Billionaire Patrick Soon-Shiongs radical cancer treatments made him one of the wealthiest physicians on Earth. Now the master of medical marketing believes his drug therapies could defeat the crisis of our time.
Patrick Soon-Shiong knows when he realized that the Covid-19 pandemic was going to pose a serious threat. It was February 24, and the part-owner of the L.A. Lakers was at the Staples Center in Los Angeles for Kobe Bryants memorial service.
With sudden, untimely demise on his mind, he found himself thinking about the emerging pandemic. Even though Covid-19 hadnt yet caused a single reported death in the United States, Soon-Shiong was worried. He recalls turning around to California Governor Gavin Newsom and telling him, Were in trouble.
His sense of urgency hasnt gone away. If I thought I was scared on February 24, he says, Im more scared now. The reason, he explains, is that what weve learned is that this virus acts like cancer. He says he has left his house only once since Bryants memorial, and that was to film a video about the coronavirus for the Los Angeles Times, which he bought, along with The San Diego Union-Tribune, for $600 million two years ago. I shut myself off from the world, he says.
And so one of the planets richest medical doctors, who made a $6.7 billion fortune developing breakthrough treatments for cancer and diabetes, seeks to battle the pandemic. The weapons in his arsenal: the cancer treatments he has spent the past decade and a half developing. Hes aiming them at all aspects of the coronavirus, from a vaccine to treatments for mild cases to therapies targeted toward patients on ventilators.
Its an enormously ambitious plan from a man who has often been accused of being a hype artist. In an earlier incarnation, Soon-Shiong was a respected surgeon and professor at UCLA Medical School, but throughout his wildly successful entrepreneurial second act, he has been derided as more showman than scientist, thought guilty of overinflating results and taking undue credit. A few years ago, for example, he boasted about using a breast cancer drug to treat a patient with cervical cancerbut other groups were already seeing similar successes. As we wrote in a 2014 cover story, While hes undeniably brilliant, Soon-Shiong is equally undeniably a blowhard.
But he also has fierce defenders of his approach to both cancer and Covid-19, including former Senate majority leader Harry Reid, who says the 68-year-old South Africaborn doctor saved my life in 2019 by providing an experimental treatment for his stage IV pancreatic cancer. Researchers say his methods are conceptually grounded in good science, though the verdict on his work will ultimately depend on results.
Weve been tracking and seeing an increase in the number of these cell-based therapies, whether theyre being repurposed from oncology or even other disease conditions, says Esther Krofah, a senior analyst who monitors the clinical development pipeline for Covid-19 vaccines and therapies for the Milken Institute. A number of themfrom large pharmaceuticals and small biotech startups alikeare going into clinical trials. For many of the latter, the pandemic offers a chance to show what their treatments can do in a shorter time frame than cancer drugs typically require. For small companies, its a worthwhile exercise to see if its successful, Krofah says.
It may seem counterintuitive, but advances in knowledge about the immune system, and how it might help kill cancer, have real applications for infectious diseases. To me, a cancer cell and a virus-infected cell are one and the same, says Dr. Wayne Marasco, an immunologist at Harvard Medical School who is currently researching coronavirus treatments. The immune system, he adds, seems to think the same way. Which is a good reason to take Patrick Soon-Shiong seriously.
Born in Port Elizabeth, South Africa, in 1952, Soon-Shiong is no stranger to the intersection of the immune system, cancer and infectious disease. Having graduated from medical school at age 22, he focused his early surgical career on transplants and cancer, both of which involve a complex pas de deux with the immune system. Crossing disciplines, he says, led him to look at the body as a system, not a single little cell. We are a biological system.
Such interdisciplinary thinking may be what led to the medicine that made his fortune: Abraxane, which took an existing chemotherapy drug, Toxol, but wrapped it in protein that made it easier to deliver to tumors. Its now used to treat advanced cases of lung, breast and pancreatic cancer. In 1998, to develop Abraxane, he purchased Fujisawa, a small, publicly traded business that sold injectable generic drugs. Soon-Shiong used its revenues to quickly move Abraxane through the regulatory process. The FDA approved it in 2005, and in 2007 Soon-Shiong split the business in two, spinning out a company called Abraxis that focused on the new cancer drug. He sold the generics business to Fresenius in 2008 for $4.6 billion. Two years later, he sold Abraxis to Celgene for $4.5 billion. Celgene, itself acquired by Bristol Myers Squibb in November 2019, reports that sales of Abraxane exceed $1 billion annually.
Soon-Shiong at Nants Los Angeles headquarters in 2017. I see [the complexity of the immune system] like an orchestra, but the challenge is to separate the violin from the cello from the drums.
The complex business deals that went into Abraxane, however, left Soon-Shiong with a reputation as more of a wheeler-dealer than a scientist, as we noted in 2014. Back then, he posted to Twitter under the grandiose handle @solvehealthcare, but today he simply uses his name. Over several recent Zoom conversations, he evinces very little showmanship. Hes visibly tired, exhibiting the most excitement when he starts talking about intricate scientific details. Im burning out a little bit, he candidly admits, adding that hes been getting only about four to six hours of sleep a night since February. Over that time, he says, his companies have concentrated on both continuing to develop his cancer treatments and working to employ them against Covid-19. He peppers his statements about his companys approach to both cancer and the coronavirus with qualifiers about the results of pending studies, carefully avoiding seeming to overpromise.
Soon-Shiong has multiple interrelated businesses organized in a complex corporate structure that would have puzzled the Byzantines. But his Covid-19 efforts come from the two companies he founded that work on developing cancer immunotherapies: NantKwest, a publicly traded outfit based in San Diego, and the privately held ImmunityBio.
Cancer immunotherapy is based on the notion that the bodys own immune system can be stimulated to treat the disease. That idea dates to the 19th century, when scientists first observed tumors getting smaller after patients developed a type of skin infection. This led to some of the first experiments in which the immune system of cancer patients was stimulated. Early efforts proved difficult to reproduce, though, and the field got sidetracked by advances in chemotherapy and radiation. Interest spiked anew in 1959, when a paper showed that the tuberculosis vaccine inhibited tumor growth in mice. After decades of intense research, the first cancer immunotherapy was approved by the FDA in 1986.
Other types of immunotherapies followed, ranging from purified antibodies that attack cancer to drugs that turn off the chemical switches that let tumor cells hide from the immune system. The latest advances involve CAR-T cell therapy, which first gained FDA approval in 2017 and involves genetically engineering immune cells from patients so that they attack certain targets found in tumor cells.
Founded in 2002, Soon-Shiongs company NantKwest focuses on developing so-called natural killer (NK) cells, which the immune system uses to destroy virally infected cells as well as early-stage tumors. The company has been working to develop a line of off-the-shelf NK cells called NK-92, which can be used to treat certain cancers as well as viral infections.
The company, which has yet to post any meaningful revenue, has lost nearly $400 million since it went public at $25 a share (a $2.6 billion market cap) in 2015. The stock has recently traded in the $10.50 range, off a bottom of around $1 a share in 2019. One reason for the stocks surge, says Jefferies analyst Biren Amin, is the companys reported research into the coronavirus pandemic. The second, he suggests, involves former Senator Reids cancer treatment, which made use of the companys products.
Harry Reid, who represented Nevada in the upper chamber from 1987 to 2017, was diagnosed with pancreatic cancer in 2018 and started chemotherapy that July. He didnt respond well. I was so sick they stopped the chemo that October, he says. In July 2019, a scan of his liver showed that the cancer had spread. That meant his only option was more chemotherapy. Around the same time, Joe Kiani, founder and CEO of Irvine, Californiabased health IT company Masimo, met with Soon-Shiong to discuss acquiring $50 million worth of assets from NantHealth. During that initial meeting, the conversation turned to Soon-Shiongs other projects, which later led Kiani to phone the former senator. I called up Harry and I said, Look, I just left this meeting. This person could have the cure. I dont know if he does, but what do you have to lose? Reach out to him and see what happens, Kiani recalls.
Two weeks later, Soon-Shiong and a doctor from NantKwest named Leonard Sender were working with Reid, using treatments from NantKwest as well as Soon-Shiongs ImmunityBio. Those treatments arent yet officially approved but were permitted under the FDAs compassionate-use rules. Reid was treated with a combination of Abraxane, NantKwests natural killer cells and a drug from ImmunityBio called N-803, which stimulates the immune system to produce its own killer cells. Soon-Shiong compares it to the triangle offense often employed by the Lakers. In November 2019, Reid reported that his scans were completely clear, showing no signs of cancer. I admire Dr. Soon-Shiong a great deal, he tells Forbes. Both for what hes done for me personally and what hes done for the health-care delivery system in this country.
Former Senator Harry Reid, pictured the same month he began treatment for pancreatic cancer with Soon-Shiong, says being in remission a few months later was kind of like a miracle.
Reids is an extraordinary story, as pancreatic cancer remains one of the deadliest forms of the disease. Within five years of diagnosis, it kills some 90% of patients, accounting for 7% of cancer deaths globally. Jeopardy! host Alex Trebek, who also suffers from pancreatic cancer, has received the same treatment, as have two other unidentified patients. But Sender cautions against declaring a cure. Its too early to tell, because this is a very nasty form of cancer, he says. Thats why NantKwest is now focused on a new randomized clinical trial, he adds, which is looking to recruit nearly 300 pancreatic cancer patients with advanced forms of the disease. Those who sign up will be given a course of treatment similar to the one Reid received.
As part of these treatments development, Soon-Shiong has spent the past five years working with the National Cancer Institute. His companies have a collaborative agreement with the NCI involving several types of treatments, including NK-92 and N-803, as well as some vaccines against two kinds of tumors. Dr. Jeffrey Schlom, chief of the NCIs laboratory of tumor immunology and biology, recalls being in sync with Soon-Shiong from the start. At our first official creative meeting, we presented our slides of our approach, he says. And then he got up and presented his approach, and they were almost identical. Schloms group has since published in peer-reviewed journals 15 papers regarding Soon-Shiongs treatments, in both preclinical and clinical settings.
Since February, NantKwest and ImmunityBio have redirected some of their attention toward the coronavirus pandemic, using a number of weapons in their collective arsenal. The first is a vaccine, based on the system Soon-Shiongs companies are developing for cancer, that has already shown positive results against Covid-19 in a study involving mice. Its also being studied in monkeys as a part of the federal governments Operation Warp Speed. As for human trials, Soon-Shiong says hes ready to go. My timeline is now dependent on the FDA letting me get out of the gate, he says. Im in the gate, the bell hasnt rung and the racehorse is frothing at the mouth.
This vaccine is delivered to the body in a common cold virus called an adenovirus that has been stripped of all the parts that can cause harm to people or trigger the body to attack it. That modified virus contains two individual segments of the Covid-19 coronavirus: the spike protein, the surface protein on the virus that triggers an antibody response; and a nucleocapsid protein, which is found in the center of the virus. Most of the more than 100 vaccines that are currently in clinical development for Covid-19 focus on the spike protein to generate an immune response. Soon-Shiong thinks that wont be enough, though, which is why hes including the nucleocapsid protein. My concern is that the spike protein mutates, he says. Its mutated even through this pandemic.
Beyond potential mutations, another concern about merely eliciting an antibody response is that from the data seen so far, antibodies to the Covid-19 virus just dont last very long. Levels of antibodies in the blood are really low after a few months, says Marasco, whos not associated with Soon-Shiongs companies or their vaccine research. I think its uncertain how long immunity will remain after successful vaccination. Using the nucleocapsid protein couldnt hurt, he adds, and it could elicit not only antibodies but virus-killing T-cells as well.
The second weapon is the application of NantKwests NK-92 and ImmunityBios N-803 against Covid-19. NK-92 is being adapted to directly attack virus-infected cells, while the N-803 stimulates the patients immune system to produce its own natural killer cells against the virus. The treatments might be used either together or separately depending on the particular patient, Soon-Shiong says. Human trials of these treatments have already begun. Its a fantastic thing that theyre applying them to infectious disease to see how patients fare, says Gigi Gronvall, an immunologist at Johns Hopkins Center for Health Security, who is not involved in the research. The concept is great, she adds, cautiously, but we need to see what the data says.
The third weapon NantKwest and ImmunityBio are developing to combat Covid-19 involves the use of mesenchymal stem cells, which are derived from bone marrow. This type of stem cell has been investigated over the past decade for diseaseslike Covid-19that can cause the bodys immune system to go into overdrive and attack itself. This treatment would be for the most severely sick Covid-19 patients, who are experiencing a cytokine storm, in which the immune system overreacts. Small-scale studies have suggested this might be an effective treatment, and several companies, including Melbourne, Australiabased Mesoblast, are already in late-stage clinical trials for severe Covid-19 patients. Soon-Shiongs companies are working with hospitals to recruit patients for human trials.
If Soon-Shiongs approaches to Covid-19 bear fruit in clinical trials, the next step may prove harder still: getting those treatments to needy patients. This is especially so for the vaccine, because at the moment neither NantKwest nor ImmunityBio has the resources to scale up manufacturing. Im now behind the eight ball, Soon-Shiong admits, because theres no way I could have 100 million doses unless somebody supports me. Maybe I have a million doses or 2 million doses. He expresses some frustration at the government: Billions of dollars are going to companies that have billions [in] revenues. Hes not wrong about that. In July, pharma giant Pfizer (2019 revenue: $51.8 billion) received a $2 billion federal contract to manufacture a vaccine its developing.
Things are brighter for the companies N-803 and NK-92 products, as NantKwest has the ability to manufacture at scale, but these treatments will face certain competition from others being developed by a number of pharmaceutical companies. I think there are a lot of alternatives that are more practical than a cellular therapy for an acute infectious disease, Marasco says, though he does acknowledge that the companies plans to use stem cells against the more severe cases of disease have potential.
Despite his frustrations, Soon-Shiong appears determined to do his part in the health-care industrys war against the coronavirus. This is the crisis of our time, he says. Its almost existential. The United States could have 20 to 30 million infected. You could have a million deathsthis is not a joke.
- US FDA Approves Naxitamab for the Treatment of Neuroblastoma - OncoZine - November 29th, 2020
- Coronavirus treatments and vaccines. Here are the latest developments - San Francisco Chronicle - November 29th, 2020
- Dr Apar Kishor Ganti Outlines the Effectiveness of Lurbinectedin and Benefits Over Competition - AJMC.com Managed Markets Network - November 26th, 2020
- Commonly used antibiotic shows promise for combating Zika infections - National Institutes of Health - November 26th, 2020
- A real life Superman celebrates 5 years of survival from one of the deadliest cancers - Newswise - November 26th, 2020
- Global Cell Harvesting Market to Reach US$381,4 Million by the Year 2027 - Salamanca Press - November 26th, 2020
- Tanya Siddiqi, MD, Discusses the Promise of Reduced Toxicity With Liso-Cel - AJMC.com Managed Markets Network - November 26th, 2020
- Tetracycline-based Antibiotics Show Promise for Combating Zika Infections - Global Biodefense - November 26th, 2020
- Study Suggests AYAs Treated for AML Have High Risk of Developing Long-Term Complications - Cancer Network - November 26th, 2020
- Mustang Bio Announces Positive Opinion from the European Medicines Agency on Orphan Drug Designation for Its Lentiviral Gene Therapy for the Treatment... - November 26th, 2020
- Study Finds Racial and Ethnic Disparities in Treatment of AL Amyloidosis - DocWire News - November 22nd, 2020
- New Virtual Reality Tool, Domestic Cats are SARS-CoV-2 Carriers, Combination Therapy Advances: COVID-19 Updates - Bio-IT World - November 22nd, 2020
- SEE | Smoking worsens Covid-19 infection in the airways, new study reveals - Health24 - November 22nd, 2020
- Could Cell Therapy Be The Answer To COVID-19? - CBS Boston - November 3rd, 2020
- CA Prop 14 Explained: What To Know Before You Vote Election Day - Los Angeles, CA Patch - November 3rd, 2020
- GMP Cell Banking Services Market Predicted to Accelerate the Growth by 2019-2029 - TechnoWeekly - November 3rd, 2020
- Making Progress Against Relapsed/ Refractory DLBCL Without CAR T - OncLive - November 3rd, 2020
- Orchard Therapeutics to Host Virtual R&D Investor Event on Friday, November 13, 2020 - GlobeNewswire - November 3rd, 2020
- Editorial Article: Combating cancer: The incubation technology accelerating CAR-T cell therapy development - SelectScience - October 31st, 2020
- Richters Transformation: When a Slow-Growing Cancer Turns Aggressive - SurvivorNet - October 31st, 2020
- Detroit Pistons, Make-A-Wish put a smile on the face of Commerce Township boy - The Oakland Press - October 31st, 2020
- NexImmune Establishes Research Initiative with City of Hope to Focus on Novel Immunotherapeutic Approaches to Acute Myeloid Leukemia - Yahoo Finance - October 31st, 2020
- HBS and Harvard's Department of Stem Cell and Regenerative Biology Receive $25 Million Gift from The Chris and Carrie Shumway Foundation to Support... - October 23rd, 2020
- Harnessing regeneration of retinal tissues: An option almost within reach - Ophthalmology Times - October 23rd, 2020
- Fate Therapeutics' and Celyad's CAR therapies in oncology offer potential - pharmaceutical-technology.com - October 23rd, 2020
- World Wide Stem Cell Treatment Centers Provides Exceptional Regenerative Treatment Options To Those in Need - GlobeNewswire - October 16th, 2020
- Proposition 14: Stem cell research bonds City Times - City Times - October 16th, 2020
- BrainStorm Announces Financial Results for the Third Quarter of 2020 and Provides a Corporate Update - PRNewswire - October 16th, 2020
- How a UCSF team is giving Cronutt the sea lion a second chance with neuroscience - University of California - October 16th, 2020
- Caliber Pain is Featured as a 2020 Top NYC Patient Rated Pain Management Practice by Find Local Doctors - PR Web - October 10th, 2020
- Report of the president: Appointments and promotions | Stanford News - Stanford University News - October 10th, 2020
- UTSW Scientist: 'We Need More Women Thinking Creatively in the Lab and Pushing Science Forward' - dallasinnovates.com - October 10th, 2020
- Here's what is known about Trump's COVID-19 treatment - Science Magazine - October 4th, 2020
- Election Guide: Here's What You Need to Know About Proposition 14 - NBC Bay Area - October 4th, 2020
- ASX up 2.3%, banks and energy outperform - The Sydney Morning Herald - October 4th, 2020
- Autologous Stem Cell and Non-Stem Cell Based Therapies MARKET 2020 |INDUSTRY ANALYSIS, SIZE, SHARE, TRENDS, MARKET DEMAND, GROWTH, OPPORTUNITIES AND... - September 25th, 2020
- Finding The Achilles Heel of A Killer Parasite - Newswise - September 25th, 2020
- SHE Initiative Shines Light on Gender Disparities in Oncology Workforce - Targeted Oncology - September 25th, 2020
- Actinium Pharmaceuticals Successfully Completes First Dosing Cohort in the Phase 1 Study of Actimab-A and Venetoclax Combination Therapy in... - September 23rd, 2020
- Advances in the Treatment of Mantle Cell Lymphoma are Greatly Improving the Long-Term Outlook for Patients - Curetoday.com - September 23rd, 2020
- CytoDyn's Phase 2 Study of Leronlimab for Mild-to-Moderate COVID-19 Selected for Oral Presentation at the Special isirv-AVG Virtual Conference on... - September 23rd, 2020
- Opdivo (nivolumab) Demonstrated Superior Disease-Free Survival in Patients with Resected Esophageal or Gastroesophageal Junction Cancer Compared to... - September 23rd, 2020
- Coronavirus Researchers Discover How COVID-19 May Trigger Fatal Levels of Lung Inflammation - SciTechDaily - September 21st, 2020
- The Holistic Sanctuary Announces Exciting Plans to Expand Over Next 4 Years and Save More Lives - PRNewswire - September 21st, 2020
- Robert E. Windsor, MD, is being recognized by Continental Who's Who - PRNewswire - September 21st, 2020
- City of Hope Enters Licensing Agreement With Chimeric to Develop Its Pioneering Chlorotoxin CAR T Cell Therapy - Business Wire - September 21st, 2020
- Emerging immunotherapies in multiple myeloma - The BMJ - September 21st, 2020
- ADC Therapeutics Submits Biologics License Application to the U.S. Food and Drug Administration for Loncastuximab Tesirine for Treatment of Relapsed... - September 21st, 2020
- Oakland 24-year-old seeking multiethnic bone marrow donor - The Jewish News of Northern California - September 21st, 2020
- First-Line Treatment With Merck's KEYTRUDA (pembrolizumab) Doubled Five-Year Survival Rate (31.9%) Versus Chemotherapy (16.3%) in Certain Patients... - September 21st, 2020
- Coronavirus, Charity, and the Trolley Problem - Crooked - September 12th, 2020
- Targeted Approach Considered for the Treatment of Accelerated/Blast Phase MPNs - Targeted Oncology - September 1st, 2020
- Royal Biologics Announces the Acquisition of FIBRINET - PRNewswire - September 1st, 2020
- Novel Targets Outside of JAK Inhibition Inching into Myelofibrosis Treatment Landscape - Targeted Oncology - September 1st, 2020
- MaaT Pharma to Announce Clinical Data with its Lead Microbiota Biotherapeutic in Intestinal Acute GvHD at Virtual 46th Annual Meeting of the European... - August 28th, 2020
- Mustang Bio: Slow, Steady Progress Towards Multiple Gene And CAR-T Therapy Goals - Seeking Alpha - August 25th, 2020
- Study sheds light on why retinal ganglion cells are vulnerable to glaucoma - Jill Lopez - August 19th, 2020
- Coronavirus Thursday update: UMN announces new stem cell treatment - TwinCities.com-Pioneer Press - August 15th, 2020
- Health and Fitness: Hip replacement surgery: getting back to what you love - taosnews - August 14th, 2020
- How MC Hammer And Other Performing Artists Are Sharing Their Love Of Science - Forbes - August 12th, 2020
- Chromosomal Rearrangements Associated with Chemotherapeutic Drug Resistance | McDonnell Boehnen Hulbert & Berghoff LLP - JD Supra - August 8th, 2020
- Chinese Govt-Compensated Experts Plead Guilty to Thieving Investigation From an American Childrens Medi ... - 90Xtra - August 7th, 2020
- US government considers ethics of aborted tissue research - Angelus News - August 7th, 2020
- Mesa Discusses Treating Myelofibrosis and Other MPNs - Targeted Oncology - August 7th, 2020
- Startup Accelerator: Volumetric Aims to Be the Tissue Bioprinting Farm of the Future - 3DPrint.com - August 6th, 2020
- Cord blood offers hope for rare diseases and ethnic minorities - The Province - August 6th, 2020
- FDA touts advanced manufacturing to address Covid-19 shortfalls - Endpoints News - August 5th, 2020
- Cancer Research Institute Awards $30.2 Million in Grants and Fellowships to Support Basic and Clinical Research in Immunology and Cancer Immunotherapy... - August 5th, 2020
- RenovaCare Appoints Dr. Lydia M. Evans to Its Board of Directors and Increases Board Membership - GlobeNewswire - August 4th, 2020
- MediVet Biologics Rebrands as Ardent Animal Health - Benzinga - August 3rd, 2020
- Church Point Police Captain dies from COVID-19 complications: 'Go and protect the heavens, my dearest friend' - The Advocate - August 1st, 2020
- BMT survivor study finds significant breast cancer risk in young women who received total body irradiation - The Mix - July 31st, 2020
- Hyperbaric Oxygen Therapy Can Enhance Cognition in Healthy Older Adults - PsychCentral.com - July 29th, 2020
- The surprising recovery with stem cells of 26 COVID-19 patient in Hidalgo - Explica - July 29th, 2020
- Johnny Tabaie is proud to announce the most powerful Stem Cell Therapy - Press Release - Digital Journal - July 29th, 2020
- COVID-19 Fibroblast Based Cell Therapy Candidate Shown to Reduce Lung Scarring in Aggressive Animal Model - El Paso Inc. - July 25th, 2020
- 'Self-eating' process of stem cells may be the key to new regenerative therapies - 7thSpace Interactive - July 23rd, 2020
- R3 International Now Including Exosomes with Stem Cell Therapy Program for Autism in Mexico - PR Web - July 23rd, 2020
- CAR T-Cell Therapy Offers Potential Solution for Relapse in MCL, But With Toxicity Risk - Targeted Oncology - July 22nd, 2020
- Fine-tuning adoptive cell therapy for advanced cancers - Newswise - July 22nd, 2020