dr. Carqueville recommends sticking with just a hyaluronic acid serum and a thin layer of Vaseline on top if your skin feels a little dry. Or, try a bland, basic, fragrance-free moisturizer, and keep your skin makeup free.

If improving pigment (like melasma) is the goal, Dr. Carqueville likes incorporating a dark-spot-correcting cream after a couple of days of initial healing (around 48 to 72 hours after) while it still can penetrate really well. "When you do microneedling, you open up your skin channels to better absorb topical medications," says Dr. Carqueville. "It does help the skin become more amenable to absorbing those active ingredients."

The number-one thing you should not do? Go out in the sun. Dr. Carqueville explains that because vampire facials compromise the top layer of your skin, you dont have as much protection from the sun, so you need to be really cautious. Avoid exposure the best you can during the initial healing period, then use lots of sunscreen and wear all the sun protection gear to keep your skin safe.

The price depends largely upon where you're receiving the treatment, but microneedling alone costs at least $200, on the very low end, and once you throw in the PRP (e.g., the blood draw, centrifuge, etc.), that price will increase to the $1,000-$2,000 range. It's not cheap, but do you really want to bargain shop when you're getting blood drawn and needles stuck in your face? No, no you do not.

On a scale from one to Brazilian bikini wax, Id rate the pain a five. I was numbed up, both with a topical numbing cream and lidocaine injections (honestly, the shots were the worst part), but I still felt the whole treatment and can't imagine going through it if I had full sensation of my face. Basically, numbing is mandatory. All in all, after waiting 45 minutes for the numbing cream to set in, the process was quick, so any pain or discomfort was temporary.

I wish I could look at you in your eyes when saying this because it's *that* important: No, you should not try to DIY a vampire facial at home. Considering all the numbing beforehand and, ya know, the whole drawing and spinning of your blood, this treatment can only be performed by a trained, experienced provider, or ideally, a physician.

Dermarolling, on the other hand, is a treatment much milder than a vampire facial that can be accomplished at home (sans blood) with a needle-covered roller. It doesn't penetrate as deeply (or involve any PRP for that matter), so it isn't nearly as effective as a vampire facial or even in-office microneedling, but as long as you adjust your expectations (and as long as your dermatologist gives you the OK), dermarolling is a much more affordable and accessible treatment.

Ora Microneedle Face Roller System

StackedSkincare Micro-Roller .2mm

BeautyBio GloPRO Microneedling Regeneration Tool

Jenny Patinkin Rose on Rose Derma Roller

Despite the gory nickname and photos, a vampire facial is actually great for your skin. Dr. Carqueville says the side effects of a vampire facial are usually low, as long as it's performed by a physician or experienced provider who's knowledgeable in PRP treatments. Still, as with anything that disrupts the skin barrier, theres always a risk of infection, bruising, redness, swelling, and tenderness, she says. Scarring, hyperpigmentation, and hypo-pigmentation are also risks and can be exacerbated with sun exposure, so here is your second reminder to slather on that sunscreen.

Expensive? Yes. Painful? If you weren't numbed up, probably. Worth it? Absolutely, IMO. Unlike other pricey skin treatments, like chemical peels, you actually get long-term benefits out of a vampire facial by stimulating that collagen in your dermis. It's only been a handful of days since my treatment, so I'm still waiting on my long-term results (and for my face to heal completely, TBH), but I already see improvements and would definitely recommend it to friends.

As long as you've got a week where no one's going to see your face (and you don't have a fear of needles, because there are a lot of those involved), I'd say it's worth all the blood, sweat, and internal tears over my bank account.

I Got a Microcurrent Facial, Now My Skin Is Amaze

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Vampire Facial 2021: My Before and After Pics of PRP Microneedling - Cosmopolitan

Treatment of Keloids Using PSR Combined with Radiation. | CCID – Dove Medical Press


Keloids, a type of histologically localized dermal inflammation, are the result of an aberrant healing process featuring abnormal proliferation of fibrous tissue and chronic inflammation after skin injuries reach the reticular dermis.1 Due to the excessive amounts of collagen and glycoprotein accumulating in the dermis, keloids progress and enlarge by growing beyond the boundaries of the original wounds, which distinguishes them from hypertrophic scars. The affected skin usually stiffens and gets pruritic, with various color ranges from pink to dark brown.

The current mainstays of treating hypertrophic scars and keloids remain nonstandard with multiple modalities involved, including surgical excision, intralesional steroids, silicone gel, pressure therapy and laser therapy. Surgical excision alone has been proved to result in high recurrence rate because of post-traumatic collagen synthesis stimulation, while subtotal excision with lateral undermining might possibly improve outcome.2 In recent years, several studies reported low recurrence rate by following surgical excision with other modalities, usually radiation therapy or intralesional steroids injection.3,4 Silicone gel, often used as adjuvant treatment after surgery or laser, has also been reported by some studies to be effective in reducing recurrence rate.5 Laser therapy includes a series of treatment modalities including neodymium-doped yttrium aluminium garnet (Nd:YAG) laser, carbon dioxide laser and diode laser.68 Though laser treatment alone had less effectiveness on keloid than hypertrophic scar with high recurrence rate, a combination of laser and other single-application treatments such as silicone gel, and intralesional steroid injections were proven to be an effective and safe therapeutic approach.8

In recent years, a novel device, plasma skin regeneration system (PSR) is applied to treat mesh skin-grafted scars and traumatic scars.9 Unlike laser therapy which directly applies radio frequency to skin, PSR uses radio frequency to convert nitrogen to plasma, a high-energy state of matter that is emitted at 515 millisecond pulses to deliver 14 J of energy.9 Plasma then conveys energy to the wounded skin and causes a thermal effect that gasifies proliferative fibrous tissue in the dermis. The effect on skin rejuvenation depends on the amount of plasma energy delivered. Thus, it enables operators to adopt various energy levels and different number of treatments to different wound types and locations.

In this study, the authors innovatively removed keloids with PSR. Given that single treatment may result in high recurrence rate, the authors administrated adjuvant radiotherapy. Radiation therapy has been illustrated to be effective in the control of keloid recurrence by inducing keloid fibroblast apoptosis and destroying collagen structure.2,10 The aim of this study is to evaluate the effectiveness and safety of PSR combined with radiation therapy in the treatment of keloids on different body parts.

This study was conducted in accordance with the Declaration of Helsinki. Ethical approval was obtained from the ethics committee of Peking Union Medical College Hospital. Patient data confidentiality was maintained in accordance with the regulations. Written informed consent was waived in light of the retrospective nature of this study. A total of 71 consecutive patients (aged 1569) with 98 dermal lesions clinically diagnosed as keloids were enrolled in this uncontrolled prospective study, with stipulated selection criteria. The skin types of enrolled patients were type III or IV. The over-extensive growth pattern unconfined to the original wound edges was required as a clinical distinction of keloids from hypertrophic scars.

Patients were excluded from this study if they had previously undergone at least one of the following treatments within the last six months: surgical excision, free-flap grafting, carbon dioxide resurfacing, triamcinolone intralesional injection, silicone gel sheeting, and pressure therapy. Pregnant and lactating patients and those with systemic comorbidities including cardiovascular diseases, diabetes mellitus, and chronic renal failure were also excluded to avoid unnecessary potential risks.

A clinical evaluation process was developed primarily based on the number, thickness, and texture of the lesions (Figure 1). Each patient admitted for the treatment of keloids underwent this evaluation process. PSR was mainly applied for progressive keloids with multiple lesions. Ideal lesions were no thicker than 4 mm. Patients whose keloids were thicker than 10 mm were recommended not to receive this treatment, because thick lesions needed high level of energy and too much energy would cause severe side effects. For lesions 4 to 10mm thick or those much stiffer than usual, we administered intralesional injections of betamethasone (Diprospan) to soften the lesions before PSR.

Figure 1 Clinical evaluation and treatment process for keloids.

Plasma was administrated to qualified keloid lesions right after subdermal injection of 0.5% lidocaine (540mL, depending on the size of lesion), which spared patients from pain when receiving PSR treatment. Doctors resurfaced the lesions using PSR, making them as flat as the surrounding skin. The patients were asked to cover the lesion with topical antibacterial spray to prevent potential topical infection. External beam irradiation was administered with a total dose of 18 Gy in two fractions, one week apart. Specifically, the first radiation therapy was performed within 24 hours after treatment, and the second was performed 1 week later. The minimum follow-up period was 12 months.

Digital photographs were taken to record the morphological characteristics of the keloids before treatment, immediately after treatment and at the end of follow-up. The patient and observer scar assessment scale (POSAS) was used to evaluate the effect of PSR.11 Both patients and observers were asked to fill in the numeric scale before treatment and 12 months posttreatment. To avoid bias, the POSAS observer study was performed independently by an experienced plastic surgeon who was not involved in the treatment.

Means and standard deviations were calculated for each variable. The Students t-test was performed using SPSS 23.0 (IBM, New York, USA) to analyze and summarize all the original data. P values of <0.05 were considered statistically significant.

A total of 71 patients (32 males and 39 females) were enrolled in our study. The demographics are summarized in Table 1. Twenty-nine patients were self-reported to have clear incentive such as acne, trauma, and surgical incision. Moreover, 33 patients reported familial inheritance. The 98 lesions were distributed as follows: 23 lesions (23.5%) on face and neck, 26 (26.5%) on chest, 16 (16.3%) on shoulders, 16 (16.3%) on the back and 17 (17.3%) on limbs. The average lesion size was 5.030.72 cm. The average re-epithelization duration was 33.7810.46 days.

Table 1 Patient Demographics

According to the patients (Table 2), POSAS scoring showed a significant improvement in the 98 keloids, with the mean score decreasing from 35.059.94 before treatment to 21.847.04 (p value <0.05). The mean score of keloids on the face and neck dropped significantly from 36.4310.60 to 20.006.62 (p value <0.05), with an improvement over 40%. The mean score of keloids on chest and back also decreased from 41.0810.29 and 29.564.16 to 24.157.82 (p value <0.05) and 18.195.31 (p value <0.05), respectively. However, improvement of keloids on shoulders and limbs was limited though still statistically significant. Table 3 demonstrates the six items that were evaluated by each patient. Comprehensive improvements were made on all items. Amelioration on pain and itchiness was over 50%.

Table 2 Total Patient-Reported Scores of Keloids on Different Body Parts Before and After Treatment

Table 3 Results of POSAS According to Patients

The results from the independent observer (Table 4) and the patients were consistent. The mean score of all 98 keloids dropped from 37.598.17 to 23.477.53 (p value <0.05). Keloids on face and neck, chest and back responded better to the treatment than those on shoulders and limbs. The observer score of six items is shown in Table 5. All items were significantly improved. Pigmentation (the extent of improvement in color) and relief (the extent of improvement in irregularities) were not improved remarkably as compared to the other four items, which corresponded with the results from the patient score. Figures 2Figures 3Figures 4Figures 5 showed keloids on different locations before and after treatment.

Table 4 Total Observer-Reported Scores of Keloids on Different Body Parts Before and After Treatment

Table 5 Results of POSAS According to Observer

Figure 2 A patient with multiple lesions of keloids on his face prior to treatment (A) and 1 year after PSR treatment with 2 radiation therapy thereafter (B). No recurrence was found.

Figure 3 A patient with multiple lesions of keloids on his chest prior to treatment (A) and 1 year after PSR treatment with 2 radiation therapy thereafter (B). No recurrence was found.

Figure 4 A patient with multiple lesions of keloids on her shoulder prior to treatment (A) and 1 year after PSR treatment with 2 radiation therapy thereafter (B). No recurrence was found.

Figure 5 A patient with multiple lesions of keloids on her arm prior to treatment (A) and 1 year after PSR treatment with 2 radiation therapy thereafter (B). No recurrence was found.

Adverse effects after radiation therapy are summarized in Table 6. Erythema and edema were common complications that occurred to almost all patients, but soon disappeared without special treatment. Local infection was reported by eight patients, and the type of infection was acne folliculitis. It was the main reason for which patients revisited our center in weeks after treatment. Late adverse effects included hyperpigmentation, hypopigmentation and radiation dermatitis. No case of carcinogenesis was reported. Complications of PSR were mild. Hyperpigmentation and hypopigmentation were complaints made by seven and five patients, respectively. During follow-up, 15 keloids (15.3%) were observed or reported to relapse. Recurrent lesions were further treated with dye laser or steroid injection.

Table 6 Summary of Adverse Effects

Keloid has long bothered clinicians and patients as there is no standard therapy that gains universally approval. Single treatment, either surgical excision or laser therapy, has been repeatedly proven to result in high recurrence rate.12 In the light of this, combination of keloid removal and adjuvant therapy has received much attention and increasingly more studies have shown its effectiveness with low recurrence rate.35 Adjuvant therapy includes a series of treatments that are administrated after surgical excision or laser therapy. Radiation therapy, steroid injection and silicone gel have all been reported to be effective adjuvant therapies. Park and Rah treated helical rim keloids with surgical excision plus silicone gel pressure therapy.13 The therapy protocol resulted in improvement on most items in the POSAS with recurrence-free rate of 95%. Garg et al evaluated the effect of CO2 laser ablation followed by steroid injection.14 Their study illustrated that CO2 laser alone was not efficient enough while adding steroid injection as adjuvant therapy could significantly reduce recurrence rate. Hersant et al reported a pilot study using platelet-rich plasma injection as adjuvant therapy to surgical excision.15 Vancouver Scar Scale score was reduced by more than 50% after 2-year follow-up though 29% of keloids relapsed. Considering that the keloids of interest did not respond to conventional therapies, it was a satisfactory result.

Multiple treatments of PSR have been proven to be clinically effective for traumatic scars, mesh skin-grafted scars, and wrinkles at an interval of 3 weeks to 1 month.9,16 In this study, we reported single-dose PSR treatment combined with radiotherapy as an effective management for keloids. The endpoint of PSR therapy was when the lesions were almost as flat as the surrounding normal skin although red in color. More energy was applied for thicker lesions. An intralesional injection of the compound betamethasone was administered before PSR for thick lesions (thickness >4 mm) to avoid excessive plasma irradiation that could cause serious side effects and longer recovery time. However, for keloids less thick than 4 mm, PSR was administered without the steroid injection.17 After PSR, a total of 18 Gy of radiation were administrated in two fractions, 24 hours posttreatment and again 1 week later. We regard adjuvant radiotherapy important in the prevention of recurrence. Numerous studies have shown surgery excision alone was followed by high recurrence rate, and that radiation therapy after keloid removal could significantly reduce recurrence rate to a desirable level.2,3 The mechanism of radiotherapeutic prevention remains unclear. One possible explanation is suggested to be the elimination of abnormally activated fibroblasts and stimulation of normal ones.18 Kal et al recommended biologically effective dose for keloid prevention should be 3040 Gy, which could be achieved by either a single fraction of 1315 Gy or 1720 Gy in 2 fractions.19 Furthermore, radiotherapy was advocated to be administrated immediately after keloid removal or within 2 days.20 We strictly complied with these suggestions in this study.

Plasma combined with radiation therapy results in good clinical outcome, though improvement varies on different body parts. Keloids on face and neck, chest and back were significantly improved after treatment according to both patients and observers. However, improvement of keloids on shoulders and limbs was limited. The frequent movement of these body parts results in high stretch tension that impedes collagen renewal and dermal remodeling. Though excessive proliferative fibrous tissue is removed, the rebuilding process of dermal architecture is relatively slower than that of lesions with less stretch tension.

In this study, complications are categorized by treatment area and duration. Complications after radiation therapy are considered adverse effects that occur within the radiation field beyond the lesion. Complications that limit to the lesion area are PSR-related. Acute adverse effects are defined as complications that disappeared within 4 weeks, while long-term adverse effects usually last longer than 1 month.

In terms of complications after radiation therapy, erythema and edema were reported by almost all patients in the first few days, but usually disappeared in 2 weeks without medication. In our follow-up, no patients resorted to medical treatment for long-lasting erythema or edema. Speranza et al confirmed that erythema was the most frequent acute side effect, but it had no association with patient satisfaction.21 Late complications reported by our patients include skin color change and chronic radiodermatitis. Permanent pigmentation and depigmentation are commonly reported to be a major late complication with incidence rate varying from 30% to 60% according to other studies.21,22 In this study, no case of necrosis or carcinogenesis was reported. Risk of radiation-induced tumor has been repeatedly proven to be very low.22 However, clinicians should always be cautious about the radiation energy in total when applying adjuvant radiotherapy. Sakamoto et al illustrated that relapse rate and adverse-effect were both dose-related.23 They recommended an optimal dose of 20 Gy in five fractions. We agreed that 18 Gy in 2 fractions is a nice balance between adverse effects and recurrence rate.

A few lesions developed hyperpigmentation or hypopigmentation limited to the area that received PSR treatment. These complications were considered PSR-related and had nothing to do with radiation therapy. Lesions with PSR-related complications were all thicker than 4mm before treatment. However, it should be mentioned that not every thick lesion developed these complications. We speculate that this is because intralesional injection of steroid is insufficient for some thick lesions. Thick lesions with insufficient steroid are not completely soften and thus require more energy to be flatten. The high energy level leads to adverse effects that do not develop at lower level of energy. In general, PSR should be considered a safe therapy with mild complications. An in vivo study showed that PSR could consistently achieve thermal injury into the papillary dermis resulting in collagen remodeling without permanent pigmentary or textural irregularities.24 Other studies also confirmed that PSR treatment caused less complications. According to Fosters study, no patient developed permanent hypopigmentation, a complication that is generally observed in 820% of CO2 resurfacing patients, although a very small proportion (4%) of patients reported transient hyperpigmentation, which should be treated with hydroquinone creams or combination creams containing a mild topical corticosteroid, retinoid, and hydroquinone.25 Fitzpatrick et al reported that the thermal damage by PSR for any energy level was at most equivalent to medium fluence of the carbon dioxide laser and that the damage was confined within 15 m depth, in contrast to 33.4 m thermal damage created by high fluence of the carbon dioxide laser.26

In fact, not many risk factors other than ancestry, early age and skin injuries are known about keloid. But even less is known about factors that could possibly affect long-term curative effect. For example, sexuality, age, familial inheritance, and lesion size are all possible to influence clinical improvement. This study indicates keloids on different body parts may respond differently to the combination therapy. In the future, other factors that affect clinical outcome should be further studied with keloid location as a control factor.

This study has some limitations. Firstly, this is an observational study that evaluates the effectiveness and safety of PSR with adjuvant radiation therapy, while it does not compare PSR with other common treatment modalities. Randomized controlled studies are necessary for further evaluation of PSR. Secondly, the observation period of this study is relatively short to evaluate long-term curative effect, as previous studies reported that the control rate of keloid decreased 5 or 10 years or more after treatment.27,28 Thirdly, this study used a standardized scale for the evaluation of therapeutic effects. It has been mentioned that scale evaluation is subjected to a number of human factors and that objective assessment tools should be advocated.29 Application of objective assessment tools such as laser speckle contrast imaging and three-dimensional imaging could yield quantitative and more robust results.30,31

Plasma Skin Regeneration combined with adjuvant radiation therapy should be regarded as a safe, low-risk, effective treatment for keloids. Steroid could be administrated for thick lesions before PSR to avoid excessive thermal effect that increases the rate of side effects.

The authors declare no conflicts of interest for this work.

1. Ogawa R. Keloid and hypertrophic scars are the result of chronic inflammation in the reticular dermis. Int J Mol Sci. 2017;18(3):606.

2. Al-Attar A, Mess S, Thomassen JM, Kauffman CL, Davison SP. Keloid pathogenesis and treatment. Plast Reconstr Surg. 2006;117(1):286300. doi:10.1097/01.prs.0000195073.73580.46

3. Jones ME, Ganzer CA, Bennett D, Finizio A. Surgical excision of keloids followed by in-office superficial radiation therapy: prospective study examining clinical outcomes. Plast Reconstr Surg Glob Open. 2019;7(5):e2212. doi:10.1097/GOX.0000000000002212

4. Chua SC, Gidaszewski B, Khajehei M. Efficacy of surgical excision and sub-dermal injection of triamcinolone acetonide for treatment of keloid scars after caesarean section: a single blind randomised controlled trial protocol. Trials. 2019;20(1):363. doi:10.1186/s13063-019-3465-6

5. Stromps JP, Dunda S, Eppstein RJ, Babic D, Har-Shai Y, Pallua N. Intralesional cryosurgery combined with topical silicone gel sheeting for the treatment of refractory keloids. Dermatol Surg. 2014;40(9):9961003. doi:10.1097/

6. Koike S, Akaishi S, Nagashima Y, Dohi T, Hyakusoku H, Ogawa R. Nd:YAG laser treatment for keloids and hypertrophic scars: an analysis of 102 cases. Plast Reconstr Surg Glob Open. 2014;2(12):e272. doi:10.1097/GOX.0000000000000231

7. Henderson DL, Cromwell TA, Mes LG. Argon and carbon dioxide laser treatment of hypertrophic and keloid scars. Lasers Surg Med. 1984;3(4):271277. doi:10.1002/lsm.1900030402

8. Li K, Nicoli F, Xi WJ, et al. The 1470 nm diode laser with an intralesional fiber device: a proposed solution for the treatment of inflamed and infected keloids. Burns Trauma. 2019;7:5. doi:10.1186/s41038-019-0143-6

9. Kono T, Groff WF, Sakurai H, Yamaki T, Soejima K, Nozaki M. Treatment of traumatic scars using plasma skin regeneration (PSR) system. Lasers Surg Med. 2009;41(2):128130. doi:10.1002/lsm.20723

10. Berman B, Maderal A, Raphael B. Keloids and hypertrophic scars: pathophysiology, classification, and treatment. Dermatol Surg. 2017;43(Suppl 1):S3S18. doi:10.1097/DSS.0000000000000819

11. Draaijers LJ, Tempelman FRH, Botman YAM, et al. The patient and observer scar assessment scale: a reliable and feasible tool for scar evaluation. Plast Reconstr Surg. 2004;113(7):19601965. doi:10.1097/01.PRS.0000122207.28773.56

12. Arno AI, Gauglitz GG, Barret JP, Jeschke MG. Up-to-date approach to manage keloids and hypertrophic scars: a useful guide. Burns. 2014;40(7):12551266. doi:10.1016/j.burns.2014.02.011

13. Park TH, Rah DK. Successful eradication of helical rim keloids with surgical excision followed by pressure therapy using a combination of magnets and silicone gel sheeting. Int Wound J. 2017;14(2):302306. doi:10.1111/iwj.12547

14. Garg GA, Sao PP, Khopkar US. Effect of carbon dioxide laser ablation followed by intralesional steroids on keloids. J Cutan Aesthet Surg. 2011;4(1):26. doi:10.4103/0974-2077.79176

15. Hersant B, SidAhmed-Mezi M, Picard F, et al. Efficacy of autologous platelet concentrates as adjuvant therapy to surgical excision in the treatment of keloid scars refractory to conventional treatments: a Pilot Prospective Study. Ann Plast Surg. 2018;81(2):170175. doi:10.1097/SAP.0000000000001448

16. Theppornpitak N, Udompataikul M, Chalermchai T, Ophaswongse S, Limtanyakul P. Nitrogen plasma skin regeneration for the treatment of mild-to-moderate periorbital wrinkles: a prospective, randomized, controlled evaluator-blinded trial. J Cosmet Dermatol. 2019;18(1):163168. doi:10.1111/jocd.12767

17. Park KY, Lee Y, Hong JY, Chung WS, Kim MN, Kim BJ. Vibration anesthesia for pain reduction during intralesional steroid injection for keloid treatment. Dermatol Surg. 2017;43(5):724727. doi:10.1097/DSS.0000000000001040

18. Stadelmann WK, Digenis AG, Tobin GR. Physiology and healing dynamics of chronic cutaneous wounds. Am J Surg. 1998;176:28S38S. doi:10.1016/S0002-9610(98)00183-4

19. Kal HB, Veen RE, Jurgenliemk-Schulz IM. Dose-effect relationships for recurrence of keloid and pterygium after surgery and radiotherapy. Int J Radiat Oncol Biol Phys. 2009;74(1):245251. doi:10.1016/j.ijrobp.2008.12.066

20. Bischof M, Krempien R, Debus J, Treiber M. Postoperative electron beam radiotherapy for keloids: objective findings and patient satisfaction in self-assessment. Int J Dermatol. 2007;46:971975. doi:10.1111/j.1365-4632.2007.03326.x

21. Speranza G, Sultanem K, Muanza T. Descriptive study of patients receiving excision and radiotherapy for keloids. Int J Radiat Oncol Biol Phys. 2008;71(5):14651469. doi:10.1016/j.ijrobp.2007.12.015

22. Ogawa R, Yoshitatsu S, Yoshida K, Miyashita T. Is radiation therapy for keloids acceptable? The risk of radiation-induced carcinogenesis. Plast Reconstr Surg. 2009;124(4):11961201. doi:10.1097/PRS.0b013e3181b5a3ae

23. Sakamoto T, Oya N, Shibuya K, Nagata Y, Hiraoka M. Dose-response relationship and dose optimization in radiotherapy of postoperative keloids. Radiother Oncol. 2009;91(2):271276. doi:10.1016/j.radonc.2008.12.018

24. Tremblay JF, Moy RL. Treatment of post-auricular skin using a novel plasma resurfacing system: an in vivo clinical and histologic study. Lasers Surg Med. 2004;34:25.

25. Foster KW, Moy RL, Fincher EF. Advances in plasma skin regeneration. J Cosmet Dermatol. 2008;7:169179. doi:10.1111/j.1473-2165.2008.00385.x

26. Fitzpatrick R, Bernstein E, Iyer S, Brown D, Andrews P, Penny K. A histopathologic evaluation of the Plasma Skin Regeneration System (PSR) versus a standard carbon dioxide resurfacing laser in an animal model. Lasers Surg Med. 2008;40(2):9399. doi:10.1002/lsm.20547

27. Shen J, Lian X, Sun Y, et al. Hypofractionated electron-beam radiation therapy for keloids: retrospective study of 568 cases with 834 lesions. J Radiat Res. 2015;56(5):811817. doi:10.1093/jrr/rrv031

28. Maemoto H, Iraha S, Arashiro K, Ishigami K, Ganaha F, Murayama S. Risk factors of recurrence after postoperative electron beam radiation therapy for keloid: comparison of long-term local control rate. Rep Pract Oncol Radiother. 2020;25(4):606611. doi:10.1016/j.rpor.2020.05.001

29. Chong Y, Long X, Ho YS. Scientific landscape and trend analysis of keloid research: a 30-year bibliometric review. Ann Transl Med. 2021;9(11):945. doi:10.21037/atm-21-508

30. Xu C, Ting W, Teng Y, Long X, Wang X. Laser speckle contrast imaging for the objective assessment of blood perfusion in keloids treated with dual-wavelength laser therapy. Dermatol Surg. 2021;47(4):e117e121. doi:10.1097/DSS.0000000000002836

31. Ruccia F, Zoccali G, Cooper L, Rosten C, Nduka C. A three-dimensional scar assessment tool for keloid scars: volume, erythema and melanin quantified. Skin Res Technol. 2021; Epub. doi:10.1111/srt.13050

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Treatment of Keloids Using PSR Combined with Radiation. | CCID - Dove Medical Press

Case study: Use of platelet-rich plasma and bone marrow …

April 21, 2018

The patient is a fit 83-year-old who, as a former flight attendant, is used to being on her feet. In 2014, she presented with osteoarthritis pain that started to affect her left knee and threatened her mobility, and she was searching for treatments that wouldn't interfere with her active lifestyle.

In January 2015, the patient had received two separate injections of platelet-rich plasma (PRP). The PRP injections alone did not provide adequate symptom relief. In July, she received an injection of bone marrow aspirate concentrate (BMAC) and PRP.

Jay Smith, M.D., a physiatrist and the director of Regenerative Medicine within the Rehabilitation Medicine Research Center at Mayo Clinic's campus in Rochester, Minnesota, evaluated the patient and administered the BMAC and PRP injections. To date, Dr. Smith and colleagues at Mayo have administered PRP or BMAC injections in more than 400 patients. Current scientific literature indicates that between 40 and 70 percent of individuals who receive this treatment find some level of pain relief, according to Dr. Smith. "It doesn't work 100 percent of the time," he says. "But we have a pretty good success rate when the primary goal is to improve symptoms and allow patients to do the things they want to do."

Dr. Smith says that a portion of the conversation he has with patients is that regenerative medicine strives to restore health by harnessing the body's natural ability to heal itself. "We tell our patients that it's an acceptably safe orthopedic procedure, and it may or may not modify their level of pain," Dr. Smith says.

What is known about the treatments is that they most likely lessen the inflammatory process caused by degrading joint cartilage. "Treatment with PRP is built upon the knowledge that platelets carry a multitude of growth factors," Dr. Smith says. "They are the first responder cells when we get injured, and they control the damage and start the healing process."

For PRP therapy, platelets are extracted from a vein in the patient's arm and concentrated using a centrifuge. The concentrate is then injected back into the patient's joint, where the growth factors mitigate inflammation.

BMAC contains not only platelets but also a variety of other powerful cells, including stem cells. Stem cells also have significant anti-inflammatory properties and can powerfully influence other cells involved in inflammation and healing. They also have the ability to become other types of cells. The bone marrow is drawn from a patient's pelvic bone, concentrated in a centrifuge and then injected into the problematic area. "The bone marrow concentrate and platelet rich plasma very naturally modify the inflammatory and immune response," Dr. Smith says.

A few hours after receiving treatment, the patient walked out of the procedure room with the aid of crutches and a knee brace, which she used for one week. The patient indicated that the injections eased the pain enough for her to return to her previous level of activity.

Dr. Smith notes that the patient's overall health contributed to the treatment's chance of success.

"One of the things I feel is relevant to her success is that she's very healthy," Dr. Smith says. "We are working with biologic products. They are only as healthy as the people they come from. I strongly believe that the healthier you are, the more likely these treatments are to succeed."

PRP and BMAC are not yet approved by the Food and Drug Administration (FDA) for use in treating osteoarthritis pain and therefore are typically not covered by insurance. In addition to treating patients with PRP and BMAC, Dr. Smith and colleagues are conducting FDA-approved clinical trials on the use of purified stem cells to treat knee arthritis. And researchers at Mayo Clinic's campus in Jacksonville, Florida, are conducting clinical trials comparing conventional PRP treatment with concentrated bone marrow stem cell injections for osteoarthritis of the knee.

A Study of the Safety and Usability of Culture Expanded STEM Cells Derived from the Patient's Own Fat Tissue for Treatment of Knee Osteoarthritis. Mayo Clinic.

Conventional Platelet-Rich Plasma Versus Concentrated Bone Marrow Stem Cell Injections for Osteoarthritis of the Knee. Mayo Clinic.

Continued here:
Case study: Use of platelet-rich plasma and bone marrow ...

The PRP Alternative to Knee and Other Surgeries – Sahuarita Sun

Last month we talked about using hyaluronic acid (HA) injections as an alternative to knee replacement surgery. Another alternative to knee replacement is platelet rich plasma, known simply as PRP.

PRP promotes natural healing.

Steroid injections have been one of the standard treatments used as an alternative to knee surgery. But steroids have limitations in how often they can be used, and may not work well for long-term results.

PRP uses the patients own blood components. After blood is drawn, it is placed into a centrifuge, which spins to isolate the platelets. The PRP is then injected into the affected area. The concentrated PRP promotes healing of the injured or inflamed area. Relief begins within a few weeks of the injection, and pain decreases even more as the healing continues.

In addition to being a viable alternative to knee surgery, PRP is effective for rotator cuff issues, pelvic pain and instability, tennis elbow, tendonitis, muscle strains and more.

Now at affordable prices.

Insurance may or may not cover PRP, but it is now affordable enough for most patients to pay for PRP on their own.

For more information, call Pima Orthopedics at 520-624-0888 and ask about the Non-Surgical Knee Relief Program at our Tucson and Green Valley offices.

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The PRP Alternative to Knee and Other Surgeries - Sahuarita Sun

Platelet Rich Plasma Market: Applications, Business Trends by Size 2021: Growth Statistics and Key Players Insights by Types, and Development Analysis…

The rising prevalence of the arthritis is augmenting the demand of the blood products, which is ultimately helping the growth of the platelet-rich plasma market.

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Key Market Trends:

Pure PRP Segment by Type is Expected to Hold the Largest Market Share

The pure PRP segment of the global platelet rich plasma market is believed to have the largest market share.

The prime factor responsible for the growth of this segment is the significance of this type of platelet plasma for the person. Pure PRP has an edge over traditional PRP, as it requires a two-step concentration process that helps in eliminating unwanted red blood cells (RBCs) and neutrophils. RBCs (that have no therapeutic effects for regeneration) can create a more viscous solution that can be more painful when injected. Neutrophils, a type of white blood cell, have inflammatory components that may increase pain and inflammation post-treatment.

Pure PRP helps the stem cells and regenerative cells in the repair and in rebuilding the damaged tissue. This ultimately speeds up the healing process and reduces pain. In addition, it promotes increased strength and improves the overall function. Therefore, owing to the contribution of pure PRP in the healing process and the rising use of it as a blood product, the segment is expected to dominate the market in the coming future.

North America Dominates the Market and is Expected to Continue the Same Trend for Next Few Years

North America currently dominates the platelet-rich plasma market and is expected to continue its stronghold for a few more years. The United States is a major market, and this is mainly due to the US governments initiatives to develop blood products. In addition, the emergence and adoption of novel technologies are going to help the market in a positive manner.

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Detailed TOC of Platelet Rich Plasma Market Segmented by Geography Growth, Trend, and Forecast:

1 INTRODUCTION 1.1 Study Deliverables 1.2 Study Assumptions 1.3 Scope of the Study



4 MARKET DYNAMICS 4.1 Market Overview 4.2 Market Drivers 4.2.1 Rising Incidences of Sports Injuries 4.2.2 Increasing Number of Androgenic Alopecia Patients 4.2.3 Growing Use of Platelet-rich Plasma in Various Therapeutic Areas 4.2.4 Rising Prevalence of Arthritis 4.3 Market Restraints 4.3.1 Stringent Regulatory Policies 4.3.2 High Prices of Plasma Therapy 4.4 Porters Five Forces Analysis 4.4.1 Threat of New Entrants 4.4.2 Bargaining Power of Buyers/Consumers 4.4.3 Bargaining Power of Suppliers 4.4.4 Threat of Substitute Products 4.4.5 Intensity of Competitive Rivalry

5 MARKET SEGMENTATION 5.1 By Type 5.1.1 Pure PRP 5.1.2 Leukocyte-rich PRP 5.1.3 Pure Platelet-rich Fibrin 5.1.4 Leukocyte-rich Fibrin 5.2 By Source 5.2.1 Autologous 5.2.2 Allogenic 5.3 By Application 5.3.1 Orthopedic Arthritis Chronic Tendinitis Bone Repair and Regeneration 5.3.2 Dermatology Androgenic Alopecia Plastic Surgery Cardiac Muscle Injury Dental Nerve Injury Other Applications 5.3.3 By End User Hospitals and Clinics Research Institutes Other End Users 5.4 Geography 5.4.1 North America United States Canada Mexico 5.4.2 Europe Germany United Kingdom France Italy Spain Rest of Europe 5.4.3 Asia-Pacific China Japan India Australia South Korea Rest of Asia-Pacific 5.4.4 Middle East & Africa GCC South Africa Rest of Middle East & Africa 5.4.5 South America Brazil Argentina Rest of South America

6 COMPETITIVE LANDSCAPE 6.1 Company Profiles 6.1.1 Bio Product Laboratory Ltd (BPL) 6.1.2 Biolife Plasma Services 6.1.3 Biotest AG 6.1.4 Cambryn Biologics LLC 6.1.5 China Biologic Products Inc. 6.1.6 CSL Ltd 6.1.7 Grifols International SA 6.1.8 Kedrion SpA 6.1.9 LFB SA 6.1.10 Octapharma AG


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Coping With Cancer Treatment’s Effects on Skin –

As she walked into Memorial Sloan Kettering Cancer Center, Erin Hazelton was struck by the appearance of the woman in front of her. Hazelton was at the New York, New York, cancer center to begin treatment for stage 2 invasive ductal carcinoma.

I walked into the center right after another woman, and when I heard her give her date of birth (to the receptionist), I realized that she was only a couple of years older than me, but she looked like she was my mothers age, recalled Hazelton, who received her diagnosis in 2018. When you (get a diagnosis) at age 37 (like I did), its scary. So much of my identity was tied up in how I looked. I was terrified.

Although many cancers are unseen, different types of treatment can lead to painful, visible side effects. After starting treatment, Hazelton experienced skin side effects including universal hair loss; facial wrinkles and loss of collagen; melasma (dark/discolored patches) on her face; dry skin; seeping wounds; scars; and radiation tattoos.

In addition to the regular side effects of chemotherapy, which can be devastating to quality of life, newer targeted therapies and immunotherapies have additional side effects of the skin that can be very frequent and very specific, says Dr. Nicole LeBoeuf, a dermatologist at Brigham and Womens Hospital and director of the skin toxicities program at Dana- Farber Cancer Institute in Boston, Massachusetts.

According to LeBoeuf, systemic cancer treatments can generally be grouped into three categories, and the types of side effects patients could experience will depend on the patients treatment regimen and cancer type.

The first category is cytotoxic, or classic, chemotherapy, which most commonly causes side effects including alopecia, or hair loss; painful rashes on the hands and feet; and general rashes elsewhere on the body that can lead to swelling, pain and itchiness.

Hazeltons initial regimen included Adriamycin (doxorubicin), a chemotherapy drug known as the red devil because of its harsh side effects, followed up with Taxol (paclitaxel). I lost all my hair eyelashes, eyebrows, everything and my skin looked like I had aged a good 15 to 20 years toward the end of it, Hazelton says. My cheeks had wrinkles because the collagen wasnt being renewed; I had melasma, which I hadnt expected, that was made worse by the sun.

She also experienced skin-related side effects from radiation and scars from her lumpectomy. My skin started slowly breaking down over the course of my radiation, and at the end of six weeks, I had seeping wounds, Hazelton says. My nipple looked like it was going to separate from my body.

The second category of treatment that can lead to skin side effects are targeted therapies, which are linked to the specific drug used for that patients treatment. The most commonly talked-about skin side effect of targeted therapy is called a papulopustular, or an acne-like, rash from EGFR inhibitors, or drugs that target the epidermal growth factor receptor mutation. This mutation is found in lung cancers, head and neck cancers, some colon cancers and, rarely, in breast cancer, LeBoeuf says. In fact, 85% of patients who are treated with drugs that target that particular genetic mutation will develop that rash.

Another common skin side effect from targeted therapies is hand-foot skin reaction, which causes painful calluses and blisters on pressure points. These blisters can occur from doing very normal activities, LeBoeuf says. Something as simple as going to the grocery store can make a patients feet look like theyve just run a marathon. Someone who works on a keyboard may experience painful blisters on their fingertips when they type.

Severe skin side effects such as these can prevent patients from resuming everyday activities and make them more likely to discontinue their cancer treatment, leading to a worse prognosis.

The third category of treatment leading to skin side effects is immunotherapy, a type of treatment that boosts the bodys natural defenses, or immune system, to fight the cancer. Immunotherapy is a beast because once you unleash the immune system, you can turn on any and all skin diseases that would happen outside the cancer setting. Anything that could possibly happen in the field of dermatology has been triggered by activating the immune system, LeBoeuf says. It is amazing and it is groundbreaking...but it can also lead to autoimmune disease in any organ.

The most common skin-related side effects of immunotherapies include psoriasis, with bumpy red patches covered in white scales; vitiligo, or whitish patches from lost pigment; and lichen planus, an autoimmune disease that can cause swelling and irritation of the skin, hair, nails and mucous membranes.

Sometimes the adverse immune events that are activated through immunotherapy persist after the treatment has ended. Our approach to these side effects is always to try to uncouple the toxicity from the effects of the drug on the cancer, then target the side effects as specifically as possible, LeBoeuf says. This leaves the rest of the immune system intact to fight the cancer.

Given the variety of possible side effects and the degree to which it may affect a given individual, it can be hard for patients to know which ones to expect and how to manage them if they arise during and after treatment.

Dr. Anisha Patel, an associate professor of dermatology at The University of Texas MD Anderson Cancer Center in Houston, recommends that patients follow good hair, skin and nail habits before starting treatment: Moisturize often, avoid perfumed products, and decrease the use of lacquer on your nails, she says.

Patients who have a history of skin conditions prior to their cancer diagnosis are more likely to see worsening during treatment. If you already have eczema, psoriasis, or acne, those things are more likely to be exaggerated, Patel says. If you have a preexisting skin condition, that should be taken care of before your therapy starts, as well.

During treatment, certain practices can help prevent the most common side effects. For example, wearing ice- cold gloves and socks and using scalp cooling treatments to restrict blood vessels reduces the chances of hair loss and hand-foot syndrome.

Patients should also take steps at home to minimize side effects. Wearing sunscreen, avoiding direct sun exposure and wearing a hat when outdoors can prevent photosensitivity side effects, Patel says.

To manage her symptoms, Hazelton applied organic shea butter daily and wore gloves and socks to bed to keep her skin as moisturized as possible. My nails were actually amazing during treatment because I was moisturizing them so religiously, she says. Whatever your skin can drink up during that time that is nontoxic, contains no preservatives and has no scents will help.

For patients who are undergoing targeted therapy or immunotherapy, dealing with side effects can be more complicated. In general, the newer cancer therapies (like immunotherapy) have very specific side effects, which may require specific treatment, Patel says. Patients have to go into it with the mindset that they will have some sort of side effect and ask their treatment team what to expect and what they can do to minimize it.

LeBoeuf recommends that patients seek the advice of a dermatologist, who can work with the medical oncologist to manage skin side effects. Whenever possible, if a specific dermatologic diagnosis can (be) made, then the most appropriate treatment can be instituted as quickly as possible, LeBoeuf says. If you treat the side effect specifically, based on dermatologic literature, then often, patients will recover and can continue their cancer treatment, as well.

Both Patel and LeBoeuf urge that the mental and emotional side effects of treatment-related skin conditions receive as much attention as the physical side effects. Often, patients are embarrassed or they feel like they shouldnt be concerned about a side effect that isnt life-threatening, LeBoeuf says. But the reality is, if a side effect affects your quality of life, increases your stress or changes your course of treatment, it can also affect your ability to fight the cancer. So be open, ask for help and advocate for referrals if you feel you arent getting the treatment you need. Maintaining skin health can also prevent secondary problems such as infections or ulcers and can minimize scarring.

Taking one day at a time helped Hazelton maintain a positive mindset. Thinking Am I going to burn during radiation? or Whats my scar going to look like? doesnt help you mentally. Just approach it as it comes, she says.

Patients might be surprised to learn that there is a silver lining to skin-related side effects: Skin side effects to some of the newer targeted and immune therapies is correlated to having a better tumor response, Patel says. It is correlated to the bodys immune system being revved up to fight the cancer.

Post treatment, patients should be advised about options to help restore the health of their skin, hair and nails. What happens after the treatment isnt talked about as much, Dr. Anthony Rossi, a dermatologist and surgeon specializing in skin cancer, lasers and cosmetic surgery at Memorial Sloan Kettering Cancer Center, says. Radiation can cause chronic changes in the skin; surgery, obviously, leaves a lot of scars, and high-dose steroids can leave stretch marks that last forever.

To combat these side effects, Rossi and his team at Memorial Sloan Kettering are working on what they call restorative oncodermatology, which, he says, aims to restore patients who go through cancer treatment and help them get back the form and function of their skin.

Through the use of treatments such as topical retinoids, topical skincare, chemical peels, lasers, botulinum neurotoxin (such as Botox) and platelet- rich plasma (or PRP) injections an experimental therapy that uses injections of the patients own blood platelets to prompt hair growth Rossi reports that many survivors are seeing life-changing results. There is definitely a cosmetic aspect that people want to improve... but these treatments help with skin functionality and overall quality of life, most importantly, he says.

Hazelton has received chemical peels and laser treatments to reduce her wrinkles and melasma, as well as used over- the-counter eyelash serums to help her hair grow back.

I thought my life was over when I got my diagnosis. I thought I would never look the same or feel the same ... but there are people out there to help you fix these physical things that remind you of your sickness, she says. A lot of people bounce back more than they expect they will. ... Your body really does recover; you just have to give it a chance.

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Coping With Cancer Treatment's Effects on Skin -

Ricki Lake Opens Up About Her Stunning Hair Transformation and How Sex Is the Best Anti-Ager – NewBeauty Magazine

Last year, Ricki Lake revealed her battle with hair loss on social media after posting an image of herself with a newly-shaved head. The actress and former talk show host had been struggling for more than 30 years with hair damage caused by heavy extensions, years of over styling and yo-yo dieting habits that would trigger yet more hair loss.She says it all started with her iconic role as Tracey Turnblad in the 1988 classic Hairspray.

Although the experience of going public with her condition was freeing for the star, she also worried that her hair wouldnt ever grow back. Lake says prior to shaving it off, she had gone through almost every treatment option, including Rogaine, supplements, spironolactone, steroid shots and platelet-rich plasma injections.

Now, a year later, she is sharing the latest part of her journey that includes a full head of healthy grey hair thanks to the Scandinavian brand Harklinikken, which specializes in hair loss. Here, the star talks about whats happened since she went public and the hair-care routine that has given her a new look and a new hope.

NewBeauty:Before going public with your hair loss journey, what did your day-to-day hair-care routine look like? Ricki Lake:I was wearing a hairpiece, like an extension with bangs in the front. I was living in London for a couple months for a job and the wear and tear of this piece being attached to my hair pulled it and caused it to get more and more frail. I had been on a diet and lost all this weight, so all my hair was shedding and it was just getting heavier on my head. I was supposed to take it off after one month, but I would leave it in for like four or five months because I didnt want to deal with the realityI was in denial.

When the piece came off it was bad. It was right around the holidays, so I bought a wig for $5,000 and only wore it for 15 minutes. I just couldnt wear it. After that, I confided in my boyfriend at the time and shared what was going on. I wouldnt ever let him run his hands through my hair, I was so self-conscious. So, that was the moment for me and I decided to shave it on New Years Day and document it with a photographer friend. I had my closest friends with meand I know it sounds dramatic because its just hair but it was like everything. It was my identity and my femininity, so it was really huge leap to just surrender and take this into my own hands.

NB: What was it like to shave your head. Did you learn anything about yourself or your scalp from the experience? RL:I mean, showering was such a giftI called it orgasmic earlier which is really funny. I hated showering so much before that. I hated getting my head massaged because they would touch me underneath and I was afraid they would feel what was happening. So, to not have to worry about it and to just the positive response I recieved from people that loved how I looked or people who could also relateit just was overwhelmingly positive even though it was about something I was so frightened of. It was really liberating and Ive never looked back. Its been a huge gift of growth for me and Im grateful for it, even the pain.

NB: How has Harklinikken helpedyou regrow your hair? RL:I was skeptical because I tried literally everything. Nine weeks after starting Harklinikken, I went back and we did a before and after of my hair and it was not only growing back, the quality of my hair has improved so much. I have something called androgenetic alopecia, which is so common for so many women. Its basically genetic diffused thinning of my hair through aging and through stress, hormonal birth control, and all the things. And, you know, I can honestly say my hair is in the best shape its ever been. I no longer color my hair. Im embracing my natural gray and silver and Ive been given my life back. It sounds dramatic, but thats truly how I feel.

NB: Yes, its so crazy sometimes how that works. The thing you fear the most, once youve gone through it, its sometimes the thing that helps you progress the most. RL:Yes, and its been true in other areas of my life, like you know I lost my husband almost four years ago to suicide and mental illness, and that was a gift too. Obviously losing my partner was the worst thing that ever happened to me, but then its through time and through the process of healing that you see the gifts that come out of that, like loving myself in the way that he loved me. For a long time, I didnt value myself enough. Losing him and knowing how much he loved me, I now do value myself and that has led me to the relationship Im in now. So, all of it is like this journey that we go on and these trials and tribulations that lead us to a better place hopefully.

NB: Is there any advice you would give to a younger you if you could? RL:I wouldnt have taken hormonal birth control. I would have stopped the yo-yo dieting and the self-loathing. I mean I just I beat myself up so much. I think so much of this has to come with age. You know people often say it and I didnt believe it to be true, but now I do see that when you turn 50 you dont really care what people think. What people think of me is none of my business. So, I definitely would have been kinder to my younger self if I had the opportunity.

NB: How has your approach to skin care and anti-aging changed from decade to decade? Is there anything youre doing now that you swear by? RL:Not really, I mean I get a lot of sleep I take really good care of myself. I eat well. I have a really active sex life. I mean I feel like Im in my sexual prime and my partner would agree. Im lucky that I do not have wrinkles! Im 52 and I think its purely genetic. I would get a facial every couple of months, but I dont anymore because of COVID. I used to get fake eyelashes and I dont even do that anymore!

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Ricki Lake Opens Up About Her Stunning Hair Transformation and How Sex Is the Best Anti-Ager - NewBeauty Magazine

Why Hair Goes Gray, and How to Cover It If You Want To – NewBeauty Magazine

For many women, salon closures and stay-at-home orders meant embracing their gray strands after decades of dye; for others, it meant hours of research about at-home hair color, root cover-ups, and lots of really cute headbands.

Lets get into the science behind it: As hair is being formed, melanocytes inject pigment into keratinocytesthe cells containing keratinwhich is the protein making up hair, skin and nails, says Wayne, NJ plastic surgeon and hair specialist Jeffrey B. Wise, MD. Over time, melanocytes continue to inject pigment into the hairs keratin, which is where hair gets its color. In the aging process, melanocytes slow down and eventually stop secreting melanin, which causes a lack of pigment, and the hair turns gray.

According to Chicago dermatologist Dr. Quenby Erickson, going gray is programmed in our genetic code, which means we can get clues as to how extensively and when it will happen by looking at our parents. However, a 2020 study published in Science Daily shows there may also be a link between stress and gray hair. When testing on mice, researchers found that the type of nerve involved in the fight-or-flight response causes permanent damage to the pigment-regenerating stem cells in the hair follicle. The study makes perfect sense, says Dr. Wise. Stress is a huge factor in premature aging, as well as hair thinning. Naturally, it should also affect hair graying as well. There is also a lot of evidence that shows smoking cigarettes plays a role in making hair go gray earlier.

Color isnt always the only factor either; textural changes can ensue as well. Some people are blessed with gorgeous gray hair, but for most of us, the gray is accompanied with thinning and rougher texture that leave our hair finer and harder to style, Dr. Erickson says. There are no proven ways to prevent hair from turning gray, but both Drs. Erickson and Wise have seen some promising results from platelet-rich plasma (PRP) injections. Because these treatments are aimed at waking up your own stem cells, they could potentially reinvigorate melanocyte production as well, explains Dr. Wise. We have seen growth of darker, thicker hairs on some of our stem cell therapy patients, even though the original goal was to combat thinning. Treatment results are dependent on the patients individual conditions, so realistic expectations should be set by your doctor.

Celebrity colorists Chad Kenyon and Rita Hazan say none of their clients embraced their grays during quarantine, or they tried, but caved eventually. For those in camp cover them up, topical dyes and root concealers can help camouflage. The process to cover gray hair is the same on both blonds and darker shades, but my clients with lighter hair can go longer in between touch-ups because gray hairs blend with blond hairs more easily, says Kenyon. Celebrity colorist Aura Friedman often suggests adding a darker pepper tone to silver hair for people who feel more comfortable being darker, but dont want the two-, three- or four-week regrowth touch-up thats needed.

For those who want to permanently cover their grays at home, Nikki Lee, celebrity colorist and cofounder of Nine Zero One Salon, recommends Garnier Nutrisse Nourishing Color Creme ($8). There are more than 75 shades and you can easily find your match using a virtual shade selector, she says. If DIY color makes you nervous, temporary root sprays are great to use in between salon appointments.

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Why Hair Goes Gray, and How to Cover It If You Want To - NewBeauty Magazine

Dr. Teresa Cody Offers Solution For Health And Wellness In 2021 – Press Release – Digital Journal

Platelet Rich Plasma Able to Assist in Healing Multiple Issues

Dr. Teresa Cody, a Sugar Land dentist, owner of the C and C Wellness and author of You Healing You, offers a solution for continued good health and wellness for multiple issues in 2021.

The underlying miraculous golden healing liquid known as Platelet Rich Plasma (PRP) in the medical industry is Codys tool to help people overcome some of their most difficult injuries and wounds.

Cody explains how doctors use this knowledge to concentrate this priceless blood component and reintroduce it into your body to heal injuries or as an esthetic treatment. Readers can learn how your own body holds the key to healing. It truly is you healing you.

One example is a patient with Rotator Cuff Injury where range of motion improved after two injection with the patients own PRP according to Cody. In her blog, Cody detailed that there are many reports of a professional sports person using PRP on tendon or ligament injuries.

He planned on getting surgery in a few months, however he thought he would give PRP a try first. Two injections in his shoulder and within 10 minutes his pain was gone, and his range of motion improved dramatically. This is not the first time we have seen this type of reaction. My theory is that the muscles surrounding the injury relax allowing greater range of motion. Muscles tend to tense and not let go. I know the rotator cuff has not repaired itself in 10 minutes, wrote Cody.

Another example of the effectiveness of PRP Cody explained in a blog post was regarding a patient with Dupuytrens contracture. This is a condition wherein the tissue in the palm of the hand thickens like a stiff cable causing the fingers to bend toward the palm. It most often affects the 4th or ring finger and 5th or little finger.

The PRP results are phenomenal.

After injecting PRP into the thick tissue, 80 percent of the thickness softened within 2 days, said Cody in her blog. The best part is that PRP is not a pharmaceutical it is the healing factors inside of each of us. We draw a small amount of blood and run it in a centrifuge so that the heavier red blood cells fall to the bottom and the plasma floats on top. After the plasma is pipetted into a syringe, it is injected into the injured area concentrating the bodys own healing factors.

Codys book is available on Amazon at

For more information, go to

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Dr. Teresa Cody Offers Solution For Health And Wellness In 2021 - Press Release - Digital Journal

The 9 Best Hair Growth Products That Work, According to Dermatologists – PureWow

Can we all agree that 2020 was a stressful year? So perhaps it comes as no surprise that there has been an uptick in people reporting hair loss, which can be triggered by stress, among other things.

To shed some light on how to best treat shedding hairs, we spoke to two board-certified dermatologistsAnnie Chiu, who is the founder of The Derm Institute in Los Angeles and Tess Mauricio in Beverly Hills, and Dr. Sophia Kogan, co-founder and Chief Medical Advisor of Nutrafolas well as Jen Atkin, a celebrity hairstylist, for some advice.

For starters, youve got to try and relax as much as you can. Right now [due to COVID-19], we are living through a prolonged period of stressful events, so this type of stress-induced hair loss is occurring at a higher rate than usual, explains Chiu. Time almost always helps, but in the meantime, you can find ways to help you manage your stress, like journaling, aromatherapy, taking long baths, and drinking chamomile tea.

Kogan also recommends incorporating activities like reading a book, meditating, yoga and dance into your day. Stress can be a trigger for hair thinning in many people, particularly women who tend to be more sensitive to its effects. Incorporating stress reduction techniques into your routine can do wonders for your body, mind and hair health.

When you are experiencing telogen effluvium, or sudden hair loss due to physical or mental stress to your body, its important to supply it with a well-balanced diet, says Chiu. Iron and biotin in particularly are very important. I also like collagen, overall vitamins, as well as saw palmetto extract.

You should also check your shampoos and other styling products. Chiu recommends staying away from drying and harsh ingredients like denatured alcohol and heavy silicones that can cause breakage and weigh your hair down. And avoid heat-styling your hair and being too rough with it when brushing. Both can lead to more breakage, which amplifies the look of hair loss.

Another consideration from Atkin: Switch to using a silk pillowcase, because ordinary pillowcases (which are typically made of other fabrics like cotton) can cause your hair to pull and tangle while you sleep. Also, its important to care for your hair with weekly masks and trims every three or so months to keep the ends healthy and prevent any splitting.

The ingredients to look for can vary based on the specific needs of an individual, and I always recommend consulting with your physician before adding anything new to your routine, cautions Kogan. Given the proliferation of products available to us, "its important to note that not all vitamins and supplements are created equal, so you want to pay close attention to the sourcing, quality and dosage of the ingredients contained in the products you are ingesting," she adds.

With that said, Mauricio shared some ingredients that have been shown to help with hair health and growth:

What results can you realistically expect from taking hair growth vitamins or supplements?

Most people report that their ponytail is thicker than it was previously and that their hair is growing much faster, says Chiu. However, all of the experts we interviewed agree that there is no single miracle cure for hair thinning and loss and treating it is a long game that requires patience and consistency.

Any product that claims to cure hair loss overnight or in a number of weeks should be viewed with skepticism, adds Kogan. Supplements can support hair growth and help build healthier hair, but they cannot bring dead follicles back to life. Nothing can.

When we are young and healthy, hair follicles contain and produce multiple hairs at once. With age, hair quality and growth can change due to multiple factors, explains Kogan. In some people, hair follicles can shrink, go dormant, die and then be replaced. Some dormant follicles have potential for regrowth, but others do not. A board-certified dermatologist can help distinguish what type of hair disorder is present and what may help.

Bottom line: Healthy hair growth is a slow and steady process that can be supported by promoting wellness from within the body, which is where supplements and vitamins come in. On their own, they dont solve the issue of hair loss, but they can support growth by creating an optimal environment for hair health and by targeting the underlying causes of hair thinning such as stress, hormones, gut health, nutrition and other environmental factors.

Because of the hair cycle (on average, your hair grows up to one inch in two months), it may take a few months before you see results from taking hair supplements, says Mauricio. There is no instant gratification. You have to be dedicated and patient.

The exact timeline varies from person to person, but ideally youll see results within six months, says Chiu, at which point youll notice more baby hairs coming in and your scalp will be less visible.

These supplements are best for people experiencing sudden hair loss due to a temporary shock to their body, whether its from stress, illness (like a bad cold or flu), or post-partum. If youre experiencing hair loss due to a more serious issue, supplements might help but its best to consult your physician first.

If you have any food allergies, I would take caution, says Chiu. For some people, biotin supplements can lead to acne. Also, if youre getting bloodwork done for anything, let your physician know that you are currently taking biotin as it can interfere with certain lab tests, she adds. Depending on the test, your physician may ask that you stop to ensure accurate results.

Kogan, who is the co-founder and Chief Medical Advisor of Nutrafol (a hair supplement), cautions that it's for adult use only and also recommends that pregnant or breastfeeding women refrain from taking [their] supplements. We likewise recommend that anyone on medications (especially blood thinners) or with medical conditions check with their primary care physician before starting a new supplement regimen.

Mauricio agrees, adding that because there are many reasons for hair loss and thinning, which can include underlying medical conditions, its important to consult with your doctor because treating the underlying condition can result in the reversal of hair loss altogether.

Topical scalp serums like Foligains Triple Action Hair Total Solution can help stimulate follicles to help with hair growth, says Chiu. And if seeing a board-certified dermatologist is an option, Platelet-Rich Plasma (PRP) injections can be effective for many types of hair loss.

Luckily, this is a growing field. We now have many more potential treatments for hair loss than ever before, says Mauricio. In addition to nutritional supplements, there are prescription medications like Finasteride, topical treatments like Rogaine and exosomes, at-home laser devices, and regenerative therapies like the use of patients own growth factors from platelet-rich plasma, platelet-rich fibrin matrix, and fat-derived stem cells. When used in combination, you can get the best results.

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The 9 Best Hair Growth Products That Work, According to Dermatologists - PureWow