New research center to explore muscle health and disease – Newswise


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Newswise With collaborating labs across the University of Washington campus and at other Seattle-area institutions and beyond, the Center for Translational Muscle Research will encompass a myriad of muscle science and disease investigations. Studies will range from the basics of muscle-related proteins, genes and cell biology to the design of potential treatments for devastating muscle diseases. At present, only symptom management and supportive care is available for many of these conditions.

The latest advances in such areas as gene therapy and stem cell biology are putting medical science closer to finding options for people with as-yet incurable muscle conditions that cause disability and shorten lives. A few of these disorders eventually result in neuromuscular breathing weakness or failure requiring mechanical ventilation.

What the new muscle research center offers patients with these diseases, many of whom are racing against time, is hope, said center director Michael Regnier, professor of bioengineering, a jointly operated department of the University of Washington College of Engineering and the UW School of Medicine.

A few of the several diseases for which the new center initially will be seeking answers are

Time is of the essence for many patients eagerly awaiting treatment progress in muscle diseases that are characterized by a decline and weakening.

Clinical partners include pediatric experts in rare genetic disorders and physical medicine physicians who care for patients with neuromuscular disorders at the UW Medical Center Rehabilitation Medicine Clinic and other settings.

One of several areas in which the center is expected to take a major leadership role is in growing human stem cells, some of which will be derived from patient cells, to produce disease-in-a-lab-dish models. These models will improve understanding of how the disease pathology begins and develops, and will also serve for testing possible treatments.

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New research center to explore muscle health and disease - Newswise

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