Reactivation of the pluripotency program precedes formation of the cranial neural crest – Science Magazine

Reactivating neural crest pluripotency

Cranial neural crest cells (CNCCs) are a transient cell group with an extraordinary differentiation potential that extends beyond its ectodermal lineage to form the majority of facial mesenchyme. Zalc et al. identified a neuroepithelial precursor population that transiently reactivates pluripotency factors to generate CNCCs. The pluripotency factor Oct4 is required for the expansion of CNCC developmental potential to form facial mesenchyme. Analysis of the chromatin landscape of Oct4+ CNCC precursors showed that these cells resemble those of epiblast stem cells, with additional features suggestive of future priming for neural crest programs. Thus, to expand their cellular potency, CNCC precursors undergo a natural in vivo reprogramming event.

Science, this issue p. eabb4776

Cell differentiation is classically described as a unidirectional process that progresses through a series of lineage restriction events, with cellular potential being increasingly reduced as the embryo develops, a concept famously illustrated by Conrad Waddington in his epigenetic landscape. However, the vertebrate-specific transient cell population called cranial neural crest cells (CNCCs) challenges this paradigm. Although they originate in the ectoderm and are capable of differentiating into cell types typical of this germ layer, CNCCs can also give rise to mesenchymal cell types canonically associated with the mesoderm lineage, such as bone, cartilage, and smooth muscle. How CNCCs expand their differentiation potential beyond their germ layer of origin remains unresolved.

We hypothesized that unbiased analysis of transcriptional heterogeneity during the early stages of mammalian CNCC development may identify a precursor population and provide clues as to how these specialized cells gain their extraordinary differentiation potential. To test this, we combined single-cell RNA-sequencing analysis of murine CNCCs from staged mouse embryos with follow-up lineage-tracing, loss-of-function, and epigenomic-profiling experiments.

We found that premigratory CNCCs are heterogeneous and carry positional information reflective of their origin in the neuroepithelium, but this early positional information is subsequently erased, with delaminating CNCCs showing a relatively uniform transcriptional signature that later rediversifies as CNCCs undergo first commitment events. We identify an early precursor population that expresses canonical pluripotency transcription factors and gives rise to CNCCs and craniofacial structures. Rather than being maintained from the epiblast, pluripotency factor Oct4 is transiently reactivated in the prospective CNCCs after head-fold formation, and its expression shifts from the most anterior to the more posterior part of the cranial domain as development progresses. Oct4 is not required for the induction of CNCCs in the neuroepithelium, but instead is important for the specification and survival of facial mesenchyme, thus directly linking this pluripotency factor with the expansion of CNCC cellular potential. Open chromatin landscapes of Oct4+ CNCC precursors are consistent with their neuroepithelial origin while also broadly resembling those of pluripotent epiblast stem cells. In addition, we saw priming of distal regulatory regions at a subset of loci associated with future neural crest migration and mesenchyme formation.

Our results show that premigratory CNCCs first form as a heterogeneous population that rapidly changes its transcriptional identity during delamination, resulting in the formation of a transcriptionally (and likely also functionally) equivalent cell group capable of adapting to future locations during and after migration. Such functional equivalency and plasticity of CNCCs is consistent with previous embryological studies. Furthermore, the demonstration that CNCC precursors transiently reactivate pluripotency factors suggests that these cells undergo a natural in vivo reprogramming event that allows them to climb uphill on Waddingtons epigenetic landscape. Indeed, our results show that at least one of the pluripotency factors, Oct4, is required for the expansion of CNCC developmental potential to include formation of facial mesenchyme. Whether this mechanism is specific to CNCCs and if such expansion of cellular plasticity could be harnessed for regenerative medicine purposes remain interesting questions for future investigations.

(A) Single-cell RNA (scRNA) sequencing of genetically labeled murine CNCCs over 14 hours of development revealed rapid transcriptional changes and identified a precursor population expressing pluripotency factors. (B) Uphill on Waddingtons epigenetic landscape, reactivation of Oct4 endows CNCC precursors with the ability to form derivatives typical of mesoderm, such as mesenchyme.

During development, cells progress from a pluripotent state to a more restricted fate within a particular germ layer. However, cranial neural crest cells (CNCCs), a transient cell population that generates most of the craniofacial skeleton, have much broader differentiation potential than their ectodermal lineage of origin. Here, we identify a neuroepithelial precursor population characterized by expression of canonical pluripotency transcription factors that gives rise to CNCCs and is essential for craniofacial development. Pluripotency factor Oct4 is transiently reactivated in CNCCs and is required for the subsequent formation of ectomesenchyme. Furthermore, open chromatin landscapes of Oct4+ CNCC precursors resemble those of epiblast stem cells, with additional features suggestive of priming for mesenchymal programs. We propose that CNCCs expand their developmental potential through a transient reacquisition of molecular signatures of pluripotency.

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Reactivation of the pluripotency program precedes formation of the cranial neural crest - Science Magazine

Should We Double The Age When Science Can Experiment On Babies? – 550 KTSA

Back when embryonic-stem-cell and other types of experimentation on early embryos commenced, the scientists promised they would always limit their activities to embryos in Petri dishes to the maximum of 14 days in development. Just a collection of undifferentiated cells, they sophistically maintained. Well stop when the nervous system begins to develop. It was all a ruse. The 14 day rule, as it came to be known, only prevented that which could not be done. You see, the state of the science was such that embryos could not be maintained for longer. But it assuaged the peasants.

Besides, the scientists knew that the boundary wasnt intended to be permanent. It was just a way station until embryos could be maintained outside a womans body for more than two weeks. That time is now arriving, and so, of course, the push is now on to expand the limit to 28 days.

To talk about this push to disect babies, Lars spoke with Wesley Smith, an author and a senior fellow at the Discovery Institutes Center on Human Exceptionalism.

To read Wesleys full article click HERE

Listen to the interview below:

The post Should We Double The Age When Science Can Experiment On Babies? appeared first on The Lars Larson Show.

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Should We Double The Age When Science Can Experiment On Babies? - 550 KTSA

Why Cynata is hopeful its COVID treatment trial will succeed where others have failed – Business News Australia

Cynata Therapeutics (ASX: CYP), founded by two clever stem cell researchers and one wise Australian techpreneur, is in the process of developing a treatment for COVID-19.

Using its in-house stem cell technology Cymerus, the ASX-listed biotech hopes to treat one of the deadliest complications of COVID-19 -acute respiratory distress syndrome (ARDS).

In doing so Cynata would achieve what competitor Mesoblast (ASX: MSB) couldn't with FDA approval.

By deploying an industrialised approach to stem cell therapeutics, Cynata CEO Ross Macdonald (pictured) is confident the clinical trial process won't leave the company hamstrung.

In 1981 scientists discovered a way to derive embryonic stem cells from early mouse embryos.

The discovery thrilled scientists, and eventually led to the development of a method to do the same in lab-grown human embryos by 1998.

While there have been plenty of discussions surrounding the ethics of using of embryonic stem cells, these major scientific movements have pushed researchers to discover new and inventive ways of treating a whole raft of diseases and infections.

One such researcher, Dr Ian Dixon, saw potential for the use of mesenschymal stem cells (MSCs) - a type of stem cell that can differentiate into a variety of cell types enabling the treatment of many diseases and infections.

However there was still an obstacle to overcome: how do you mass produce enough cells needed to commercialise a treatment?

Luckily, two researchers at the University of Wisconson, Professor Igor Slukvin and Dr Maksym Vodyanik, had invented a biotechnological breakthrough called Cymerus.

The technology was able to do exactly what Dixon needed: the consistent manufacture of MSCs on an ultra-large scale; basically what Henry Ford did to the industrialisation of the auto industry, but for stem cells.

So in 2003 Dixon partnered with the two researchers to start Cynata - now an ASX-listed biotechnology company trialing a number of different treatments for a wide variety of ailments.

Most recently, Cynata's focus has been on developing a treatment for a complication of COVID-19 called acute respiratory distress syndrome (ARDS).

The complication ravages COVID-19 infected patients, destroying their organs through what is known as a cytokine storm. The complication is estimated to kill up to half of COVID-19 patients that suffer from it.

Melbourne-based Cynata is currently in the very early stages of its investigation into whether its MSCs will be able to treat the coronavirus complication overwhelming hospitals globally.

If this all sounds familiar, you might be thinking of another ASX-listed biotech called Mesoblast (ASX: MSB).

In March last year Mesoblast, also based in Melbourne, saw its shares surge after announcing plans to evaluate its stem cell treatment solutions on COVID-19 patients.

The group commenced the arduous clinical trial process to see if its remestemcel-L therapy could treat ARDS by using bone marrow aspirate from healthy donors - a similar approach the company had already taken to treat a condition many suffer from after receiving bone marrow transplants.

Mesoblast was riding high on the ASX following positive announcements surrounding the clinical traila process, especially back in April 2020 when a trial at New York City's Mt Sinai hospital found its remestemcel-L therpay achieved "remarkable" results.

Serious attention gathered around Mesoblast, with the company even securing $138 in funds from investors to continue its important research.

The company went so far as to sign a commercialisation deal for the COVID-19 treatment with Novartis, and the US Food and Drugs Administration (FDA) fast tracked the approvals process for the potential game-changing treatment.

However, in December 2020, Mesoblast hit a stumbling block.

Mesoblast's COVID-19 treatment flunked the test - its remestemcel-L therapy failed to show a lower mortality rate for patients in the prescribed 30-day timeframe of treatment.

At that point Cynata had commenced research into its own ARDS treatment. But did Mesoblast's failure unnerve Cynata CEO Ross Macdonald? Not a chance.

"I'm more confident that our trial will be successful where theirs was a failure," Macdonald said.

"If you use a process like we have developed - we don't rely on multiple different [stem cell] donations. You start with exactly the same material every time."

To explain, Macdonald used the analogy of a local caf; you normally expect a coffee from one caf to taste more or less exactly the same every time you go there - the same beans are used every time.

Whereas Macdonald said Mesoblast's process is like going to the same caf every day, but each visit they use different beans from a different supplier which leads to inconsistency in taste and flavour.

Cynata's approach with its MSCs is in line with the first example - what you get the first time from them will be replicated in each and every dose of the drug - while MSB's is like the latter.

"Yes, you still got the coffee, but the experience of the taste is totally different than it was yesterday," he said.

"The FDA said to Mesoblast, well you've got a manufacturing problem that is reliant upon multiple donors prepared to donate bone marrow and that is flawed.

"So with that in mind it's perhaps not surprising that they had a pretty disappointing result in the clinical trials."

Additionally, Macdonald said the initial investor reactions to MSB's early COVID-19 trail results were overblown.

"The initial data from their trial that got everybody excited was, in my view, quite flawed, because they said "look at how many patients are dying in intensive care units with COVID compared the patients that we treated," he said.

"But the reality of the situation was quite different. The control group at that time - the death rate was way, way higher than you would typically see for ARDS, whether its COVID or anything else. And it was simply because of the chaos that existed in intensive care units in New York in the first wave.

"So we think that the initial enthusiasm was perhaps a little misguided."

When asked why Mesoblast is receiving so much attention compared to Cynata, especially considering the above, Macdonald said it was simply because MSB is bigger and has been around for longer. For context, MSB has a market capitalisation of $1.46 billion, whereas Cynata's is just $94.56 million.

"I'd love to know why there is less attention, and how we can get our market cap above a billion dollars," joked Macdonald.

"I think the answer though is that they've been around for a lot longer than we have, they have spent a hell of a lot more money than we've spent - their monthly spend is more than we've spent for pretty much our entire existence.

"But I think the fundamental reason why is that data drives value in biotech, so the more clinical data you generate that shows your product works, the more attention you attract from investors."

That's not to say Cynata is being totally ignored in favour of the larger Mesoblast.

The company secured a $15 million placement led by $10 million from healthcare investor BioScience Managers in December.

The funds will be used to expand Cynata's clinical development pipeline and scale their operations in Australia.

As such, the company is preparing to expand its clinical development pipeline to include idiopathic pulmonary fibrosis, renal transplantation, and diabetic foot ulcers.

"So we're starting to garner that attention now that says two things - one, cell therapies are definitely a medical revolution and two, Cynata is part of that new generation of companies," Macdonald said.

As for the company's pipeline, in addition to the COVID treatment trials, Cynata is planning on launching three new clinical candidates that will get under way this year.

There's also Cynata's osteoarthritis trial, which Macdonald describes as significant for the biotech company; with 2 million patients in Australia and 30 million in the United States the company is hoping to tap into an $11 billion plus addressable market.

"It will ultimately show whether MSCs are useful in that particularly devastating condition," he said.

"It doesn't just affect people who want to go and play golf or tennis, it affects, particularly manual labourers who can no longer work.

"So the cost to the economy of osteoarthritis is quite significant, which is of course one of the reasons why the Australian Government is funding this trial."

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Global Human Embryonic Stem Cells Market increasing demand with Industry Professionalist |know the Brand Players forecast 2027 Jumbo News – Jumbo…

Global Human Embryonic Stem Cells Market 2021IndustrialAnalysis, Regional Survey, and Forecast Report: Supply, Demand, Suppliers, Porters Five Forces Analysis, Segment-wise Trends, Statistical Survey, Pricing Analysis, Geographical Exploration, Revenues, Historical Data, and Projections to 2027

This research study evaluates the global Human Embryonic Stem Cellsmarket status, growth rate, player market shares, player positioning, projection trends, competition landscape, market drivers, challenges and opportunities, pricing analysis, deployment channels, and distributors.Syndicate Market Research AnalysesResearch Methodology overview consists ofSecondary Research,Primary Research,Company Share Analysis,Model ( including Demographic data, Macroeconomic indicators, andIndustry indicators i.e. Expenditure, infrastructure, sector growth, and facilities, etc),Research Limitations and Revenue Based Modeling.The establishment of the Human Embryonic Stem Cells showcase is additionally referenced in the report that can permit the customers in applying essential strategies to increase the upper hand. Such a sweeping and through and through research investigation gives the fundamental development with key proposals and impartial quantifiable examination. This can be utilized to upgrade the present position and structure future expansions in a particular zone in the Human Embryonic Stem Cells showcase. The report likewise gauges inclines in the market alongside mechanical headways in the business.It also has an In-depth analysis of the industrys competitive landscape, restraints, detailed information about different drivers, and global opportunities. Key competitors included in Global Human Embryonic Stem Cells Market areESI BIO, Thermo Fisher, BioTime, MilliporeSigma, BD Biosciences, Astellas Institute of Regenerative Medicine, Asterias Biotherapeutics, Cell Cure Neurosciences, PerkinElmer, Takara Bio, Cellular Dynamics International, Reliance Life Sciences, Research & Diagnostics Systems, SABiosciences, STEMCELL Technologies, Stemina Biomarker Discovery, Takara Bio, TATAA Biocenter, UK Stem Cell Bank, ViaCyte, Vitrolife

Our Research SpecialistAnalysesResearch Methodology overview includingPrimary Research, Secondary Research, Company Share Analysis,Model ( including Demographic data, Macro-economic indicators, andIndustry indicators: Expenditure, infrastructure, sector growth, and facilities ),Research Limitations and Revenue Based Modeling. Company share analysis is used to derive the size of the global market. As well as a study of revenues of companies for the last three to five years also provides the base for forecasting the market size (2021- 2027) and its growth rate.Porters Five Forces Analysis, impact analysis of covid-19 and SWOT Analysisare also mentioned tounderstand the factors impacting consumer and supplier behaviour.

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The point of this exploration report is to characterize, break down, portion, and estimate the size of the Human Embryonic Stem Cells showcase based on types, applications, end-clients, key districts, and key players. This report gives the worldwide market size of Human Embryonic Stem Cells in key topographies viz.Europe, North America, Asia Pacific, Central, and South America Middle East and Africa, with the prime spotlight on significant economies including Canada, U.S, Mexico, UK, Germany, Spain, France, Russia, Italy, India, China, South Korea, Japan, Southeast Asia, Indonesia, Australia, Argentina, Brazil, South Africa, GCC nations, Turkey and Egypt among other remarkable nations in rest of the world.The report centers around the offers of Human Embryonic Stem Cells in the previously mentioned districts/ nations. This exploration report arranges the worldwide Human Embryonic Stem Cells showcase by top brands/players/sellers, type, applications, end-users, regions, and Countries

Key Highlights of the TOC provided by Syndicate Market Research:

Major Product Type of Human Embryonic Stem Cells Covered in Market Research report:Totipotent Stem Cells, Pluripotent Stem Cells, Unipotent Stem Cells

Application Segments Covered in Market Research Report:Research, Clinical Trials

Global Human Embryonic Stem Cells Industry Market: By Region

North America

Europe

Asia Pacific

Latin America

The Middle East and Africa

Table of Content include Human Embryonic Stem Cells Market Worldwide are:

1 Study Coverage 1.1 Human Embryonic Stem Cells Product 1.2 Key Market Segments in This Study 1.3 Key Manufacturers Covered 1.4 Market by Type 1.4.1 GlobalMarket Size Growth Rate by Type (Totipotent Stem Cells, Pluripotent Stem Cells, Unipotent Stem Cells) 1.5 Market by Application 1.5.1 Global Market Size Growth Rate by Application (Research, Clinical Trials) 1.6 Study Objectives 1.7 Years Considered

2 Executive Summary 2.1 Global Human Embryonic Stem Cells Market Size 2.1.1 Global Human Embryonic Stem Cells Revenue 2013-2025 2.1.2 Global Human Embryonic Stem Cells Production 2013-2025 2.2 Human Embryonic Stem Cells Growth Rate (CAGR) 2021-2027 2.3 Analysis of Competitive Landscape 2.3.1 Manufacturers Market Concentration Ratio (CR5 and HHI) 2.3.2 Key Manufacturers 2.3.2.1 Manufacturing Base Distribution, Headquarters 2.3.2.2 Manufacturers Product Offered 2.3.2.3 Date of Manufacturers Enter into Market 2.4 Key Trends for Markets & Products

3 Human Embryonic Stem Cells Market Size by Manufacturers 3.1 Production by Manufacturers 3.1.1Production by Manufacturers 3.1.2 Production Market Share by Manufacturers 3.2 Revenue by Manufacturers 3.2.1 Revenue by Manufacturers (2013-2018) 3.2.2 Revenue Share by Manufacturers (2013-2018) 3.3 Price by Manufacturers 3.4 Mergers & Acquisitions, Expansion Plans

4 Human Embryonic Stem Cells Production by Regions 4.1 Global Production by Regions 4.1.1 Global Production Market Share by Regions 4.1.2 Global Revenue Market Share by Regions 4.2 United States 4.2.1 United States Production 4.2.2 United States Revenue 4.2.3 Key Players in United States 4.2.4 United States Import & Export 4.3 Europe 4.3.1 Europe Production 4.3.2 Europe Revenue 4.3.3 Key Players in Europe 4.3.4 Europe Import & Export 4.4 China 4.4.1 China Production 4.4.2 China Revenue 4.4.3 Key Players in China 4.4.4 China Import & Export 4.5 Japan 4.5.1 Japan Production 4.5.2 Japan Revenue 4.5.3 Key Players in Japan 4.5.4 Japan Import & Export 4.6 Other Regions 4.6.1 South Korea 4.6.2 India 4.6.3 Southeast Asia

5 Human Embryonic Stem Cells Consumption by Regions 5.1 Global Human Embryonic Stem Cells Consumption by Regions 5.1.1 Global Human Embryonic Stem Cells Consumption by Regions 5.1.2 Global Human Embryonic Stem Cells Consumption Market Share by Regions 5.2 North America 5.2.1 North America Human Embryonic Stem Cells Consumption by Application 5.2.2 North America Human Embryonic Stem Cells Consumption by Countries 5.2.3 United States 5.2.4 Canada 5.2.5 Mexico 5.3 Europe 5.3.1 Europe Human Embryonic Stem Cells Consumption by Application 5.3.2 Europe Human Embryonic Stem Cells Consumption by Countries 5.3.3 Germany 5.3.4 France 5.3.5 UK 5.3.6 Italy 5.3.7 Russia 5.4 Asia Pacific 5.4.1 Asia Pacific Human Embryonic Stem Cells Consumption by Application 5.4.2 Asia Pacific Human Embryonic Stem Cells Consumption by Countries 5.4.3 China 5.4.4 Japan 5.4.5 South Korea 5.4.6 India 5.4.7 Australia 5.4.8 Indonesia 5.4.9 Thailand 5.4.10 Malaysia 5.4.11 Philippines 5.4.12 Vietnam 5.5 Central & South America 5.5.1 Central & South America Human Embryonic Stem Cells Consumption by Application 5.5.2 Central & South America Human Embryonic Stem Cells Consumption by Country 5.5.3 Brazil 5.6 Middle East and Africa 5.6.1 Middle East and Africa Human Embryonic Stem Cells Consumption by Application 5.6.2 Middle East and Africa Human Embryonic Stem Cells Consumption by Countries 5.6.3 GCC Countries 5.6.4 Egypt 5.6.5 South Africa

6 Market Size by Type 6.1 Global Production by Type 6.2 Global Revenue by Type 6.3 Price by Type

7 Market Size by Application 7.1 Overview 7.2 Global Breakdown Dada by Application 7.2.1 Global Consumption by Application 7.2.2 Global Consumption Market Share by Application (2021-2027)

8 Manufacturers Profiles Overall Companies available in Human Embryonic Stem Cells Market 8.1.1 Company Details 8.1.2 Company Overview 8.1.3 Company Human Embryonic Stem Cells Production Revenue and Gross Margin (2014-2020) 8.1.4 Human Embryonic Stem Cells Product Description 8.1.5 Recent Development and others

9 Production Forecasts 9.1 Human Embryonic Stem Cells Production and Revenue Forecast 9.1.1 Global Human Embryonic Stem Cells Production Forecast 2021-2027 9.1.2 Global Human Embryonic Stem Cells Revenue Forecast 2021-2027 9.2 Human Embryonic Stem Cells Production and Revenue Forecast by Regions 9.2.1 Global Human Embryonic Stem Cells Revenue Forecast by Regions 9.2.2 Global Human Embryonic Stem Cells Production Forecast by Regions 9.3 Human Embryonic Stem Cells Key Producers Forecast 9.3.1 United States 9.3.2 Europe 9.3.3 China 9.3.4 Japan 9.4 Forecast by Type 9.4.1 Global Human Embryonic Stem Cells Production Forecast by Type 9.4.2 Global Human Embryonic Stem Cells Revenue Forecast by Type

10 Consumption Forecast 10.1 Human Embryonic Stem Cells Consumption Forecast by Application 10.2 Human Embryonic Stem Cells Consumption Forecast by Regions 10.3 North America Market Consumption Forecast 10.3.1 North America Human Embryonic Stem Cells Consumption Forecast by Regions 2021-2027 10.3.2 United States 10.3.3 Canada 10.3.4 Mexico 10.4 Europe Market Consumption Forecast 10.4.1 Europe Human Embryonic Stem Cells Consumption Forecast by Regions 2021-2027 10.4.2 Germany 10.4.3 France 10.4.4 UK 10.4.5 Italy 10.4.6 Russia 10.5 Asia Pacific Market Consumption Forecast 10.5.1 Asia Pacific Human Embryonic Stem Cells Consumption Forecast by Regions 2021-2027 10.5.2 China 10.5.3 Japan 10.5.4 South Korea 10.5.5 India 10.5.6 Australia 10.5.7 Indonesia 10.5.8 Thailand 10.5.9 Malaysia 10.5.10 Philippines 10.5.11 Vietnam 10.6 Central & South America Market Consumption Forecast 10.6.1 Central & South America Human Embryonic Stem Cells Consumption Forecast by Regions2021-2027 10.6.2 Brazil 10.7 Middle East and Africa Market Consumption Forecast 10.7.1 Middle East and Africa Human Embryonic Stem Cells Consumption Forecast by Regions 2021-2027 10.7.2 GCC Countries 10.7.3 Egypt 10.7.4 South Africa

11 Value Chain and Sales Channels Analysis 11.1 Value Chain Analysis 11.2 Sales Channels Analysis 11.2.1 Human Embryonic Stem Cells Sales Channels 11.2.2Distributors 11.3Customers

12 Market Opportunities & Challenges, Risks and Influences Factors Analysis 12.1 Market Opportunities and Drivers 12.2 Market Challenges 12.3 Market Risks/Restraints 12.4 Key World Economic Indicators

13 Key Findings in the Global Human Embryonic Stem Cells Study

14 Appendix 14.1 Research Methodology 14.1.1 Methodology/Research Approach 14.1.1.1 Research Programs/Design 14.1.1.2 Market Size Estimation 14.1.1.3 Market Breakdown and Data Triangulation 14.1.2 Data Source 14.1.2.1 Secondary Sources 14.1.2.2 Primary Sources 14.2 Author Details 14.3 Disclaimer

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Missouri State Representative Indicted Over Alleged Stem Cell Therapy Scam – IFLScience

Tricia Derges, a member of the Missouri House of Representatives and doctor, has been indicted by a grand jury for among other things allegedly injecting people with amniotic fluid and telling them mesenchymal stem cells made it a miracle cure. Derges has pled not guilty, and IFLScience cannot assess the accuracy of the charges. However, the case brings attention to growing use of unproven and dangerous stem cell treatments.

The case against Derges is being taken by Tim Garrison, the U.S. Attorney for Missouri's Western District. Garrison alleges Derges acquired stem cell-free amniotic fluid and told patients it contained stem cells that would cure a variety of conditions, charging them four times what the fluid cost her to inject them with it. Garrison charged Derges with false statements over the use of the fluid, as well as illegal distribution of controlled substances and wire fraud in relation to other activities at the clinics she runs.

Among long posts on her Facebook page professing her innocence, Derges posted a picture of David and Goliath, writing, I actually thought that I was making a difference. What I didnt account for was how much satan would fight back.

Whatever the truth of the allegations in Derges' specific case, by charging astate representative, Garrison has highlighted what is definitely a growing problem: deceptive use of stem cell therapies.

Multipotent stem cells have the remarkable capacity to convert into the cells that make up many bodily tissues. The hematopoietic stem cells have been used for decades to treat leukemia with well-proven results. Hundreds of other applications are either under investigation in the laboratory, or currently in clinical trials, but a much smaller number have been approved by America's FDA and equivalent bodies worldwide.

Understandably, many people don't feel able to wait, making them vulnerable to quack doctors for whom stem cells are the 21st Century snake oil. Unlike embryonic stem cells, which often originate from abortions, amniotic stem cells are seen as an alternative acceptable to pro-life individuals. However, having been discovered more recently, research into them is less advanced, making any therapeutic value speculative.

Dirges' vocal opposition to abortionpresumably made amniotic cells attractive to her for this reason, but Garrison alleges the fluid Derges was using didn't even contain stem cells. Moreover, he claims the University of Utah where Derges bought the fluid told her that, so she would have known it couldn't possibly have been effective.

Derges gained a medical degree from the Caribbean Medical University in Curaao and ran a series of low-cost medical clinics, where volunteers saw patients and recommended to her what medication to prescribe. Although licensed as an assistant physician, Derges was not accepted into a post-graduate residency program and was not licensed as a physician. She fought to change licensing rules, and ran for Missouri state District 140, narrowly winning the Republican primary before being unopposed last November. Since being elected, Derges has made changing the law on physician licensing her first priority.

In a statement, Garrison allegedDerges used the fluid on patients with everything from Lyme disease to erectile dysfunction and kidney disease, despite the improbability a single fluid would cure such different ills. Although Derges' clinics are famous for charging just $5 for an ordinary visit, the costs of this treatment averaged $40,000 per patient.

The program came to Garrison's attention after she appeared on television claiming the same amniotic fluid should be used to treat COVID-19 and making similar claims on Facebook.

H/T Springfield News Leader

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Missouri State Representative Indicted Over Alleged Stem Cell Therapy Scam - IFLScience

Push on to Allow Expanded Human-Embryo Research – National Review

(gorodenkoff/Getty Images)

Back when embryonic-stem-cell and other types of experimentation on early embryos commenced, the scientists promised they would always limit their activities to embryos in Petri dishes to the maximum of 14 days in development. Just a collection of undifferentiated cells, they sophistically maintained. Well stop when the nervous system begins to develop.

It was all a ruse. The 14 day rule, as it came to be known, only prevented that which could not be done. You see, the state of the science was such that embryos could not be maintained for longer. But it assuaged the peasants. Besides, the scientists knew that the boundary wasnt intended to be permanent. It was just a way station until embryos could be maintained outside a womans body for more than two weeks.

That time is now arriving, and so, of course, the push is now on to expand the limit to 28 days.

How is that justified, based on past assurances? Well, first deploy relativism.

Scientifically, an embryo is an embryo, wherever it might be located. But well pretend that what really matters regarding moral value is geography. From The Time has Come to Extend the 14-Day Limit:

Elsejin Kingma considers the idea that the location of an embryowhether it is in a pregnant woman or in a petri-dishmay affect its moral status and/or value. She argues that it is not just the stage of the embryo that is relevant to its moral status or value, but whether it is, or will be, in an environment that promotes its further development. She concludes that this means there is (further) good reason for a moral distinction between research embryos and reproductive implanted embryos.

Given that almost all if not all of these bioethicists believe in abortion on demand, this is a load of hooey. Yes, that is the logic, and the paper goes there:

Notwithstanding the importance of the scientific basis for human embryo research, there are ethical and philosophical reasons why this rule is now ready for amendment.

In the UK, in line with the Abortion Act 1967, an abortion is legally permitted up to the 24th week of pregnancy. Conventionally, a human embryo is termed a fetus from 9 weeks after fertilisation. It is legal to abort an embryo or fetus substantially older than 14 days, and, with appropriate consent, to do research on its tissues, yet it is illegal to experiment on an embryo beyond 14 days that was never to be implanted.

Why stop at 28 days? What are the limiting principles? What is the permanent line with regard to unborn life beyond which science will never be allowed to go regardless of the potential knowledge to be attained especially in the U.S., where some states have removed gestational limits on abortion and that is the goal of the national Democratic Party and Biden administration?I cant see any.

How is this excused? Princetons Peter Singer the New York Times favorite moral philosopher and other bioethicists claim that human life, per se, is morally irrelevant. What matters are capacities such as self-awareness that earn that human being the label of person.

Embryos are not conscious. Neither are fetuses. They are, hence, human non-persons. So why not permit experimentation and body-part harvesting through the ninth month since, in essence, unborn life are mere things? Indeed, before that time arrives, why not pay women to gestate longer before obtaining an abortion so we could get the parts an odious idea already proposed in the bioethics literature.

This isnt just philosophical musing. We may soon have the ability to maintain fetuses in artificial wombs. Once that happens, what is to prevent scientists from creating embryos, implanting them in artificial wombs and treating fetuses as a mere natural resource to be exploited and harvested?

Live fetal experimentation was conducted in the late 60s, after all, and was only stopped (pre-Roe) because people still believed in the sanctity of human life. That great moral principle no longer holds sway over great swaths of society. The important thing now is preventing suffering by almost any means necessary.

I could go on and on, and probably will. But the bottom line for this post is this: When scientists and bioethicists promise to draw ethical lines about experimenting on unborn life, they dont really mean it. Its all a big con. They will only agree to forbid that which they cannot yet do. And once they can go there, the lines will be redrawn to permit them to do whatever they want.

And then they wonder, Where is the trust?

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Stem Cell Therapy Market Size, Top Key Players, Applications, Business Statistics, Trends and Forecast 2021-2027 The Bisouv Network – The Bisouv…

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The global informative report begins with a brief introduction of Stem Cell Therapy market and market overview, classification, application, technologies, products or services, and key players operating across the globe. The global informative report elaborates on the global market scope, market scope at the present, and prediction of demand from global clients in the future. The global market research report has been presented in a clear and professional manner for easy and better understanding to readers. The driving forces, limitations, and global opportunities are listed for the Stem Cell Therapy market to get the gist of different dynamics of the global market. It has been compiled through proven research techniques such as primary research and secondary research.

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Market Segments and Sub-segments Covered in the Report are as per below:

1.Stem Cell Therapy Market, By Cell Source:

Adipose Tissue-Derived Mesenchymal Stem Cells Bone Marrow-Derived Mesenchymal Stem Cells Cord Blood/Embryonic Stem Cells Other Cell Sources

2.Stem Cell Therapy Market, By Therapeutic Application:

Musculoskeletal Disorders Wounds and Injuries Cardiovascular Diseases Surgeries Gastrointestinal Diseases Other Applications

3.Stem Cell Therapy Market, By Type:

Allogeneic Stem Cell Therapy Market, By Application Musculoskeletal Disorders Wounds and Injuries Surgeries Acute Graft-Versus-Host Disease (AGVHD) Other Applications Autologous Stem Cell Therapy Market, By Application Cardiovascular Diseases Wounds and Injuries Gastrointestinal Diseases Other Applications

Geographical scenario:

The geographical analysis of the Stem Cell Therapy market has been done by examining different global regions such as North America, Latin America, Middle East, Asia-Pacific, and Africa on the basis of different parameters. The primary target for the Stem Cell Therapy market are the Stem Cell Therapy countries. The Stem Cell Therapy market has broadly compiled through extensive research and analysis techniques such as qualitative and quantitative analysis. Furthermore, it offers a blend of SWOT and Porters five techniques to analyze the data of the global market. Moreover, this report offers a complete analysis of different business perspectives such as the ups and downs of the global market shares. To expand the market at the global level, it makes use of different techniques and sales methodologies for achieving the outcomes of the businesses.

Collectively, this research repository encapsulates data of Stem Cell Therapy market to offer strategic decision-making abilities to various investors, business owners, decision-makers as well as policymakers.

The Stem Cell Therapy Market is divided into the following regions:

North America (USA, Canada) Latin America (Chile, Brazil, Argentina, rest of Latin America) Europe (UK, Italy, Germany, France, rest of the EU) Asia Pacific (India, Japan, China, South Korea, Australia, rest of APAC) Middle East and Africa (Saudi Arabia, United Arab Emirates, South Africa, rest of MEA)

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Following major key questions are addressed through this global research report:

1. What will be the Stem Cell Therapy market size over the forecast period? 2. What are the demanding regions for making significant growth in the upcoming future? 3. What are the challenges in front of the Stem Cell Therapy market? 4. Who are the key vendors in Stem Cell Therapy market? 5. What are the effective sales patterns and methodologies for boosting the performance of the Stem Cell Therapy market? 6. What are the different ways to find out potential customers as well as global clients? 7. Which factors are hampering the Stem Cell Therapy market? 8. What are the outcomes of SWOT and porters five techniques? 9. What are the demanding trends of the Stem Cell Therapy market?

Key strategic developments in the Stem Cell Therapy market:

This global study also includes the key strategic developments of the Stem Cell Therapy market including the new product launchings, partnerships and collaboration among the key players functioning at the global level.

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Key target audience for Stem Cell Therapy report:

The report is insightful documentation and provides significant insights to customers, business owners, decision-makers, providers, distributors, suppliers, policymakers, manufacturers, investors, and individuals who have a keen interest in the Stem Cell Therapy market.

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Stem Cell Therapy Market Size, Top Key Players, Applications, Business Statistics, Trends and Forecast 2021-2027 The Bisouv Network - The Bisouv...

Stem Cells Market is Expected to Thrive at Impressive CAGR by 2025 Murphy’s Hockey Law – Murphy’s Hockey Law

This report studies the Stem Cells market size (value and volume) by players, regions, product types and end industries, history data 2013-2017 and forecast data 2018-2025; This report also studies the global market competition landscape, market drivers and trends, opportunities and challenges, risks and entry barriers, sales channels, distributors and Porters Five Forces Analysis.

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Stem cells are a class of undifferentiated cells that are able to differentiate into specialized cell types. Commonly, stem cells come from two main sources: Embryos formed during the blastocyst phase of embryological development (embryonic stem cells) and Adult tissue (adult stem cells).

Both types are generally characterized by their potency, or potential to differentiate into different cell types (such as skin, muscle, bone, etc.).

Stem Cells market, by technology, is Cell Acquisition, Cell Production, Cryopreservation, Expansion, and Sub-Culture. Stem Cell Therapy in China is not mature, so in this report we mainly cover Stem Cell Banking market.

Stem Cells market, by technology, is Cell Acquisition, Cell Production, Cryopreservation, Expansion, and Sub-Culture. Stem Cell Therapy in China is not mature, so in this report we mainly cover Stem Cell Banking market.

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Geographically, this report is segmented into several key regions, with sales, revenue, market share and growth Rate of Stem Cells in these regions, from 2013 to 2025, covering

North America (United States, Canada and Mexico)

Europe (Germany, UK, France, Italy, Russia and Turkey etc.)

Asia-Pacific (China, Japan, Korea, India, Australia, Indonesia, Thailand, Philippines, Malaysia and Vietnam)

South America (Brazil etc.)

Middle East and Africa (Egypt and GCC Countries)

The various contributors involved in the value chain of the product include manufacturers, suppliers, distributors, intermediaries, and customers. The key manufacturers in this market include

CCBC

Vcanbio

Boyalife

Beikebiotech

By the product type, the market is primarily split into

Umbilical Cord Blood Stem Cell

Embryonic Stem Cell

Adult Stem Cell

Other

By the end users/application, this report covers the following segments

Diseases Therapy

Healthcare

We can also provide the customized separate regional or country-level reports, for the following regions:

North America

United States

Canada

Mexico

Asia-Pacific

China

India

Japan

South Korea

Australia

Indonesia

Singapore

Malaysia

Philippines

Thailand

Vietnam

Rest of Asia-Pacific

Europe

Germany

France

UK

Italy

Spain

Russia

Rest of Europe

Central & South America

Brazil

Rest of Central & South America

Middle East & Africa

GCC Countries

Turkey

Egypt

South Africa

Rest of Middle East & Africa

The study objectives of this report are:

To study and analyze the global Stem Cells market size (value & volume) by company, key regions/countries, products and application, history data from 2013 to 2017, and forecast to 2025.

To understand the structure of Stem Cells market by identifying its various subsegments.

To share detailed information about the key factors influencing the growth of the market (growth potential, opportunities, drivers, industry-specific challenges and risks).

Focuses on the key global Stem Cells manufacturers, to define, describe and analyze the sales volume, value, market share, market competition landscape, SWOT analysis and development plans in next few years.

To analyze the Stem Cells with respect to individual growth trends, future prospects, and their contribution to the total market.

To project the value and volume of Stem Cells submarkets, with respect to key regions (along with their respective key countries).

To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market.

To strategically profile the key players and comprehensively analyze their growth strategies.

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Stem Cell Therapy Market Size to Reach USD 5,040 Million by 2028 | Rising Public-Private Investments and Developing Regulatory Framework for Stem Cell…

Key participants include Virgin Health Bank, Celgene Corporation, ReNeuron Group plc, Biovault Family, Precious Cells International Ltd., Mesoblast Ltd., Opexa Therapeutics, Inc., Caladrius, Neuralstem, Inc., and Pluristem, among others.

Vancouver, British Columbia, Jan. 29, 2021 (GLOBE NEWSWIRE) -- Stem Cell Therapy Market Size to Reach USD 5,040 Million by 2028 | Rising Public-Private Investments and Developing Regulatory Framework for Stem Cell Therapeutics will be the Key Factor Driving the Industry Growth, States Emergen Research

The global stem cell therapy market size was valued at USD 342.7 Million in 2019 and is anticipated to reach USD 3,693.6 Million by 2027 at a CAGR of 36.2%, over the forecast period, according to most recent analysis by Emergen Research.

Growing prevalence of chronic diseases will drive the growth of the stem cell therapy market. Increased investment in research activities, development of advanced genetic techniques, and rise in public-private partnership will contribute to the growth of the stem cell therapy market.

Stem cells are used to improve health and manage disease. The growing popularity of regenerative medicine has encouraged the growth of stem cell therapy market. Regenerative medicines are used to replace, repair, and regenerate tissues affected by disease, injury, and aging process. Regenerative medicines are used in research to find a cure for diabetes, Parkinson's, and Alzheimer's disease.

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However, ethical concerns regarding embryonic stem cells and less developed research infrastructure will hinder the stem cell therapy market's growth.

Companies Profiled in Stem Cell Therapy Market Research Report:

Virgin Health Bank, Celgene Corporation, ReNeuron Group plc, Biovault Family, Precious Cells International Ltd., Mesoblast Ltd., Opexa Therapeutics, Inc., Caladrius, Neuralstem, Inc., and Pluristem.

Story continues

Key Highlights of Report

Autologous stem cell therapy is growing at a higher rate during the forecast period due to the low risk of complications associated with autologous treatment. Other factors expected to drive the growth of the segment are the improved survival rate of patients, affordability, and no risk of graft-versus-host diseases.

Diabetes is a growing cause of concern all across the globe. In 2019, approximately 463 million adults had diabetes, and the number is expected to grow to 700 million by 2045. Stem cell therapy offers greater potential for enhancing glucose control in patients with type 1 diabetes, which will drive the growth of the segment.

Clinic segment is growing at a rate of 36.4% during the forecast period as they are equipped with sophisticated equipment and reagents for use in stem cell therapies. Clinics are offering stem cell therapies, but the cost of the treatment is high.

The stem cell therapy market is growing in Asia Pacific due to increasing collaboration between research institutes and industries for development of drugs to treat chronic diseases. In 2019, AVITA Medical in Australia collaborated with scientists at the Gates Center for regenerative medicine at the University Of Colorado School Of Medicine to explore development of spray-on treatment of genetically modified cells for patients.

Check Our Prices@ https://www.emergenresearch.com/select-license/83 Emergen Research has segmented the global stem cell therapy market in terms of type, application, end-users, and region:

Type Outlook (Revenue, USD Million; 2018-2028)

Application Outlook (Revenue, USD Million; 2018-2028)

End-users Outlook (Revenue, USD Million; 2018-2028)

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Stem Cell Therapy Market Size to Reach USD 5,040 Million by 2028 | Rising Public-Private Investments and Developing Regulatory Framework for Stem Cell...

Stem Cell Therapy Market 2021: Global Key Players, Trends, Share, Industry Size, Segmentation, Forecast To 2027 KSU | The Sentinel Newspaper – KSU |…

Stem Cell Therapy Market is valued at USD 9.32 Billion in 2018 and expected to reach USD 16.51 Billion by 2025 with the CAGR of 8.5% over the forecast period.

Rising prevalence of chronic diseases, increasing spend on research & development and increasing collaboration between industry and academia driving the growth of stem cell therapy market.

Scope of Stem Cell Therapy Market-

Stem cells therapy also known as regenerative medicine therapy, stem-cell therapy is the use of stem cells to prevent or treat the condition or disease. Stem cell are the special type of cells those differentiated from other type of cell into two defining characteristics including the ability to differentiate into a specialized adult cell type and perpetual self-renewal. Under the appropriate conditions in the body or a laboratory stem cells are capable to build every tissue called daughter cells in the human body; hence these cells have great potential for future therapeutic uses in tissue regeneration and repair. Among stem cell pluripotent are the type of cell that can become any cell in the adult body, and multipotent type of cell are restricted to becoming a more limited population of cells.

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The stem cell therapy has been used to treat people with conditions including leukemia and lymphoma, however this is the only form of stem-cell therapy which is widely practiced. Prochymal are another stem-cell therapy was conditionally approved in Canada in 2012 for the treatment of acute graft-vs-host disease in children those are not responding to steroids. Nevertheless, hematopoietic stem cell transplantation is the only established therapy using stem cells. This therapy involves the bone marrow transplantation.

Stem cell therapy market report is segmented based on type, therapeutic application, cell source and by regional & country level. Based upon type, stem cell therapy market is classified into allogeneic stem cell therapy market and autologous market.

Stem Cell Therapy Companies:

Stem cell therapy market report covers prominent players like,

Based upon therapeutic application, stem cell therapy market is classified into musculoskeletal disorders, wounds and injuries, cardiovascular diseases, surgeries, gastrointestinal diseases and other applications. Based upon cell source, stem cell therapy market is classified into adipose tissue-derived mesenchymal stem cells, bone marrow-derived mesenchymal stem cells, cord blood/embryonic stem cells and other cell sources

The regions covered in this stem cell therapy market report are North America, Europe, Asia-Pacific and Rest of the World. On the basis of country level, market of stem cell therapy is sub divided into U.S., Mexico, Canada, U.K., France, Germany, Italy, China, Japan, India, South East Asia, GCC, Africa, etc.

Stem Cell Therapy Market Segmentation

By Type

Allogeneic Stem Cell Therapy Market, By Application

Autologous Market, By Application

By Therapeutic Application

By Cell Source

Stem Cell Therapy Market Dynamics

Rising spend on research and development activities in the research institutes and biotech industries driving the growth of the stem cell therapy market during the forecast period. For instance, in January 2010, U. S. based Augusta University initiated Phase I clinical trial to evaluate the safety and effectiveness of a single, autologous cord blood stem infusion for treatment of cerebral palsy in children. The study is estimated to complete in July 2020. Additionally, increasing prevalence of chronic diseases creating the demand of stem cell therapy. For instance, as per the international diabetes federation, in 2019, around 463 million population across the world were living with diabetes; by 2045 it is expected to rise around 700 million. Among all 79% of population with diabetes were living in low- and middle-income countries. These all factors are fuelling the growth of market over the forecast period. On the other flip, probabilities of getting success is less in the therapeutics by stem cell may restrain the growth of market. Nevertheless, Advancement of technologies and government initiative to encourage research in stem cell therapy expected to create lucrative opportunity in stem cell therapy market over the forecast period.

Stem Cell Therapy Market Regional Analysis

North America is dominating the stem cell therapy market due increasing adoption rate of novel stem cell therapies fueling the growth of market in the region. Additionally, favorable government initiatives have encouraging the regional market growth. For instance, government of Canada has initiated Strategic Innovation Fund Program, in which gov will invests in research activities carried out for stem cell therapies. In addition, good reimbursing scheme in the region helping patient to spend more on health. Above mentioned factors are expected to drive the North America over the forecast period.

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