Category Archives: Gene Therapy Clinics

Precision Medicine Market Global Forecast to 2028: Increasing … – GlobeNewswire

Dublin, Nov. 17, 2023 (GLOBE NEWSWIRE) -- The "Precision Medicine Market by Type (Inhibitors, Monoclonal Antibodies, Cell & Gene Therapy, Antivirals, Antiretroviral), Indication (Oncology, Rare diseases, Hematology, Infectious), End user (Hospitals & Clinics, Home care) & Region - Global Forecast to 2028" report has been added to ResearchAndMarkets.com's offering.

The precision medicine market is expected to reach USD 50.2 billion by 2028 from USD 29.1 billion in 2023, at a CAGR of 11.5% during the forecast period. The key factors driving the growth of the precision medicine market include growing initiatives related to genomic research, and the increasing number of regulatory approvals for personalized therapeutics. Moreover, rising demand for cell and gene therapies is an opportunity area for this market.

The precision medicine market has been segmented based on type, indication, end user and region.

By type, the monoclonal antibodies segment accounted for the second largest share of the precision medicine market

Based on type, the precision medicine market is categorized into inhibitor drugs, monoclonal, cell & gene therapy, antiviral & antiretroviral drugs, and other therapeutic products. In 2022, monoclonal antibodies accounted for the highest growth rate owing to factors such as the benefits offered by monoclonal antibodies over traditional medicines. These advantages have led to shifting focus of the clinical pipeline dominantly on monoclonal antibodies.

By end user, the hospitals and clinics segment accounted for the largest share in the precision medicine market

Based on end user, the precision medicine market is segmented into hospitals and clinics and home care settings. In 2022, the hospitals and clinics segment accounted for the largest share of the precision medicine market. Growth in this market segment can be attributed to the availability of services such as genetic testing, diagnostics and counselling in hospital setups. Besides, hospitals have easy accessibility to therapeutic products which are made available for patients opting for precision medicine regimes.

North America: the largest share of the precision medicine market

North America accounted for the largest share of the precision medicine market. The large share of the North America region can be attributed to major factors such presence of technologically advanced infrastructure in healthcare settings offering precision medicines, and easy accessibility to advanced therapeutics among others. Besides, the region has a well established healthcare system which further supports the growth of this market.

Europe: The fastest-growing region in the precision medicine market.

The European precision medicine market is projected to grow at the highest CAGR during the forecast period. This is attributed to one of the major factors including the growing initiatives for precision medicine advancements with the presence of some of the key players in the market. Some examples of these players include F. Hoffmann-La Roche Ltd. (Switzerland), Novartis AG (Switzerland), AstraZeneca (UK), and GlaxoSmithKline plc (UK) among others.

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Precision Medicine Market Global Forecast to 2028: Increasing ... - GlobeNewswire

EU Approval of AAV5 DetectCDx Provides Access to Companion … – PR Newswire

SALT LAKE CITY, Nov. 10, 2023 /PRNewswire/ -- ARUP Laboratories today announced that it has gained the Conformit Europenne (CE) mark for AAV5 DetectCDx single-site use under the European Union's In Vitro Diagnostic Medical Devices Regulation (IVDR). AAV5 DetectCDx is a companion diagnostic developed in partnership with BioMarin Pharmaceutical Inc. to aid in the selection of adult patients eligible for BioMarin's new gene therapy for severe hemophilia A, valoctocogene roxaparvovec-rvox (ROCTAVIAN).

The new EU regulation requires that emerging medical devices meet rigorous standards for quality management and patient safety. Although AAV5 DetectCDx had already received a CE mark under the previous In Vitro Diagnostic Medical Devices Directive (IVDD) in August 2020, achieving the more stringent IVDR approval will enable ARUP to continue to provide patients access to testing in the EU after May 2026, when all medical devices will require IVDR approval. With EU approval, samples from those living in the EU and other countries that follow EU regulations can be tested at ARUP's centralized lab in Salt Lake City.

We are proud to be involved in this effort to support the needs of patients with severe hemophilia A.

"We are proud to be involved in this effort to support the needs of patients with severe hemophilia A," said Jay Patel, MD, MBA, vice president of Clinical Trials and PharmaDx at ARUP. "We've demonstrated by our ability to execute on these stringent regulatory requirements that we're committed to patient safety and access to testing."

Hemophilia A is a rare, X-linked genetic bleeding disorder caused by a deficiency in coagulation factor VIII (FVIII). People living with hemophilia A may experience painful and/or potentially life-threatening bleeding from even modest injuries because they lack sufficient clotting protein.

BioMarin's new gene therapy uses adeno-associated virus serotype 5 (AAV5) as a vector to deliver a functional copy of the gene for FVIII in a one-time infusion, with the goal of reducing or eliminating the need for chronic prophylactic treatment. AAV5 DetectCDx will be used to detect the presence of preexisting anti-AAV5 antibodies that can inhibit the efficacy of the treatment. Only individuals without anti-AAV5 antibodies will be eligible.

The approval of AAV5 DetectCDx is the result of a close collaboration between ARUP and BioMarin.

"We are gratified to see the results of this colossal effort from both teams and to fulfill an unmet need for patients with rare diseases such as hemophilia A," said Jennifer Granger, PhD, group manager of the PharmaDx Companion Diagnostics team at ARUP, who has played a key role in the pursuit of IVDR approval.

European regulators based their authorization on data from clinical trials for which ARUP's test was used to determine patient eligibility.

As a national reference laboratory closely aligned with an academic medical center, ARUP has a unique ability to support the development of companion diagnostics for emerging medical treatments. In addition to its College of American Pathologists (CAP) and Clinical Laboratory Improvement Amendments (CLIA) certifications, ARUP also has an International Organization for Standardization (ISO) 15189 certification, an internationally recognized quality standard, and meets the quality management requirements for medical devices, including title 21, Code of Federal Regulations (CFR), part 820.

"Very few clinical labs have the quality management system and competencies in place to execute on a new companion diagnostic at this regulatory level," Patel said. "We are proud of our ability to deliver at the highest levels for patients and for our partners."

AAV5 DetectCDx also received FDA approval on June 29, 2023, becoming the first FDA- approved companion diagnostic immunoassay for a gene therapy.

About ARUP Laboratories

Founded in 1984, ARUP Laboratories is a leading national reference laboratory and a nonprofit enterprise of the University of Utah and its Department of Pathology. ARUP offers more than 3,000 tests and test combinations, ranging from routine screening tests to esoteric molecular and genetic assays. ARUP serves clients across the United States, including many of the nation's top university teaching hospitals and children's hospitals, as well as multihospital groups, major commercial laboratories, group purchasing organizations, military and other government facilities, and major clinics. In addition, ARUP is a worldwide leader in innovative laboratory research and development, led by the efforts of the ARUP Institute for Clinical and Experimental Pathology. ARUP is ISO 15189 CAP accredited.

ARUP Media Contact

Lisa Carricaburu, [emailprotected], 801-583-2787 ext. 3842

SOURCE ARUP Laboratories

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EU Approval of AAV5 DetectCDx Provides Access to Companion ... - PR Newswire

Experts’ Perspectives: Top News in Cardiology for 2023 – MD Magazine

As the last meeting of the 3 flagship professional societies in cardiology, the American Heart Association Scientific Sessions serves as a yearly send-off for the community and, by extension, a celebration of the advances that defined the past year in medicine. This years meeting was no exception, with a wealth of breakthroughs showcased at AHA 2023.

With an interest in capturing the perspective of leading experts in the field as the cardiology community looks ahead to the close of 2023, the editorial team of HCPLive Cardiology asked 12 leading experts in cardiology what they will remember as the defining piece of news or advancement within the field from the past year.

Expert opinions spotlighted in this feature include those of Steve Nissen, MD, chief academic officer of the Heart Vascular and Thoracic Institute at Cleveland Clinic, Michelle Albert, MD, MPH, immediate-past president of the AHA and the Walter A. Haas-Lucie Stern Endowed Chair in Cardiology and Professor in Medicine at the University of California at San Francisco, Marc Bonaca, MD, MPH, director of Vascular Research at the University of Colorado Anschutz Medical Campus and executive director of CPC Clinical Research, Sadiya S. Khan, MD, assistant professor of cardiology and epidemiology at Northwestern University Feinberg School of Medicine and a Northwestern Medicine physician, James E. Ip, MD, an associate professor of clinical medicine at Weill Cornell Medicine at New York-Presbyterian Hospital, Rahul Aggarwal, MD, cardiology fellow at Brigham and Womens Hospital, Viet T. Le, DMSc, PA-C, researcher and physician associate at the Intermountain Health, Ahmad Masri, MD, director of the Hypertrophic Cardiomyopathy Center atOregon Health & Science University, Mandeep Mehra, MD, medical director of the Heart and Vascular Center at Brigham and Womens Hospital, Christian T. Ruff, MD, MPH, director of general cardiology at Brigham and Womens Hospital and senior investigator for the TIMI Group, Paul Ridker, MD, MPH, director of the Center for Cardiovascular Disease Prevention at Brigham and Women's Hospital, Deepak Bhatt, MD, MPH, director of Mount Sinai Heart and the Dr. Valentin Fuster Professor of Cardiovascular Medicine at the Icahn School of Medicine at Mount Sinai, and Ty Gluckman, MD, medical director of the Center for Cardiovascular Analytics, Research, and Data Science at the Providence Health.

Top Row (L to R): Deepak Bhatt, MD, MPH; Sadiya Khan, MD; Ahmad Masri, MD, MS; Michelle Albert, MD; Viet Le, DMSc, PA-C; Mandeep Mehra, MD Bottom Row (L to R): Marc Bonaca, MD; James Ip, MD; Paul Ridker, MD, MPH; Rahul Aggarwal, MD; Ty Gluckman, MD; Christian Ruff, MD, MPH; Steve Nissen, MD

Included below the responses of the aforementioned experts is a behind-the-scenes clip from the AHA 2023 episode of Dont Miss a Beat, where hosts Muthiah Vaduganathan, MD, MPH, codirector of the Center for Implementation Science at Brigham and Womens Hospital, and Steve Greene, MD, advanced heart failure specialist at the Duke Clinical Research Institute, discuss the same question.

Editors Note: These transcripts have been edited for grammar and clarity.

Nissen: I think that 2023 is the year that we get began the pivot from what the old way of developing drugs, which was small molecules given with the hope that the favorable effects would exceed the unfavorable, to the directed therapies involving these short-interfering RNAs and antisense oligonucleotides. We're in that pivot. As you know inclisiran was approved, it was the first short-interfering RNA in the cardiovascular space and now, there are others for amyloidosis. It is an explosion of new approaches to drug development, and this is the year when that transition really began to accelerate.

Albert: Well, I think the trial that we saw about semaglutide, weight reduction, and perhaps this tie to cardiovascular risk reduction. Although, right now, we do not know that the weight reduction is what was tied to cardiovascular risk reductioIt could be the drug itself and how it's working on other mechanisms.

I think the other thing is the big news in the heart failure field. Whether you have heart failure with reduced ejection fraction or heart failure with preserved ejection fractionwhether you have diabetes or don't have diabetes the SGLT2 inhibitors are extremely beneficial. I think those are the two big things I think about so far.

I would also add, as it relates to the last year, when we think about late breaking science, we a lot of times do not include social factors and social determinants of health. I think the growing recognition among all scientists and clinicians of the importance of social determinants of health is an advance, honestly. I would say 5 years ago, it was tougher to bring clinicians and researchers over that hump.

Bonaca: That's a great question. I haven't had a lot of time to think through this, but off the top of my head, I would say the focus on cardiometabolic disease. I think at ESC, STEP-HFpEF reminded us that you do not need a big trial to have a big impact. There has been a notion of "healthy obesity," and I believe it dispels, at least in part, the idea that treating individuals who are obese with a GLP-1 receptor agonist might benefit those with heart failure with preserved ejection fraction.

Now, everybody asking the question, "Is it the weight loss or the heart failure?". And the answer is yes, because these things are linked, right? They're not independent. Then SELECT is going to be presented at AHA. So, I think this story of cardiometabolic disease and weight loss is really what I think is the story of 2023. Where the field is moving, I think brings big challenges, though. Patients cannot access these drugs. They are super expensive, and you can't come off. So, I think that the future is going to play out as: How we use these agents? Are there better agents? How do we sustain the benefits without lifelong treatment with it being a very expensive therapy?

There's a big, what I would say is a corollary story, is the first digital therapeutic for treating diabetes was approved by the FDA. This approach utilizes cognitive behavioral therapy and nutritional cognitive behavioral therapy to genuinely educate individuals on lifestyle modification. To me, it prompts the question of how we conceptualize cardiometabolic disease. Should we consider these potent new drugs, such as semaglutide and others in the pipeline, as inducers for rapid weight loss? Then, can we view digital cognitive behavioral therapy and other strategies as maintenance tools that could potentially facilitate individuals coming off these interventions? I think this is a big part of 2023.

Khan: I think it is going to be the GLP-1 receptor agonists for 2023. I think in 2022 it was the SGLT2 inhibitors. Now, 2023 is the GLP-1 receptor agonists. I would say, from a trial perspective, that's true. But I would caution by saying, I actually don't want to say that's the story of 2023.

I think they are amazing therapies and it's wonderful that we are at this point, but I think the story should be: How do we get the right therapies to the right patients? So, maybe that's 2024, because it's wonderful that there are wonderful drugs that are very helpful and effective, but we need to make sure that the right patients are getting them at the right time.

Ip: As an electrophysiologist, I am very excited. I'm involved in various aspects of EP, but the one that I was most excited about, especially this week because it's so fresh in my mind, is dual chamber lead list pacing. We now have technology that can have two devices, separately, one placed in the right atrium and one in the right ventricle that can speak wirelessly. That has opened up the world of leaderless pacing for patients who need pacemaker therapywhere their sinus node dysfunction, or atrial ventricular block where they need two systems before we only had one on the bottom. Now, we have that. It was FDA approved earlier this year and we did our first commercial implants this week. So, that that was certainly a highlight of my year and my week. But I would also highlight the results of ReVeRa, because etripamil is also very exciting. I mean with the NODE studies and this study, I think that there are a lot of new exciting things, at least within EPthere are also other technologies that are being explored, but those are the ones that come to my mind.

Aggarwal: I think this year the major kind of changes, there's a lot of emphasis not just on what therapies work, but on ensuring that patients get the therapy, and the therapy is prescribed. So, for me, I think what's going to really stand out is that we're really focusing on how can we initiate therapy early? How can we get patients on therapy who may not reach their follow up or who may not see their follow up provider very quickly? So, I think the emphasis is shifting a little bit from just finding therapies that work to also how do we get the therapies to reach our patients. I think that's been a major shift in focus within a lot of the population health-based studies this year.

Le: It's a little unfair to pick one, because there are 3 things that I think about that have kind of come the confluence of things that have happened in 2023.

First of all, I think as we look back to 2023, what we'll recognize is the power of nucleic acid therapies. So, these are the antisense oligonucleotides and the siRNA. We're seeing it across lipids. We're seeing it not just in LDL-C, but were seeing it in Lp(a) now. Also in the hypertension space, where it's one injection for three or six months of therapeutic benefit, at least in terms of reduction of blood pressure. We'll see if that translates otherwise.

Here, the American Heart Association just presented what we all kind had been dancing around, which is CKM or cardiovascular-kidney-metabolic. This confluence of we need to work together upstream. These are the patients that we see in our cardiovascular clinics, but we need to be working on all of the organs and certainly the constellation of what diseases do to lead to cardiovascular outcomes and morbidities.

Lastly, this is the year obesity has really come to the forefront with this idea that it is not just an inability to choose lifestyle or right things. We're recognizing this is much deeper than that. It is social determinants, and it is deeper in our biology, in terms of obesity. We have therapies that touch upon and can help really relieve the burden as well as stigma that a lot of our patients face when they go to their provider and are told, "You probably are just eating too much or not exercising enough". My heart is just sick when I get referrals for patients and that is what they've heard. So, this is the year that we have awakened the reality to obesity management and that it is a diseasenot just willful ignorance or choice to feel poorly. I think those are the main 3 takeaways from to 2023.

Masri: It's been a very, very busy year for us in 2023. So, I honestly cannot take a single item to talk about as the biggest one,but I'll allude to some advancements in the cardiomyopathy space. The first one is that we presented data from aficamten and nonobstructive HCM from the REDWOOD-HCM cohort 4 study, which allowed us to progress to a large phase three trial in this space.

The second one is related to amyloidosis. We received the first chunk of data from a phase 1 trial for anti-ATTR antibody. That was published in the New England Journal of Medicine and showed that there is a strong rationale behind this and some more data is coming out. From the National Amyloidosis Centre in the UK, we also saw the autoantibodies that naturally develop in amyloidosis. That was also important.

The first patient with MYBPC3 hypertrophic cardiomyopathy was dosed in the Tenaya gene therapy program. This is the first patient ever to be loaded with gene therapy specifically for MYBPC3 hypertrophic cardiomyopathy. We're also seeing a lot of the data coming out from the phase one gene editing in transthyretin amyloidosis. We know that the FDA also just gave the go-ahead to proceed with the phase 3 global trial for CRISPR-Cas9 in ATTR cardiomyopathy. Last but not least, we have also seen proof of concept for gene editing in preclinical hypertrophic cardiomyopathythere are two Nature papers on this. So, it's been really, really busy, but a lot of good things are happening in our space. We're very excited to see how these progress over time.

Mehra: The big story of 2023 is that we now have great medications to undo the problems of our own personal lifestyles, but, with this, we have created an opportunity that will expose healthcare disparities in a much more magnified way. I think that's terrible and I think we're going to have to all attend to that, you know, as a community.

Ruff: I think it really has to be, and we have seen it even in the lay press, the role of the GLP-1 receptor agonists broadly in health, but particularly in cardiovascular health the impact could be just enormous. Obviously, these drugs were initially developed to lower blood glucose and people with diabetes and then, many years ago, we learned they have cardiovascular benefit in diabetes and then they have cardiovascular benefit in non-diabetics.

The fact that they cause tremendous amounts of weight loss, will, even in patients with no known heart disease, reduce their risk of heart disease. There may be no other drug in clinical practice that has such an enormous effect on health across such a broad population of patients who have diabetes or preexisting cardiovascular disease as well as the effects on the epidemic of obesity. I think that's really going to be one of the landmark findings of this year that will have a lasting impact on the way we treat patients in cardiology and really in all medicine.

Ridker: It has been a remarkable year for cardiovascular advances. For my interest, I put them in three categories. The first is the remarkable ability of the SGLT2is to actually change outcomes in our patients who have heart failure and to see this data extend out into other settings, like chronic kidney disease has been quite remarkable. The second has to obviously be the success of the GLP-1 receptor agonist. We're seeing multiple different drugs coming on market very fast, with multiple different ways of addressing these issues. We're seeing not just weight loss, but event reduction in patients with diabetes. As we're all looking forward to the data from the AHA on event reduction in patients who don't have diabetes and realizing that this is going to change how medicine is practiced. The challenges for us will be to figure out how, where, and why, but that'll be interesting.

Third is my own arena. I think it's been exciting to see the US FDA, pretty much on its own, decide that it was time to label a drug, low-dose colchicine, for anti-inflammatory therapy. That's a big issue for the vascular biology world to say, "Yes, the regulators, as well as the vascular biologists, now believe that the data are rock solid that we should be targeting inflammation, as well as hyperlipidemia".

I think a fourth area is the novel therapeutics we're seeing. Without going into specifics, we're seeing new types of drugs where maybe we can actually change the underlying biology of cells in the liver on a lifetime basis, to alter Lp(a) or to alter ApoB production or to alter various different proteins. To watch many different scientists working with industry to figure out a whole new way of addressing whether we can modify disease on a lifelong basis. Particularly for extremely high riskI think of a patient with homozygous FH or maybe very severe heterozygous FHis there a way to change their underlying hepatic biology?

We don't know whether it's completely safe yet, but the preliminary data look like it might be. I recognize we have to wait 10 to 15 years perhaps to know about safety, but it's a very exciting direction to think about: Can we actually alter the biology, rather than just simply giving drugs on a chronic basis? So, all those things to me are very exciting and, again, it's a real reminder of how science moves forward and how we as clinicians have new options for our patients.

Bhatt: The year 2023 was a really good year for cardiology, cardiometabolic disease, and cardiorenal disease. There are a lot of advances, there were a ton of stuff that just came out of the AHA, at the ESC before that, and at the ACC before that. So, it has been a good year. There have been a lot of important practice-changing trials. If you force me to just pick one thing, I think what Verve Therapeutics announced here, in terms of data that they've produced in a relatively small number of patients, was amazingthe first use of human gene-editing to lower cholesterol levels.

They were targeting PCSK9 and, at the higher doses, saw about a 50% percent reduction in LDL cholesterol that was durable out to 6 months of data. To me, that concept of editing genes in humans in a way that will hopefully be safe and durablewe will need more patients followed for longerso far looks like a really promising approach and opens the door for that approach for a variety of cardiovascular disease conditions and risk factors, including things like Lp(a). So, to me, that's really exciting for that particular approach and could be an opening-the-door strategy to a variety of approaches in the future.

To me, genetics and AI are really two exciting areas that have been hyped for years, at least with respect to cardiovascular applications, where there really was not anything, but now we have FDA-approved AI algorithms for ECGs for echocardiograms, among other things, and now we have gene editing in humans that actually seems to be really effective. It's a whole new world out there. Again, to me, those are some really exciting developments.

I was also excited to announce to the American Heart Association from the podium the TRANSFORM trial. This is going to be a randomized clinical trial of about 7500 patients or so followed for a while in the primary prevention universe.

So, we are taking primary prevention patients and then getting a CT scan on them, which will use an AI-enabled algorithm to determine the staging of the coronary plaque. Stage 0, for example, means you don't have any plaques, or you probably don't need to be on a bunch of meds. Then the successive stages 1, 2, and 3sort of like staging cancerwith staging plaque based on plaque volume, plaque burden across all the different coronary arteries, and plaque composition. So, incorporating all that in a pretty sophisticated AI-enabled algorithm to take the risk of that individual patient, based on their stage of plaque, and then, using that information, to counsel the patient on lifestyle, but also to titrate, very intensive medical therapy beyond what the guidelines currently recommend, including things like colchicine, SGLT1/2 inhibitors, or bempedoic acid, where all these agents have outcome data in different sorts of settings. We want to see, can you use plaque to add agents, these and others, to really refine how we treat patients with respect to cardiovascular risk reduction. Patients will be randomized to that approach or a guideline-based approach following current guidelines where they also get a CT at baseline and also at 2 years. That arm will be blinded until the end of the trial, but we will know the answers in the investigation arm.

So, this will give us 3 different opportunities within TRANSFORM. TRANSFORM-Classify will see if this approach is better than conventional risk scores. TRANSFORM-Plaque will look at CT at baseline and a repeat CT at 2 years to see if there is plaque progression and whether we can impact that with intense medical therapy versus standard guideline-directed therapy as it currently stands as well as whether those changes in plaque that may occur from baseline and 2 years do or don't predict subsequent cardiovascular events. Then, in TRANSFORM-Outcomes, we are actually going to look at major adverse cardiovascular events to see if the strategy using AI-enabled imaging and then incorporating that information to intensify medical therapy is better than just doing what the guidelines would tell us to do. So, that's the cardiovascular outcome part of the trial.

This is something that will take a few years to reach the end, but when it's done, whatever it shows, I think it will be informative about whether imaging should be part of how we stratify patients in terms of their risk in the primary prevention world and whether we can or should not use that information to them titrate their medical therapies.

Gluckman: I would say 2023 has been a year and maybe several years leading up to it that has really reinforced the importance of targeted therapies for cardiovascular, metabolic, and kidney disease. Maybe that's all ensconced in the fact that a therapy that can help facilitate weight reduction as a GLP-1 receptor agonist and that translates into blood pressure improvement, cholesterol improvement, anti-inflammatory properties improvement, and glycemic control can improve cardiovascular outcomes at-risk individuals, but I think the intersection of high cholesterol, diabetes, high blood pressure, obesity, chronic kidney disease, nonalcoholic fatty liver disease really reinforces the importance from a public health standpoint, from a cardiovascular prevention standpoint, when close to 70-plus percent of the US population is overweight or obese. When we have rising rates of diabetes and unacceptably, high rates of lack of control for high blood pressure and high cholesterol. We need to do better. So, I hope that this is a furthering of acceleration in terms of therapeutic approaches that can wind that back.

Click here for the full AHA 2023 episode of Dont Miss a Beat, which focuses on SELECT results and DAPA-MI.

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Experts' Perspectives: Top News in Cardiology for 2023 - MD Magazine

NANT Pediatric Cancer Consortium Spearheads Research That Identifies Targeted Therapy for High-Risk Neuroblastoma – Newswise

Newswise It is rare that a clinical trial is changed mid-investigation. But when results are striking enough, it can occur. Such striking results have been reported in a study led by the New Approaches to Neuroblastoma (NANT) pediatric cancer consortium, which is headquartered at Childrens Hospital Los Angeles.

For patients with relapsed or refractory neuroblastoma who have an alteration in the ALK gene, lorlatinib has been shown to be a safe, effective targeted therapy. This phase 1 findingpublished today in Nature Medicineis so significant that the Childrens Oncology Group (COG) is now modifying its phase 3 protocol to replace another ALK inhibitor (crizotinib) with lorlatinib to treat newly diagnosed neuroblastoma arising from an ALK alteration.

NANT is the only clinical trials consortium focused on developing new treatments and biomarkers for children and young adults with neuroblastoma. It is an international collaboration of expert investigators from around the world working to fast-track investigation into promising new therapies to benefit young patients with neuroblastoma.

Araz Marachelian, MD, Medical Director of NANTs Operations Center and Medical Director of CHLAs Neuroblastoma MIBG Program, is the studys sponsor and co-senior author on the Nature Medicine publication.

At NANT, we are pleased to have had a leadership role in this important discovery, says Dr. Marachelian. NANTs participation included early collaboration on evaluating laboratory data, trial design, securing FDA approval and industry sponsorship, study oversight and coordination, safety monitoring, creating and maintaining the study database, and analyzing and disseminating study results.

Neuroblastoma is the third most common cancer in children and originates in the nerve cells outside the brain of infants and young children. It most commonly affects children 5 years of age or younger. Half of patients are considered to have high-risk disease and require intensive therapy that includes chemotherapy and biologic therapy, surgery, transplant, radiation and immunotherapy. Despite this multimodal approach, only 50% of high-risk patients survive.

We are thrilled to see many years of NANTs planning and operation come to fruition with the results of this important study, says Julie Park, MD, Chair of the NANT consortium. Families are urgently waiting for new treatment possibilities like this one. Dr. Park is an established neuroblastoma expert and chair of the Department of Oncology at St. Jude Childrens Research Hospital.

NANT brings together a diverse team of investigators that cannot be found at a single institution to identify promising treatment candidates, perform preclinical testing and then to design and carry out early-phase testing of these novel treatments. Because neuroblastoma is a rare disease with only 700 to 800 new cases in the U.S. each year, no single site could enroll enough patients to produce meaningful data. NANT sites enroll patients and collect consistent data that can then form the basis for a Childrens Oncology Group clinical trial and offer patients access to novel therapies across a broad geographic area in North America and Europe.

First author on the paper is Kelly C. Goldsmith of Childrens Healthcare of Atlanta and co-senior author is Yael P. Mosse of Childrens Hospital of Philadelphia. The trial was conducted at national and international sites including: Vanderbilt University Medical Center, Childrens Hospital Los Angeles, USC Keck School of Medicine, Childrens Hospital of Philadelphia, University of Iowa Hospital and Clinics, Childrens Hospital of Philadelphia, Stanford University School of Medicine, Perelman School of Medicine at the University of Pennsylvania, The Royal Marsden Hospital, London, UK, Cook Childrens Medical Center, , Department of Pediatrics, University of Chicago, Department of Pediatrics, University of Michigan, Hospital for Sick Kids, Toronto, ON, Harvard Medical School, Childrens Hospital Colorado, Seattle Childrens Hospital, Institut Curie, Paris, France and UCSF Benioff Childrens Hospital.

The study was funded by National Cancer Institute grant P01CA217959, Pfizer Inc. and other grants and foundations.

About Childrens Hospital Los Angeles Childrens Hospital Los Angeles is at the forefront of pediatric medicine, offering acclaimed care to children from across the world, the country, and the greater Southern California region. Founded in 1901, Childrens Hospital Los Angeles is the largest provider of care for children in Los Angeles County, the No. 1 pediatric hospital in the Pacific region and California, and among the top 10 in the nation on U.S. News & World Reports Honor Roll of Best Childrens Hospitals. Clinical expertise spans the pediatric care continuum for newborns to young adults, from everyday preventive medicine to the most advanced cases. Inclusive, kid- and family-friendly clinical care is led by physicians who are faculty members of the Keck School of Medicine of USC, and proven discoveries reach patients faster through The Saban Research Institute of Childrens Hospital Los Angelesamong the top 10 childrens hospitals for National Institutes of Health funding. The hospital also is home to the largest pediatric residency training program at a freestanding childrens hospital in the western United States. To learn more, follow us on Facebook, Instagram, LinkedIn, YouTube and Twitter, and visit our blog at CHLA.org/blog.

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NANT Pediatric Cancer Consortium Spearheads Research That Identifies Targeted Therapy for High-Risk Neuroblastoma - Newswise

Rare Neurological Disease Treatment Market is estimated to be US$ 18367 million by 2030 with a CAGR of 7.50% – – EIN News

Rare Neurological Disease Treatment Market -PMI

The report "Rare Neurological Disease Treatment Market, By Drug Type and By Region - Market Trends, Analysis, and Forecast till 2030

The report "Rare Neurological Disease Treatment Market, By Drug Type (Biologics and Small Molecules), By Mode of Administration (Injectables, Oral and Other Modes of Administration), and By Region (North America, Europe, Asia Pacific, Latin America, and Middle East & Africa) - Market Trends, Analysis, and Forecast till 2030

Key Highlights: In 2021, -Global Genes, a prominent international rare illness advocacy organisation, today announced the beginning of a multi-stakeholder programme called Patient Identification and Engagement for RARE CNS Disorders (PIE4CNS). The PIE4CNS initiative will address major gaps in the timely and comprehensive diagnosis of rare central nervous system (CNS)-related conditions, as well as challenges in finding and engaging patient populations in clinical research in gene therapy and other promising technologies that could lead to significant advancements in rare disease treatment.

Analyst View: The absence of appropriate therapy is the most notable driving factor for the market's main players, which will assist it develop in the forecast period's approaching years. A focus on fast-track approvals for novel and future medicines to treat such illnesses is another major element for market growth. Furthermore, recent technical breakthroughs in the fields of neurology and neurobiology have aided the growth of the global market for neurological disorder therapy. In addition, raising awareness about early detection of these conditions may aid market growth in the coming years.

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Scope of the Report: 1.Market Preview >Executive Summary >Key FindingsGlobal Outlook for Rare Neurological Disease Treatment Strategies Key Questions this Study will Answer Market Snippet, By Drug Type Market Snippet, By Mode of Administration >Opportunity Map Analysis >Executive Summary3 Big Predictions 2.Market Dynamics, Regulations, and Trends Analysis >Market Dynamics Drivers Restraints Market Opportunities Market Trends >DR Impact Analysis >PEST Analysis >Porters Five Forces Analysis >Opportunity Orbit >Market Investment Feasibility Index >Macroeconomic Factor Analysis 3.Global Rare Neurological Disease Treatment Market, By Drug Type, 2020 2030, (US$ Mn) >Overview Market Value and Forecast (US$ Mn), and Share Analysis (%), 2020 2030 Y-o-Y Growth Analysis (%), 2020 2030 Segment Trends >Biologics Overview Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2020 2030 >Small Molecule Overview Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2020 2030 4.Global Rare Neurological Disease Treatment Market, By Mode of Administration, 2020 2030, (US$ Mn) >Overview Market Value and Forecast (US$ Mn), and Share Analysis (%), 2020 2030 Y-o-Y Growth Analysis (%), 2020 2030 Segment Trends >Injectables Overview Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2020 2030 >Orals Overview Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2020 2030 >Others Overview Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2020 2030

Key Market Insights from the report: Global Rare Neurological Disease Treatment Market accounted for US$ 8931.49 million in 2020 and is estimated to be US$ 18367 million by 2030 and is anticipated to register a CAGR of 7.50%. The Global Rare Neurological Disease Treatment Market is segmented based on drug type, mode of administration and region. Based on Drug Type, Global Rare Neurological Disease Treatment Market is segmented into Biologics and Small Molecules. Based on Mode of Administration, Global Rare Neurological Disease Treatment Market is segmented into Injectables, Oral and Other Modes of Administration. By Region, the Global Rare Neurological Disease Treatment Market is segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa.

Competitive Landscape & their strategies of Global Rare Neurological Disease Treatment Market: CSL Ltd Kedrion Biopharma Inc US WorldMeds LLC Merz Pharma GmbH & Co. KGaA Aquestive Therapeutics Inc Bayer AG Pfizer Inc Novartis AG Merck & Co. Inc. (EMD Serono Inc.) Jazz Pharmaceuticals PLC.

The market provides detailed information regarding the industrial base, productivity, strengths, manufacturers, and recent trends which will help companies enlarge the businesses and promote financial growth. Furthermore, the report exhibits dynamic factors including segments, sub-segments, regional marketplaces, competition, dominant key players, and market forecasts. In addition, the market includes recent collaborations, mergers, acquisitions, and partnerships along with regulatory frameworks across different regions impacting the market trajectory. Recent technological advances and innovations influencing the global market are included in the report.

Some Important Points Answered in this Market Report Are Given Below: Explains an overview of the product portfolio, including product development, planning, and positioning Explains details about key operational strategies with a focus on R&D strategies, corporate structure, localization strategies, production capabilities, and financial performance of various companies. Detailed analysis of the market revenue over the forecasted period. Examining various outlooks of the market with the help of Porters five forces analysis, PEST & SWOT Analysis. Study on the segments that are anticipated to dominate the market. Study on the regional analysis that is expected to register the highest growth over the forecast period

Questions answered by Rare Neurological Disease Treatment Market:

1.What is the current size of the rare neurological disease treatment market, and what are the growth projections for the market in the coming years? The current size of the rare neurological disease treatment market is estimated to be around $10 billion. The market is projected to grow at a compound annual growth rate (CAGR) of around 6% during the forecast period from 2021 to 2028, driven by factors such as increasing prevalence of rare neurological diseases, growing investments in R&D, and favorable government initiatives.

2.What are the major drivers and challenges in the rare neurological disease treatment market, and how are they impacting the growth of the market? The major drivers in the rare neurological disease treatment market include increasing prevalence of rare neurological diseases, growing investments in R&D, and favorable government initiatives. However, the market also faces challenges such as high cost of treatments, limited patient population, and difficulty in diagnosis and clinical trials. These factors can impact the growth of the market by influencing access to treatments, funding for research, and regulatory policies.

3.What are the major trends in the rare neurological disease treatment market, and how are they expected to shape the market in the future? Some of the major trends in the rare neurological disease treatment market include increasing adoption of precision medicine, growing focus on gene therapy and biologics, and development of innovative treatment approaches such as gene editing and stem cell therapy. These trends are expected to shape the market by improving treatment outcomes and expanding the range of treatment options available for rare neurological diseases. Additionally, the emergence of digital technologies such as telemedicine and wearable devices is also expected to revolutionize the way rare neurological diseases are diagnosed and treated.

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Rare Neurological Disease Treatment Market is estimated to be US$ 18367 million by 2030 with a CAGR of 7.50% - - EIN News

Pharmerging Market is estimated to be US$ 4426.72 billion by 2030 with a CAGR of 16.5% during the forecast – EIN News

Pharmerging Market-By PMI

Pharmerging Market, By Products, By Economy , By Indication, By Distribution Channel and By Region - Trends, Analysis and Forecast till 2030

Region Analysis: The Middle East and Africa, Asia Pacific, North America, and Europe are all regions where the worldwide pharmerging market is reported to be present. In 2020, Asia Pacific dominated this market due its fast urbanization, rising patent expiration, and spike in spending in medical research, researchers. As the primary domestic market for pharmaceutical innovation in Asia Pacific, China has emerged. Europe and Latin America are projected to have strong growth in the near future, among other geographical markets for pharmerging. The Latin American healthcare industry is anticipated to grow due to technological improvements, significant research and development techniques, and rising public awareness of the administration and treatment of healthcare facilities

Key Highlights: In 2022, Saudi pharmaceutical company Jamjoom Pharma has announced the opening of a new factory in Egypt as it looks to expand its exports to newer markets in Africa. During the partnership signing event between Egypt and Saudi Arabia, the announcement was made. In 2022, Medical Marijuana, Inc., the world's first publicly traded cannabis company to introduce cannabis-derived nutraceutical products, brands, and supply chains, announced today that its first pharmaceutical subsidiary, HM Pharma, has begun operations in Brazil.

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Scope of the Report: 1.Market Preview >Executive Summary >Key FindingsGlobal Pharmerging Market Key Questions this Study will Answer Market Snippet, By Product Type Market Snippet, By Economy Market Snippet, By Indication Market Snippet, By Distribution Channel Market Snippet, By Region >Opportunity Map Analysis >Executive Summary3 Big Predictions 2.Market Dynamics, Regulations, and Trends Analysis >Market Dynamics Drivers Restraints Market Opportunities Market Trends >DR Impact Analysis >PEST Analysis >Porters Five Forces Analysis >Opportunity Orbit >Market Investment Feasibility Index >Macroeconomic Factor Analysis 3.Global Pharmerging Market, By Product, 2020 2030, (US$ Bn) >Overview Market Value and Forecast (US$ Bn), and Share Analysis (%), 2020 2030 Y-o-Y Growth Analysis (%), 2020 2030 Segment Trends >Pharmaceuticals Overview Market Size and Forecast (US$ Bn), and Y-o-Y Growth (%), 2020 2030 >Healthcare Overview Market Size and Forecast (US$ Bn), and Y-o-Y Growth (%), 2020 2030 >Others Overview Market Size and Forecast (US$ Bn), and Y-o-Y Growth (%), 2020 2030 4.Global Pharmerging Market, By Economy , 2020 2030, (US$ Bn) >Overview Market Value and Forecast (US$ Bn), and Share Analysis (%), 2020 2030 Y-o-Y Growth Analysis (%), 2020 2030 Segment Trends >Tier-1 Overview Market Size and Forecast (US$ Bn), and Y-o-Y Growth (%), 2020 2030 >Tier-2 Overview Market Size and Forecast (US$ Bn), and Y-o-Y Growth (%), 2020 2030 >Tier-3 Overview Market Size and Forecast (US$ Bn), and Y-o-Y Growth (%), 2020 2030 5.Global Pharmerging Market, By Indication, 2020 2030, (US$ Bn) >Overview Market Value and Forecast (US$ Bn), and Share Analysis (%), 2020 2030 Y-o-Y Growth Analysis (%), 2020 2030 Segment Trends >Lifestyle Disease Overview Market Size and Forecast (US$ Bn), and Y-o-Y Growth (%), 2020 2030 >Cancer & Autoimmune Disease Overview Market Size and Forecast (US$ Bn), and Y-o-Y Growth (%), 2020 2030 >Infectious Disease Overview Market Size and Forecast (US$ Bn), and Y-o-Y Growth (%), 2020 2030 6.Global Pharmerging Market, By Distribution Channel, 2020 2030, (US$ Bn) >Overview Market Value and Forecast (US$ Bn), and Share Analysis (%), 2020 2030 Y-o-Y Growth Analysis (%), 2020 2030 Segment Trends >Hospitals Overview Market Size and Forecast (US$ Bn), and Y-o-Y Growth (%), 2020 2030 >Clinincs Overview Market Size and Forecast (US$ Bn), and Y-o-Y Growth (%), 2020 2030 >Retail Pharmacies Overview Market Size and Forecast (US$ Bn), and Y-o-Y Growth (%), 2020 2030 >E-Commerce Overview Market Size and Forecast (US$ Bn), and Y-o-Y Growth (%), 2020 2030 >Drug Stores Overview Market Size and Forecast (US$ Bn), and Y-o-Y Growth (%), 2020 2030

Key Market Insights from the report: Pharmerging Market size accounted for US$ 971.94 billion in 2020 and is estimated to be US$ 4426.72 billion by 2030 and is anticipated to register a CAGR of 16.5%. The Global Pharmerging Market is segmented based on product type, economy, indication, distribution channel and region. Based on Product Type, Pharmerging Market is segmented into Pharmaceuticals, Healthcare and Others (IT and Record Management). Based on Economy, Pharmerging Market is segmented into Tier-1, Tier-2 and Tier-3. Based on Indication, Pharmerging Market is segmented into Lifestyle Disease, Cancers & Autoimmune Diseases and Infectious Disease. Based on Distribution Channel, Pharmerging Market is segmented into Hospitals, Clinics, Retail Pharmacies, E-Commerce and Drug Stores. By Region, the Pharmerging Market is segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa.

Competitive Landscape & their strategies of Pharmerging Market: Sanofi S.A. Pfizer Inc. AstraZeneca Plc GlaxoSmithKline Plc F. Hoffmann-La Roche AG (Roche AG) Eli Lilly and Company Johnson & Johnson Abbott Laboratories Novartis AG Teva Pharmaceutical Limited

Questions answered by Pharmerging Market: What are the major drivers and challenges in the pharmerging market, and how are they impacting the growth of the market? The major drivers in the pharmerging market include growing demand for healthcare services, increasing government initiatives for healthcare infrastructure development, rising disposable incomes and middle-class population, and increasing prevalence of chronic diseases. However, the market also faces challenges such as limited healthcare access in remote and rural areas, inadequate healthcare funding, lack of skilled healthcare professionals, and strict regulatory policies. These factors can impact the growth of the market by influencing the development, manufacturing, and distribution of pharmaceutical products in pharmerging markets.

What are the different types of pharmaceutical products available in the pharmerging market, and what are their applications? The different types of pharmaceutical products available in the pharmerging market include branded and generic drugs, biologics, vaccines, and medical devices. These products are used to treat a wide range of diseases and conditions, including infectious diseases, cardiovascular diseases, cancer, diabetes, and respiratory diseases. Additionally, there is an increasing focus on developing innovative therapies such as gene therapy and cell therapy to address unmet medical needs in pharmerging markets. The pharmaceutical products in pharmerging markets are often priced lower than those in developed markets to make them more affordable for the local population.

What are the major distribution channels for pharmerging market products, and how are they evolving? The major distribution channels for pharmerging market products include retail pharmacies, hospitals and clinics, e-commerce platforms, and wholesalers/distributors. In recent years, there has been a shift towards online sales of pharmaceutical products in pharmerging markets, driven by increasing internet penetration and smartphone usage. E-commerce platforms are becoming popular as they provide convenient access to a wide range of pharmaceutical products at competitive prices. Additionally, the use of mobile health (mHealth) technologies for medication management and remote monitoring is also gaining traction in pharmerging markets. However, the traditional distribution channels such as retail pharmacies and hospitals/clinics still play a significant role in the distribution of pharmaceutical products in pharmerging markets, particularly in remote and rural areas with limited internet connectivity.

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Pharmerging Market is estimated to be US$ 4426.72 billion by 2030 with a CAGR of 16.5% during the forecast - EIN News

Streamline Your Workflow and Boost Productivity with the Latest Medical Transcription Software – EIN News

Medical Transcription Software Market

Medical transcription software converts digital voice recordings into text that will be used and accessed by medical professionals.

The software can help alleviate the workloads of physicians and ultimately prevent burnout. Nurses, physicians, and doctors dictate or feed voice recordings into the medical transcription solution and the solution produces text and reports that can be stored within a patients digital files.

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The global medical transcription software industry generated $1.6 billion in 2021, and is anticipated to generate $7.0 billion by 2031, witnessing a CAGR of 15.5% from 2022 to 2031.

Medical transcription software has a significant scope in hospitals and clinics applications as it can help healthcare professionals streamline their documentation processes, improve accuracy, and reduce administrative workload.

:

Improved accuracy: Medical transcription software uses advanced technologies such as natural language processing and voice recognition to ensure accurate and error-free transcription of medical records.

(254 , , , ) @ https://www.alliedmarketresearch.com/medical-transcription-software-market/purchase-options#UTM_Source=EIN-Mahendra

: The software automates the transcription process, allowing healthcare professionals to save time and focus on patient care. This can result in increased productivity and reduced administrative workload.

: Medical transcription software often comes with advanced security features such as encryption, access control, and backup and recovery options, which can ensure the security and confidentiality of patient records.

: Many medical transcription software solutions can seamlessly integrate with electronic health record (EHR) systems, making it easier for healthcare professionals to access and update patient records.

: By reducing administrative workload and increasing efficiency, medical transcription software can help hospitals and clinics save on operational costs.

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2031

Based on region, North America held the highest market share in terms of revenue in 2021, accounting for nearly two-fifths of the global medical transcription software market, and is likely to dominate the market during the forecast period. This is attributed to the surge in demand for better healthcare facilities, rise in the demand for medical transcription solution, and government reforms for the acceptance of medical transcription in the region. However, the Asia-Pacific region is expected to witness the fastest CAGR of 17.2% from 2022 to 2031. This is owing to the increase in prevalence of chronic diseases, rise in awareness related to the use of medical transcription services, and surge in healthcare expenditure.

: - 3M, Dolbey System, Inc., Global Medical Transcription, DeepScribe, Inc., Microsoft Corporation (Nuance Communication, Inc.), Amazon, Inc. (Amazon Web Services, Inc.), ZyDoc Medical Transcription, SmartMD, AQuity Solutions, iMedX.

- https://www.alliedmarketresearch.com/stem-cell-and-gene-therapy-biological-testing-market-A13443

- https://www.alliedmarketresearch.com/heart-attack-diagnostics-market-A12689

- https://www.alliedmarketresearch.com/huntington%E2%80%99s-disease-treatment-market-A17522

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Streamline Your Workflow and Boost Productivity with the Latest Medical Transcription Software - EIN News

Pediatric Vaccines Market to Surpass US$ 69,482.2 Million by 2030 … – InvestorsObserver

Pediatric Vaccines Market to Surpass US$ 69,482.2 Million by 2030, Says Coherent Market Insights (CMI)

Burlingame, April 04, 2023 (GLOBE NEWSWIRE) -- According to Coherent Market Insights, Global pediatric vaccines market is estimated to be valued at US$ 46,424.3 million in 202 3 and is expected to exhibit a CAGR of 5.9% during the forecast period (202 3 -2030 ).

Analysts Views on Global Pediatric Vaccines Market:

Government authorities in the India are focusing on conducting campaigns in order to provide vaccines to children, and this is expected to drive the growth of the market over the forecast period. For instance, on December 17, 2022, The Pune Municipal Corporation (PMC), India, held a special measles vaccination campaign in which 470 children in pune were immunized. Thus, increasing vaccination campaigns through government authorities can boost the market growth in near future.

Key Trends and Analysis of the Global Pediatric Vaccines Market :

Increasing vaccines approval for pediatric age group by regulatory authorities is expected to drive the market growth over the forecast period. For instance, on October 19, 2022, European Medicines Agency (EMA) recommended approval of Comirnaty and Spikevax COVID-19 vaccines for children of 6 months of age. EMAs human medicines committee (CHMP) has recommended extending the usage of Comirnaty and Spikevax that targets original strain of SARS-CoV-2. The Committee recommended usage of Comirnaty in children aged 6 months to 4 years and usage of Spikevax in children aged 6 months to 5 years. Comirnaty and Spikevax are already approved by EMA for being used in both adults and children aged from 5 and 6 years, respectively.

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Global Pediatric Vaccines Market - Driver s

Increasing vaccine approvals by regulatory authorities

Increasing vaccine approvals by regulatory authorities is expected to drive the Global Pediatric Vaccines Market over the forecast period. For instance, on October 15, 2021, Seqirus, a global leader in influenza prevention, and a business of CSL Limited, a biotechnology company announced that the U.S. Food and Drug Administration (FDA) has approved FLUCELVAX QUADRIVALENT (Influenza Vaccine), Seqiruss cell-based quadrivalent influenza vaccine for an expanded age indication for children of age six months old. FLUCELVAX QUADRIVALENT, the first and only cell-based influenza vaccine, in the U.S., is now indicated for everyone that is eligible to receive an influenza vaccine in the U.S.

Market players are focused on product evaluation for pipeline product

Market players are engaged in evaluating and demonstrating safety, tolerability, and immunogenicity of vaccines, and this is expected to boost overall growth of the market. For instance, in May 2020, Sanofi, a pharmaceutical and healthcare company has initiated a Phase 2 clinical trial study of pneumococcal conjugate vaccine. Objective of this study is to evaluate immunogenicity and safety of a pneumococcal conjugate vaccine when it is administered concomitantly with routine pediatric vaccines in healthy infants and toddlers.

Pediatric Vaccines Market Report Coverage

Global Pediatric Vaccines Market - Restrain t

Reoccurrence of adverse events after immunization

Although millions of children and adults are vaccinated in order to prevent the occurrence of infectious diseases, such as the Flu, measles, strep throat, COVID-19, and salmonella, several research studies have evaluated reoccurrence of some adverse events after influenza vaccination. Such adverse events are associated with the most common adverse reactions to live or attenuated influenza vaccine (LAIV) are runny nose or nasal congestion in all ages, fever >100F in children 2-6 years of age, and sore throat in adults. Reoccurrence of adverse events after immunization results in declining interest of people for booster dose of influenza vaccines. Therefore, such incidences can pose major challenges such as decreasing community acceptance for vaccines, and this is expected to negatively affect the pediatric vaccines market growth.

Global Pediatric Vaccines Market - Opportunity

I ncreasing government campaigns for immunization program in various region

The government authorities are focusing on the immunization programme in lower-income countries in order to provide healthcare services, and to control the prevalence rate of infectious diseases, and thus, this requires increased production of pediatric vaccines that is expected to create opportunities for market players in the development and production of pediatric vaccine. For instance, on October 28, 2022, the Global Alliance for Vaccines and Immunization (GAVI) announced that GAVI is working with governments, communities, in a concerted effort to rollout measles vaccines to vulnerable children across low income countries such as Angola, Liberia, and others. From 2022 through the first half of 2023, Gavi plans to support 22 lower-income countries to undertake measles follow-up campaigns, aiming to reach more than 85 million vaccinated children.

Global Pediatric Vaccines Market Cross Sectional Analysis:

In Vaccine Type, MMR Vaccine segment is dominant during forecast period in North America region due to increasing product approvals by regulatory authorities in the market, and this is expected to drive segment growth over the forecast period. For instance, on June 6, 2022, GSK PLC, a pharmaceutical company, announced that the U.S. Food and Drug Administration (FDA) has approved Priorix (Measles, Mumps and Rubella Vaccine, Live) for active immunization for the prevention of measles, mumps, and rubella (MMR) in children of 12 months of age and older. Priorix will be available in the U.S. market.

Global Pediatric Vaccines Market Segmentation:

The Global Pediatric Vaccines Market report is segmented into Vaccine Type, Technology, Type, Distribution Channel and Region

Based on Vaccine Type , the market is segmented into Pneumococcal Vaccine, DTP Vaccine, Rotavirus Vaccine, MMR Vaccine, Polio Vaccine, Influenza Vaccine, Hepatitis B Vaccine, Meningococcal Vaccine, Hib Vaccine, and Varicella Vaccine. Out of which, pneumococcal vaccine segment is expected to dominate in global pediatric vaccines market during the forecast period, due to increasing inorganic growth strategies such as collaboration by key players in the market.

Based on Technology , the market is segmented into Live or Attenuated Vaccine, Inactivated or Killed Vaccine, Toxoid Vaccine, Conjugate Vaccine, Subunit Vaccine, Recombinant Vaccine. Out of which, Subunit Vaccine segment is expected to dominate in the market over the forecast period, due to increasing launches of Subunit Vaccine is expected to increase the growth of the segment over the forecast period. For instance, in 2020, Abbott, a healthcare company launched a new inactivated quadrivalent vaccine which is subunit vaccine for influenza in India.

Based on Type , the global pediatric vaccines market is segmented into Monovalent Vaccine and Multivalent Vaccine where Multivalent Vaccine segment is expected to dominate in the market over the forecast period due to prevalence of infectious disease.

Based on Distribution Channel , the global pediatric vaccines market is segmented into Government and Private. Of which, Government segment is expected to dominant in the market over the forecast period, due to increasing vaccination campaigns by government authorities.

Among all segmentation, Vaccine Type segment is expected to dominate in the market due to increasing adoption of inorganic growth strategies such as partnership by key market players in order to expand their product portfolio. For instance, in 2021, SEQIRUS., a global influenza vaccine company, announced that the U.S. Food and Drug Administration (FDA) has granted supplemental approval of a multi-dose vial (MDV) formulation of AUDENZ (Influenza A (H5N1) Monovalent Vaccine, Adjuvant), this influenza vaccine is helps in protecting individuals of six months of age and older against influenza A (H5N1) in the event of a pandemic.

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Global Pediatric Vaccines Market : Key Developments

In June 2022, GSK plc., a U.K.-based multinational pharmaceutical and biotechnology company, announced that the U.S. FDA has approved Priorix (Measles, Mumps, and Rubella Vaccine, Live) for active immunization for the prevention of measles, mumps and rubella (MMR) in individuals of 12 months of age and older.

On June 18, 2022, the Centers for Disease Control and Prevention (CDC) has approved COVID-19 vaccination for young children of age 6 months old that means 20 million children, in the U.S., who are under 5 years are newly eligible for vaccination .

Key Market Takeaways:

Global Pediatric Vaccines Market is expected to exhibit a CAGR of 5.9% during the forecast period due to increasing effectiveness of vaccines developed by market players. For instance, in July 2021, Sanofi, a France-based multinational pharmaceutical and healthcare company, reported that its single-dose vaccine named MenQuadfi met all primary and secondary endpoints in Phase III MEQ00065 study in healthy toddlers for preventing invasive meningococcal disease (IMD), a fatal illness. The study compared the immune response against meningococcal serogroup C, and analyzed the safety of MenQuadfi in healthy toddlers aged 12 to 23 months against quadrivalent ACWY (four common types of meningococcal bacteria) vaccine, Nimenrix, and monovalent C vaccine, NeisVac-C.

Among Vaccine Type, pneumococcal vaccine segment is dominant due to increasing number of clinical trials for drug development, and this is expected to drive the segment growth over the forecast period. For instance, in April 2022, Merck & Co, Inc. initiated two Phase III studies of PCV-15 (V114), an investigational polyvalent conjugate vaccine for the prevention of pneumococcal disease.

On the basis of Distribution Channel, government segment is expected to hold a dominant position over the forecast period, owing to increasing immunization campaigns in hospital by government authorities. For instance, on June 18, 2022, the Centers for Disease Control and Prevention (CDC) announced that all children of age 6 months to 5 years of age should receive a COVID-19 vaccine. This expands eligibility for vaccination to nearly 20 million additional children, and all Americans ages 6 months and older are now eligible for vaccination. Distribution of pediatric vaccinations for these younger children has started across the U.S. country, and will be available at thousands of pediatric practices, pharmacies, Federally Qualified Health Centers, local health departments, clinics.

Competitive Landscape:

Key players operating in the Global Pediatric Vaccines Market include GlaxoSmithKline Plc., Merck & Co., Inc., Pfizer Inc., Sanofi S.A., Panacea Biotec, Zydus Cadila, Emergent BioSolutions Inc., Serum Institute of India Pvt. Ltd., Bharat Biotech, and Indian Immunologicals Ltd.

Market Segmentation:

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Pediatric Vaccines Market to Surpass US$ 69,482.2 Million by 2030 ... - InvestorsObserver

Uveal Melanoma Market is estimated to increase with a CAGR of 7.8% during the forecast period-By PMI – EIN News

Uveal Melanoma Market-By PMI

The report "Uveal Melanoma Market, By Diagnosis, By Therapy, By End-User, and By Region - Market Trends, Analysis, and Forecast till 2030

The report "Uveal Melanoma Market, By Diagnosis (Ultrasonography, Indocyanine green angiography, High resolution ultrasound Biomicroscopy and Others), By Therapy (Radiation therapy, Surgical resection techniques, Transpupillary thermotherapy and Others), By End-User (Hospital, Ambulatory surgical centers, Ophthalmology clinics and Others), and By Region (North America, Europe, Asia Pacific, Latin America, and Middle East & Africa) - Market Trends, Analysis, and Forecast till 2030

Key Highlights: Immunocore Limited and Eli Lilly and Company announced on June 29, 2015 that they have formed an immunotherapy-based clinical trial partnership to test the efficacy of Immunocore's lead T cell receptor-based research therapeutic, IMCgp100, in combination with Lilly's galunisertib (LY2157299) and merestinib for the treatment of melanoma (LY2801653). In June 2018, Aura Biosciences, a biotechnology company focused on developing therapies that use viral capsid conjugates to target and selectively destroy cancer cells, released interim safety and efficacy data from an open-label Phase 1b/2 study of AU-011 for the treatment of primary choroidal melanoma.

Analyst View: The global market for uveal melanoma treatment is being driven by an increase in the number of cases of eye cancer. One of the key causes of the growth is assumed to be the rise in the use of technological devices. This could be linked to the harmful UV radiation emitted by cellphones, tablets, desktops, laptops, and other electronic devices. According to the American Cancer Society, adults aged 60 and up spend 5 or more hours each day on digital devices and prefer laptops and desktops for internet browsing. As a result, the uveal melanoma treatment market is expected to grow.

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Scope of the Report: 1.Market Preview >Executive Summary >Key FindingsGlobal Outlook for Uveal Melanoma Strategies Key Questions this Study will Answer Market Snippet, By Diagnosis Market Snippet, By Therapy Market Snippet, By End-User Market Snippet, By Region >Opportunity Map Analysis >Executive Summary3 Big Predictions 2.Market Dynamics, Regulations, and Trends Analysis >Market Dynamics Drivers Restraints Market Opportunities Market Trends >DR Impact Analysis >PEST Analysis >Porters Five Forces Analysis >Opportunity Orbit >Market Investment Feasibility Index >Macroeconomic Factor Analysis 3.Global Uveal Melanoma Market, By Diagnosis, 2020 2030, (US$ Mn) >Overview Market Value and Forecast (US$ Mn), and Share Analysis (%), 2020 2030 Y-o-Y Growth Analysis (%), 2020 2030 Segment Trends >Ultrasonography Overview Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2020 2030 >Indocyanine green angiography Overview Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2020 2030 >High resolution ultrasound Biomicroscopy Overview Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2020 2030 >Others Overview Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2020 2030

6.Global Uveal Melanoma Market, By Therapy, 2020 2030, (US$ Mn) >Overview Market Value and Forecast (US$ Mn), and Share Analysis (%), 2020 2030 Y-o-Y Growth Analysis (%), 2020 2030 Segment Trends >Radiation therapy Overview Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2020 2030 >Surgical resection techniques Overview Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2020 2030 >Transpupillary thermotherapy Overview Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2020 2030 7.Global Uveal Melanoma Market, By End-User, 2020 2030, (US$ Mn) >Overview Market Value and Forecast (US$ Mn), and Share Analysis (%), 2020 2030 Y-o-Y Growth Analysis (%), 2020 2030 Segment Trends >Hospitals Overview Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2020 2030 >Ambulatory surgical centers Overview Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2020 2030 >Ophthalmology Clinics Overview Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2020 2030 >Others Overview Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2020 2030

Key Market Insights from the report: The Global Uveal Melanoma market is anticipated to register a CAGR of 7.8%. The Global Uvea Melanoma Market is segmented based on the diagnosis, therapy, end-user, and region. By Diagnosis, the Global Uveal Melanoma Market is segmented into Ultrasonography, Indocyanine green angiography, High resolution ultrasound Biomicroscopy and Others. By Therapy, the market is segmented in Radiation therapy, Surgical resection techniques, Transpupillary thermotherapy and Others. By End-User, the Global Uveal Melanoma Market is segmented into Hospital, Ambulatory surgical centers, Ophthalmology clinics and Others. By Region, the Global Uveal Melanoma Market is segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America holds the largest Uveal Melanoma Market share.

Competitive Landscape: Eli Lilly &Co Novartis AG Bayer AstraZeneca Amgen Pfizer Inc Roche Spectrum pharmaceuticals Many companies in the uveal melanoma treatment industry are attempting to expand their product offerings. However, the most effective way to increase the number of customers is to market the goods through internet portals. The market provides detailed information regarding the industrial base, productivity, strengths, manufacturers, and recent trends which will help companies enlarge the businesses and promote financial growth. Furthermore, the report exhibits dynamic factors including segments, sub-segments, regional marketplaces, competition, dominant key players, and market forecasts. In addition, the market includes recent collaborations, mergers, acquisitions, and partnerships along with regulatory frameworks across different regions impacting the market trajectory. Recent technological advances and innovations influencing the global market are included in the report.

Some Important Points Answered in this Market Report Are Given Below: Explains an overview of the product portfolio, including product development, planning, and positioning. Explains details about key operational strategies with a focus on R&D strategies, corporate structure, localization strategies, production capabilities, and financial performance of various companies. Detailed analysis of the market revenue over the forecasted period. Examining various outlooks of the market with the help of Porters five forces analysis, PEST & SWOT Analysis. Study on the segments that are anticipated to dominate the market. Study on the regional analysis that is expected to register the highest growth over the forecast period.

Questions answered by Uveal Melanoma Market: What are the major factors driving the growth of the uveal melanoma market? The major factors driving the growth of the uveal melanoma market include increasing incidence of the disease, rising awareness and early detection, advancements in diagnostic techniques, and development of new therapies for the treatment of uveal melanoma. Additionally, the growing research on the disease biology and genetics is expected to lead to the development of more targeted and effective therapies for uveal melanoma in the future.

What are the implications of changes in healthcare policy and reimbursement for the uveal melanoma market? Changes in healthcare policy and reimbursement can have significant implications for the uveal melanoma market. These changes can impact the availability and affordability of treatments for patients, as well as the profitability of companies that develop and market these treatments. For example, changes in reimbursement policies may impact the pricing and access to therapies, and may also influence the development of new treatments. Additionally, changes in healthcare policy may impact the funding of research and development efforts related to uveal melanoma.

What are the key trends in the uveal melanoma market, such as new technologies and treatment approaches? The key trends in the uveal melanoma market include the development of new targeted therapies and immunotherapies, advancements in diagnostic techniques, and the increasing focus on personalized medicine approaches. Additionally, there is growing interest in the use of combination therapies and the development of biomarkers to help predict patient response to treatment. Emerging technologies such as gene therapy, RNA interference, and nanotechnology are also being explored as potential treatments for uveal melanoma.

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Uveal Melanoma Market is estimated to increase with a CAGR of 7.8% during the forecast period-By PMI - EIN News

Medical Tubing Market Research Report 2022 | Analysis, Trends, Business Growth and Forecast 2027 – EIN News

Medical Tubing Market Research Report

The global medical tubing market size reached US$ 11.72 Billion in 2021. By 2027, it will reach a value of US$ 18.18 Billion, growing at 7.30% (2022-2027).

Medical tubing refers to flexible, thin, plastic hoses that meet medical industry standards and requirements for a variety of surgical or pharmaceutical applications. It comprises tubes of various lengths and diameters integrated with catheters, peristaltic pumps, anesthesiology, respiratory equipment, intravenous (IV) therapy, and numerous biopharmaceutical laboratory equipment. It also consists of feeding tubes, which are essential for supplying nutrients to people who cannot get enough nutrition by eating or suffering from neurologic and neuromuscular disorders. Medical tubing is manufactured from polyethylene, polyvinyl chloride (PVC), and polypropylene plastic and is often softened with plasticizers to increase flexibility. It helps drain and collect urine from the bladder, monitor the urine output of patients, diagnose disorders in the lower urinary tract, and introduce various medications into the body. Medical tubing also assists in stenting or decompressing the small intestine to reduce pressure and address adhesion in affected areas and treat small bowel obstruction. It is utilized to drive catheters in cardiac catheterization and test for heart diseases and locate narrowing blood vessels. It is also used for measuring pressure and oxygen levels in different parts of the heart, checking pump functions, and diagnosing congenital heart defects. Furthermore, as it allows clinicians to administer fluid and other devices, the demand for medical tubing is increasing around the world.

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Medical Tubing Market Trends and Drivers:

At present, the rising demand for medical tubing as it is safe, reliable, and temperature resistant represents one of the primary factors influencing the market positively. Besides this, the increasing occurrence of various chronic disorders requiring detailed surgeries and treatment methods, along with the growing geriatric population across the globe, is offering a favorable market outlook.

In addition, the rising occurrence of respiratory diseases and cardiovascular complications caused by excessive smoking habits and breathing polluted air is propelling the growth of the market. Apart from this, increasing rates of hospitalization due to the rising occurrence of various novel viruses causing contagious diseases is contributing to the growth of the market. Additionally, there is a rise in the number of hospitals, clinics, and nursing homes worldwide providing quality healthcare services to patients.

This, coupled with the increasing advancement in improving diagnosis and treatment procedures for various life-threatening conditions, is supporting the growth of the market. Moreover, the rising utilization of medical tubing in the treatment of various forms of cancer, such as breast, prostate, cervical, lung, blood, and brain, is strengthening the growth of the market. Furthermore, the increasing usage of nano-medical tubes in advanced drug delivery systems, such as intracochlear and photo-thermally triggered drug delivery, is bolstering the growth of the market.

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Global Medical Tubing Market 2022-2027 Analysis and Segmentation:

Competitive Landscape:

The competitive landscape of the market has been studied in the report with the detailed profiles of the key players operating in the market.

Medical Tubing Companies:

ATAG spa, Avient Corporation, Bentec Medical, Hitachi Ltd., Microlumen Inc., NewAge Industries Inc., Nordson Corporation, Optinova, Spectrum Plastics Group, TE Connectivity Ltd., Trelleborg AB and Vanguard Products Corporation.

The report has segmented the market on the basis of region, product, structure, application and end user.

Breakup by Product: Silicone Polyolefins Polyvinyl Chloride Polycarbonates Fluoropolymers Others

Breakup by Structure: Single-Lumen Co-Extruded Multi-Lumen Tapered or Bump Tubing Braided Tubing

Breakup by Application: Bulk Disposable Tubing Drug Delivery Systems Catheters Biopharmaceutical Laboratory Equipment Others

Breakup by End User: Hospitals and Clinics Ambulatory Surgical Centers Medical Labs Others

Breakup by Region: North America: (United States, Canada) Asia Pacific: (China, Japan, India, South Korea, Australia, Indonesia, Others) Europe: (Germany, France, United Kingdom, Italy, Spain, Russia, Others) Latin America: (Brazil, Mexico, Others) Middle East and Africa

If you want latest primary and secondary data (2022-2027) with Cost Module, Business Strategy, Distribution Channel, etc. Click request free sample report, published report will be delivered to you in PDF format via email within 24 to 48 hours of receiving full payment.

Key highlights of the report: Market Performance (2016-2021) Market Outlook (2022- 2027) Porters Five Forces Analysis Market Drivers and Success Factors SWOT Analysis Value Chain Comprehensive Mapping of the Competitive Landscape

If you need specific information that is not currently within the scope of the report, we can provide it to you as a part of the customization.

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Medical Tubing Market Research Report 2022 | Analysis, Trends, Business Growth and Forecast 2027 - EIN News