To view as PDF, see: CLI Fact Sheet Adult Stem Cell Research and Transplants
Last updated: November 21, 2017
Adult stem cell transplants are already widely used to the benefit of over a million people.
Adult stem cell transplants are being used to treat dozens of conditions in patients.
[i] Gratwohl A et al., One million haematopoietic stem-cell transplants: a retrospective observational study, Lancet Haematology 2, e91-e100, March 2015. doi:10.1016/S2352-3026(15)00028-9.
[ii]Niederwieser D, Baldomero H, Szer J, Gratwohl M, et al., Hematopoietic stem cell transplantation activity worldwide in 2012 and a SWOT analysis of the Worldwide Network for Blood and Marrow Transplantation Group including the global survey. Bone Marrow Transplant. 51(6):778-785, 2016. doi:10.1038/bmt.2016.18.
[iii] General FAQ. U.S. Department of Health and Human Services, Health Resources and Services Administration. http://bloodcell.transplant.hrsa.gov/about/general_faqs/index.html, accessed August 3, 2016.
[iv] Ballen KK, Gluckman E, Broxmeyer HE, Umbilical cord blood transplantation: the first 25 years and beyond, Blood. 122:491-498, 2013. doi:10.1182/blood-2013-02-453175.
[v] Gratwohl A et al., One million haematopoietic stem-cell transplants: a retrospective observational study, Lancet Haematology 2, e91-e100, March 2015. doi:10.1016/S2352-3026(15)00028-9.
[vi] Search term: http://www.clinicaltrials.gov/ct2/results?term=adult+stem+cell+transplants&type=Intr, accessed August 2, 2016.
[vii] Patel AN et al., Ixmyelocel-T for patients with ischaemic heart failure: a prospective randomised double-blind trial. Lancet 387:2412-2421, 2016. doi: 10.1016/S0140-6736(16)30137-4.
[viii] Steinberg GK, Kondziolka D, Wechsker LR et al., Clinical Outcomes of Transplanted Modified Bone MarrowDerived Mesenchymal Stem Cells in Stroke: A Phase 1/2a Study. Stroke. 447: 1817-1824, 2016. doi: 10.1161/STROKEAHA.116.012995; Cox CS, Hetz RA, Liao GP, et al., Treatment of Severe Adult Traumatic Brain Injury Using Bone Marrow Mononuclear Cells. Stem Cells. 35:1065-1079, 2017. doi: 10.1002/stem.2538; Hess, DC et al., Safety and Efficacy of Multipotent Adult Progenitor Cells in Acute Ischaemic Stroke (MASTERS): A Randomised, Double-Blind, Placebo-Controlled, Phase 2 Trials. Lancet. 16 (5):360-368, 2017. doi: 10.1016/S1474-4422(17)30046-7; Savitz SI, Misra V, Kasam M, et al., Intravenous Autologous Bone Marrow Mononuclear Cells for Ischemic Stroke. Annals of Neurology. 70:59-69, 2011. doi: 10.1002/ana.22458.
[ix]See Bernaudin F et al., Long-term results of related myeloablative stem-cell transplantation to cure sickle cell disease. Blood. 110:2749-2756,2007. doi: 10.1182/blood-2007-03-079665. Hematopoietic stem cell transplantation (HSCT) is the only curative therapy for sickle cell disease.
[x] Lima C, Pratas-Vital J, Escada P, Hasse-Ferreira A, Capucho C, Peduzzi JD. Olfactory Mucosal Autografts and Rehabilitation for Chronic Traumatic Spinal Cord Injury. Neurorehabil Neural Repair January 24:10-22, 2010. doi: 10.1177/1545968309347685; Lima C, Pratas-Vital J, Escada P, Hasse-Ferreira A, Capucho C, Peduzzi JD. Olfactory Mucosa Autografts in Human Spinal Cord Injury: A Pilot Clinical Study. The Journal of Spinal Cord Medicine. 29(3):191-203, 2006.
[xi] Burt RK et al., Association of Nonmyeloablative Hematopoietic Stem Cell Transplantation With Neurological Disability in Patients With Relapsing-Remitting Multiple Sclerosis, JAMA. 313(3):275-284, 2015. doi: 10.1001/jama.2014.17986.
[xii] Cai J et al., Umbilical Cord Mesenchymal Stromal Cell With Autologous Bone Marrow Cell Transplantation in Established Type 1 Diabetes: A Pilot Randomized Controlled Open-Label Clinical Study to Assess Safety and Impact on Insulin Secretion, Diabetes Care. 39, 149, 2016. doi: 10.2337/dc15-0171; Gaipov, A et al., Autologous Bone-Marrow-Derived Stem Cells Transplantation in Type 1 Diabetes Mellitus. Nephrol. Dial. Transplant. 31 (suppl 1):i217, 2016. doi: 10.1093/ndt/gfw169.03; DAddio F et al., Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in New-Onset Type 1 Diabetes: A Multicenter Analysis, Diabetes.63(9),3041-3046, 2014.doi:10.2337/db14-0295; Zhao et al., Reversal of type 1 diabetes via islet cell regeneration following immune modulation by cord blood-derived multipotent stem cells. BMC Medicine. 10(3), 2012. doi: 10.1186/1741-7015-10-3; Voltarelli JC and Couri CEB, Stem cell transplantation for type 1 diabetes mellitus, Diabetology & Metabolic Syndrome 1, 4, 2009. doi: 10.1186/1758-5996-1-4; Couri CEB et al., C-Peptide Levels and Insulin Independence Following Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus, JAMA 301, 1573-1579, 2009; Voltarelli JC et al., Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus, JAMA. 297, 1568-1576, 2007.
[xiii] Weiss JN, Levy S, Malkin A. Stem Cell Ophthalmology Treatment Study (SCOTS) for retinal and optic nerve diseases: a preliminary report. Neural Regen Res 2015; 10:982-8; Weiss JN, Levy S, Benes SC. Stem Cell Ophthalmology Treatment Study (SCOTS) for retinal and optic nerve diseases: a case report of improvement in relapsing auto-immune optic neuropathy. Neural Regen Res 2015; 10:1507-15.
[xiv] Burt RK et al., Nonmyeloablative Hematopoietic Stem Cell Transplantation for Systemic Lupus Erythematosus, JAMA 295, 527-535, 2006, doi: 10.1001/jama.295.5.527; Illei GG et al., Current state and future directions of autologous hematopoietic stem cell transplantation in systemic lupus erythematosus, Annals of the Rheumatic Diseases 70, 2071-2074, 2011 doi: 10.1136/ard.2010.148049; Szodoray P et al., Immunological reconstitution after autologous stem cell transplantation in patients with refractory systemic autoimmune diseases, Scandinavian Journal of Rheumatology 41, 110-115, 2012, doi: 10.3109/03009742.2011.606788; Alchi B et al., Autologous haematopoietic stem cell transplantation for systemic lupus erythematosus: data from the European Group for Blood and Marrow Transplantation registry, Lupus 22, 245-253, 2013, doi: 10.1177/0961203312470729; Alexander T et al., Autologous hematopoietic stem cell transplantation in systemic lupus erythematosus, Z. Rheumatologie 75, 770-779, 2016, doi: 10.1007/s00393-016-0190-3
[xv]Search term selection: multiple myeloma/plasma cell disease (PCD) http://bloodcell.transplant.hrsa.gov/RESEARCH/Transplant_Data/US_Tx_Data/Data_by_Disease/national.aspx, accessed August 3, 2016.
[xvi] Press release: The Lancet Hematology: Experts warn of stem cell underuse as transplants reach 1 million worldwide (Feb 26, 2016) http://www.eurekalert.org/pub_releases/2015-02/tl-tlh022515.php, accessed August 2, 2016.
See the article here:
Fact Sheet: Adult Stem Cell Research and Transplants ...
- BioRestorative Therapies Emerges from Chapter 11 Reorganization Other OTC:BRTX - GlobeNewswire - November 20th, 2020
- Jakafi and Dacogen May Improve Overall Survival in Patients with MPN - Curetoday.com - November 20th, 2020
- BRTX-100; the Story of BioRestorative Therapies Inc (OTCMKTS: BRTX) - MicroCap Daily - November 20th, 2020
- As California Passes Prop 14, What Is Stem Cell Research and Why Is It Controversial? - Newsweek - November 16th, 2020
- Organoids mimic the early development of the heart in mouse embryos - BioNews - November 16th, 2020
- Human mesenchymal stromal cells do not express ACE2 and TMPRSS2 and are not permissive to SARS-CoV-2 infection - DocWire News - November 16th, 2020
- Cynata Therapeutics (ASX:CYP) begins phase three osteoarthritis trial - The Market Herald - November 16th, 2020
- $ 30.1 billion Worth Cell Expansion Market, Led by Thermo Fisher Scientific Inc, Becton, Dickinson and Company, Terumo BCT and Others. re:Jerusalem -... - November 3rd, 2020
- Impact of COVID-19 on Advanced Wound Care Management Market : Implications on Business Strategies, Countermeasures, Economic Impact - The Think... - November 1st, 2020
- Stem Cells Market 2020 Is Growing with Highest Size, Share of Top Key Players in the Industry and Forecast Survey Till 2024 - Zenit News - October 30th, 2020
- Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease - DocWire News - October 30th, 2020
- JadiCell Stem Cells Licensed by Therapeutic Solutions International for Brain Injury Significantly Increased Survival of COVID-19 Patients in Double... - October 29th, 2020
- Impact Of Covid 19 On Adult Stem Cells Market 2020 Industry Challenges, Business Overview And Forecast Research Study 2026 - PRnews Leader - October 29th, 2020
- APstem Therapeutics Announces Successful FDA INTERACT Meeting Regarding AP-Skin-01, an Off-the-Shelf Allogeneic Stem Cell Product for the Treatment of... - October 29th, 2020
- Why Small Businesses Matter in Wilton (Reimagined): Interventional Orthopedics Connecticut - HamletHub - October 29th, 2020
- Covid-19 Impact On Orthopedic Regenerative Medicine Market 2020 Future Development, Manufacturers, Trends, Share, Size And Forecast to 2027 |... - October 29th, 2020
- Cell Expansion Market a comprehensive study by key players- Thermo Fisher Scientific, Inc, Becton, Dickinson and Company, Terumo BCT, Merck KGaA and... - October 24th, 2020
- Genmab Announces IFM, HOVON and Janssen Achieve Positive Topline Results in Second Part of Phase 3 CASSIOPEIA Study of Daratumumab in Multiple Myeloma... - October 24th, 2020
- What Is the Role of Allogeneic-SCT in Adult Acute Lymphoblastic Leukemia in the Era of Targeted Therapies? - Targeted Oncology - October 21st, 2020
- Cell Therapy Market Size, Share, Market Research and Industry Forecast Report, 2020-2027 (Includes Business Impact of COVID-19) - Eurowire - October 17th, 2020
- Global Stem Cell Therapy Market (Covid-19 updated report), Trends, Top Manufacturers, Exponential Growth and Forecast 2020 to 2027 By Reportspedia -... - October 17th, 2020
- Was Trump's Regeneron 'Cure' Developed Using Stem Cells and Fetal Tissues? - Snopes.com - October 13th, 2020
- The complicated story of Trump's COVID treatment, stem cells and abortion politics - Baptist News Global - October 13th, 2020
- BrainStorm to Present at the 2020 Cell & Gene Meeting on the Mesa - PRNewswire - October 13th, 2020
- Human heart organoids provide unmatched insight into cardiac disease and dysfunction - BioWorld Online - October 13th, 2020
- Sickle Cell Disease Association of America and Aruvant Sciences Forge New Partnership to Educate Around Gene Therapy - Herald-Mail Media - October 13th, 2020
- Q Stock; The Rise of BioRestorative Therapies Inc (OTCMKTS: BRTXQ) - MicroCap Daily - October 8th, 2020
- A Uniquely Patient-Focused Take on Treating AML in Older Adults - Medscape - October 8th, 2020
- Dust off the crystal ball: It's time for STAT's 2020 Nobel Prize predictions - STAT - October 3rd, 2020
- BrainStorm Cell Therapeutics to Announce Third Quarter Financial Results and Provide a Corporate Upd - PharmiWeb.com - October 3rd, 2020
- Cell Harvesting Market to Witness Steady Expansion During 2018-2023 - The Market Records - October 1st, 2020
- Global Mesenchymal Stem Cells Market to Witness Exponential Rise in Revenue Share During the Forecast Period - Lake Shore Gazette - September 7th, 2020
- Keeping kids and adults alike healthy with Colostrum - North Coast Courier - September 4th, 2020
- Newly discovered molecule could play key role in treating osteoarthritis - Irish Examiner - September 4th, 2020
- Stem Cell Therapy Market (Covid 19 Impact) Research Outlook, Recent Trends and Growth Forecast 2020-2025 - TC BizNews - September 4th, 2020
- Shielded Stem Cells Improve The Cells' Ability To Heal Heart Injuries - Interesting Engineering - August 21st, 2020
- Steadman Philippon Research Institute (SPRI) Receives Multi-Million-Dollar Matching Grant from the National Institutes of Health - GlobeNewswire - August 21st, 2020
- Worldwide Dilated Cardiomyopathy (DCM) Market Insights, Epidemiology and Forecast - 2030 - ResearchAndMarkets.com - Business Wire - August 21st, 2020
- Genmab Announces Janssen Granted U.S. FDA Approval for DARZALEX (daratumumab) in Combination with Carfilzomib and Dexamethasone in Relapsed or... - August 21st, 2020
- Huntington's Disease Alters Human Development in the Fetal... : Neurology Today - LWW Journals - August 21st, 2020
- Researchers find method to regrow cartilage in the joints - Stanford Medical Center Report - August 18th, 2020
- Global Stem Cell Reconstructive Market- Industry Analysis and Forecast (2020-2027) - Good Night, Good Hockey - August 15th, 2020
- This revolutionary new coronavirus cure is already saving lives - BGR - August 14th, 2020
- Survivors of Pediatric Cancers May Experience Lasting Impact on Heart, Metabolic Health Following Radiation Therapy - Pharmacy Times - August 14th, 2020
- TG Therapeutics Umbralisib Development, And Other News: The Good, Bad And Ugly Of Biopharma - Seeking Alpha - August 14th, 2020
- Stem Cell And Regenerative Therapy Market Industry Outlook, Growth Prospects and Key Opportunities - Kentucky Journal 24 - August 13th, 2020
- Radiation to treat pediatric cancers may have lasting impact on heart and metabolic health - Science Codex - August 13th, 2020
- Opportunities in the Global Induced Pluripotent Stem Cell (iPS Cell) Industry - PRNewswire - August 11th, 2020
- Human Embryonic Stem Cells market to see major growth by 2026 | Lonza Group Ltd., Life Technologies Corporation, NuVasive Inc., TiGenix NV, Sumanas,... - August 11th, 2020
- Stem Cell Banking Market Industry Analysis & Forecast (2019-2026) by Type, Service, Application and Geography. - Good Night, Good Hockey - August 11th, 2020
- Salles Speaks to the Potential Benefit of the Tafasitamab Combo in the R/R DLBCL Setting - Targeted Oncology - August 10th, 2020
- Stem Cell And Regenerative Therapy Market: Global Forecast over COVID-19 2024 - eRealty Express - August 10th, 2020
- Edited Transcript of ALLO.OQ earnings conference call or presentation 5-Aug-20 12:30pm GMT - Yahoo Finance - August 6th, 2020
- Edited Transcript of XNCR.OQ earnings conference call or presentation 4-Aug-20 8:30pm GMT - Yahoo Finance - August 5th, 2020
- Global Adrenoleukodystrophy Treatment Trends and Highlights - Bulletin Line - August 4th, 2020
- Global Stem Cell Reconstructive Market- Industry Analysis and Forecast (2020-2027)-by Sources, Cell Type, Application, End User and Region. - WOLE TV - August 3rd, 2020
- Stem Cell Reconstructive Market Will Reflect Significant Growth Prospects of US$ Mn during 2020-2025 with Major Key Player: NuVasive, Cytori... - July 30th, 2020
- Global Stem Cell Reconstructive Market- Industry Analysis and Forecast (2020-2027)-by Sources, Cell Type, Application, End User and Region. - Red... - July 30th, 2020
- Orthopedic Regenerative Medicine Market Insights and Business Outlook By Top Players Curasan, Inc., Carmell Therapeutics Corporation, Anika... - July 29th, 2020
- Books: Five new books to read this week - HeraldScotland - July 29th, 2020
- Orthopedic Regenerative Medicine Market Research Report 2020 Overall Analysis and Forecast up to the Year 2027 - Sanford Philosopher - July 28th, 2020
- BrainStorm Cell Therapeutics to Announce Second Quarter Financial Results and Provide a Corporate and R&D Update - Yahoo Finance - July 27th, 2020
- New Study Offers First Glimpse Into How Widespread COVID-19 Antibodies are in Canada's Adult Population - Canada NewsWire - July 24th, 2020
- US regulations for regenerative medicine advanced therapies - Regulatory Focus - July 24th, 2020
- Scientists discovered the real reason behind goosebumps - Tech Explorist - July 24th, 2020
- Study finds the real reason you get goosebumps - Big Think - July 24th, 2020
- Stem Cell Therapy Market to Surpass US$ 40.3 Billion by 2027, Owing to Increasing Incidence of Spina - PharmiWeb.com - July 24th, 2020
- Celltex Therapeutics Webinar | Houston, TX Patch - Patch.com - July 23rd, 2020
- New study offers first glimpse into how widespread COVID-19 antibodies are in Canada's adult population - McGill Newsroom - July 23rd, 2020
- Data Shows Direct Link Between COVID-19 and Acute Respiratory Distress Syndrome (ARDS) In Infected P - PharmiWeb.com - July 22nd, 2020
- The global cell expansion market size is estimated to be USD 14.9 billion in 2020 and projected to reach USD 30.1 billion by 2025, at a CAGR of 15.1%... - July 22nd, 2020
- Charles Darwin Investigated Goosebumps Now Harvard Scientists Discover the Real Reason Behind Them - SciTechDaily - July 21st, 2020
- Higher Steaks Creates World's First Lab-Grown Bacon and Pork Belly - The Spoon - July 21st, 2020
- Stem Cells Market Analysis Growth Opportunities and Demand Drives by 2016 to 2028 - Jewish Life News - July 19th, 2020
- Local scientists create 'mini livers' to trial therapies for liver diseases - The Straits Times - July 17th, 2020
- Can banking your stem cells prevent aging? | Well+Good - July 16th, 2020
- Expected Growth In Stem Cells Market from 2020-2026 to Guide : Trends, Analysis by Manufacturers, Regions, Type and Application - Owned - July 16th, 2020
- The Baxter Foundation supports USC research on epilepsy and lung injury - USC News - July 16th, 2020
- Adult Stem Cell Success Story Leukemia | BRMS - July 16th, 2020
- Researchers find that fish oil may help with depression - Jill Lopez - July 15th, 2020