Category Archives: Stem Cell Medicine

UCF Researchers Develop Novel Therapy for Incurable Brain Cancer – UCF

College of Medicine researchers are developing a more effective way to treat glioblastoma an aggressive, incurable form of brain cancer. Patients currently live just 12 to 15 months after diagnosis despite surgery, radiation and chemotherapy.

New research led by Kiminobu Sugaya, a stem cell researcher and neuroscientist at UCFs Burnett School of Biomedical Sciences, found that targeting a drug resistant mechanism in cancer stem cells significantly enhanced the efficacy of traditional cancer therapies making them four times more effective against glioblastoma. Current FDA-approved drugs kill less than 25% of glioblastoma cancer stem cells (CSCs).

These cells are a subpopulation of cancer cells that are highly resistant to current therapies. Scientists theorize that cancer returns and spreads because CSCs remain in the body. Thats why they are exploring ways to kill them outright.

Cancer stem cells are bad stem cells that are programed to become a cancer, Sugaya says. They withstand cancer therapies, raise their ugly head, regrow and metastasize.

Sugayas team developed a new drug delivery system by creating a technology that destroys the RNA, or ribonucleic acid, that the stem cells use as a blueprint to produce proteins. This unique strategy inhibits the expression of embryonic stem cell genes that are pivotal in CSCs drug resistance. And because embryonic stem cell genes are not expressed in normal adult cells, this breakthrough approach reduces potential for side effects in healthy cells.

Jonhoi Smith is a doctoral student under Sugaya and the first author on their research paper published in the journal Genes. He said the treatment could increase life expectancy for glioblastoma patients.

This treatment could be a precious gift for glioblastoma patients. When I think about the loved ones Ive lost in my life my father, my grandmother I often wish I could have had more time with them, he says. The idea of offering the potential of a whole new life to people who are facing a death sentence in less than a year means a lot to me.

One of the significant challenges in treating glioblastoma is effectively delivering treatments to the brain. Thats because the brain is protected from external germs and substances by the blood-brain barrier, which can also prevent treatments from reaching brain tissues.

To overcome this obstacle, Sugayas therapy is based on exosomes, nano-sized particles with a lipid membrane that are naturally produced by cells. Exosomes function as cellular communicators, transporting proteins, lipids and genetic material between cells, thereby influencing a wide array of biological processes and functions. Their efficiency in carrying molecules across various parts of the body has inspired scientists to investigate exosomes as potential drug delivery vehicles.

Many current drug delivery systems, including viruses, may cause side effects, Sugaya explains. Were using the bodys natural delivery systems and have developed technologies to modify them to carry therapeutic molecules with targeted delivery to specific tissues.

Marvin Hausman is CEO of Exousia AI, the company that is funding the glioblastoma exosome preclinical research. He heard about Sugayas lab and says that when he visited the lab at UCFs Academic Health Sciences Campus in Lake Nona, he was inspired by its capacity for innovative discoveries.

I have thoroughly analyzed this exosome-based targeted drug delivery system many times, and the potential that this unique technology offers. Hausman says. We are embarking on a revolutionary new development in medicine.

Thanks to funding from Exousia AI, the research is advancing to mouse models carrying human glioblastoma, with preliminary results expected as early as this summer.

Sugaya has dedicated more than 40 years to neuroscience research focused on Alzheimers disease, with an emphasis on stem cells for the last 26 years. He moved to the U.S. after receiving his doctoral degree from the Science University of Tokyo in 1988. He joined UCF as a professor in 2004. His cancer research began in 2010 when he discovered stemness gene expressions, the self-renewing and differentiating property that allows stem cells to grow and spread, in CSCs. He is recognized as an expert in the field of exosome research and recently received Florida Innovation Funding from the State Department of Health for his studies.

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UCF Researchers Develop Novel Therapy for Incurable Brain Cancer - UCF

CuSTOM Organoid Research Evolving From Tool to Treatment – Research Horizons – Research Horizons

Two scientists at Cincinnati Childrens describe the fast-evolving field of organoid medicine as todays research tool, tomorrows organ transplant solution.

A special feature published March 14, 2024, in Science explores advances made by the Cincinnati Childrens Center for Stem Cell and Organoid Medicine (CuSTOM). The article features organoid experts Takanori Takebe, MD, PhD, and Mingxia Gu, MD, PhD.

These 3D formations, grown from induced pluripotent stem cells (iPSCs), are living mini-organs that include the key cell types of full-sized organs.

Already, organoids are showing value as test platforms for preclinical drug testing and ongoing basic studies of human development. Longer term, experts at CuSTOM envision organoids grown from a patients own cells serving as a new method to treat disease and repair organ damage.

Read more about CuSTOM in Science.

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CuSTOM Organoid Research Evolving From Tool to Treatment - Research Horizons - Research Horizons

New Positive Data Presented on Briquilimab Conditioning in Patients with Fanconi Anemia – GlobeNewswire

REDWOOD CITY, Calif., March 15, 2024 (GLOBE NEWSWIRE) -- Jasper Therapeutics, Inc. (Nasdaq: JSPR) (Jasper), a biotechnology company focused on development of briquilimab, a novel antibody therapy targeting c-Kit (CD117) to address mast cell driven diseases such as chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU), announced additional positive Phase 1b/2a data on briquilimab as a conditioning agent in the treatment of Fanconi Anemia (FA).

The data was presented at the 2024 Stanford Medicine Center for Definitive and Curative Medicine Symposium on March 13, 2024, in Palo Alto, California.

The ongoing investigator initiated Phase 1b/2a clinical trial is evaluating a conditioning regimen that includes intravenous briquilimab as a potential treatment for FA patients in bone marrow failure. Data from the study show that briquilimab infusion has a promising safety profile and appears to be well tolerated in patients with FA, with all six patients treated achieving full donor engraftment and full blood count recovery.

We continue to be encouraged by the results from Stanford Medicine's Phase 1b/2a study in Fanconi Anemia, which demonstrates the potential of briquilimab to serve as a key component of non-toxic conditioning regimens for stem cell transplant, said Edwin Tucker, Chief Medical Officer of Jasper. Wed like thank our collaborators at Stanford Medicine for their work evaluating briquilimab in this vulnerable patient population.

About Briquilimab

Briquilimab (formerly JSP191) is a targeted aglycosylated monoclonal antibody that blocks stem cell factor from binding to the cell-surface receptor c-Kit, also known as CD117, thereby inhibiting signaling through the receptor. This inhibition disrupts the critical survival signal, leading to the depletion of the mast cells via apoptosis which removes the underlying source of the inflammatory response in mast cell driven diseases such as chronic urticaria. Jasper is currently conducting clinical studies of briquilimab as a treatment in patients with CSU or with CIndU. Briquilimab is also currently in clinical studies as a treatment for patients with LR-MDS and as a conditioning agent for cell and gene therapies for rare diseases. To date, briquilimab has a demonstrated efficacy and safety profile in more than 145 dosed participants and healthy volunteers, with clinical outcomes as a conditioning agent in severe combined immunodeficiency (SCID), acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), FA, and sickle cell disease (SCD).

About Fanconi Anemia

Fanconi Anemia (FA) is a rare but serious blood disorder that prevents the bone marrow from making sufficient new red blood cells. The disorder can also cause the bone marrow to make abnormal blood cells. FA typically presents at birth or early in childhood between five and ten years of age. Ultimately, it can lead to serious complications, including bone marrow failure and severe aplastic anemia. Cancers such as acute AML and MDS are other possible complications. Treatment may include blood transfusions or medicine to create more red blood cells, but a hematopoietic stem cell transplant (HSCT) is currently the only cure.

About Phase 1/2 clinical trial (NCT04784052)

The Stanford sponsored, investigator initiated Phase 1/2 study is an open-label clinical trial evaluating briquilimab as a potential treatment for FA patients in bone marrow failure (BMF) requiring allogeneic transplant. Utilizing briquilimab, the regimen eliminates the need for busulfan chemotherapy or total body irradiation. Participants with FA with BMF receive allo-HCT with TCR+ T-cell/CD19+ B-cell depleted hematopoietic grafts from 10/10 unrelated, 9/10 unrelated or haploidentical family donors. A 0.6 mg/kg dose of briquilimab is administered in combination with standard FA dosing of anti-thymocyte globulin (ATG), cyclophosphamide, fludarabine, and rituximab as lymphodepletion. The primary outcomes include safety, efficacy, and engraftment success.

About Jasper

Jasper is a clinical-stage biotechnology company developing briquilimab, a monoclonal antibody targeting c-Kit (CD117) as a therapeutic for chronic mast and stem cell diseases such as chronic urticaria and lower to intermediate risk MDS and as a conditioning agent for stem cell transplants for rare diseases such as SCD, FA and SCID. To date, briquilimab has a demonstrated efficacy and safety profile in more than 145 dosed participants and healthy volunteers, with clinical outcomes as a conditioning agent in SCID, acute myeloid leukemia, MDS, FA, and SCD. For more information, please visit us atwww.jaspertherapeutics.com.

Forward-Looking Statements

Certain statements included in this press release that are not historical facts are forward-looking statements for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995. Forward-looking statements are sometimes accompanied by words such as believe, may, will, estimate, continue, anticipate, intend, expect, should, would, plan, predict, potential, seem, seek, future, outlook and similar expressions that predict or indicate future events or trends or that are not statements of historical matters. These forward-looking statements include, but are not limited to, statements regarding briquilimabs potential, including its potential as a conditioning agent in the treatment of FA and FA patients in bone marrow failure and its safety profile, its potential to serve as a key component of non-toxic conditioning regimens for stem cell transplant and its potential to address mast cell driven diseases such as CSU and CIndU. These statements are based on various assumptions, whether or not identified in this press release, and on the current expectations of Jasper and are not predictions of actual performance. These forward-looking statements are provided for illustrative purposes only and are not intended to serve as, and must not be relied on by an investor as, a guarantee, an assurance, a prediction or a definitive statement of fact or probability. Many actual events and circumstances are beyond the control of Jasper. These forward-looking statements are subject to a number of risks and uncertainties, including general economic, political and business conditions; the risk that the potential product candidates that Jasper develops may not progress through clinical development or receive required regulatory approvals within expected timelines or at all; the risk that clinical trials may not confirm any safety, potency or other product characteristics described or assumed in this press release; the risk that Jasper will be unable to successfully market or gain market acceptance of its product candidates; the risk that prior study results may not be replicated; the risk that Jaspers product candidates may not be beneficial to patients or successfully commercialized; patients willingness to try new therapies and the willingness of physicians to prescribe these therapies; the effects of competition on Jaspers business; the risk that third parties on which Jasper depends for laboratory, clinical development, manufacturing and other critical services will fail to perform satisfactorily; the risk that Jaspers business, operations, clinical development plans and timelines, and supply chain could be adversely affected by the effects of health epidemics; the risk that Jasper will be unable to obtain and maintain sufficient intellectual property protection for its investigational products or will infringe the intellectual property protection of others; and other risks and uncertainties indicated from time to time in Jaspers filings with the SEC, including its Annual Report on Form 10-K for the year ended December 31, 2023 and subsequent Quarterly Reports on Form 10-Q. If any of these risks materialize or Jaspers assumptions prove incorrect, actual results could differ materially from the results implied by these forward-looking statements. While Jasper may elect to update these forward-looking statements at some point in the future, Jasper specifically disclaims any obligation to do so. These forward-looking statements should not be relied upon as representing Jaspers assessments of any date subsequent to the date of this press release. Accordingly, undue reliance should not be placed upon the forward-looking statements.

Contacts:

Joyce Allaire (investors) LifeSci Advisors 617-435-6602 jallaire@lifesciadvisors.com

Alex Gray (investors) Jasper Therapeutics 650-549-1454 agray@jaspertherapeutics.com

Lauren Walker (media) Real Chemistry 646-564-2156 lbarbiero@realchemistry.com

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New Positive Data Presented on Briquilimab Conditioning in Patients with Fanconi Anemia - GlobeNewswire

BioCardia and StemCardia Announce Biotherapeutic Delivery Partnership – Diagnostic and Interventional Cardiology

March 15, 2024 BioCardia, Inc., a biotechnology company focused on advancing late-stage cell therapy interventions for cardiovascular disorders, andStemCardia, Inc., a biotechnology company focused on cell and gene therapy to re-muscularize the failing heart, today announced a long-term partnership to advance StemCardias investigational pluripotent stem cell product candidate for the treatment of heart failure.

Under the partnership, BioCardia is the exclusive biotherapeutic delivery partner for StemCardias cell therapy candidate through studies expected to result in FDA approval of an investigational new drug application (IND) and the anticipated Phase I/II clinical development to follow.

BioCardia has established safe and minimally invasive delivery of cellular medicines directly into the heart, said Chuck Murry, MD, PhD, StemCardias Founder and CEO. Having worked with BioCardia to successfully deliver our bona fide cardiac muscle cells in large animal models of heart failure, we are excited for this partnership to accelerate clinical development and broaden future commercial access to an off-the-shelf heart regeneration treatment.

StemCardias team encompasses recognized leaders in the field of cardiac regenerative medicine who are pursuing an elegant strategy to repair the failing heart. We look forward to supporting their efforts with our experienced team and proven, proprietary Helix biotherapeutic delivery system, said BioCardia CEO Peter Altman, PhD. This partnership is expected to enhance future treatment options for millions of people suffering from heart failure, offset the costs of biotherapeutic delivery development for our own programs, and provide our investors with meaningful revenue sharing should our efforts together contribute to StemCardias successful therapeutic development.

For more information:www.biocardia.com

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BioCardia and StemCardia Announce Biotherapeutic Delivery Partnership - Diagnostic and Interventional Cardiology

Striving to Support Gender Equality in Health Care – City of Hope

Nadia Carlesso, M.D., Ph.D.

As a member of the newest class of 24 women selected nationwide to participate in the Carol Emmott Fellowship, Nadia Carlesso, M.D., Ph.D., wants to take this unique and competitive opportunity to move the needle in advancing diversity, equity and inclusion (DEI) on both sides of the research bench.

The Carol Emmott Foundation is a national nonprofit organization that is dedicated to achieving fully inclusive gender equality in health care leadership and governance. The fellowship includes a 14-month experience in which fellows can receive mentorship for their personal projects that support gender equity in health care.

Based on the Duarte, California, campus, Carlesso joined City of Hope in 2016. She is currently professor and chair of the Department of Stem Cell Biology and Regenerative Medicine.

As a scientist in the stem cell field and as chair of the Department of Stem Cell Biology and Regenerative Medicine, I feel the responsibility and commitment to contribute, in the measure I can, to decreasing health disparities in the areas of innovative cell and gene therapies, Carlesso said.

Carlesso said health disparities exist in some part due to the prohibitive costs associated with getting treatment and participating in clinical trials.

We are living in exciting times in terms of the progress and availability of cell and gene therapies potentially curative therapies, she said. But these products have a high cost that can unfortunately widen the care gap. Access to innovative therapies is expensive for many complex reasons. As a community, scientists, technologists and health care professionals must come together to be part of the solution.

There's no easy answer, and not a problem that will be resolved tomorrow, but the conversation has started within scientific circles, and Carlesso wants to further that dialogue and parlay it into actions that can truly make progress.

One step in the right direction is to increase diversity within the scientific community in all aspects, in the name of advancing clinical knowledge.

City of Hope is a diverse and inclusive organization, and I would like to leverage that commitment, Carlesso said. The Emmott Fellowship has given me the opportunity to focus more intently on growing the diversity within our scientific environment.

Innovative biomedical research flourishes when people with different perspectives, experience and skills are empowered to explore new ideas and to work collaboratively and inclusively, she continued. Recruiting, training, retaining and nurturing a workforce representing all dimensions of diversity is critical for the development and implementation of leading-edge therapies that can reach underserved populations. These communities have not had their voices heard: Targeting these communities to be active participants of this specialized workforce and future leaders in this sector is key to decrease barriers to health equity.

Another key step toward this goal is to increase awareness among these communities that their voices are important.

There is not sufficient knowledge out there that they are needed, Carlesso explained. There are cultural biases that have to be overcome. If patients can see themselves in our medical and scientific staff, they will feel more represented and more comfortable that their best interests are at heart.

As an Emmott Fellow, Carlesso said she has identified three areas that she wishes to address in her research project.

The first part is for me to get the numbers, to look at the current diversity within our clinical trials, within our GMP teams, clinical trial coordinators, research nurses, clinicians and basic scientists, she said. At any given time, we have more than 30 investigational new drug applications and 300 clinical trials going on. I want to take advantage of this ideal setting and generate a complete database of the progress weve made, the challenges we still face, and where the bottlenecks are that are compromising diversity and inclusion at all levels.

Establishing a discourse, conversations among peers, is essential to stimulate a reaction toward diversity in research that will benefit all of us, Carlesso said.

A cohesive stem cell research community is critical not only to generate discoveries but also to bring awareness in health disparities and generate synergistic efforts to tackle this problem, she said.

Carlesso maintained that we can empower patients by empowering a diverse workforce, and one way we can do that is to recruit individuals from diverse backgrounds into careers in science, technology, engineering and math (STEM).

A powerful way to give a voice to underserved communities and people of underrepresented backgrounds, and to mitigate health disparities, is to train a workforce that represents them, she said. If underserved families start to have kids going to high school and college doing internships in science and contemplating a carrier in nursing, biomanufacturing, research, then they will have more information, more access and will be less afraid to ask and to pursue more advanced therapeutic solutions or participate to clinical trials.

City of Hope is committed to training the next generation of leaders in stem cells, gene therapy and regenerative medicine, and in fostering an inclusive and safe environment that embraces diversity. Our laboratories host interns every year from the California Institute for Regenerative Medicine bridge program, for example, and we recruit from all communities for our Eugene and Ruth Roberts Summer Student Academy. We also partner with California State Universities in our area and local high schools near the Duarte campus to grow the interest in STEM careers.

As an organization, we need to know that our research has great potential and is helping to close the care gap between socially economically disadvantaged groups and others, Carlesso said. Knowing where we are now is important, so we can define where we are going and how we are going to get there.

I am very excited and thankful to have been chosen for the Emmott Fellowship and the opportunities it represents, she said. I am thrilled and look forward to what I can learn, accomplish and change for the better in my work.

Learn more about the Carol Emmott Fellowship, Carlesso and other members of the Class of 2024, here.

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Striving to Support Gender Equality in Health Care - City of Hope

Transitioning from traditional surgical methods to the innovative use of stem cells – pharmaphorum

Patient lives are being transformed by a transitioning from traditional surgical methods to the innovative use of stem cells.

In todays podcast, host Nicole Raleigh welcomes Dr Jeffrey Gross, founder of ReCELLebrate, neurological surgeon, and expert in the field of regenerative medicine, to discuss this development. Their conversation delves into the recent appetite for the use of stem cells for longevity and explores the health span notion that is being ever more frequently spoken of.

But, essentially, regenerative medicine deals with the functional restoration of specific tissue and/or organ of patients, patients who might be suffering from severe injuries or chronic disease conditions, and who are in a state where the bodys own regenerative responses do not suffice and that is where stem cells, endorsed with indefinite cell division potential and the ability to transdifferentiate into other types of cells, are emerging as a frontline regenerative medicine source.

Yet, when it come to health and vitality, and to epigenetics and prolonged health, scepticism remains and Dr Gross attempts to demystify the landscape for listeners on that, too, including especially the most regenerative source of stem cells: the placenta.

You can listen to episode 121a of thepharmaphorum podcastin the player below, download the episode to your computer, or find it - and subscribe to the rest of the series - iniTunes,Spotify,acast,Stitcher,andPodbean.

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Transitioning from traditional surgical methods to the innovative use of stem cells - pharmaphorum

Pelage Pharmaceuticals Announces $16.75M Series A Financing led by GV to Revolutionize Regenerative Medicine … – BioSpace

LOS ANGELES , Feb. 27, 2024 /PRNewswire/ -- Pelage Pharmaceuticals, a clinical-stage regenerative medicine company pioneering a new generation of treatments for hair loss, announced today that the company has closed a $16.75 million Series A financing led by GV with participation from Main Street Advisors, Visionary Ventures and YK BioVentures, to advance a first-in-class treatment for androgenetic alopecia or pattern baldness, and other types of alopecia including chemotherapy-induced hair loss.

"Our scientific co-founders have uncovered a unique biological mechanism with the potential to reactivate hair growth in people with alopecia," said Daniel Gil, Ph.D., Chief Executive Officer, Pelage Pharmaceuticals. "We are pleased to announce that we have completed a first-in-human Phase 1 clinical trial that demonstrated seven days of topical dosing with PP405 was safe and well-tolerated, and showed statistically significant activation of hair follicle stem cells. With the support of GV, Main Street Advisors and other top-tier investors, we expect to advance our lead program to a Phase 2a clinical trial in the second half of this year."

The Phase 1 trial evaluating PP405, a novel topical agent designed to treat androgenetic alopecia and other forms of hair loss, showed 0.05% PP405 topical treatment for seven days is safe and tolerable with no adverse events, and provided confirmation of a daily dosing regimen. Importantly, the study demonstrated biological activity, proof of mechanism of action seen in preclinical studies, and showed treatment with PP405 stimulated statistically significant activation of a critical hair follicle stem cell activation marker. Translational data will be presented at the American Academy of Dermatology meeting in March.

Androgenetic alopecia, also known as pattern balding, is the most common form of alopecia and accounts for more than 90% of all hair loss, impacting both men and women. Additionally, PP405 may also have applications for other types of hair loss such as telogen effluvium (stress-induced hair loss) and chemotherapy-induced hair loss.

"What we've observed is that in people who experience hair loss, the actual hair follicle stem cells are still present but have reverted to a dormant state. We have uncovered a small molecule able to stimulate cellular metabolism to re-awaken hair follicle stem cells and spur new hair growth," said William Lowry, Ph.D., scientific co-founder, Pelage Pharmaceuticals. The discovery was made by Drs. Lowry, Heather Christofk and Michael Jung, of the University of California, Los Angeles. PP405 is designed to inhibit the mitochondrial pyruvate carrier (MPC) to specifically reactivate the dormant hair follicle stem cells.

"Hair loss is an incredibly common health problem with few effective solutions," said Cathy Friedman, Executive Venture Partner, GV and Board Director, Pelage Pharmaceuticals. "GV is excited by the incredible science behind the Pelage technology. Pelage is pioneering an innovative approach with the potential to disrupt the treatment landscape, moving beyond agents that merely slow the progression of hair loss to a treatment solution that actually helps to regrow hair."

Along with the financing and Phase 1 topline data, Pelage has announced the appointment of Qing Yu Christina Weng, M.D., as the company's Chief Medical Officer (CMO). Dr. Weng is a physician-scientist, Harvard-trained board-certified dermatologist at Massachusetts General Hospital, and faculty at Harvard Medical School. In addition to her clinical expertise, Dr. Weng brings a background in corporate startup strategy and business development. At Pelage, Dr. Weng's experience will inform the company's development of PP405 as it advances to Phase 2 studies.

"The current therapeutic landscape is dominated by reformulations of existing products. Pelage is built on rigorous science and offers the opportunity to target the follicle stem cells directly," said Dr. Weng. "I am thrilled to work with the Pelage team to advance this discovery in pursuit of a novel non-invasive solution for all people who experience hair loss."

About Pelage Pharmaceuticals

Pelage Pharmaceuticals is a clinical-stage regenerative medicine company developing novel treatments for hair loss including androgenetic alopecia and chemotherapy-induced-alopecia. With a focus on molecular and stem cell biology, Pelage is advancing a new class of treatments designed to reactivate dormant hair follicle stem cells and restore the body's ability to naturally grow hair. Its lead program, PP405, is currently in clinical trials. Through its rigorous scientific foundation, topical formulation, and novel mechanism of action, Pelage is pioneering first-in-class hair growth solutions for people of all hair types experiencing hair loss.

About PP405

PP405 is a novel, non-invasive, topical small molecule designed to reactivate dormant hair follicle stem cells and restart hair growth. Through a regenerative medicine approach, the treatment focuses on addressing the metabolic processes that regulate the activation and inactivation phases of hair follicle stem cells. Early results from a Phase 1 trial show that PP405 was well-tolerated and demonstrated statistically significant activation of hair follicle stem cells. In 2018, Pelage Pharmaceuticals licensed the intellectual property to PP405 and related topical small molecules from the UCLA Technology Development Group.

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SOURCE Pelage Pharmaceuticals

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Pelage Pharmaceuticals Announces $16.75M Series A Financing led by GV to Revolutionize Regenerative Medicine ... - BioSpace

Summer research program open to students interested in stem cell and regenerative medicine research – The Daily | Case Western Reserve University

The ENGAGE summer research training program supports undergraduate, masters and medical students interested in stem cell and regenerative medicine research. Students are provided opportunities for scientific growth by working with our renowned scientific investigators.

The National Center for Regenerative Medicine funds these student research training projects. Each award provides $4,000 as a trainee summer stipend. An additional $500 is given to the hosting laboratory for research materials and supplies. The funded project is expected to last eight weeks.

Learn more about the ENGAGE summer program and find out how to apply. The deadline to apply is March 27 at 11:59 p.m.

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Summer research program open to students interested in stem cell and regenerative medicine research - The Daily | Case Western Reserve University

UC Irvine advances stem cell research with $4 million CIRM grant for shared resources lab – UCI News

Irvine, Calif., Feb. 26, 2024 The University of California, Irvine has received a five-year, $4 million grant from the California Institute for Regenerative Medicine to establish a shared resources lab in the Sue & Bill Gross Stem Cell Research Center. The facility will offer essential technologies and training for the development of novel in vitro stem cell-based modeling that will serve researchers across the campus and the state.

Stem cells possess the potential to transform into particular cell types, offering promising avenues for rejuvenating and restoring tissues harmed by injury or affected by disease, said principal investigator Craig Walsh, UCI professor of molecular biology and biochemistry. Utilizing stem cell modeling facilitates the development of new treatments and drug screening platforms and also provides deeper understanding of both discovery and translational research processes.

The grant will expand the UCI stem cell centers current lab capabilities, including the addition of new and upgraded equipment, instrumentation and components, and establish new services and user training in four key areas: foundational technologies, bioengineering and organoids, gene editing, and high-dimensional spatial analysis. Training is essential to characterize stem cell models, develop novel regenerative medicine therapeutics, and ensure that theres a workforce capable of implementing new strategies.

Our state-of-the-art facility and cutting-edge training opportunities demonstrate our commitment to advancing stem cell research and discovery, as well as to education and skill enhancement, said Aileen Anderson, Ph.D., director of the UCI stem cell center and professor of physical medicine & rehabilitation at the UCI School of Medicine.

The impact of the labs initiatives will foster collaborations with academic and industrial partners throughout California and leverage existing training programs such as CIRM Bridges to accelerate innovation. This effort underscores the scientific communitys drive to transform the landscape of regenerative medicine.

The Sue & Bill Gross Stem Cell Research Centers shared resources lab will contribute to the broader CIRM mission to develop a stem cell-based modeling ecosystem throughout California, supporting the basic and translational research necessary to advance scientific discoveries and the development of new therapeutic solutions for unmet medical needs, ranging from neurological diseases to cancer.

About UCIs Brilliant Future campaign:Publicly launched on Oct. 4, 2019, the Brilliant Future campaign aims to raise awareness and support for UCI. By engaging 75,000 alumni and garnering $2 billion in philanthropic investment, UCI seeks to reach new heights of excellence instudent success, health and wellness, research and more. The School of Biological Sciences plays a vital role in the success of the campaign. Learn more by visitinghttps://brilliantfuture.uci.edu/school-of-biological-sciences.

About the University of California, Irvine:Founded in 1965, UCI is a member of the prestigious Association of American Universities and is ranked among the nations top 10 public universities byU.S. News & World Report. The campus has produced five Nobel laureates and is known for its academic achievement, premier research, innovation and anteater mascot. Led by Chancellor Howard Gillman, UCI has more than 36,000 students and offers 224 degree programs. Its located in one of the worlds safest and most economically vibrant communities and is Orange Countys second-largest employer, contributing $7 billion annually to the local economy and $8 billion statewide.For more on UCI, visitwww.uci.edu.

Media access: Radio programs/stations may, for a fee, use an on-campus ISDN line to interview UCI faculty and experts, subject to availability and university approval. For more UCI news, visit news.uci.edu. Additional resources for journalists may be found at communications.uci.edu/for-journalists.

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UC Irvine advances stem cell research with $4 million CIRM grant for shared resources lab - UCI News

Top Stem Cell Clinics in the World: Pioneering Future Medicine – Corporate Wellness Magazine

The realm of regenerative medicine, particularly stem cell therapy, has witnessed exponential growth over the past few decades. Stem cells offer the remarkable potential to repair, regenerate, and rejuvenate tissues and organs, presenting new horizons in treating various diseases and injuries. This article delves into the pioneering world of stem cell clinics, showcasing institutions leading the charge in harnessing the transformative power of stem cell therapies. These clinics are not just medical facilities; they are the epicenters of innovation and research that are reshaping the future of medicine.

Stem cell clinics across the globe are pushing the boundaries of medical science. They specialize in harvesting, manipulating, and deploying stem cells to treat a myriad of conditions, from chronic diseases to orthopedic injuries and beyond. These institutions are characterized by their state-of-the-art facilities, interdisciplinary teams of experts, and a commitment to research and development.

The top stem cell clinics are renowned for their pioneering work in developing and applying cutting-edge treatments. They utilize a variety of stem cells, including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and adult stem cells, each serving different therapeutic purposes. Treatments range from repairing damaged cartilage in joints, treating autoimmune diseases, to pioneering efforts in neurodegenerative diseases like Parkinsons and Alzheimers.

Research is a cornerstone of these leading clinics. They are often affiliated with academic institutions and participate in global research initiatives, contributing to the growing body of scientific literature on stem cell therapies. These clinics are at the forefront of translating laboratory discoveries into clinical applications, ensuring that treatments are both safe and effective.

The global nature of top stem cell clinics reflects the universal demand for advanced medical treatments. Many of these clinics have become hubs for medical tourism, attracting patients worldwide seeking access to the latest in regenerative medicine. This international aspect underscores the importance of regulatory standards and ethical considerations in stem cell therapy, areas in which these clinics lead by example.

Adhering to stringent ethical and regulatory standards is paramount. The best stem cell clinics operate with transparency, obtaining proper consents, and following rigorous protocols to ensure patient safety and treatment efficacy. They navigate the complex landscape of stem cell research and therapy with integrity, contributing to the field's ethical advancement.

What sets these clinics apart is their holistic, patient-centric approach. Understanding that each patient's needs and conditions are unique, they offer personalized treatment plans. This bespoke approach ensures that patients receive the most appropriate stem cell therapy, maximizing the potential for successful outcomes.

As the field of regenerative medicine continues to evolve, so too will the role of stem cell clinics. With ongoing research and technological advancements, the potential applications of stem cell therapy will expand, offering hope for incurable and untreatable conditions. These clinics are not just treating patients; they are shaping the future of healthcare.

In conclusion, The top stem cell clinics in the world are more than medical facilities; they are beacons of hope for patients and catalysts for change in the medical community. Their pioneering work in regenerative medicine exemplifies the power of stem cell therapy to transform lives. As they continue to innovate and lead, the promise of future medicine becomes increasingly tangible, marking a new era in healthcare where regeneration and healing are at the forefront.

Given his unparalleled expertise and success in treating elite athletes and high-profile individuals, we highly recommend Dr. Chad Prodromos for anyone seeking top-tier stem cell treatment. His work at the Prodromos Stem Cell Institute is at the forefront of regenerative medicine, offering innovative solutions for a range of conditions. To explore how Dr. Prodromos can assist in your health journey, consider reaching out through his clinic's website for more detailed information and to schedule a consultation. visit Prodromos Stem Cell Institute.

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Top Stem Cell Clinics in the World: Pioneering Future Medicine - Corporate Wellness Magazine