Category Archives: Platelet Rich Plasma Injections

Donations For OVC Lameness Research – Standardbred Canada

Published: September 19, 2019 2:38 pm ET

A team of equine veterinarians and researchers from the Ontario Veterinary College (OVC) are excited to announce clinical trials are ready to begin using allogeneic umbilical cord blood stem cells in the treatment of superficial digital flexor tendonitis or bowed tendons in horses.

The goal is to develop a readily available treatment to prevent the formation of scar tissue and create good quality tendon tissue to replace the damaged tissues, which are less prone to re-injury. The team includes Dr. Thomas Koch, Dr. Nathalie Cot, Dr. Stephanie Nykamp, graduate student Alejandro Merchan Munoz, led by primary investigator Dr. Judith Koenig.

Many thanks goes to Ontario Equestrian (OE) and its members who scrapped their membership cards to create the Member Equine Research Fund program in 2017. This year, OE members chose to donate to lameness studies resulting in a donation of just over $30,000. The Equinosis Q Lameness Locator , previously donated to the OVC by the Equine Foundation of Canada (EFC) will play an integral role in this study. Funding has also been provided by Equine Guelph.

There is a great demand in the industry for more efficient treatment options for superficial digital tendonitis, improved recovery, and prevention of re-injury. Currently, the re-injury rates reported are between 56 to 75 per cent for superficial digital flexor tendon injuries once the horses return to competition, shares Dr. Koenig.

Cultured bone marrow derived stem cell treatments have been found to be effective and also boasts a low re-injury rate, but there is a short time frame for this treatment to be effective. A study out of England found that the tendon needs to be injected within six weeks of an injury in order to be beneficial, however this can be hard to accomplish depending on the expansion time needed to harvest the bone marrow.

In a pilot study conducted by Dr. Koenig with three horses, it was found that repeated injections of the allogeneic stem cells were very effective and that two of the horses were able to successfully return to racing and the third was able to start a career as a competitive sport horse.

My hope is that we can develop a treatment that can be available within an hour of taking out of the freezer, says Koenig. This treatment uses allogeneic stem cells, which means the stem cells do not need to be from the recipient. These stem cells are collected non-invasively from the umbilical cords of newborn foals and then stored for later use. See video and prior research leading up to these clinical trials.

The next challenge is to enroll horses in this study. The study requires very tight parameters in order to have meaningful results, says Koenig. The horses need to be Thoroughbreds in race training that have raced at least three times and incurred an injury to their superficial digital flexor tendon (SDFT) and have sustained lesions that have been diagnosed by a veterinarian. The lesions also will need to fall between specific measurements. The treatment and rehab period is expected to take between eight months to one year. The owners will receive cost incentives for enrolling their horses and following treatment and rehab protocols (more details on enrollment).

A lameness evaluation will be performed followed by an assessment using the Equinosis Q Lameness Locator . The Lameness Locator, which is the current gold standard for semi quantitative field measurements of lameness, will be used as an additional objective evaluation to confirm the diagnosis. The Lameness Locator will prevent any biases as it does not know what study group the horse is in (treatment or control). Initial blood work will be done to evaluate baseline immune status. Comparisons in blood work will be performed over the treatment period. The person that is carrying out all these tests will be blind to which study group the horse is in. A strict exercise and rehab protocol will be provided. Each horses progress will be monitored at monthly intervals.

It is the hopes of the study that the horses will return to full work within eight months to a year. The progress of the horses in the stem cell treatment group will be compared to that of a control group which will be receiving platelet rich plasma (PRP) injections. PRP is currently a common treatment used in the field for superficial digital flexor tendonitis.

Having more efficient and effective treatment options for superficial digital flexor tendonitis will improve the health of the horse, extend competitive careers, and reduce economic losses. This clinical trial will provide insight on the very promising treatment of allogeneic umbilical cord blood stem cells. Thanks to industry support from Ontario Equestrian and its members, Equine Foundation of Canada, and Equine Guelph this clinical trial is imminent and may bring the industry one step closer to providing optimal SDFT treatment options for our equine partners.

(Equine Guelph)

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Donations For OVC Lameness Research - Standardbred Canada

The global platelet-rich plasma market is expected to register a CAGR of approximately 14% – Yahoo Finance

NEW YORK, Sept. 11, 2019 /PRNewswire/ --

Market OverviewThe global platelet-rich plasma market is expected to register a CAGR of approximately 14% over the forecast period. The key factors that are augmenting the growth of the market include rising incidences of sports injuries, increasing number of androgenic alopecia patients, growing use of platelet-rich plasma in various therapeutic areas, and rise in the prevalence of arthritis.

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Osteoarthritis (OA) is the most common form of chronic disorder of the joints, and it has some detrimental effects on the quality of life of the patients. Progressive cartilage destruction, osteophyte formation, and subchondral sclerosis are characteristic to osteoarthritis. Platelet-rich plasma (PRP) is an autologous concentration of a high number of platelets in a small volume of plasma. PRP is prepared to centrifuge blood. In knee OA, PRP injections target to promote cartilage repair in order to relieve symptoms of osteoarthritis, hence delaying the need for joint replacement surgery.

The rising prevalence of the arthritis is augmenting the demand of the blood products, which is ultimately helping the growth of the platelet-rich plasma market.

Scope of the ReportAs per the scope of the report, platelet-rich plasma (PRP) prolotherapy, like dextrose prolotherapy, is a method of injection designed to stimulate healing. Platelet-rich plasma is defined as autologous blood with concentrations of platelets above baseline levels, which contains at least seven growth factors.

Key Market TrendsPure PRP Segment by Type is Expected to Hold the Largest Market Share

The pure PRP segment of the global platelet rich plasma market is believed to have the largest market share.

The prime factor responsible for the growth of this segment is the significance of this type of platelet plasma for the person. Pure PRP has an edge over traditional PRP, as it requires a two-step concentration process that helps in eliminating unwanted red blood cells (RBCs) and neutrophils. RBCs (that have no therapeutic effects for regeneration) can create a more viscous solution that can be more painful when injected. Neutrophils, a type of white blood cell, have inflammatory components that may increase pain and inflammation post-treatment.

Pure PRP helps the stem cells and regenerative cells in the repair and in rebuilding the damaged tissue. This ultimately speeds up the healing process and reduces pain. In addition, it promotes increased strength and improves the overall function. Therefore, owing to the contribution of pure PRP in the healing process and the rising use of it as a blood product, the segment is expected to dominate the market in the coming future.

North America Dominates the Market and is Expected to Continue the Same Trend for Next Few Years

North America currently dominates the platelet-rich plasma market and is expected to continue its stronghold for a few more years. The United States is a major market, and this is mainly due to the US government's initiatives to develop blood products. In addition, the emergence and adoption of novel technologies are going to help the market in a positive manner.

Competitive LandscapeCompanies, such as Biotest AG, China Biologic Products Inc., CSL Ltd, Octapharma AG, and LFB SA, are some of the key players operating in the global platelet-rich plasma market. With the advancement in technology, new players are expected to come in the market.

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The global platelet-rich plasma market is expected to register a CAGR of approximately 14% - Yahoo Finance

Revolutionary Cosmetic Skin and Sexual Wellness Treatments Are Coming to Central New Jersey – P&T Community

EAST BRUNSWICK, N.J., Sept. 17, 2019 /PRNewswire/ -- Botox, dermal fillers, and sexual wellness treatments are among the new aesthetic treatment procedures available at IVIV Health and Aesthetics, a medical aesthetic practice located in the heart of central New Jersey.

IVIV Health and Aesthetics is owned and operated by Dr. Tanya Weissman, a board-certified physician with extensive experience working with PRP treatments, stem cell treatments, and Botox injections to help manage chronic pain and heal damaged tissues and tendons. Weissman was named by NJ TopDocs as a 2019 Top Doctor.

"We take a physician-first approach at IVIV Health and Aesthetics because we want our patients to know that their health and safety is our priority," Weissman said. "Patients feel reassured by our use of nurses and nurse practitioners, who are fully trained in the protocol required for these treatments, including drawing blood and injection safety."

This makes IVIV Health and Aesthetics one of very few establishments that offer such a variety of wellness services and most importantly have an experienced medical professional to ensure they are administered in a safe and comfortable fashion.

Weissman is joined by Dr. Aleksandra Novik, a nurse practitioner who brings experience in aesthetics, cardiology, endocrinology and physical medicine and rehabilitation to IVIV Health and Aesthetics.

"Dr. Novik takes pride in making sure patients feel their best and achieve natural-looking results," Weissman said. "We are thrilled to welcome her to the IVIV Health and Aesthetics family."

According to Weissman, adding Botox injections to the practice enables her and Novik to treat medical conditions as well as cosmetic treatments. Botox is a common treatment for hyperhidrosis (excessive sweating), migraines, and TMJ, as well as for cosmetic enhancement such as fine lines, wrinkles, and crow's feet.

"These injections can be a very effective treatment for patients seeking to control excessing sweating in the palms, feet, and underarms," Weissman said.

According to Weissman, many treatments at IVIV Health and Aesthetics, particularly platelet-rich plasma (PRP) aesthetic treatments, are designed to support and enhance the body's natural healing power. The sexual wellness treatments added to the medical spa's lineup of services use PRP rejuvenation to increase blood flow to the genital area in both men and women, which helps with performance, sensitivity, and satisfaction.

"With regenerative treatments, the body uses its own resources to heal itself by enhancing its natural healing processes," Weissman said. "Whenever the body detects injury, platelets rush to the site to help facilitate the healing process. Platelet-rich plasma is full of those same growth factors that enable your body to regenerate using its own characteristics, making it an excellent option for acne scarring and reviving skin for a youthful, refreshed look."

Botox, dermal fillers and sexual wellness treatments join the medical spa's lineup of physician-administered aesthetic treatments, including PRP treatment for hair restoration and regrowth, PRP treatment for face and skin, vitamin drips, and IV therapy. For more information or to book an appointment, visit http://www.IVIVHealth.com.

ABOUT IVIV HEALTH AND AESTHETICS

Based in the heart of central New Jersey, IVIV Health and Aesthetics offers rejuvenation treatments in a safe and relaxing atmosphere. Under the care and guidance of a doctor and nurse practitioners, clients can receive treatments such as Juvderm, Botox, platelet-rich plasma (PRP) treatments for hair and skin rejuvenation, IV drip and vitamin therapy, and PRP-based sexual wellness treatments. For more information or to book an appointment, visit http://www.IVIVHealth.com.

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Revolutionary Cosmetic Skin and Sexual Wellness Treatments Are Coming to Central New Jersey - P&T Community

Platelet Rich Plasma for hair loss: Does it work? – Global Village space

Platelet-rich plasma (PRP) is a treatment that doctors use to accelerate healing in various areas of the body. It may help restore hair growth.

Doctors typically use this treatment whenhair lossresults fromandrogenetic alopecia, a common condition that causes hair follicles to shrink. In males, this is called male patternbaldness.

AlthoughPRPis a relatively new approach, there is some scientific evidence to suggest that it can promote hair growth. In this article, we describe how doctors use PRP to treat hair loss and what researchers say about its effectiveness.

To understand how PRP works, it is important to be aware of the role that platelets play in healing. Platelets are a component of blood, along with red and white blood cells. When a person sustains a cut or wound, the platelets are some of the bodys first responders that arrive to stop the bleeding and promote healing.

PRP is not a cure for conditions that cause hair loss. For this reason, a person would need to receive multiple PRP treatments over time to maintain hair growth results.

Researchers theorized that if they could extract concentrated platelets and inject them into damaged areas of the body, they could accelerate healing.

To produce PRP, a medical professional will take a blood sample and put it into a machine called a centrifuge. This machine spins at a rapid rate, which separates the components of the blood. The medical professional then extracts the platelets for injection.

PRP contains a range ofgrowth factors and proteinsthat speed tissue repair. As some types of hair loss result from damage to hair follicles, researchers initially hypothesized that PRP could help regrow hair by reversing the process that occurs in androgenetic alopecia.

Since then, PRP has become a popular method of restoring hair growth. Doctors have also used PRP to treat injuries to the tendons, muscles, and ligaments, such as those that people sustain during sporting activities.

Read more: Got thin hair? Find out why!

In 2019, a team of researchers carried out a systematic review of the research on PRP as a treatment for hair loss. Their findings appear in the journalAesthetic Plastic Surgery.

The analysis ultimately focused on 11 research papers that included a total of 262 participants with androgenetic alopecia. According to the authors, most of the studies found that injections of PRP reduced hair loss and increased the diameter of hairs and the density of hair growth.

They acknowledged, however, that the treatment is controversial, noting that small sample sizes and low quality of research were among the limiting factors of their investigation.

Another 2019 systematic review, which featured inDermatologic Surgery, examined the findings of 19 studies investigating PRP as a treatment for hair loss. These studies recruited 460 people in total. According to the authors of the review, most studies reported that PRP treatments led to hair regrowth in those with androgenetic alopecia andalopecia areata.

The authors of an additional review of clinical studies, which theInternational Journal of Womens Dermatologypublished, considered PRP to be a promising treatment for hair loss, based on their findings.

However, the team noted that because various researchers and clinics use different preparations, session intervals, and injection techniques to administer PRP, its effects can vary.

At this point, without a standardized protocol for injections, the authors explain, it is difficult to conclude that the treatment is effective.

The following steps are an example of a common approach to PRP injections for hair loss:

The entire process may take about 1 hour, and several sessions may be necessary. After receiving PRP treatment, a person can usually return to their regular activities without any limitations.

PRP is not a cure for conditions that cause hair loss. For this reason, a person would need to receive multiple PRP treatments over time to maintain hair growth results. The same is true of medications that doctors commonly use to treat androgenetic alopecia, such as topical minoxidil (Regaine) and oral finasteride (Propecia).

The doctors recommendations for how often a person should have PRP will vary depending on a persons condition and the results of their initial treatment. The doctor may suggest having maintenance injections every36 monthsonce hair loss is under control.

Read more: Men and hair loss an unavoidable animosity

Possible side effects include a headache, mild pain at the injection site, and scalp tenderness.

As the PRP solution consists of a persons own blood components, there are few risks of a reaction to the solution itself.

However, people undergoing PRP treatments for hair loss may experience the following side effects:

Researchers have found evidence that PRP can lead to renewed hair growth. However, due to the limitations of these studies such as small sample sizes and the variation in technique and protocol among doctors, further research is necessary to confirm whether PRP is effective.

Doctors and researchers also need to identify the best candidates for PRP and develop universal treatment protocols.

At present, anyone with mild-to-moderate hair loss who is interested in PRP should ask a doctor whether they are likely to benefit from the treatment.

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Platelet Rich Plasma for hair loss: Does it work? - Global Village space

Kourtney Kardashian Got Scalp Injections to Treat a Bald Spot – Glamour

Ever since she figured out how to manage her relationship with Scott Disick, Kourtney Kardashian's storylines on Keeping Up With the Kardashians have been relatively drama-free. But during the show's season 17 (!!!) premiere Sunday night, the eldest sister was facing a beauty emergency.

During a scene with Kim, the sisters discuss a not-small bald spot that has formed on the top of Kourt's head. "Kourtney, you have a really big spot on the top of your head, Kim said. Look down, Kourtney. Oh my God, Im afraid for your life. Have you seen that?

No, but I feel it, Kourtney replied. "Its a hole in my head. I swear its from my ponytail, it was so tight that I had a bump on my head like this. Obviously, Kim is being overly dramatic, but the spot is noticeable in the clip below.

"Hair loss is not always genetic in nature," plastic surgeon Steve Fallek, M.D., medical director at BeautyFix Med Spa in New York City, tells Glamour. "Physical and mechanical stress can weaken and even damage the hair follicle, leading to hair loss. Tight ponytails can certainly pull your hair out of the hair follicle and are a common cause of hair loss. Coloring your hair or treating your hair with harsh chemicals can also contribute to this. Weight loss, nutritional changes, medications, as well as stress are other typical factors for hair loss."

Of course, when you're a Kardashian, you have pretty much any beauty treatment available to you at any given moment, so Kourtney heads to see Dr. Jason Diamond later in the episode to address the bald spot with scalp injections. Today Im getting PRP [platelet-rich plasma], which is where they take your blood and spin it and they use your plasma and they inject it in my head for my hair to grow back, she said.

Plasma treatments for conditions like alopecia are becoming more popular, and Kourtney did a pretty good job explaining the basics. Blood is taken from the patient and put into a centrifuge to separate out the plasma that will then be used for the injections. According to the Cleveland Clinic, the plasma "helps repair blood vessels, promote cell growth and wound healing, and stimulate collagen production."

"Given its name, PRP is rich in platelets which have multiple growth factors, which help the hair follicles to grow," Fallek says. "The PRP is then injected into your scalp where there is hair loss. A topical anesthetic is normally applied prior to injections, and the treatment takes about 5 to 10 minutes." He says that treatment is varied but that most doctors will inject areas of alopecia monthly for three months initially and then twice a year for maintenance. You can expect to notice improvement after two to three months.

Here's hoping Kourt gives us a hair-growth update soon.

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Kourtney Kardashian Got Scalp Injections to Treat a Bald Spot - Glamour

Kourtney Kardashian Just Got PRP to Fix a Bald Spot – NewBeauty Magazine

Many of us have differing opinions on all things Kardashian, but one thing we can probably agree on is that we love their candidness about beauty problems and beauty treatments. And in the Season 17 premiere of Keeping Up With the Kardashians Sunday night, we got a major dose of just that.

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As Kim was casually chatting with Kourtney, she spotted a bald patch on the top of Kourtney's head and immediately freaked out. Kourtney, you have a really big spot on the top of your head, Kim said. Look down, Kourtney. Oh my god, Im afraid for your life. Have you seen that? Kourtney responded, No, but I feel it, and attributed it to the sky-high (and apparently incredibly tight) ponytail she had worn at a recentgala. Its a hole in my head.I swear its from my ponytailit was so tight that I had a bump on my head like this [she used her hand to demonstrate a big bump].

Crazy enough, that canactually happen. This is called traction alopecia, which is a type of hair loss resulting from a constant pulling force being applied to the hair," says Beverly Hills, CA facial plastic surgeon and hair restoration specialist Natalie Attenello, MD. "This is commonly seen in people who consistently wear tight ponytails, pigtails or braids."

To fill in the bald area, Kourtney opted for platelet-rich plasma (PRP) injections, which is becoming an increasingly popular nonsurgical treatment for thinning hair and hair loss. Today Im getting PRP, which is where they take your blood and spin it and they use your plasma and they inject it in my head for my hair to grow back, she said on the show at a visit to her doctor, who assured her it could take a while for the hair to grow back.

You May Also Like: 5 Expert-Recommended Hair Loss Treatments

For those interested in PRP for hair loss, New York facial plastic surgeon Jennifer Levine, MD recommends three treatments spaced a month apart. "Usually you can see some difference after the second treatment, but it may take six months to experience the full effect." Dr. Attenello adds, "If there is a minimal improvement seen, a more definitive option of a hair transplant may be considered."

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5 Treatments Derms Say You Should Never Buy on Groupon – NewBeauty Magazine

If you want to incite the ire of a group of board-certified dermatologists, say the word Groupon around them. The good stewards of hair, skin and nails do not mince words when it comes to procuring medical treatments on the local discount marketplace. Dont Groupon your face, cautioned Portland dermatologist Gretchen Vanderbeek, MD.

This is the main sentiment expressed by most of the doctors we interviewed, and we agree with their expert opinion, but we wanted to know exactly which procedures are completely off limits or if maintenance treatments like chemical peels, microdermabrasion or laser hair removal are considered ok. Here, the experts weigh-in and sound off on the dangers of bargain cosmetic treatments.

You May Also Like: Black Market Beauty: 5 Clues You're Getting Fakes

1.Laser Skin Resurfacing TreatmentsWarwick, RI dermatologist Caroline Chang, MD says I would not use a Groupon for laser treatments. Lasers are high-powered devices that, in the hands of an unqualified medical professional, can cause severe risks such as permanent scarring.

Ontario,Canada dermatologist Dusan Sajic,MDsays laser treatments are definitely on his no-no list: I like to classify absolute no-nos basedon if the treatment can burn or permanently scar, disfigure, cause infection or cause life-threatening problems or organ threatening problems. Anything ablative, whether fractional of not, actually burns and damages the skin in a controlled manner. This includes radio-frequency microneedling and Fraxel and Halo lasers. All lasers and IPLs can cause burns, but these are particularly worrisome. There are also specific skin types like darker skin tones that have amuch higher risk for burns or discoloration. Many of my patients need pre-treatment with specific and very tailored skin care like hydroquinone for preventative measures. Not only are you safer getting this done in a board-certified dermatologist office, but should there be a complication, these are the skin experts you want by your side to treat it. Like with any complication, timing is everything.

Township, MI dermatologist Linda Honet, MD says to never ever use Groupon where theres a needle or powerful device like a laser involved. The best that can happen is that it doesnt work or last, she says. The worst that can happen is that you may have less than desirable results or permanent side effects or complications that are tough to reverse or fix. Dont gamble on your health or cut costs. Seek the care of a knowledgeable, well-trained, skilled core physician like a board-certified dermatologist. Remember that full price means full care. Ask any dermatologist if they would ever do a Groupon cosmetic treatment on themselves, and the answer will be a swift, horrified 'No!

Bannockburn, IL dermatologist Heather Dowes, MD agrees. Burns and scars from lasers and IPL devices are a major cause of lawsuits. The only time Ive seen burns or scars from laser treatments was in patients who were lasered by someone who was NOT a board-certified dermatologist.

2.MicroneedlingGermantown, TN dermatologistPurvisha Patel, MD says to scroll past the micro-injury inducing microneedling offers, too. I would say anything that requires knowledge of anatomy and science, pass on. Especially procedures where blood is involved, from injections to microneedling to lasers. These procedures should be performed in a medical setting where MDs are present. If you can bleed or the skin gets poked, disrupted or starts bleeding, this treatment needs to be done in a medical setting which is likely not the place that places Groupon ads.

Its important to not let yourself be fooled into thinking that a laser or an injectable such as a filler or toxin is not a medical procedure, says New York dermatologist Jennifer Silverman Kitchin, MD, because they most definitely are medical treatments. And they are treatments with real risks. If you are considering any type of invasive medical treatment for your skin, such as lasers, injectables, peels or radio-frequency microneedling, you should see the only true skin expert, a board-certified dermatologist.

3.Laser Hair RemovalOklahoma City, OK dermatologist Kimberly Jerdan, MD says to be wary of the laser hair removal membership offers: I would say no to laser hair removal with a Groupon. Laser hair removal should be tailored to the patients skin type and type of hair, and you never know what kind of laser the facility has, and whether it suits your skin or hair best. Ive seen many burns or permanent scarring this way. Also, when done well with people who understand the science of the wavelengths, one shouldnt have to continue treatment for more than six to nine months. Ive seen many patients get scammed with a monthly laser hair removal fee that theyve been doing for two years! It should be tailored to the patient, not the number of sessions.

4.Platelet-Rich Plasma (PRP) Therapy for Skin and HairOne of the biggest regenerative medicine trends has finally made its way on Groupon and Chantilly, VA dermatologist BrendaDintiman, MD says to stay far, far away from PRP coupon deals: Platelet-Rich Plasma (PRP) has very specific blood collecting tubes to collect and spin to separate the platelets. No shortcuts or substitutions can be made, or the patient is put at risk for infections such as hepatitis B and C and HIV; which has already reportedly happened in a clinic in New Mexico. When the price is so low on a Groupon, you can be sure that they are cutting safety corners and patient safety is not their first priority. There are other ways to save money, but not when it comes to healthcare and cosmetic procedures like PRP for hair loss and microneedling!

Beverly, MA dermatologist Vladimir Ratushny, MD adds: I would avoid any invasive medical procedure advertised on venues such as Groupon. You should always look at the credentials of the individual doing the procedure and select an expert such as a board-certified dermatologist to trust with your skin and hair health. PRP involves drawing up blood and one has to be very careful with any blood products. As a board-certified dermatologist that does hair transplantation, I have the training to ensure patient safety and outcomes.

5.Botox and Fillers"Just say no to injectable treatments," says every single doctor we interviewed, including Washington DC dermatologist Thomas Adrian, MD. Whenever anyone asks me why I dont do Groupons, I tell them that I dont do Groupon Botox, I just fix Groupon Botox.

Dr. Dowes notes, These Groupon offers typically come from med spas who do not employ board-certified dermatologists or plastic surgeons, but rather estheticians, nurses, and other providers who have not been residency- or fellowship-trained in cosmetic dermatology. I spoke to one med spa owner who told me she purchases Botox for her medspa at half price through a reseller who imports it from other countries. This is illegal. And it is impossible to know if the Botox is authentic. Botulinum toxins and fillers can only be LEGALLY purchased at full price through their respective U.S. manufacturers such as Allergan and Galderma. How else could these med spas afford to offer such low Groupon prices for these injections?

Glendale, AZ dermatologist TonyNuara, MD cautions, Most cosmetic injectables carry a National Drug Code (NDC) number. They are prescription medical devices and as such should really only be done by a qualified physician. For the life of me, I still dont understand how it is legal for spas to do this. If they were selling prescription medications, the authorities would be all over it.

Dr. Sajic says a bad result isnt the only reason to avoid injectables on the coupon app. Injection into an artery can cause blindness. It is crucial that one picks a doctor who knows anatomy exquisitely and who goes to conferences very frequently to brush up on it. While this has been mostly reported with fillers, there has been one reported case of platelet-rich plasma causing blindness! Flushing, NY dermatologist Winifred Chu, MD says, If not performed by a board-certified dermatologist or plastic surgeon who are physicians specially trained in facial anatomy, serious complications can occur which includes but not limited to infections or vascular occlusion leading to skin necrosis and blindness.

Know Before You BuyNew Orleans dermatologistMary Lupo, MD said it best when she cautioned, Good cosmetic treatments are not cheap and cheap cosmetic treatments arent good. But there are some reputable doctors who have used the site to get new patients in the door. The good doctors we spoke to said if you really want to Groupon your treatments, research your practitioner and make sure he or she is legit. Rockwall, TX dermatologist Elizabeth BaharHoushmand, MD says, I think asking who is performing the procedure is critical. Is it a board-certified dermatologist or plastic surgeon? Some colleagues offer Groupon to gain new patients, but I personally dont. It is important for the public to do their homework before buying.

Groupon can be perfectly fine for any cosmetic treatment, as long as it is performed by someone with adequate trainingnamely, a board-certified dermatologist, advises Milford, MA dermatologistDennis Porto, MD. The issue is that very few dermatologists use Groupon because we are already very busy with the huge number of patients who seek the care of an expert. Thus, Groupon is often a place for those who are less qualified to find unsuspecting patients seeking a bargain. This isnt always the case, however, so just check to make sure the treating physician is a board-certified dermatologist and you can rest assured. These dermatologists are identified with a 'FAAD' after their name.

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5 Treatments Derms Say You Should Never Buy on Groupon - NewBeauty Magazine

Archer (right shoulder) done for season – MLB.com

CHICAGO -- With two weeks left in the season, the Pirates have decided to shut down rehabbing right-hander Chris Archer rather than rushing him back to the mound. We had a game plan if everything went well, and it didnt go perfectly. So theres no point in trying to force

CHICAGO -- With two weeks left in the season, the Pirates have decided to shut down rehabbing right-hander Chris Archer rather than rushing him back to the mound.

We had a game plan if everything went well, and it didnt go perfectly. So theres no point in trying to force anything to happen, Archer said Sunday at Wrigley Field. Theres still a little bit of soreness in there. As opposed to continuing to throw through it, might as well just continue to rest it.

Archer, who has been out since Aug. 20 due to right shoulder inflammation, has continued to work out with the team and play catch on flat ground. He hasnt suffered a new injury, and he shouldnt need any more treatment than initially expected, but the Pirates simply ran out of time to get him built back up to start one of their final 12 games.

Hes worked hard, hasnt progressed as he had hoped or we had hoped. Were just running out of days, general manager Neal Huntington said on Sunday. Lets turn our attention to offseason prep, let him have a great baseball offseason, which he hasnt had as a Pirate.

Archer underwent a procedure to repair a bilateral hernia last November and didnt even start his rehabilitation work until December. Archer hasnt used the operation as an excuse, but the Pirates believe his interrupted offseason -- and that of Joe Musgrove, who also had abdominal surgery last winter -- may have affected him on the mound this season.

Now, Archer will have 4-6 weeks to rest and rid himself of the soreness in his shoulder before beginning a normal offseason routine.

In my time, Ive come to recognize that that is a huge factor in a players season the next year, Huntington said. Were excited for Chris and Joe to have a baseball offseason, come in next year and be the pitchers we expect and need them to be.

Archer, acquired from the Rays last summer for Austin Meadows, Tyler Glasnow and pitching prospect Shane Baz, will finish his first full season with the Pirates with a 3-9 record, a 5.19 ERA and 143 strikeouts in 119 2/3 innings over 23 starts. His contract includes a $9 million club option for next season that the Pirates seemingly intend to exercise.

The 30-year-old right-hander was hoping to put together a strong finish to this year, and he was encouraged by some of the work he did after a rough start. In his final 11 outings, Archer struck out 74 batters and walked only 22 in 55 innings while holding opponents to a .234/.314/.402 slash line.

It stinks because it puts our team in a tough position, and I was feeling a lot better the second half of the season, Archer said. The smart play going forward is just to come back fully healthy, have a normal offseason and continue to fine-tune the things that I found in the second half and maybe even find ways to get better.

Trainers room

The Pirates havent shut down any of their other injured players, a list that most notably includes first baseman Josh Bell (left groin discomfort), center fielder Starling Marte (sprained left wrist) and catcher Jacob Stallings (back tightness). Only Marte was available off the bench for Sundays series finale vs. the Cubs at Wrigley Field, and he was limited to pinch-running duty.

Theres always value in players finishing healthy if the calendar allows them to, Huntington said. In Joshs case, weve still got some inflammation in there and hes working through that, and well know more in the coming days. In Starlings case, hes continued to try to work through [it]; theres just some inflammation in that wrist thats still hindering his ability to swing the bat.

The Pirates will reassess Bell and Marte on Tuesday, Huntington said, as Mondays off-day gives them additional time to rest and recover.

If theres risk for further damage, then the shutdown becomes easy, Huntington said. If its just an inflammation thing that theyre battling through, then the ideal situation becomes that they work themselves back when theyre ready to go.

Right fielder Gregory Polanco, who was previously shut down due to lingering left shoulder inflammation, is receiving a series of platelet-rich plasma injections with the hope of having a relatively healthy, normal offseason after another injury-plagued season.

The PRP sequencing is having the effects that we hoped it would have, Huntington said. As we sit here today, very positive path.

Worth noting

Huntington said the Pirates need to learn from the clubhouse fight that took place Monday between closer Felipe Vazquez and reliever Kyle Crick, which resulted in Crick sustaining a season-ending hand injury and Vazquez needing stitches on his nose. But the Pirates dont feel obligated to deal away either Crick or Vazquez, Huntington added.

Its not fine. Its not good, Huntington said. We dont have to trade either one. Talking with veteran baseball guys, fights happen in clubhouses every year. This one became very public because of the injuries, and its not OK. Were not just passing it off as, Well, it happens and boys will be boys. Thats not the way we feel at all. At the same time, there are times when things do escalate, they become physical and both players are able to move on and coexist.

As we sit here today, if theres an opportunity to improve the club, if theres an opportunity to take some of our right-handed depth to add to our left-handed depth, if theres an opportunity to get an elite return, thats a decision we make regardless of what happened between those two. Its an unfortunate situation. Its not acceptable. Its not OK. Well learn from it and move on.

Adam Berry has covered the Pirates for MLB.com since 2015. Follow him on Twitter and Facebook and read his blog.

Continued here:
Archer (right shoulder) done for season - MLB.com

The Ultimate Guide to Thinning Hair – NewBeauty Magazine

This article first appeared in the Fall 2019 issue of NewBeauty. Clickhereto subscribe.

Hair is way more than inanimate protein attachedto our heads. It highlights our personal style, acts as a security blanket and boosts confidence. Theres a reasonhashtag #goodhairday has been used nearly 1.5 milliontimes on Instagram: When someones hair looks good,they want to show it off. But for the millions sufferingfrom hair loss, there may be more bad hair days thangood. Thanks to cutting-edge products, devices and procedures, this doesnt have to be the case.

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WHY HAIR THINSThe average person has about 100,000 hairs ontheir head and loses about 100 of them every day (to thedetriment of shower drains and bathroom floors everywhere). But, if those hairs dont grow back at the same rate,or more than 100 hairs fall out, it may be a sign of thinning.And shockingly, the American Academy of Dermatologycites that a whopping 40 percent of women have visiblehair loss by age 40. The sooner you seek care, the betteryour chances are of successfully treating it, says BeverlyHills, CA hair restoration specialist Dr. Craig Ziering. Butin order to prescribe a treatment, we need to determinethe reason for the thinning. These are the most common:

GeneticsAndrogenic alopecia (AGA), or male and female patternhair loss, is the most common form of hair loss and affects nearly 50 million men and 30 million women in theU.S., according to the National Institutes of Health.Chances are, if sparse strands are common on either sideof your family, you will experience the same. Femalehair thinning shows up in three different ways: enlargingof the center hairline part, frontal hair line recession anda diffuse thinning pattern, says Beverly Hills, CA hairrestoration specialist Natalie H. Attenello, MD.

Although often hereditary and occurring in healthyindividuals, AGA has been associated with serious conditions such as hypertension, diabetes and polycysticovarian syndrome, so see your doctor if you have concerns, says Pittsburgh plastic surgeon Brian V. Heil, MD.

DietIn addition to taking the patients personal and familialhistories into account, doctors often suggest a blood test,which can reveal mineral and vitamin deficiencies thatmay be affecting hair. Low vitamin D and iron can beculprits, and its common to see depleted levels of themthese days, says New York dermatologist Dhaval G. Bhanusali, MD. In those cases, I generally prescribe a dailydose of 5,000 IU vitamin D and an iron supplement. Beverly Hills, CA dermatologist Rhonda Rand, MD saysvegetarians often have less hair because they dont eat asmuch protein. You need 40 grams a day, and most of myvegetarian and vegan patients arent getting that much.

HormonesA key hair loss offender is the DHT hormone (dihydrotestosterone), a derivative of testosterone that binds to receptors in hair follicles on the scalp and shrinks themuntil they can no longer function. Blood work can disclose testosterone levels, and if theyre elevated, medication can balance them out, says Dr. Rand.

Sharp hormone shifts after pregnancy are also commonly tied to hair thinning, although the effects are temporary. Women have some of the thickest hair theyllever have right before they give birth, and then two tofour months post-partum, many of them experiencetelogen effluvium, a dramatic, yet temporary change asthe hair goes into resting phase for two to four monthsand thins out, Dr. Rand explains. Around eight monthsafter childbirth, the hair should be back to normal.

Menopause can stir up hair issues too, as lowerestrogen levels are linked to thinning. Many women losesubstantial amounts of hair after menopause, says Dr.Ziering. Their hair tends to thin out all over, rather thandevelop a signature spot like men do at a similar age.

StressAlopecia areata is a form of sudden hair loss thats oftencaused by stress and shows up in circular bald patches.Its considered an autoimmune disease because the immune system gets stressed and attacks the hair follicles,causing them to weaken and fall out, Dr. Bhanusali says.Theres no cure yet, but Dr. Ziering says it can be treatedsuccessfully with injectable steroidstypically everythree to six weeksthat suppress the immune system.

IllnessAny auto immune disorder could cause hair loss, saysDr. Heil, but its most common with lupus and thyroiddisease due to the alteration of the bodys ability to function normally. Once the disorder is treated and the bodyis in remission, hair growth should return to normal.

MIRACLE GROW:The three stages ofthe hair growth cycle

1. The Anagen Phase (lasts 26 years)Also known as thegrowing stage, thisis when the cellsin the root of eachhair divide, pushingthe previous strandout to make room fora new one. Hairthats in anagen forless than two yearsis usually thinning,says Dr. Rand, andthe length of apersons anagenphase is geneticallypredetermined.

2. The Catagen Phase (lasts 23 weeks) Hair takes a breakfrom growing andprepares to shedso it can eventuallyrenew. This isreferred to as thetransitional phase,during which clubhair (hair that hasstopped growing)begins to form.

3. The Telogen Phase (lasts 3 months) This is the restingphase, during whichclub hair is fullyformedif one ispulled from the root,youll see a hard,white substance onits tip. Dr. Rand saysabout 10 percent ofhair is usually in thetelogen stage.

HOW TO TREAT ITThinning hair isnt a quick-fix conditionoftentimes a multipronged approach withchanges to diet, products and treatments delivers the best results. Some nonsurgicalsolutions are both preventive and effective,providing reasonable improvements," saysDr. Ziering, but its important to have realistic expectations, as results can take monthsto manifest.

Essential OilsWhether theyre applied solo or infused into hair-care products, essentialoils are praised for their stimulating,balancing and calming properties that havebeen shown to spur healthy hair growth.Tea tree and cypress are proven to improvemicro-circulation deep in the scalp and increase blood flow to each follicle, saysFranois Hourcastagnou, CEO of hair-carebrand PHYTO and Als Group, USA. Rosemary can gently but effectively exfoliate thescalp, sage can help calm irritation andlemon oil can balance sebum production sofollicles dont get clogged. According to integrative medicine specialist Dr. Elizabeth Trattner, one study on 84alopecia areata patients revealed that massaging a mix of cedarwood, lavender, thymeand rosemary oils with either jojoba or grapeseed carrier oils into the scalp for sevenmonths produced significant hair growthimprovement in 44 percent of the group,compared to 15 percent of patients who usedjojoba or grape seed alone. Another studyshowed 3 percent peppermint oil appliedtopically helped facilitate hair growth bypromoting circulation in the hair dermalpapilla [cells at the base of hair follicles], sheadds. (Note: Applying essential oils directlyto the scalp could be too strong and cause irritation, which is why most are mixed withcarrier oils. Doing a patch test at the nape ofthe neck to check their compatibility withyour skin is recommended.)

Diet + NutraceuticalsTo strengthen brittle hair, Dr. Attenello says its best to follow a balanced diet that includes protein and foodssuch as eggs, fish and nuts that contain omega-3 fatty acids. We also recommend zinc,iron and biotin supplements, all of whichhave been shown to improve hair texture andcaliber, she adds.Dr. Ziering likes Viviscal, a daily supplement that contains a marine complex calledAminoMar that helps promote existinghealthy hair growth from within, but is notan option for patients with shellfish allergies. Another expert favorite is Nutrafol,which New York plastic surgeon Jennifer Levine, MD says is good for both thinninghair and anti-aging. It neutralizes free radicals, rebalances stress-producing hormones and contains botanicals that promote theabsorption of hair-boosting nutrients, sheadds. With the majority of hair supplements,some users can see results after one month,but experts say three months is standard.

AcupunctureIn Chinese medicine, acupunctureis often used as a remedy. Needlesare placed on the face, body andscalp to promote blood and energy circulation to the scalp, stimulating hair growth,says Dr. Trattner. Studies show it can helptreat female thinning better than male, although reasons for this are undetermined. Aseries of treatments need to be done weeklyor biweekly to restore balance, and thenmaintenance depending on individual results. Some people get better outcomes thanothers, but when combined with Chineseherbal medicine, results are synergistic andalmost always better, Dr. Trattner adds. It isalso important to find a licensed practitionerwho is familiar with hair loss.

Hair CareThinning hair demands extra TLC,so any products used on it shouldhave scalp health and hair growthproperties. Some brands tout biotin as astrand booster, but Dr. Rand says minoxidilknown over-the-counter as Rogaineisthe only FDA-approved OTC ingredient thathas been clinically proven to increase the diameter of the hair follicle, producing thickerhair. Results may take months to exhibit,and side effects associated with topical minoxidil can include scalp itching and flaking,so it's not an option for everyone. For those going the natural route, botanical-based topicals can also be effective:French hair-care brand Ren Furterer formulates with follicle-energizing pfaffia extract (aka Brazilian ginseng) and sebumreducing curbicia (a patented extract fromsquash seeds) to promote growth. No matter the product used, Dr. Rand notes:If you stop using it, the results will stop too.

Product Picks: Ren Furterer Triphasic Strengthening Shampoo ($32); PHYTO Phytopolline Botanical Scalp Treatment ($40); Nutrafol Core for Women ($79); Viviscal Advanced Hair Health Supplements ($50).

However, a new platform called HairStim is now being offered by dermatologists around the country, who can customize products to include a mix of prescription-strength ingredients such as topical finasteride and spironolactone, depending on the patients concerns. Weve seen impressive results so far on both men and women, Dr. Bhanusali says.

Oral finasteride (you may know it by its brand name Propecia) is commonly prescribed in a 1 milligram dosage for men, and sometimes for post-menopausal women as well"its not advised for childbearing women because of its hormone interference, says Dr. Attenello. This also applies to oral spironolactone. A double-blind study in 2014 revealed that 400-milligram capsules of pumpkin seed oil could mimic the effects of oral finasteride in men, but there hasnt been much research since, and no studies that included women.

Light TherapyLow-Level Laser Therapy (LLLT)technologiesusually in theform of laser headbands and hatsthat can be worn at home or in a doctorsofficeare designed to improve folliclefunction and reverse the effects of thinninghair and hereditary hair loss. LLLT is anoninvasive, pain-free and FDA-clearedsolution that uses diodes that emit infraredor red light, says Dr. Ziering. It increasesblood circulation to the scalp and helps thefollicles produce thicker, longer, healthierhairs with improved pigment.

Dr. Rand says there are many doctorswho use LLLT, and while the devices cangrow some hair in carefully selected patients, they tend to work better on thosewho are balding (or quite thin) rather thanthose with moderate thinning. The issue isthat the lights cant penetrate down to thescalp tissue if theres hair in the way, whichis why I prefer combs rather than caps forwomen because they separate the hair, sheexplains. In general, these devices tend towork better on men; however, as technology evolves and more hair loss studies aredone on women, this may change.

Product Pick: The most high-tech headband weveever seen, HairMax LaserBand 41 ($549) delivers follicle-stimulating energyto the scalp via 41 medical-gradelasers and is super easy to use. Justput it on your head, press the buttonand voila. Wearing it three times aweek for just three minutes treatsthe entire scalp.

Platelet-Rich Plasma (PRP)Platelet-rich plasma (PRP)is a newer biotechnologyused to treat early androgenic alopecia or thinning hairand involves drawing a smallsample of the patients bloodfrom the arm before puttingit through a centrifugation process to extractthe blood plasmarich in proteins andgrowth factorsand eliminate the red bloodcells. The plasma is then injected into thehair follicles in thinning regions of the scalp,and the platelets bond to receptors in thestem cells of the scalp tissue," says Las Vegasplastic surgeon Julio L. Garcia, MD, an earlyadopter of PRP treatments. "This activatesthe active hair growth phase and allows hairto grow back where it has been lost.

Dr. Attenello says the treatments are best served for patients with hairthinning, where the hair bulbsstill exist for the PRP to nourish them, rather than thosewith hair loss that has beenpresent for more than a year,where the hair bulb is likelynot intact anymore. Preliminary studies have shown favorable results interms of hair count and density, but larger-scale trials are warranted, she adds.

Most PRP protocols involve treatmentonce a month for three months, and then awaiting period of an additional three monthsbefore results are visible; maintenance treatments every three to six months followingmay be necessary depending on the needsof the patient.

There is also a next-generation form ofPRP called PRF, or platelet-rich fibrin, whichis extracted similarly to PRP, but containsmore growth factors. Dr. Levine prefers PRFbecause it allows the platelets to remain viable while releasing growth factors in a controlled manner that can last hours to days;PRP growth factors only last a few minutes tohours. The benefits of longer-lasting growthfactors, she explains, are that they promotemore hair growth.

Critics point to the treatments lack ofFDA-approval and regulation: Dr. Garciasays there are numerous PRP preparationsystems on the market today with FDA clearance for PRP used in bone graft procedures,but not those for hair. Therefore, the use ofPRP outside this setting is considered off label and scrutinized by the FDA, he explains. Nevertheless, it is widely consideredsafe. Pasadena, CA plastic surgeon GordonSasaki, MD and a team of doctors are currently conducting the first randomized-controlled clinical trials to study the safety andefficacy of low versus high amounts of PRPfor hair regrowth in patients with androgenetic alopecia. By four months, an increasein both terminal [longer, darker hairs] andvellus [shorter, thinner hairs]have been documented withminimal to no side effects orcomplications, Dr. Sasaki notes.Ian Sanderson, president ofskin-care brand AnteAGE, isdedicating his efforts to a newerarea of researchthe topicalapplication of growth factors to battle thinning hairwhich, he hopes, will one daymake PRP injections obsolete.

PRP is mostly effective by deployinggrowth factors like VEGFvascular endothelial growth factorand other stem cellby-products like cytokines to restart dormanthair follicles. Weve been able to engineer atopical treatment solution containing allthose hair growth factors in precise dosages,along with several bio-signals that go beyondwhats possible with PRP alone, he says, adding that its also an alternative to minoxidil.Its been recently understood that one ofminoxidils key mechanisms of action is up regulation of VEGF. Using this growth factortopicallyits a key ingredient in our hairtreatmentswe may make minoxidil obsolete, along with its potential side effects."

THE PRP DEBATENot all doctors see eye to eye when it comes to PRP.PRO: I advocate the use ofPRP for androgenicalopecia in men andwomen. Excellentclinical outcomes areseen after a series offour monthly injections.Diminished hair lossand noticeable newhair growth is typical.Washington, D.C. dermatologist Tina Alster, MD

CON:There is some evidencethat it can benefit thosewith hair loss, but itsstill very controversialbecause theres nota wealth of good data orresearch done underappropriate FDAguidelines. There havealso been some issuesof PRP being done insalons and spas withcatastrophic outcomessuch as contaminationand the spread of HIV.La Jolla, CA plastic surgeon Robert Singer, MD

SURGICAL SOLUTIONWhen nonsurgical solutions have beenexhausted without success, hair restoration surgery can dramatically improveones appearance and self-confidence. Thegold-standard surgical option for hair loss isa hair transplant, which entails surgicallyremoving hair from the back of the headthe area thats most resistant to DHTandimplanting it into thinning areas, says Dr.Attenello. It can be done on both men andwomen, but because women have a differentpattern of hair loss and hair thinning, not allfemale patients are ideal candidates.

The Two Main TypesFollicular Unit Transplantation (FUT): Astrip of hair is removed from the back of thehead, and then the hairs are separated andimplanted into the areas that need to beaddressed, says Dr. Levine. The advantageto FUT is that youre able to cover a largersurface area of baldness, but the downtimeis typically five to seven days.

Follicular Unit Excision and Extraction(FUE): The surgeon (the procedure can beperformed robotically or manually) cutsaround each individual hair follicle, removing and implanting it back into thinning areas. Many surgeons use handheld motorizeddevices to enhance the hair extraction process. These procedures are lengthy and cantake five to eight hours, depending on thesize of the treatment area, says Dr. Levine.But, the recovery time is fastertwo to fivedaysthan with the FUT method and thereis no linear scar on the head.

Power PlayNo matter how skilled the surgeon, robotscan offer exactness human hands cantthey also dont tire after hours in an OR. Themost advanced surgical technology currently available to treat hair loss is the ARTASrobotic system, which utilizes state-of-the-art technology to assist physicians with difficult, manual placements of grafts that require repetitive and precise movements,says Dr. Heil. ARTAS was developed withleading hair transplant physicians and researchers, and offers a clinically proven, permanent solution that provides natural results without stitches, staples or linear scars.Regardless of how the grafts are placed,Dr. Ziering says the hair will continue togrow and function like it normally would,although some routine maintenance maybe needed. Post-procedure, patients cantcolor their hair for four weeks and need toavoid direct sun exposure for at least threemonths to reduce risk of hyperpigmentation, therefore many patients opt to havetransplant surgeries in the winter. Dr. Ziering adds, Noticeably thicker, natural-looking hair growth begins around six months,and the final outcome is seen one year following treatment.

Medically reviewed byLa Jolla, CA plastic surgeon Robert Singer, MD,Eugene, OR plastic surgeon Mark Jewell, MDand Montclair, NJ dermatologist Jeanine B. Downie, MD

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The Ultimate Guide to Thinning Hair - NewBeauty Magazine

Highlights of the BMC series: August 2019 – BMC Series blog – BMC Blogs Network

BMC Bioinformatics Novel deep learning model for more accurate prediction of drug-drug interaction effects

The most efficient therapy to many diseases is often the result of a combination of drugs. Administration of more than one molecule in cases of cancer, hypertension, asthma and AIDS can lead to an increase in drug efficiency and decrease in toxicity and resistance by the target cells. Nevertheless, different molecules can also interact in a detrimental way for the body. Hence the importance of being aware if multiple drugs are prescribed to patients. Different studies have been carried out, trying to foresee possible drug-drug interactions inside the body. In vivo testing is often limiting because it requires a long time to screen different compounds. In silico studies, instead, have proved to be more powerful.

Figure 1, Lee et al., https://doi.org/10.1186/s12859-019-3013-0

Computational methods, usually, take into account known characteristics of molecules, such as structure, target and side effects. An article published this month by Lee et al. in BMC Bioinformatics shows the formulation of a new deep learning model to predict drug-drug interaction, that takes into consideration three concepts: target similarity profiles (TSP), Gene Ontology (GO) term similarity profiles (GO term gives information about the gene function, where it acts inside the cell and in which biological process it is involved) and Structural similarity profiles (SSP). Three similarity profiles are traced for any given drug pair. These are then joined together to provide an estimation of the level of interaction between the two molecules. This approach allowed the authors to identify, with the same or greater accuracy, drug-drug interactions that were characterized using different methodologies.

BMC Cancer Molecular features of lung adenocarcinoma in young patients

Christian Darkin/Science Photo Library

Incidence of lung cancer in the population increases with age and it is rarely diagnosed in young people. It has been shown that clinic-pathological features of lung cancer in younger and older patients are not the same. However, previous research in the field has not shown conclusive results and still remains elusive.

In this study carried by researchers of Zhejiang University (China), specimens of cancer cells from 89 young patients (35 years old or younger) with adenocarcinoma were analyzed. The majority of patients were women and only 1 in 10 were smokers.

Prognosis was also seen to vary according to the mutations involved in cancer onset.

Next-generation sequencing was used to identify the mutation of 59 cancer-related genes. The most frequently mutated genes identified were ERBB2 (Receptor tyrosine-protein kinase erbB-2) and EGFR (epidermal growth factor receptor). Fusion of ALK (Anaplastic lymphoma kinase) and ROS1 (receptor tyrosine kinase) genes was also characterized as responsible for oncogenesis. No significant correlation was seen between the mutations (or fusion) identified, the gender or the smoking habit of the patient. Overall, a prevalence of ERBB2 mutations was characterized in well/moderately differentiated tumors, while EGFR mutations and ALK fusions were identified in moderately/poorly differentiated tumors. Prognosis was also seen to vary according to the mutations involved in cancer onset.

BMC Pregnancy and Childbirth Why rural women do not use primary health centers for pregnancy care: evidence from a qualitative study in Nigeria

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Maternal mortality rates in developing countries are still unacceptable and although policies were made by local governments, around 830 women still die every day because of pregnancy or childbirth complications. 99% of these deaths happen in developing countries and they are, in most cases, preventable.

Nigeria is one of the countries with the highest maternal mortality rate, with peaks in rural areas. In 2014, the government launched a program to provide primary health care for vulnerable populations. Despite the efforts, rural pregnant women did not make use of this service and are not receiving medical support during pregnancy and delivery.

Women also reveal that often the quality of care is not adequate

A qualitative study in BMC Pregnancy and Childbirth investigated the reasons underlying womens dangerous choice of not using the primary health care facilities provided. Discussion through focus groups allowed the authors to identify some major themes behind this trend. Participants underlined the difficulty in reaching the health centers, as paved road are non-existent and it is risky to use the bad roads available. Difficulty in obtaining a mean of transportation and distance to the facilities were also identified as important barriers.

Furthermore, participants stated that those clinics are not open at all times and taking a trip there and finding them closed discouraged them from using the health care facilities on other occasions.

Strikingly, women also reveal that often the quality of care is not adequate; there is not medication to alleviate the pain, waiting times are long, the environment is not friendly and the healthcare professionals are not supportive or competent. This, in addition to the belief that traditional medicine and divine intervention would do just as much as the staff of the health centers, pushes women to avoid seeking this type of professional help. Finally, participants also mentioned that the cost of care is arbitrary and often these facilities request patients to buy consumables from them, which can be expensive.

All things considered, this study suggests that the governmental solution to maternal mortality is still far from being adequate. Improvement in facility accessibility and in the quality of care would motivate women to rely on professional help during pregnancy. However, much work still needs to be done in this direction.

BMC Palliative care Designing and developing a co-produced theoretical and evidence-based online support for family caregivers of people with dementia at the end of life

and.one / stock.adobe.com

The majority of people with dementia live in the community but receive care mostly from family members or friends. Caring for a loved person affected by this condition can be extremely challenging, especially with the progression of the disease and towards end of life.

Researchers from the University College of London designed and developed an online palliative care support website, targeting real problems of carers of people with dementia at the end of life. Among the negative effects of taking care of a relative with dementia are depression, poor physical health and poor quality of life. Researchers are positive that this tool will help carers in their role and help to improve their overall well-being.

BMC Musculoskeletal Disorders Corticosteroid injection for plantar heel pain: a systematic review and meta-analysis

fcafotodigital / Getty Images / iStock

Heel pain caused by plantar fasciitis can be insistent and impair daily activities, such as walking or running. Around 7% of the population suffers from this condition. In many cases, rest or change of habits can be sufficient to relieve the symptoms with time. However, if symptoms persist, it can be necessary to resort to different approaches, such as physiotherapy or Corticosteroid injections as they help lessen pain and inflammation. It is still unclear why Corticosteroid injections are prescribed so often, since evidence of their mode of action are still lacking.

The Corticosteroid injections would act as a placebo

A systematic review published in BMC Musculoskeletal Disorders gathered together trials and studies on the topic and elucidated in which occasions injections are effective and when they are wrongly prescribed. The review showed that Corticosteroid injections prove to be effective in the short term, in comparison to autologous blood injection, orthotics or physiotherapy. However, in the long term, platelet-rich plasma or dry needling seem to have better results. Therefore, the Corticosteroid injections would act as a placebo. Remarkably, the effect of the steroid injections seems, therefore, minimal. Further clinical trials could provide us with a better understanding of the most effective ways of treatment for this condition.

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Highlights of the BMC series: August 2019 - BMC Series blog - BMC Blogs Network