Gaborone could have stem cell storage facility this year

Gaborone could have stem cell storage facility this year

LAWRENCE SERETSE Correspondent

Speaking to Mmegi this week, Mngqibisa said Parliament was set to pave the way for the facility by means of legislation in July and that Cryo-Save intended approaching government about storing stem cells for every Motswana.

"Stem cells are the basic building blocks of our bodies and are often referred to as 'master cells,'" she said.

"And because stem cells have the potential to become almost any other cell in the body, stem cell therapies are the way of the future."

Stem cell treatment is applied to over 70 diseases and disorders, among them leukemia, lymphoma, blood cancers and bone marrow disorders like aplastic anaemia and sickle cell disease.

Mngqibisa said patients requiring a haemopoietic stem transplant will receive cells from one or three sources of bone marrow, circulating blood or umbilical cord blood.

"It is much easier to match transplant patients with immune naive cord blood stem cells than with the other sources of stem cells," she explained. "Umbilical cord blood stem cells are the most naive stem cells, hence they are best harvested from the baby at birth before they are exposed to infections and immune reactions."

She said transplant patients recovered better when they received stem cells from a related donor rather than from an unrelated donor. Brain tumors, lung cancer, plasma cell leukemia, anaemia and osteopetrosis.

Multiple sclerosis and diabetes can also help in tissue building like skin burn repairs. The newborn may be able to use his or her cord blood for some of the conditions on a long list, but not all. In some cases, a matching sibling stem cell would be the first choice.

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Gaborone could have stem cell storage facility this year

UCI researcher wins large research grant

A UC Irvine stem cell researcher won a $4.8-million grant to fund research toward a treatment for multiple sclerosis.

The California Institute for Regenerative Medicine awarded immunologist Thomas Lane, of the campus' Sue and Bill Gross Stem Cell Research Center, an Early Transitional Award last week to create a new line of neural stem cells to treat multiple sclerosis, according to a UCI press release.

"I am delighted that [the California Institute] has chosen to support our efforts to advance a novel stem cell-based therapy for multiple sclerosis," Peter Donovan, director of the research center, said in the release.

Lane is collaborating with Jeanne Loring, director of the Center for Regenerative Medicine at the Scripps Research Institute in La Jolla, and Claude Bernard, a multiple sclerosis researcher at Monash University in Australia.

The research project "really embodies what [the California Institute] is all about, which is bringing science together to treat horrible diseases like multiple sclerosis," said Lane, who is a professor of molecular biology and biochemistry.

Multiple sclerosis is a central nervous system disease that causes inflammation and a loss of myelin, a fatty tissue that insulates and protects nerve cells.

The three are working on a stem cell treatment that will stop myelin loss while promoting the growth of new myelin to mend damaged nerves.

Loring creates the neural stem cells, said Lane, while he is testing the therapeutic effects the cells have on multiple sclerosis cells in animals.

The stem cells are already having a positive effect and the scientists are trying to understand why. They hope to identify the cells that have the most promise before going to clinical trials.

"I really want to thank the [California Institute] for allowing, and for funding, us," Lane said.

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UCI researcher wins large research grant

Actium Research and McMaster University Collaborate to Commercialize Stem Cell Technologies

Arrangement pairs one of Canada's most successful biotech executive teams with academic discovery engine to address the need for better drugs targeting cancer stem cells and regenerative medicine.

TORONTO/HAMILTON, May 29, 2012 /CNW/ - Actium Research Inc., ("Actium" or the "Company") Toronto, and McMaster University ("McMaster"), Hamilton, have entered into a landmark collaboration covering McMaster's proprietary adult human stem cell lines, cancer stem cells and the directed differentiation platform developed by Dr. Mick Bhatia and his team at the McMaster Stem Cell and Cancer Research Institute ("The Stem Cell Institute"). Together these technologies and the expertise at The Stem Cell Institute provide leading edge tools for drug discovery and better treatments for serious illnesses.

Actium is a drug discovery and development company targeting two types of stem cells; cancer stem cells to improve survival and health outcomes and normal tissue stem cells to promote healing and address the need for cure in chronic diseases. Actium was founded by Dr. David Young and Helen Findlay. Dr. Bhatia joined as the scientific founder in 2012. The team will put their experience with managing drug discovery platforms, development pathways and product pipelines to work to build Actium into a leading biotech company.

Previously, Dr. David Young and Ms Helen Findlay were uniquely successful in creating ARIUS Research Inc. ("ARIUS"), a public biotech company, trading on the TSX, specializing in the discovery and development of therapeutic cancer antibodies based entirely on technology developed in its own research labs. ARIUS' FunctionFIRST technology was partnered with leading companies such as Takeda Pharmaceuticals, Japan's largest drug company, Genentech, the leader in cancer antibodies, and Protein Design Labs, a pioneer in antibody humanization. These and other partnerships represented over $400 million of value. ARIUS was a singular financial success story in Canada. The sale of the company to Roche in 2008 generated a five times return on capital, cash on cash, representing the largest return to date for investors in a Canadian biotech company. More importantly, the company created the first specific cancer stem cell drug to enter human clinical trials. The company was well recognized for its accomplishments: it was named as a top 50 company by the TSX Venture Exchange in 2005, a top 10 company by Ottawa Life Sciences Council in 2006, and Biotech Company of the Year by BioteCanada in 2009.

"After we founded Actium we were presented with many interesting technologies looking for commercialization support." said David Young, Actium CEO. "Ontario has a wealth of great researchers and I think with Dr. Mick Bhatia's leadership and the support from the community, the Stem Cell Institute at McMaster stands at the forefront. Much has been written about Canada's commercialization gap and desperate need to move our research from the bench into the clinic so that we benefit from medical innovation both as patients and as a society. The federal government placed a lot of emphasis on addressing this gap in the most recent budget and our agreement with McMaster represents a great example of academia working with the private sector to achieve these goals. Actium is pleased to join the other companies and groups working to see Ontario's medical research advanced to provide our physicians with new tools to achieve better outcomes."

McMaster University is committed to creating collaborations that help accelerate the pace intellectual property is transferred from its labs and to the marketplace, where it will have the greatest impact.

"This specific initiative will assist us in doing just that," said Mo Elbestawi, McMaster Vice-President, Research and International Affairs. "These discoveries from Dr. Bhatia's lab show great promise and we're delighted with his efforts to commercialize the results of his research, from which many will benefit."

Initially, Actium will develop anti-cancer stem cell drugs that are directed against a newly identified cancer stem cell marker in leukemia and breast cancer. Cancer stem cells are a unique group of cells within a tumor that do not respond to conventional therapies and may be responsible for cancers that spread or that return after treatment. The company will also work through research agreements with McMaster and The Stem Cell Institute to identify drugs that cause "normal" stem cells to become specialized as different tissue types to promote healing. In addition, the Actium strategy includes accessing technologies that expand drug development capabilities or fill pipeline gaps. The overall development strategy is guided by principles of pipeline management where projects compete with each other for resources, and allocations are made according to success-based performance metrics. "This is the most efficient way to allocate resources to the compounds with the best chances of becoming breakthrough drugs. In this horse race the winners go on to the next race until a champion is crowned", said Dr. Bhatia, Actium Chief Scientific Officer.

About McMaster University and the McMaster Industry Liaison Office

McMaster University, one of four Canadian universities listed among the Top 100 universities in the world, is renowned for its innovation in both learning and discovery. With a research income of more than $395 million, McMaster ranks second in research intensity among Canadian universities. It is home to more than 23,000 students, 1,300 faculty members, and 70 world-class research centres and institutes. Through the McMaster Industry Liaison Office, the University facilitates the commercialization efforts of its faculty by connecting them to the marketplace.

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Actium Research and McMaster University Collaborate to Commercialize Stem Cell Technologies

Bioheart and Ageless Regenerative Partner to Advance Stem Cell Field With New Laboratory Training Program on June 23 …

SUNRISE, Fla., May 29, 2012 (GLOBE NEWSWIRE) -- Bioheart, Inc. (OTCBB:BHRT.OB - News) announced today that it will offer another laboratory training course in partnership with the Ageless Regenerative Institute, an organization dedicated to the standardization of cell regenerative medicine, on Saturday/Sunday June 23-24, 2012. Attendees will participate in hands on, in depth training in laboratory practices in stem cell science at Bioheart, Inc.'s corporate headquarters and clean room in Sunrise, Florida. The course was designed for Laboratory technicians, Students, Physicians and Physician Assistants.

"Attendees will graduate from this one-of-a-kind course with an extensive understanding of stem cell science laboratory practices," said Kristin Comella, Chief Scientific Officer, Bioheart, Inc. "Previous attendees described the course as incredibly well orchestrated providing comprehensive know how for laboratory start up."

An emerging field with tremendous opportunities, adult stem cell research has been shown to regenerate and repair injured or diseased structures via the release of bioactive tissue growth factors and cytokines. This is the second time that The Ageless Regenerative Institute has partnered with Bioheart, Inc. to provide hands-on training in a stem cell laboratory. This course provides instruction regarding how to grow stem cells and perform quality control testing in an actual cGMP facility following FDA regulations.

The course goals and objectives include reviewing stem cell types and characteristics; learning cell culture including plating, trypsinization and harvesting, and cryopreservation; learning quality control tests including cell count, viability, flow cytometry, endotoxin, mycoplasma, sterility; and learning and performing cGMP functions including clean room maintenance, gowning and environmental monitoring.

For information on costs and to register, visit http://www.agelessregen.com or email: info@agelessregen.com.

About Bioheart, Inc.

Bioheart is committed to maintaining its leading position within the cardiovascular sector of the cell technology industry delivering cell therapies and biologics that help address congestive heart failure, lower limb ischemia, chronic heart ischemia, acute myocardial infarctions and other issues. Bioheart's goals are to cause damaged tissue to be regenerated, when possible, and to improve a patient's quality of life and reduce health care costs and hospitalizations.

Specific to biotechnology, Bioheart is focused on the discovery, development and, subject to regulatory approval, commercialization of autologous cell therapies for the treatment of chronic and acute heart damage and peripheral vascular disease. Its leading product, MyoCell, is a clinical muscle-derived cell therapy designed to populate regions of scar tissue within a patient's heart with new living cells for the purpose of improving cardiac function in chronic heart failure patients. For more information on Bioheart, visit http://www.bioheartinc.com.

About Ageless Regenerative Institute, LLC

The Ageless Regenerative Institute (ARI) is an organization dedicated to the standardization of cell regenerative medicine. The Institute promotes the development of evidence-based standards of excellence in the therapeutic use of adipose-derived stem cells through education, advocacy, and research. ARI has a highly experienced management team with experience in setting up full scale cGMP stem cell manufacturing facilities, stem cell product development & enhancement, developing point-of-care cell production systems, developing culture expanded stem cell production systems, FDA compliance, directing clinical & preclinical studies with multiple cell types for multiple indications, and more. ARI has successfully treated hundreds of patients utilizing these cellular therapies demonstrating both safety and efficacy. For more information about regenerative medicine please visit http://www.agelessregen.com.

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Bioheart and Ageless Regenerative Partner to Advance Stem Cell Field With New Laboratory Training Program on June 23 ...

CHOC Children’s Research Project Awarded $5.5 Million Grant from the California Institute for Regenerative Medicine

ORANGE, Calif.--(BUSINESS WIRE)--

A CHOC Childrens research project, under the direction of Philip H. Schwartz, Ph.D., senior scientist at the CHOC Childrens Research Institute and managing director of the facilitys National Human Neural Stem Cell Resource, has been awarded a $5.5 million grant from the California Institute for Regenerative Medicine (CIRM). The grant will be used to develop a stem cell-based therapy for the treatment of mucopolysaccharidosis (MPS I), a fatal metabolic disease that causes neurodegeneration, as well as defects in other major organ systems.

Based on a number of medical and experimental observations, children with inherited degenerative diseases of the brain are expected to be among the first to benefit from novel approaches based on stem cell therapy (SCT).

Dr. Schwartz explains, While uncommon, pediatric genetic neurodegenerative diseases account for a large burden of mortality and morbidity in young children. Hematopoietic (bone marrow) stem cell transplant (HSCT) can improve some non-neural symptoms of these diseases, but does not treat the deadly neurodegenerative process. Our approach targeting the effects of the disease on organs besides the brain with HSCT and neurodegeneration with a second stem cell therapy specifically designed to treat the brain is a strategy for whole-body treatment of MPS I. Our approach is also designed to avoid the need for immunosuppressive drugs to prevent rejection of the transplanted cells.

This research is designed to lead to experimental therapy, based on stem cells, by addressing two critical issues: early intervention is required and possible in this patient population; and teaching the immune system not to reject the transplanted cells is required. This research also sets the stage for efficient translation of this technology into clinical practice, by adapting transplant techniques that are standard in clinical practice or in clinical trials, and using laboratory cell biology methods that are easily transferrable to clinical cell manufacturing.

Nationally recognized for his work in the stem cell field, Dr. Schwartz research focuses on the use of stem cells to understand the neurobiological causes of autism and other neurodevelopmental disorders.

Named one of the best childrens hospitals by U.S. News & World Report (2011-2012) and a 2011 Leapfrog Top Hospital, CHOC Children's is exclusively committed to the health and well-being of children through clinical expertise, advocacy, outreach and research that brings advanced treatment to pediatric patients.

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CHOC Children’s Research Project Awarded $5.5 Million Grant from the California Institute for Regenerative Medicine

Makati Medical Center now offering stem cell therapy

THE MAKATI Medical Centers Cancer Center celebrated its first year anniversary and marked the occasion with the launch of its Cellular Therapeutics Laboratory. Present at the ribbon-cutting ceremony were Dr. Eric Flores, head, Spine Clinic and Stem Cell Lab; Rosalie Montenegro, Makati Medical Center president and CEO; Dr. ManuelO. Fernandez Jr., executive vice president and director, Professional Services; Dr. Remedios G. Suntay, director and treasurer, MDI Board; Dr. Benjamin N. Alimurung, medical director; Dr. Francis Chung, scientific officer, Stem Cell Lab; and Augusto P. Palisoc Jr., executive director, president and CEO, MPIC Hospital Group.

MAKATIMEDS Cellular Therapeutics Laboratory is managed by experienced scientists with extensive training and is affiliated with the International Society for Cellular Therapy.

Stem cell therapy is now being offered at Makati Medical Center (MMC) as potential cure for a wide range of illnesses, from various types of cancer and heart ailments to incurable diseases such as multiple sclerosis, Parkinsons and Alzheimers.

Stem cell therapy is believed to be effective in bone marrow transplant for leukemia patients, and with early intervention, yields desirable results among renal and prostate cancer patients.

Launched in the first year anniversary of the hospitals cancer center, MMCs Cellular Therapeutics Laboratory is equipped with technology touted to be totally unmatched in our country, says Dr. Francis Chung, scientific officer of the lab. No system exists elsewhere.

Employing the strictest sterility standards at par with that of the US Food and Drug Administration, the lab has state-of-the-art facilities. The Clinimacs CD34 Reagent System is a machine that isolates specific cells needed for the procedure, while the Flow Cytomer ensures the purity of cultured cells.

Transplantation

Sourcing the stem cells, however, is what truly sets the Philippines premier health institution apart from chi-chi spas that also push stem cell therapy for beauty and anti-aging procedures.

At MMC, healthy stem cells are acquired from the patients themselves, a process known as autologous transplantation. For those suffering from an ailment, a parent, sibling or other close relative could be the donor. The hospital strives for utmost compatibility between patient and donor through a 10-point DNA matching system.

If a battery of tests finds a patient to be up to it, medication is given to prepare him for stem cell harvest.

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Makati Medical Center now offering stem cell therapy

Americans flocking to India for stem cell therapy

Washington: A growing number of Americans are travelling to India to seek treatment for rare diseases through India's experimental embryonic stem cell therapy, according to an investigative report.

Among them Cash Burnaman, a 6-year-old South Carolina boy, who travelled with his parents to India seeking treatment for a rare genetic condition that has left him developmentally disabled, CNN reported.

"Cash is mute. He walks with the aid of braces. To battle his incurable condition, which is so rare it doesn't have a name, Cash has had to take an artificial growth hormone for most of his life," it said.

A growing number of Americans are travelling to India to seek treatment for rare diseases through experimental embryonic stem cell therapy.

His divorced parents, Josh Burnaman and Stephanie Krolick, have paid tens of thousands of dollars to have Cash undergo experimental injections of human embryonic stem cells at New Delhi's NuTech Mediworld run by Dr Geeta Shroff, a retired obstetrician and self-taught embryonic stem cell practitioner.

Shroff first treated Cash -- who presents symptoms similar to Down Syndrome -- in 2010. "I am helping improve their quality of life," she told CNN.

After five weeks of treatment, Cash and his parents returned home to the US. That's when Cash began walking with the aid of braces for the first time.

For four or five weeks of treatment, Shroff says she has charged her 87 American patients an average of $25,000.

But doctors cited by CNN said all that work and hope and money Cash's supporters have funnelled into his experimental therapy likely will have no medical benefits.

"There is zero evidence for what she (Shroff ) is doing being effective," Rutgers University's Dr Wise Young, a leading US neuroscientist, was quoted as saying.

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Americans flocking to India for stem cell therapy

Stem cell treatment regrows Whitfield man’s foot

By the time Dr. Spencer Misner had carved away the dead and diseased flesh from Bobby Rices right foot last year, little remained other than bones and tendons.

I couldnt believe it. It didnt look real. It looked like something out of a movie, recalled Rice, a Whitfield County resident.

Today, the ankle has almost completely healed. It looks like Rice had simply scraped it. And Rices foot has largely healed, too. Misner credits cutting-edge stem cell treatments for saving Rices foot and leg.

Rice, who has diabetes, stepped on a piece of glass last fall and his foot quickly became infected. After trying a home remedy, Rice eventually went to Daltons Hamilton Medical Center emergency room, where doctors found he had a rapidly spreading necrotizing fasciitis, or in laymans terms, flesh-eating bacteria.

Physicians treated the infection with antibiotics. However, Rice had one toe amputated. Doctors had to strip away much of the flesh from Rices foot and a great deal of flesh along his ankle.

We did what we had to do, Misner said. We got the infection out. We saved his life. But what do you do next? Wed normally say all you can do now is cut of his leg so he can get on with his life.

But Misner had another idea. He contacted Ed Fickey, a sales representative for Osiris Therapeutics and asked about using the companys new stem cell technologies to rebuild the foot and ankle.

Stem cells can grow and differentiate into many different types of cells. Stem cell treatments introduce these cells into damaged or diseased organs to repair them.

The problem is that Bobby is an indigent patient and didnt have the financial resources. Ed spoke to the company, and they agreed to donate the products for free, Misner said.

Osiris provided two products called Grafix and Ovation. Fickey said they are made from adult stem cells derived from donated placenta and do not come from embryos.

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Stem cell treatment regrows Whitfield man’s foot

Fat stem cells may help treat kidney ailments

Fat stem cells may help treat kidney ailments BS Reporter / Mumbai/ AhmedabadMarch 06, 2007 In a breakthrough in the stem cell research, scientist from Ahmedabad have developed a technique to encourage a new kind of stem cells called Mesenchymal stem cells generated from fat (adipose tissue) of donors, which can be used in treating kidney diseases. Mesenchymal stem cells generated from fat of donors hold great promise for the treatment of kidney diseases, claims H L Trivedi, director, Institute of Kidney Diseases and Research Center (IKDRC), Ahmedabad. We will soon patent the research, he added. The institute will soon convene a meeting of scientists working on the project and take a decision on securing the patent for the research. A team of scientists from the IKDRC, led by Trivedi, has clinically proved that when presented in the right physical context, certain growth factors encourage the survival and proliferation of fat mesenchymal stem cells grown outside the body. Trivedi says the research offers hope of cent per cent recovery for patients suffering from severe kidney diseases as the mesenchymal stem cells will nullify the rejection rate of the body, thus inducing the body to accept the newly transplanted kidney as part of its own body. Emphasising on the success of mesenchymal stem cells for kidney treatment, Trivedi further said mesenchymal stem cells were the best repair stem cells compared to other stem cells. The worlds first recipient of these kinds of stem cells is a kidney patient - Hetalben Mewada, a 30-year-old housewife from Palanpur in Gujarat, claims the scientist from IKDRC. Speaking about the financial aspect of the kidney treatment, Trivedi said, Mesenchymal stem cells using fat is simple and cheap. The latest invention would cut the cost of surgery drastically and make it affordable for the needy people. It will also reduce the chances of recurrence and complexity in the post surgery situation, he said. Mesenchymal stem cells are available in bone marrow and peripheral blood cells in smaller quantity, but the cells are not economically feasible. Mesenchymal stem cells can be easily derived from fat and is economically viable. Mesenchymal stem cells that are already in the fats are separated and grown through culturing technique in laboratory. IKDRCs scientists carried out a kidney transplant operation using Mesenchymal stem cells derived from fats along with adult hematopoietic stem cells infused into the transplanted kidney to create tolerance or acceptance by the patients. This eliminates the chance of rejection, and the patients would not need medication. Under this procedure, the mesenchymal stem cells act as a big brother to adult hematopoietic stem cells. Mesenchymal stem cells protect these hematopoietic stem cells and help their grafting into different organs by themselves getting grafted and making space for their younger siblings (adult hematopoietic stem cells) to live along with them in their vicinity. Fat stem cells may help treat kidney ailments BS Reporter / Mumbai/ Ahmedabad Mar 06, 2007, 22:52 IST

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Fat stem cells may help treat kidney ailments

UC San Diego researchers receive new CIRM funding

Public release date: 25-May-2012 [ | E-mail | Share ]

Contact: Scott LaFee slafee@ucsd.edu 619-543-6163 University of California - San Diego

Five scientists from the University of California, San Diego and its School of Medicine have been awarded almost $12 million in new grants from the California Institute for Regenerative Medicine (CIRM) to conduct stem cell-based research into regenerating spinal cord injuries, repairing gene mutations that cause amyotrophic lateral sclerosis and finding new drugs to treat heart failure and Alzheimer's disease.

The awards mark the third round of funding in CIRM's Early Translational Awards program, which supports projects that are in the initial stages of identifying drugs or cell types that could become disease therapies. More than $69 million in awards were announced yesterday, including funding for first-ever collaboratively funded research projects with China and the federal government of Australia.

"With these new awards, the agency now has 52 projects in 33 diseases at varying stages of working toward clinical trials," said Jonathan Thomas, JD, PhD and CIRM governing board chair. "Californians should take pride in being at the center of this worldwide research leading toward new cures. These projects represent the best of California stem cell science and the best international experts who, together, will bring new therapies for patients."

The five new UC San Diego awards are:

With a $1.8 million award, Lawrence Goldstein, PhD, professor in the Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute Investigator and director of the UC San Diego Stem Cell Program, and colleagues will continue their work developing new methods to find and test drug candidates for Alzheimer's disease (AD). Currently, there is no effective treatment for AD. The researchers screen novel candidates using purified human brain cells made from human reprogrammed stem cells. Already, they have discovered that these human brain cells exhibit a unique biochemical behavior that indicates early development of AD in a dish.

Mark H. Tuszynski, MD, PhD, professor of neurosciences and director of the Center for Neural Repair at UC San Diego, and colleagues seek to develop more potent stem cell-based treatments for spinal cord injuries. By combining grafts of neural stem cells with scaffolds placed at injury sites, the researchers have reported substantial progress in restoring functional improvement in impaired animal models. The new $4.6 million grant will fund work to identify the optimal human neural stem cells for preclinical development and, in an unprecedented step, test this treatment in appropriate preclinical models of spinal cord injury, providing the strongest validation for human translation.

Amyotrophic lateral sclerosis or ALS (Lou Gehrig's disease) is a progressive neurological condition that is currently incurable. Gene Yeo, PhD, assistant professor in the Department of Cellular and Molecular Medicine, and colleagues will use a $1.6 million grant to exploit recent discoveries that specific mutations in RNA-binding proteins cause neuronal dysfunction and death. They will use neurons generated from patient cells containing the mutations to identify the unique RNA "signature" of these doomed neurons and screen for drug-like compounds that bypass the mutations to correct the RNA signature to obtain healthy neurons.

Eric David Adler, MD, an associate clinical professor of medicine and cardiologist, studies heart failure, including the use of stem cells to treat it. His $1.7 million award will fund research into Danon disease, a type of inherited heart failure that frequently kills patients by their 20s. Adler and colleagues will turn stem cells created from skin cells of patients with Danon disease into heart cells, then screen hundreds of thousands of drug candidates for beneficial effects. The most promising drugs will subsequently be tested on mice with a genetic defect similar to Danon disease, with the ultimate goal of identifying a suitable candidate for human clinical trials. The research may have broader applications for other conditions with similar pathogenesis, such as cancer and Parkinson's disease.

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UC San Diego researchers receive new CIRM funding