Category Archives: Stell Cell Research

Reported stem cell treatment could give hope to Michael Schumacher – Stuff.co.nz

The news that Formula One legend Michael Schumacher was moved to a hospital in Paris last week for pioneering stem cell therapy has provoked a fever of hope and speculation among fans that his condition could be improved.

After suffering devastating head injuries in a ski accident almost six years ago, Schumacher was placed in a coma for six months and has been receiving treatment at his home in Switzerland. He has not been seen in public since the accident.

His privacy is closely guarded and, while it is understood he cannot walk or stand, and, according to former Ferrari manager, Jean Todt, he may still have trouble communicating, nothing has been confirmed officially.

No wonder then that fans have been so excited to hear Schumacher is now under the care of world-renowned cardiac surgeon Philippe Menasch, described as a "pioneer in cell surgery" at the Georges-Pompidou hospital in Paris.

READ MORE:* Schumacher 'conscious' after treatment*Corinna Schumacher provides rare update*Schumacher 'struggles' to communicate*Mick Schumacher trying to emulate his dad

Stem cells are cells that can differentiate or change into other types of cell, opening the possibility of replacing damaged cells with healthy ones. Scientists have been looking into their use since the Sixties, most successfully so far in cases of cancers of the blood or bone marrow. More than 26,000 patients are treated with blood stem cells in Europe each year.

And since the Eighties, skin stem cells have been used to grow skin grafts for patients with life-threatening burns; most recently, a new stem cell-based treatment to repair damage to the cornea (the surface of the eye) after an injury like a chemical burn, has received conditional approval in Europe.

But their flexibility offers hope for lots of illnesses and conditions including heart disease, MS and macular degeneration and clinical trials are progressing in all these areas. Chronic spinal cord injury is being researched with some promise, thanks to the Christopher & Dana Reeve Foundation, set up after actor Christopher Reeve was paralysed in a riding accident.

Crucially, for cases such as Schumacher, stem cells are also being explored for neurodegenerative diseases like Parkinson's and Alzheimer's and traumatic brain injuries like the one he suffered in a skiing accident in December 2013.

Head injuries are difficult to treat as brain damage cannot be undone and each case is different. Asked for comment by The Daily Telegraph, the hospital responded that they could neither confirm nor deny the presence of Schumacher.

However, if he is under the care of Menasch, it is likely he will have had stem cells delivered by an IV to the area of the body where it is felt they could work best - whether that is his head or heart.

CHRISTOPHE ENA/AP

Paris' Georges-Pompidou Hospital, where Michael Schumacher is reportedly a patient.

In a recent interview online, Menasch explained that stem cell treatment for cardiac conditions - his particular area of expertise - is in its infancy. "Nobody really knows how stem cells are working," he said. "They do not permanently transplant into the myocardium [the muscular tissue of the heart] - after a couple of days or weeks, they just disappear.

"But you still may have a functional benefit as during their transient stay in the heart," he explains in the Future Tech podcast, "as the cells release molecules into the tissue. The hypothesis is that the repair comes from the heart itself, stimulated by these molecules."

Should the stem cells have been intended for Schumacher's brain injury, research suggests that the treatment has potential. A University of Plymouth study published in the journal Cell Reports in June found that neural stem cells could be used to "wake up" and produce new neurons (nerve cells) and surrounding glial cells in the brain.

The research is in its infancy, says lead author Dr Claudia Barros, from the Institute of Translational and Stratified Medicine at the University of Plymouth, who acknowledges there is still a long way to go until such findings can be translated into human treatments.

"We are working to expand our findings, to bring us closer to the day when human neural stem cells can be controlled and efficiently used to facilitate brain damage repair, or even prevent brain cancer growth that is fuelled by stem-like cells," she says.

A Chinese study published last month in the journal Frontiers in Cellular Neuroscience examined the current state of progress into the effects of stem cell therapy on traumatic brain injury. But the researchers from Zhejiang University, Hangzhou warned much more work was needed: "Although a large number of basic studies have confirmed that stem cells have good effect in the craniocerebral injury," they said, "the safety of stem cells, the route of injection, the time of injection and the specific mechanism are all factors that affect the clinical application of stem cells, and are the important research point in the future study."

PREMA TEAM

Mick Schumacher doesn't mind the comparisons with his seven-time F1 champion father Michael.

In the UK, some applications of stem cell medicine are already available privately, although tightly controlled by the Human Tissue Authority and not in the brain.

Simon Checkley, CEO at the Regenerative Clinic in Brighton, explains: "It is possible to get stem cells from sources outside your body, like the umbilical cord or Wharton's jelly [the vitreous humour in the eyeball], but in the UK we can only take stem cells from our own bodies.

"It is possible to get them donated, but it is safer to use your own."

In some countries, stem cells can then be manipulated in a laboratory but that is illegal in the UK, says Checkley. "There is a concern with cultured stem cells which have been bred in a Petri dish that they may keep proliferating after you transplant them into a body. That, having triggered their growth, you can't stop it and no one knows what might happen."

At the Regenerative Clinic, stem cells are taken from adipose fat, where they are plentiful, and then injected back into the area to be treated - mostly arthritic joints.

"We are seeing fantastic results," Checkley says, "with reduced pain and improved mobility for 80 per cent of patients." He is considering a clinical trial which could see the treatment pass through the National Institute for Health and Care Excellence (NICE) and become available on the NHS.

The therapy is still only four years old, he emphasises. "We have treated 1000 patients so far and around the world, it's about 40,000. We need longer-term studies."

LUCA BRUNO/AP

Michael Schumacher has not been seen in public since suffering a serious brain injury in a skiing accident nearly six years ago.

This type of stem cell treatment is also offered in the UK for post-menopause vaginal atrophy and stress incontinence, Checkley says, plus the genital skin condition lichen sclerosis. In all these cases, he says, the mechanism is the same: the stem cells are not replicating dead or dying cells but acting as signalling devices, alerting the body that this is an area where healing is needed.

For stem cells to work in more complex conditions, they would need to be manipulated, Checkley says. In cases of brain injury or disease, that would mean altering stem cells so that they could be targeted more precisely. But he believes the role would be similar: "The idea is they would go to the area of greatest damage and signal the body to regrow tissue there."

Cost would be a huge factor, he points out. A treatment for arthritis costs about 6000 (NZ$11,700) at the Regenerative Clinic but an IV-led treatment for brain injury with manipulated stem cells could cost up to 50,000 (NZ$98,000). But then what price recovery from a traumatic brain injury? Full recovery thanks to stem cells would be a prize beyond value.

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India- Cell Counting Market Size is Estimated to Value $10679.7 Million By 2025: Grand View Research, Inc – MENAFN.COM

(MENAFN - GetNews) According to report published by Grand View Research, The global cell counting market size was estimated at USD 5,477.9 million in 2016 and is anticipated to grow at a CAGR of 7.8% during the forecast period.

The global Cell Counting Market is expected to reach USD10,679.7 million by 2025, according to a new report by Grand View Research, Inc. Government initiatives working to promote development of cell therapeutics, wherein cell counting plays an imperative role, is expanding growth prospects for the market. As a result of extensive R & D activities, the number of diseases treated with the help of stem cells increased to 82 in 2016 from 27 in 2005. Also, California Institute for Regenerative Medicine's funding of USD 271 million for stem cell therapy created 12 R & D facilities in California, and these facilities brought approximately USD 543 million funding. In addition, it is also funded by National Institutes of Health (NIH), which approximately invested USD 1,429 million in 2015.

Increase in the number of collaborations of research institutes with various public and private entities to promote R & D has provided significant boost to the market. Growing number of proposed guidelines and recommendations for public and private laboratories to ensure high-quality standards and facilitate generation of accurate results are likely to improve adoption of instruments over the coming years. For instance, in May 2016, the International Society for Stem Cell Research updated guidelines for the development of cell-based therapy and research. The proposed guidelines focus on all stages of R & D and improve quality of preclinical studies.

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India- Cell Counting Market Size is Estimated to Value $10679.7 Million By 2025: Grand View Research, Inc - MENAFN.COM

USC researchers untangle cellular reprogramming to help treat diseases – USC News

USC scientists have surmounted a big roadblock in regenerative medicine that has so far constrained the ability to use repurposed cells to treat diseases.

The researchers figured out how to reprogram cells to switch their identity much more reliably than present capabilities allow. The technique uses enzymes to untangle reprogramming DNA, somewhat similar to how a coiffeur conditions tangled hair. The technique works with near-perfect efficiency in mice and humans for all types of cells tested in the laboratories of USCs stem cell center.

Justin Ichidas lab is doing groundbreaking work in the field of stem cell research. (Photo/Damon Casarez)

The findings are significant because they clear an obstacle to help scientists find treatments for a wide range of diseases, especially neurologic impairments and conditions such as hearing loss.

This is a strategy for greatly improving our ability to perform cellular reprogramming, which could enable the regeneration of lost tissues and the study of diseases that cannot be biopsied from living patients today, said Justin Ichida, assistant professor in the department of stem cell biology and regenerative medicine at the Keck School of Medicine of USC.

The findings appear Thursday in Cell Stem Cell in a research paper titled, Mitigating antagonism between transcription and proliferation allows near-deterministic cellular reprogramming. Ichida is the lead author, joined by a team of researchers at the Keck School of Medicine.

Cellular reprogramming has enormous potential as a disease cure because it enables scientists to study cells and molecular processes at each step of disease progression in controlled conditions that have, until now, been impossible.

Reprogramming involves changing one cell into another type of cell, such as a blood cell into a muscle or nerve cell. Thats important for medical research because the technique can be used to recreate tissues lost to disease and to study diseases in tissues that cannot be biopsied from living patients.

The technique has been known for decades but hasnt met its potential. According to the USC team, thats because DNA does not respond well when manipulated to change itself. DNA molecules are twisty by nature, due to the double helix configuration. Reprogramming DNA requires uncoiling, yet when scientists begin to unravel the molecules, they knot up tighter. As a result, nucleotides become much more difficult to work with and cells wont replicate properly, Ichida explained. Current untangling techniques only work 1% of the time.

Think of it as a phone cord, which is coiled to begin with, then gets more coils and knots when something is trying to harm it, Ichida said.

To smooth the kinks, the researchers treated cells with a chemical and genetic cocktail that activated enzymes called topoisomerases. The process works by using the enzymes to open the DNA molecules, release the coiled tension and lay it smoothly. In turn, that leads to more efficient cellular reprogramming, which increases the number of cells capable of simultaneous transcription and proliferation, which is needed to promote tissue growth. Its the equivalent of a DNA detangler that relaxes the tension of reprogramming transcription and makes it easier to replicate new cell colonies or tissues in a lab.

The technique has multiple advantages over existing current practice. For example, it worked nearly 100% of the time. It was proven in human and animal cells. It can be employed today in laboratories to study disease development and drug treatments. It has immediate utility for studying schizophrenia, Parkinsons, ALS and other neurological diseases; in those instances, new cells can be created to replace lost cells or acquire cells that cant be extracted from people.

Moreover, the technique does not involve stem cells; the reprogrammed cells are not brand new but the same age as the parent cell, which is advantageous for studying age-related disease. The reprogrammed cells may be better at creating age-accurate in vitro models of human disease, which are useful to study diverse degenerative diseases and accelerated aging syndromes.

The key is to understand development of disease at a cellular level and how disease affects organs, Ichida said. This is something you can do with stem cells, but in this case, it skips a stem cell state. Thats important because stem cells reset epigenetics and make new, young cells, but this method allows you to get adult cells of same age to better study diseases in aged individuals, which is important as the elderly suffer more diseases.

This latest advance in regenerative medicine complements other recent technological gains, including gene editing, tissue engineering and stem cell development. It represents a convergence in regenerative medicine moving scientists closer to treating many diseases. It has practical utility to accelerate targeted medical treatments and precision medicine.

A modern approach for disease studies and regenerative medicine is to induce cells to switch their identity, Ichida said. This is called reprogramming, and it enables the attainment of inaccessible tissue types from diseased patients for examination, as well as the potential restoration of lost tissue. However, reprogramming is extremely inefficient, limiting its utility. In this study, weve identified the roadblock that prevents cells from switching their identity. It turns out to be tangles on the DNA within cells that form during the reprogramming process. By activating enzymes that untangle the DNA, we enable near 100% reprogramming efficiency.

The study authors include Ichida and first authors Kimberley Babos and Kate Galloway (now an assistant professor at the Massachusetts Institute of Technology), as well as Kassandra Kisler, Madison Zitting, Yichen Li, Yingxiao Shi, Brooke Quintino, Robert Chow and Berislav Zlokovic of the Keck School of Medicine.

Funding for the study comes from a California Institute of Regenerative Medicine predoctoral training grant (TG2-01161); a Kirschstein-National Research Service Award postdoctoral fellowship (5F32NS092417-03); National Institutes of Health grants (R00NS077435, R01NS097850 and 5R01DC0155300); U.S. Department of Defense grant (W81XWH-15-1-0187); grants from the Donald E. and Delia B. Baxter Foundation, the Alzheimers Drug Discovery Foundation and the Association for Frontotemporal Degeneration, the Harrington Discovery Institute, the Tau Consortium, the Pape Adams Foundation, the Frick Foundation for ALS Research, the Muscular Dystrophy Association, the John Douglas French Alzheimers Foundation, the Merkin Family Foundation, the New York Stem Cell Foundation, the Keck School of Medicine of USC, the USC Broad Innovation Award and the Southern California Clinical and Translational Science.

Ichida is a co-founder and owner of AcuraStem, a California-based precision medicine company. USC also has a financial interest in AcuraStem. The other authors declare no competing interests.

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USC researchers untangle cellular reprogramming to help treat diseases - USC News

CyTOF Inventors Receive Prestigious Science and Technology Award from the Human Proteome Organization (HUPO) – Yahoo Finance

Industry-Leading CyTOF Technology Recognized at the 18th Annual HUPO World Congress for Delivering Unprecedented Proteomic Insight at Single-Cell Resolution

SOUTH SAN FRANCISCO, Calif., Sept. 18, 2019 (GLOBE NEWSWIRE) -- The Human Proteome Organization (HUPO), an international scientific organization that promotes proteomics through international cooperation and collaborations, today recognized CyTOF inventors Dr. Scott Tanner, Dr. Vladimir Baranov, Dr. Olga Ornatsky and Dr. Dmitry Bandura and Fluidigm (FLDM) as winners of the 2019 Science and Technology Award. Announced at the 18th Annual HUPO World Congress in Adelaide, Australia, the award recognizes key innovators who have developed and commercialized industry-leading technologies, products or procedures to advance the understanding of the human proteome.

The award-winning mass spectrometry pioneers developed and commercialized cytometry by time-of-flight (CyTOF) at DVS, with the introduction of the first commercial CyTOF system in 2009. Designed to simplify highly multiplexed detection of cell surface and intracellular markers at single-cell resolution, CyTOF uses stable, isotopically distinct metal tags that can be easily distinguished in cells and tissues by atomic mass spectrometry.

In 2014, Fluidigm acquired DVS with a goal of expanding the use of CyTOF technology to new researchers and applications. Fluidigm introduced Helios, a CyTOF system, in 2015, and in 2017 it launched the Hyperion Imaging System for Imaging Mass Cytometry (IMC) applications. Fluidigm also now offers over 700 commercially available antibodies and pre-designed antibody panels for use with mass cytometry and IMC, including the recently introduced Maxpar Direct Immune Profiling System. Setting the new standard in human immune profiling, this profiling system provides the first complete sample-to-answer solution to quantify 37 different immune cell populations using a simple single-tube workflow with automated five-minute results reporting.

HUPO is excited to award Fluidigm with recognition of the developersScott, Vladimir, Olga and Dmitry with the 2019 HUPO Science and Technology award for the development of CyTOF technology, saidDr. RobertMoritz, HUPO Vice President and Chair of the HUPO Awards Committee.CyTOF is a transformative technology that is instrumental in driving groundbreaking discoveries in immunology, cancer, stem cell research, neurology and many more biological areas by enabling researchers to deeply profile protein biomarkers from cells and tissues at single-cell resolution.

Now used by leading cancer centers, academic medical centers and pharmaceutical organizations around the world, mass cytometry has powered significant advancements in the understanding of the immunome, with a growing list of more than 850 research publications.

We congratulate each member of the team for this notable award. Combining cytometry and inductively coupled plasma spectrometry to develop CyTOF technology was a landmark achievement, said Chris Linthwaite, President and CEO of Fluidigm. Over the past 10 years, we have developed an impressive suite of CyTOF systems and applications that enable researchers to understand the underlying mechanisms of disease, identify new biomarkers and accelerate therapeutic development. We are committed to further expanding the utility of this revolutionary technology to ultimately transform routine clinical testing of the immune system. With more than 50 clinical trials now powered by CyTOF, we see a tremendously bright future ahead.

About HUPOThe Human Proteome Organization (HUPO), is an international scientific organization representing and promoting proteomics through international cooperation and collaborations by fostering the development of new technologies, techniques and training. HUPO is led currently by HUPO President and Professor Stephen Pennington of the University College Dublin in Ireland and HUPO Vice President and Professor Robert Moritz of the Institute for Systems Biology in Seattle, Washington.

About FluidigmFluidigm (FLDM) is an industry-leading biotechnology tools provider with a vision to improve life through comprehensive health insight. We focus on the most pressing needs in translational and clinical research, including cancer, immunology, and immunotherapy. Using proprietary CyTOF and microfluidics technologies, we develop, manufacture, and market multi-omic solutions to drive meaningful insights in health and disease, identify biomarkers to inform decisions, and accelerate the development of more effective therapies. Our customers are leading academic, government, pharmaceutical, biotechnology, and plant and animal research laboratories worldwide. Together with them, we strive to increase the quality of life for all. For more information, visit fluidigm.com.

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Fluidigm, the Fluidigm logo, CyTOF, Direct, Helios, Hyperion, Imaging Mass Cytometry, IMC, and Maxpar are trademarks and/or registered trademarks of Fluidigm Corporation in the United States and/or other countries. All other trademarks are the sole property of their respective owners. Fluidigm products are provided for Research Use Only. Not for use in diagnostic procedures.

Forward-Looking Statement for FluidigmThis press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including, among others, statements regarding anticipated benefits of newly introduced products and the growth and potential ofFluidigmproducts for mass cytometry and Imaging Mass Cytometry. Forward-looking statements are subject to numerous risks and uncertainties that could cause actual results to differ materially from currently anticipated results, including but not limited to risks relating to challenges inherent in developing, manufacturing, launching, marketing, and selling new products; potential product performance and quality issues; intellectual property risks; and competition. Information on these and additional risks and uncertainties and other information affecting Fluidigm business and operating results is contained in Fluidigms Annual Report on Form 10-K for the year ended December 31, 2018, and in its other filings with theSecurities and Exchange Commission. These forward-looking statements speak only as of the date hereof. Fluidigm disclaims any obligation to update these forward-looking statements except as may be required by law.

Contacts:

HUPOChelsea PrangnellAssociation Manager604 558 5498office@hupo.org

FluidigmMedia: Michaeline BuntingSenior Director, Marketing 650 737 4190michaeline.bunting@fluidigm.com

Investors:Agnes LeeVice President, Investor Relations650 416 7423agnes.lee@fluidigm.com

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CyTOF Inventors Receive Prestigious Science and Technology Award from the Human Proteome Organization (HUPO) - Yahoo Finance

Genome-editing shows potential for treating HIV in patient – BioNews

16 September 2019

Chinese scientists have used the genome editing tool CRISPR in an attempt to treat HIV in a patient with blood cancer, for the first time.

The researchers created HIV-resistant stem cells, which they transplanted into the patient, where they survived for more than a year. Although the therapy did not reduce the level of HIV virus in the patient, no unintended genetic alterations were seen - one of the main areas of concern in genome editing.

'This is an important step towards using gene editing to treat human disease,' said Dr Fyodor Urnov, an expert on genome editing from University of California, Berkeley who was not involved in the study. 'Because of this study, we now know that these edited cells can survive in a patient, and they will stay there,' he told Nature News.

The team of scientists from Peking University Stem Cell Research Centre in Beijing, China, developed their approach to mimic the effects of a naturally occurring gene mutation that makes an individual resistant to HIV infection. The gene, CCR5, is responsible for making a protein that the HIV virus uses to get inside cells.

Three HIV patients are reportedly free of the virus after receiving stem cell transplants from donors with the protective mutation (see BioNews 990). However, as the mutation is rare, the team instead took stem cells from healthy donors and used genome-editing technology to delete the CCR5 gene. The edited stem cells were transplanted into the patient, as part of his cancer treatment.

The study is in marked contrast to the widely condemned work by Chinese scientist, Dr He Jiankui, who last year announced he had used genome-editing in human embryos to produce 'HIV-resistant' babies (see BioNews 977). One key difference of the current research is that the mutations were corrected in select adult cells, which would not alter the germline.

The edited cells persisted in the patient's blood during the 19-month study. However, only five to eight percent of the patient's total stem cells contained the protective edit, so the level of HIV was not significantly reduced, although the cancer was in remission.

Dr Rowena Johnston, director of research for amfAR, the Foundation for AIDS Research, told Wired: 'Ultimately, it comes down to the editing efficiency. That's the biggest challenge,' she said.

Professor Deng Hongkui who led the study told CNN that improving the efficiency of genome editing and optimising the transplantation procedure should accelerate the transition to clinical applications. 'The goal of a functional cure for AIDS is getting closer and closer,' he concluded.

The study was published in The New England Journal of Medicine.

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New technology developed to screen for Huntington’s treatments – Drug Target Review

Researchers have created a new technology which enabled them to discover more about the causes of Huntingtons disease and which can be used to test drugs.

A study has used a new technology to understand more about the causations of Huntingtons disease, when the brain is in early developmental stages. According to the researchers, their findings can be used to study the disease and test potential drugs.

The research was conducted at Rockefeller University, US. The new method, in the lab of Professor Ali Brivanlou, uses neuroloids, tiny three-dimensional (3D) tissues cultures, to research cell groupings from human embryonic stem cells. The team was able to manipulate them in the lab to study how the disease arises.

Previous studies conducted by the researchers demonstrated that the condition arises in young neurons, but the new evidence indicates that the disease is caused during neurulation. This is when the brains cellular uniformity changes and distinct structures develop.

Developmental diseases can now be studied with new technology involving tiny brain models called neuruloids, shown here (credit: Laboratory of Stem Cell Biology and Molecular Embryology at The Rockefeller University).

When the researchers introduced into neuroloids a mutation known to cause Huntingtons, it consistently caused abnormally-shaped tissue structures.

The technology is now being used by the researchers to screen for drugs to prevent these abnormalities. They hope that their work will provide an alternative to similar work being done in animal models.

This technology really opens a door toward identifying that mechanisms that govern brain development, understanding how they go awry in disease and testing drugs that set these mechanisms back on the right course, says Brivanlou.

The findings were published in Nature Biotechnology.

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New technology developed to screen for Huntington's treatments - Drug Target Review

Device can produce synthetic human embryo-like parts – Washington Times

Scientists have developed a device that can produce dozens of synthetic human embryo-like parts simultaneously, calling it a tool that could improve the understanding of early human development.

By making such embryo-like structures from human stem cells, we have now available to us reliable experimental platforms to study human development without using human embryos, said Jianping Fu, one of the studys researchers and an associate professor of mechanical engineering at the University of Michigan.

Using devices that can manipulate fluids, the team of researchers were able to build embryo-like structures that resemble the core of an implanting human embryo, according to their article published last week in the journal Nature.

They created models of the amniotic ectoderm (which develops into the membrane that encloses a developing fetus) and the epiblast (which develops into all the cell types found in the human body) from human stem cells.

But the researchers excluded some important cell types from the embryo-like parts such as the trophoblast, which develops into the placenta, Mr. Fu said.

These embryo-like structures will be very powerful for advancing human embryology and reproductive biology. These embryo-like structures will also be useful for drug and toxicity screens to prevent pregnancy failure and birth defects, Mr. Fu said, adding that the team created them in controllable, reproducible and scalable ways.

The researchers made 12 to 15 embryo-like structures simultaneously at a 95% success rate, he said. Mr. Fu estimates that since 2016 the team has produced a few hundred embryo-like parts, keeping them less than four days.

The research has raised some ethical concerns about the idea of synthetic or artificial embryos, and Mr. Fu said he understands why some people might feel uncomfortable with the concept.

We are well aware of the sensitivity of our research, he said.

But he stressed that what he and the team have created are a mass of cells that mimic portions of a developing embryo that cannot develop into a fetus. He said the research team has no intention of creating a synthetic embryo and has no scientific reason to do so.

Josephine Johnston, director of research and research scholar at the Hastings Center, a bioethics research institute, said the teams study could raise the question of whether the embryo-like structures can be manipulated to create a fetus or whether these scientific techniques are bringing society closer to creating embryos from stem cells, which she described as likely implausible but understandable concerns for the public.

Ms. Johnston also questioned if the word embryo is the correct terminology for Mr. Fus teams work if the structures cannot develop in the womb, cautioning about language use to describe scientific models.

She said the stem cell work, along with cloning research and in vitro fertilization, raise similar concerns about the prospect of embryos having no family structure, and growing them inside peoples bodies and the manipulation of human life. Ms. Johnston added that religious concerns also play a role, which is why there is opposition to in vitro fertilization.

Anytime you are modeling human biology, you are only creating a model. So its never quite the same, and it cant necessarily answer all the same questions, she said of Mr. Fus teams study and the growth of cultured cells in a dish. But it is often a really important intermediary step before moving into doing experiments with humans.

The Fu teams work is the first demonstration of a bona fide human embryo-like structure and shows that such structures can be made from pluripotent or induced pluripotent stem cells in vitro, according to Anna-Katerina Hadjantonakis, a developmental biologist for the Sloan Kettering Institute.

Whats important is that this method is very robust and reproducible. Many identical structures can be generated at once, all having similar morphology which approximates to the human embryo, she said. The work opens the door and provides an accessible method for future studies in other laboratories.

Mr. Fu said he and the team are interested in continuing to polish the stem cell in vitro system using fluid-controlling devices to prolong the culture of human embryo-like structures.

He said other scientists have been able to create structures that resemble complete mouse embryos and implant those synthetic embryos into a surrogate. However, there has been no further development of artificial animal embryos beyond early implantation, he said.

Mr. Fu said he and his group created a 3D culture system using human stem cells two years ago. Other scientists have reported building 3D systems using mouse and human stem cells.

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Device can produce synthetic human embryo-like parts - Washington Times

Global Advanced Wound Care Markets to 2024: Emerging Technologies such as Crab Shell Bandages, Bacteriophages, Platelets, and Stem Cell Therapies are…

Dublin, Sept. 17, 2019 (GLOBE NEWSWIRE) -- The "Global Advanced Wound Care Market: Focus on Advanced Wound Care Dressings, NPWT Devices, Wound Care Biologics, HBOT Devices, Ultrasonic Devices, and Electromagnetic Devices - Analysis and Forecast, 2018-2024" report has been added to ResearchAndMarkets.com's offering.

The global advanced wound care market, by-products, was valued to be $8,904.6 million in 2018 and is estimated to reach a market value of $11,059.3 million by 2024 at a CAGR of 3.62% from 2019 to 2024.

The market is subject to intense competition and the rising demand by the governments to reduce spending on healthcare is dragging the market growth. However, future growth is expected to be driven by favorable demographic factors such as the growing aging population and rising incidences of chronic wounds.

Expert Quote

Emerging technologies such as crab shell bandages (involving usage of abundant proteins, chitin, complex hydrogels), bacteriophages, platelets, and stem cell therapy are expected to drive advanced wound care market in future.

However, availability of these technologies in the market is a challenge for key players in the market as these products still need to showcase incremental improvement from current advanced wound care technologies and in order to convince regulators across countries to reimburse these costly treatments such as stem cell therapy.

It will take another 5-10 year for these emerging technologies to significantly capture market share from current technologies.

Scope of the Market

The purpose of this study is to gain a holistic view of the global advanced wound care market in terms of various influencing factors, such as regional adoption trends, and key developments, among others. The scope of this report constitutes an in-depth study of the market, including a thorough analysis of the products across different regions. The report includes an in-depth examination of the key ecosystem players and key strategies and developments taking place in this market. The report presents the reader with an opportunity to unlock comprehensive insights with respect to the market and helps in forming well-informed strategic decisions. The research uncovers some of the substantial parameters that must be taken into consideration before entering into the market.

Market Segmentation

The report on global advanced wound care market tracks trends, industry participants, and quantifies technologies that facilitate wound healing in conditions where standard wound care therapies fail. These technologies are classified under advanced wound dressings, negative pressure wound therapy, wound biologics and an array of emerging technologies such as oxygen therapy, electric simulation, spray mist, and shockwave therapy.

Diving further deep, this report also discusses and quantifies the various underlying conditions for wounds, wound care global burden, and application of advanced wound care in the management of chronic and acute wounds.

The above analysis is conducted at a regional and country level and markets have been sized and forecasted by considering the impact of various trends. Major industry participants and their products have been thoroughly analyzed and forecasts of their performance, market share, and growth rates have been provided. The report considers 2018 as the base year and forecasts the market for the period of 2019-2024.

Key Companies in the Market

Acelity (3M), Smith and Nephew, Molnlycke, ConvaTec, Coloplast, Hartmann, Integra, BSN Medical, MiMedX, Medline and Organogenesis are some of the leading players in this market.

Research Highlights

Key Topics Covered

Executive Summary

1 Product Definition

2 Scope of the Report

3 Research Methodology3.1 Research Methodology3.2 Data Sources3.2.1 Secondary Research Data Sources3.2.2 Primary Data Sources

4 Industry Analysis4.1 Industry Evolution4.2 Wound Management Cost and Supply Chain Analysis4.3 Legal and Regulatory Framework

5 Competitive Landscape5.1 Vendor Share Analysis5.2 Key Strategies and Developments5.2.1 Product Launch and Updates5.2.2 Mergers and Acquisitions5.3 Product Mapping5.4 Competitive Benchmark Mapping

6 Global Advanced Wound Care Market (by Product)6.1 Overview6.2 Advanced Wound Dressing6.2.1 Film Dressing6.2.2 Foam Dressing6.2.3 Hydrofiber Dressing6.2.4 Hydrocolloids Dressing6.2.5 Hydrogel Dressing6.2.6 Collagen Dressing6.2.7 Alginate Dressing6.2.8 Antimicrobial Dressing6.3 Negative Pressure Wound Therapies (NPWT Devices)6.3.1 Conventional Negative Pressure Wound Therapy6.3.1.1 Canisters6.3.1.2 Pumps6.3.1.3 Dressing Kits6.3.2 Single-Use Negative Pressure Wound Therapy6.4 Biologics6.4.1 Skin/Dermal Substitutes6.4.1.1 Allograft6.4.1.2 Xenograft6.4.1.3 Placenta/Amniotic Tissue6.4.1.4 Bioengineered skin/synthetic Substitutes6.4.2 Growth Factors6.4.3 Topical Agents6.5 Other Advanced Wound Care Products6.5.1 Hyperbaric Oxygen Therapy6.5.2 Ultrasonic Mist and Electrical Simulation Devices

7 Global Advanced Wound Care Therapy Market (by Wound type)7.1 Overview7.2 Chronic Wounds7.2.1 Pressure Ulcer (PU)7.2.2 Venous Leg Ulcer (VLU)7.2.3 Diabetic Foot Ulcer (DFU)7.3 Acute Wounds

8 Global Advanced Wound Care Market (by Region)8.1 North America8.1.1 U.S.8.1.2 Canada8.2 Europe8.2.1 U.K.8.2.2 Germany8.3 Asia-Pacific8.3.1 Japan8.3.2 China8.4 Rest-of-the-World (RoW)8.4.1 Brazil

9 Company Profiles9.1 3M9.1.1 Company Overview9.1.2 Role of 3M in the Market9.1.3 Financials9.1.4 SWOT Analysis9.2 Acelity9.3 B. Braun9.4 Coloplast A/S9.5 ConvaTec Group PLC9.6 Essity Aktiebolag9.7 Integra LifeSciences Corporation9.8 Medline Industries, Inc.9.9 Mlnlycke Health Care AB9.10 MIMEDX GROUP, Inc.9.11 Organogenesis Inc.9.12 Osiris Therapeutics Inc.9.13 PAUL HARTMANN AG9.14 Smith & Nephew PLC

For more information about this report visit https://www.researchandmarkets.com/r/1u8dm2

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Global Advanced Wound Care Markets to 2024: Emerging Technologies such as Crab Shell Bandages, Bacteriophages, Platelets, and Stem Cell Therapies are...

Growth of the Global Cord Blood Stem Cell Market Driven by Improvements in Product Design – Business Broker

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Growth of the Global Cord Blood Stem Cell Market Driven by Improvements in Product Design - Business Broker

Couple give embryos, ‘hope’ to UM in fight against rare disease – The Detroit News

Alexandra Cellucci was 28 when she was diagnosed with neurofibromatosis, a rare genetic disease that causes noncancerous tumors to growon thebody's nervous tissues. She was also eight months pregnant at the time, but she would eventually delivera healthy baby girl.

Neurofibromatosis,known as NF for short,runs in Cellucci'sfamily, so sheknew her daughter could have the diseaseand she could pass it on to futurechildren. So sheand her husband, Marc, used reproductive medicine to conceive another baby, hadthe embryostested for the gene that causes NFand had doctors implantembryos in her womb without the mutatedgene.

Alex Cellucci, 35, rubs fabric on her right eye, where she had a tumor removed the previous day, while watching a movie with her daughter, Maible, 6, at their home in Quincy, Mass. on Tuesday, Aug. 6, 2019. Alex and Maible both have neurofibromatosis, a genetic disorder that causes tumors to form on nerve tissue. Alex was diagnosed with neurofibromatosis type 2 at age 28 and has since endured two MRI scans every year to monitor tumors.(Photo: Nic Antaya, Special to The Detroit News)

Cellucci, now 35, never got pregnant again, despite many attempts. She and her husband have since learned their daughter Maible, now6,also carriesthe gene for NF2, one of the three forms of the disease. The day before Maible's birthday last November,the girl asked if she had the disease. Cellucci said she told her yes and that she would be OK.

That's why the Massachusetts coupledonated seven embryos with the NF2 gene to the University of Michigan soresearchers could create an embryonic stem cell line that other researchers could study, with the hope of one day discovering a breakthrough. In a perfect world, such a development would come before their daughter endures any symptoms.

Alex Cellucci, 35, poses for a portrait at her home in Quincy, Mass. on Tuesday, Aug. 6, 2019. Alex and her 6-year-old daughter, Maible, both have neurofibromatosis, a genetic disorder that causes tumors to form on nerve tissue.(Photo: Nic Antaya, Special to The Detroit News)

I just wanted hope," said Cellucci, who had surgery last monthto remove a benigntumorbehind her eye. "They could possibly find a cure for (Maible) ... and offer hope for other families."

UM researchers have turned the Celluccis' embryos intothe firststem cell line that models NF2, which is one of the more rare forms of the disease. Besides the tumor growth, NF2 comes with a host of issues, including hearing loss, ringing in the ears and loss of balance. Symptoms typically appear in the teen years.

The embryonic stem cell line modeling the disease, created by ProfessorGary Smith, director ofthe MStem Cell Laboratories,has been acceptedonto the National Institutes of Health Human Embryonic Stem Cell Registryforother scientists to study and make discoveries around interventions anda possible cure. Another line also is under review.

Alex Cellucci, 35, watches a movie at her home in Quincy, Mass., a day after having a tumor removed from behind her right eye.(Photo: Nic Antaya, Special to The Detroit News)

Researchers can apply to access the stem cell lines on thefederal registryto study how diseases form and develop, with the aim of finding ways to better understand, treat, delay and possibly even cure diseases.

Smith has derived all of UM's56embryonic stem cell lines on the national registry, including 36 disease-specific lines. Hesaid the personal stories behind all of those stem cell lines are important.

"We just don't do science to do science," Smith said. "We do science to help others. Here is a family that recognizes that. Sometimes that gets lost on people. ... We really do want to help people."

The NF2 stem cell line comes as neurofibromatosis scientists andclinicians prepare to gather next month for their annual conference in San Francisco.

Alex Cellucci, 35, and her daughter, Maible, 6, watch a movie at their home in Quincy, Mass. on Tuesday, Aug. 6, 2019. Alex and Maible both have neurofibromatosis, a genetic disorder that causes tumors to form on nerve tissue. Alex was diagnosed with neurofibromatosis type 2 at age 28 and has since had two MRI scans done every year to monitor tumors. Most recently, Alex had a tumor removed behind her right eye on Aug. 5, 2019.(Photo: Nic Antaya, Special to The Detroit News)

It also comes as Detroitbusinessman andCleveland Cavaliers ownerDan Gilbert has used philanthropy to support the small research community of neurofibromatosis. His 23-year-old son, Nick, was born with neurofibromatosis type 1.

NF2 afflicts1 in 33,000 people worldwide, while NF1 is more common, occurringin 1 in 3,000 to 4,000 people, according to the National Institutes of Health. NF1 typically begins in childhood and leads to skin changes and bone deformity.Schwannomatosis, the rarest type of NF, causes intense pain.

Gilbert, who suffered a stroke in late May,has spoken about neurofibromatosis and also about howNick, a Michigan State University student, hadto undergobrain surgery in 2018 to remove tumors.

Gilbert, a billionaire, has invested $64 million over the yearsthrough the Gilbert Family Foundation, including $12 million for gene therapy initiatives to address the underlying cause of NF1 and $11 million for vision loss in NF1 patients, which Nick grapples with, according toYooRi Kim, the foundation's scientific officer.

Marc and Alex Cellucci, and their daughter, Maible, 6, and dog Pedalino, pose for a portrait outside of their home in Quincy, Mass. on Tuesday, Aug. 6, 2019. Alex and Maible both have neurofibromatosis, a genetic disorder that causes tumors to form on nerve tissue.(Photo: Nic Antaya, Special to The Detroit News)

"With deeper understanding with each of these diseases that we've obtained over time, it's becoming more and more clear that the strategies that you would use to help each of thosepatients are going to look different," Kim said.

Even so, she said there is excitement about advances in research on other forms of NF, such as the stem cell line modeling NF2.

There arefour embryonic stem cell lines on the registry that model NF1, but theline UM created is the first for the research community studying NF2,according to Smith.

"It means a lot to the couplethat somebody is using something that otherwise would have been discarded and instead trying to make it something that can be used worldwide to understand this disease better," he said.

The stem cell line hasbeen applauded by Sally Temple, scientific director of the Neural Stem Cell Institute in Rensselaer,New York, which uses stem cell technologies to develop therapies that affect the nervous system.

Alex Cellucci, 35, and her daughter, Maible, 6, pose for a portrait outside of their home in Quincy, Mass. on Tuesday, Aug. 6, 2019. Alex and Maible, both have neurofibromatosis, a genetic disorder that causes tumors to form on nerve tissue.(Photo: Nic Antaya, Special to The Detroit News)

"It's a really wonderful and generous for the parents to do," said Temple, who is also aUM adjunct professor in the ophthalmology department. "When you make these human embryonic stem cell lines, they are essentially a resource forever for the community. It's available and it will be there for (researchers)to use forever in the future. It's not a one-time donation."

She added that this is important for the NF2 community since it is such a devastating disease.

Marc Cellucci is beyond thrilled, and hopeful of the possibilities for the stem cell line that he and his wife helped create and what it could do for his daughter, wife, in-laws and so many others with NF.

It all has to start somewhere, said Cellucci,where the scientific breakthroughs happen, and the miracles begin.

kkozlowski@detroitnews.com

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Couple give embryos, 'hope' to UM in fight against rare disease - The Detroit News