Sobi will file for a re-examination of emapalumab in Europe following negative opinion by CHMP | Antibodies | News Channels – PipelineReview.com

Details Category: Antibodies Published on Friday, 24 July 2020 14:39 Hits: 93

STOCKHOLM, Sweden I July 24, 2020 I Swedish Orphan Biovitrum AB (publ) (Sobi) (STO:SOBI) today announced that the Committee for Medicinal Products for Human use (CHMP) has adopted a negative opinion recommending a refusal of the marketing authorisation for emapalumab for the treatment of primary haemophagocytic lymphohistiocytosis (HLH) in children under 18 years of age in Europe. Given the significant unmet medical need that emapalumab addresses in patients with primary HLH with no approved treatments in Europe, Sobi will be requesting a re-examination by the CHMP with an expected opinion by end of year 2020.

Primary HLH is a rare syndrome that typically presents in infancy but can also be seen in adults and is associated with high morbidity and mortality. In spite of some treatment advances, there continues to be a very high unmet medical need in particular in patients that have failed conventional therapy as there are no approved treatment options outside the US. In the US, emapalumab is the first therapy approved by the US Food & Drug Administration (FDA) for primary HLH. Over 100 patients have been treated in the US and the benefit/risk profile continues to be favourable.

Emapalumab has demonstrated a positive benefit/risk profile in primary HLH in a post-approval real life setting in the US since the FDA approval in 2018. The product has been able to make a substantial difference for a very vulnerable group of patients in the US. We are proud of having made a significant contribution with our product in the primary HLH indication and we are gratified by the recent academic validation of our work via publication in the New England Journal of Medicine. During the last years our team has gained a lot of experience in this rather complex disease area. We will do our utmost to share these insights and address the open questions by CHMP during the re-examination with a view to secure access for primary HLH in children to this treatment in Europe, says Guido Oelkers, CEO and President of Sobi.

HLH is a rare disease but with a large unmet medical need globally. The most important markets based on number of patients for both primary and secondary HLH are China followed by the US, Europe and Japan. In addition to HLH, Sobi will initiate clinical studies with emapalumab for potential indications such as pre-emptive treatment of patients with risk factors of HSCT acute graft failure which will further expand the patient population and market potential for emapalumab. Sobis earlier communicated estimated peak sales target for emapalumab beyond USD 500 million remains unchanged regardless of an approval in Europe.

Professor Franco Locatelli, Principal Investigator in the EU says In my role as Principal Investigator of the NI-0501-04/05 studies in Europe I was significantly surprised about the EMA decision not to approve emapalumab for children with primary HLH who failed or are intolerant to front-line therapy. I had the privilege to observe that this monoclonal antibody, targeting the main cytokine involved in the disease pathophysiology, was well tolerated and effective in a large proportion of the patients, representing a model of precision medicine. While US children have since almost 2 years the possibility to be treated with this novel, safe, highly effective and targeted therapy, the EMA decision paves the way for migratory health flows towards non-European Centers that can grant this treatment.

Professor Michael Jordan, Principal Investigator in the US confirms The NI-0501-04/05 studies have demonstrated that emapalumab has clear therapeutic activity in primary HLH and have validated interferon gamma as a key target in these patients. These studies have also demonstrated that this unique and targeted approach to therapy has a very favorable safety profile. I am grateful for the opportunity to help lead these trials which were conducted with the greatest rigor and transparency, far exceeding that of any trial to date in this very challenging patient population. The worldwide team of collaborators, including physicians at many centers in the US and Europe, as well as individuals at Sobi, should be proud of this ground-breaking achievement. I believe that emapalumab will benefit patients around the world with HLH, especially as we continue to learn how to best apply this unique drug in patients with HLH.

Recently, the results from the pivotal study evaluating the efficacy and safety of emapalumab in patients with primary HLH were published in one of the highest-ranking medical journals, New England Journal of Medicine.

About emapalumab Emapalumab is a monoclonal antibody that binds to and neutralises interferon gamma (IFN). In the US, emapalumab is indicated for paediatric (newborn and older) and adult primary haemophagocytic lymphohistiocytosis (HLH) patients with refractory, recurrent or progressive disease, or intolerance to conventional HLH therapy. Emapalumab is the first and only medicine approved in the US for primary HLH, a rare syndrome of hyperinflammation that usually occurs within the first year of life and can rapidly become fatal unless diagnosed and treated. The FDA approval is based on data from the phase 2/3 studies (NCT01818492 and NCT02069899). Emapalumab is indicated for administration through intravenous infusion over one hour twice per week until haematopoietic stem cell transplantation (HSCT). For more information please see http://www.gamifant.com including the full US Prescribing Information.

About SobiTM Sobi is a specialised international biopharmaceutical company transforming the lives of people with rare diseases. Sobi is providing sustainable access to innovative therapies in the areas of haematology, immunology and specialty indications. Today, Sobi employs approximately 1,400 people across Europe, North America, the Middle East, Russia and North Africa. In 2019, Sobis revenues amounted to SEK 14.2 billion. Sobis share (STO:SOBI) is listed on Nasdaq Stockholm. You can find more information about Sobi at http://www.sobi.com.

SOURCE: Sobi

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Sobi will file for a re-examination of emapalumab in Europe following negative opinion by CHMP | Antibodies | News Channels - PipelineReview.com

Cannabis Can Relieve the Pain Associated With Sickle Cell Anemia Study Shows – Gilmore Health News

Cannabis is evolving into an effective treatment to relieve chronic pain in people with sickle cell anemia.

Sickle cell disease affects 400,000 births per year worldwide and affects approximately 100,000 Americans. This hereditary genetic disease of the blood materializes through a mutation in our DNA that causes our body to produce abnormal hemoglobin that deforms red blood cells, making them more rigid and more fragile. There is currently no treatment that can cure it, although bone marrow transplants and gene therapy offer hope.

Cannabis

Read Also: Doctors Investigate CRISPR Gene-Editing for Treatment of Sickle Cell Disease

Researchers at the University of California at San Francisco have found that cannabis can relieve patients of the chronic pain caused by sickle cell anemia. These test results show that inhaled cannabis seems generally safe, said Kalpna Gupta, a professor at the University of California at San Francisco, who co-directed the study. They also suggest that patients with sickle cell anemia may be able to ease their pain with cannabis. The results of this study were published in the Jama Network Open magazine. Currently, the main treatments for pain relief in patients are based on opiates. The increase in deaths related to the excessive use of opiates has led doctors to prescribe opiates less frequently, leaving sickle cell patients with fewer options. Cannabis could help society cope with the public health crisis caused by opioids, says Kalpna Gupta.

Read Also: Drug Addiction: Overcoming Dependencies and Avoiding Overdoses

The results have shown that the effectiveness of cannabis increases over time to reduce the pain of sickle cell anemia patients. They described having less pain while walking and better sleep. There was also a statistically significant decrease in pain that affected their state of mind. The researchers did so in a randomized, double-blind, placebo-controlled trial. This is the first study to use this method to assess the potential for pain relief from cannabis in people with sickle cell anemia. The cannabis used in the experiment contained equal amounts of THC and CBD, the plants two active ingredients. Twenty-three patients suffering from pain took cannabis or placebo during two five-day hospital stays at least 30 days apart.

Read Also: A New Class of Painkillers Could Target Neurons in the Amygdala

This study offers doctors an additional option for the treatment of chronic pain. We still need larger studies with more participants to get a better picture of how cannabis can benefit people with chronic pain, the researcher said. The results showed the effect of cannabis taken in vaporized form without other ways of using the plant being identified as effective. The pain leads many people to resort to cannabis and is in fact the main reason people give for looking for cannabis in clinics. We do not know if all forms of cannabis products will have a similar effect on chronic pain. The inhaled cannabis we have used may be safer than other forms because smaller amounts enter the bodys circulation. This study opens the door to testing different forms of medicinal cannabis for the treatment of chronic pain, concluded Kalpna Gupta.

Read Also: Use of Cannabis Edibles Comes With Risks, Doctors Warn

Effect of Inhaled Cannabis for Pain in Adults With Sickle Cell Disease: A Randomized Clinical Trial

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Global Medical Transcription Market Impact of COVID-19 Outbreak on Business Opportunities and Future Scope till 2027|iMedX, Inc., Global Medical…

Medical transcription marketis expected to gain market growth in the forecast period of 2020 to 2027. Data Bridge Market Research analyses the market growing at a CAGR of 6.0% in the above-mentioned forecast period.

A thorough market study and investigation of trends in consumer and supply chain dynamics covered in this report helps businesses draw the strategies about sales, marketing, and promotion. Besides, market research performed in this medical transcription report puts a light on the challenges, market structures, opportunities, driving forces, and competitive landscape for your business. It assists in obtaining an extreme sense of evolving industry movements before competitors. If you are willing to gain competitive advantage in this swiftly transforming marketplace, then opting for such market research report is highly suggested as it gives a lot of benefits for a thriving business.

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The major players covered in the medical transcription market report are Acusis LLC, Transcend Services, Nuance Communications, Inc., MModal LLC, iMedX, Inc., Global Medical Transcription LLC, nThrive, Inc., MTBC, Inc., Medi-Script Plus, TransTech Medical Solutions LLC, among other domestic and global players. Market share data is available for global, North America, Europe, Asia-Pacific (APAC), Middle East and Africa (MEA) and South America separately. DBMR analysts understand competitive strengths and provide competitive analysis for each competitor separately.

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Whats Driving The Global Medical Transcription Market ??

The rising pervasiveness of different persistent disorders, such as melanoma, cardiovascular, and, diabetes disorders, has constantly influenced an augmentation in the number of medicinal documents produced in clinics.

The burgeoning information amidst businesses regarding the compensations of electronic health records in maintaining data is possessing an assertive influence on the market crosswise the planet. Apart from this, companies have begun accepting the most advanced technologies, such as, instant report formatting, audio identification, and ADT normalization, that can convert the translation of voice-based documents into text-based automated data. Certain techniques benefit in diminishing the time needed for transcription and heighten the overall precision.

The advanced organizations have launched superior encryption technologies which will act as the opportunity for market growth.

Market Restraints:

With the accumulating uncertainty of administration or fraud of medicinal information acts as the restraint for the market growth.

Table of Contents:

1. Introduction 2. Market Segmentation 3. Market Overview 4. Executive Summary 5. Premium Insights 6. By Component 7. Product Type 8. Delivery 9. Industry Type 10. Geography 10.1. Overview 10.2. North America 10.3. Europe 10.4. Asia-Pacific 10.5. South America 10.6. Middle East & Africa 11. Company Landscape 12. Company Profiles 13. Related Reports

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Segmentation:Global Medical Transcription Market

Medical transcription market is segmented on the basis of services type, technology, mode of procurement and end user. The growth amongst these segments will help you analyse meagre growth segments in the industries, and provide the users with valuable market overview and market insights to help them in making strategic decisions for identification of core market applications.

Medical transcription market is segmented on the basis of services type into history and physical report, discharge summary, operative note or report, consultation report, pathology report, radiology report, and others. Medical transcription market is segmented on the basis of technology into electronic medical records/electronic health record (EMR/EHR), picture archiving and communication system (PACS), radiology information system (RIS), speech recognition technology (SRT), and others.

Medical transcription market is segmented on the basis of mode of procurement into outsourcing, offshoring, and both.

Medical transcription market is segmented on the basis of end user into hospitals, clinics, clinical laboratories, academic medical centers, and others.

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Impact of COVID-19 on Stem Cell Media Market Latest trending report is booming globally by Top Leading Players Thermo Fisher, STEMCELL Technologies,…

Note: Due to the pandemic, we have included a special section on the Impact of COVID 19 on the Stem Cell MediaMarket which would mention How the Covid-19 is Affecting the Industry, Market Trends and Potential Opportunities in the COVID-19 Landscape, Key Regions and Proposal for Stem Cell Media Market Players to battle Covid-19 Impact.

The Stem Cell MediaMarket report is compilation of intelligent, broad research studies that will help players and stakeholders to make informed business decisions in future. It offers detailed research and analysis of key aspects of the Stem Cell Media market. Readers will be able to gain deeper understanding of the competitive landscape and its future scenarios, crucial dynamics, and leading segments of the global Stem Cell Media market. Buyers of the report will have access to accurate PESTLE, SWOT and other types of analysis on the global Stem Cell Media market. Moreover, it offers highly accurate estimations on the CAGR, market share, and market size of key regions and countries. Players can use this study to explore untapped Stem Cell Media markets to extend their reach and create sales opportunities.

The study encompasses profiles of major Companies/Manufacturers operating in the global Stem Cell Media Market.Key players profiled in the report include:Thermo Fisher, STEMCELL Technologies, Merck Millipore, Lonza, GE Healthcare, Miltenyi Biotec, Corning, CellGenix, Takara, PromoCell and More

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Market Segment By Type: Pluripotent Stem Cell Culture Hematopoietic Stem Cell Culture Mesenchymal Stem Cell Culture Others

Market Segment By Application: Scientific Research Industrial Production

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The authors of the report have analyzed both developing and developed regions considered for the research and analysis of the global Stem Cell Media market. The regional analysis section of the report provides an extensive research study on different regional and country-wise Stem Cell Media industry to help players plan effective expansion strategies.

Regions Covered in the Global Stem Cell Media Market: The Middle East and Africa (GCC Countries and Egypt) North America (the United States, Mexico, and Canada) South America (Brazil etc.) Europe (Turkey, Germany, Russia UK, Italy, France, etc.) Asia-Pacific (Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia)

Years Considered to Estimate the Market Size: History Year: 2015-2019 Base Year: 2019 Estimated Year: 2020 Forecast Year: 2020-2026

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Impact of COVID-19 on Stem Cell Media Market Latest trending report is booming globally by Top Leading Players Thermo Fisher, STEMCELL Technologies,...

Stem Cell Umbilical Cord Blood Market Key Players, Industry Overview, Application and Analysis to 2020-2026 – CueReport

The Global Stem Cell Umbilical Cord Blood market report offers key information about the industry, helpful and important facts and figures, expert opinions, and the latest developments across the world. The research report represents a comprehensive presumption of the market and encloses imperative future estimations, industry-authenticated figures, and facts of the global market. It predicts inclinations and augmentation statistics with emphasis on abilities & technologies, markets & industries along with the variable market trends. The Stem Cell Umbilical Cord Blood market report analyses and notifies the industry statistics at the global as well as regional and country levels to acquire a thorough perspective of the entire Stem Cell Umbilical Cord Blood market.

The Stem Cell Umbilical Cord Blood market report intends to offer significant information of this business space while elaborating on the key global trends. The document emphasizes on the growth opportunities as well as the drivers that will influence the profitability graph of this business vertical over the estimated timeframe. It also measures the challenges & restraints that may inhibit the expansion of the market.

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The research repot delivers a comparative statement regarding the existing and predicted market scenario to derive the growth rate of this industry vertical over the study duration. Additionally, it measures the effect of COVID-19 outbreak on the regional as well as overall market to denote the methodologies that can help in decision making.

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Major details from Table of Contents:

Product landscape

Application scope

Regional Analysis

Competitive arena

In short, the Stem Cell Umbilical Cord Blood market provides a granular assessment through numerous segmentations, while evaluating the other aspects including sales channel and supply chain processes which consist of downstream buyers, upstream suppliers, and distributors of this business space.

Key Answers Captured in Study Objectives are

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Stem Cell Umbilical Cord Blood Market Key Players, Industry Overview, Application and Analysis to 2020-2026 - CueReport

Biologics Safety Testing Market 10-Year Market Forecast and Trends Analysis Research Report 2019-2029 – Jewish Life News

Changing landscape of healthcare markets around the world have propelled the need for having a deep understanding before measuring the future of pharmaceutical manufacturing procedures such as biologics safety testing. Designing these genetically-engineered proteins called biologics, which are derived from human genes, involves a series of testing procedures to weigh their safety in treatment of various disorders, and their inclusion in production of drugs and medicine. XploreMR has developed a market study, titled Biologics Safety Testing Market: Global Industry Analysis (2012-2016), and Forecast (2017-2022), which offers insights on the foreseeable future of global market for biologics safety testing. The report has analyzed key trends influencing the dynamics ofbiologics safety testing market, delivering global market size valuations over a five-year historical period. These assessments have been redirected as primary reference to construe estimations on the global biologics safety testing market for the forecast period, 2017-2022.

Report Synopsis

The first section in the report offers an executive summary, wherein the analyzed and anticipated expansion of global biologics safety testing market across various regions has been highlighted. The report offers a comprehensive overview of the market, which includes a formal introduction to the global biologics safety testing market, and a standard definition on biologics safety testing. This section offers market size estimations in metrics such as compounded annual growth rates (CAGRs) and Year-on-Year (Y-o-Y) growth rates.

The report further delivers an analysis on industry trends, cost structure, pricing, and supply chain. Factors impacting the growth of biologics safety testing market have also been analyzed, and the report also delivers an illustrative intensity map that plots the presence of market participants across all regions.

Key chapters in the report offer a segmented analysis and forecast on the global biologics safety testing market. The global market for biologics safety testing has been segmented on the basis of product-type, test-type, application, and region. These sections also provide cross-segmental data and country-wise market analysis & forecast. The report concludes by profiling key market players in detail. This section reveals the overall competitive landscape of the global biologics safety testing market, tracking all notable developments of companies and disclosing their current market standings.

Market Taxonomy

A concise taxonomy on the global market for biologics safety testing has been summarized in the table below:

Region

Product Type

Test Type

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Application

North America

Kits & Reagents

Endotoxin Tests

Vaccine and Therapeutics Development

Latin America

Instruments

Sterility Tests

Blood and Blood-related Products Testing

Europe

Services

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Cell Line Authentication and Characterization Tests

Cellular and Gene Therapy

Japan

Residual Host Contamination Detection Tests

Tissue and Tissue-related Products Testing

APEJ

Adventitious Agent Detection Tests

Stem Cell Research

MEA

Bioburden Tests

Other Tests

Research Methodology

Our research methodology is underpinned by robust methodical approaches adopted by our analysts. Firstly, data on revenues of market participants is procured by secondary and primary resources, which include authoritative databases. This data is aggregated to generate market size estimations for the past five years. Quantitative data is further infused with qualitative insights to offer an assorted assessment on the future of biologics safety testing. Market size estimations have been quantified in US dollars (US$) by converting regional market evaluations with 2017 currency exchange rates. The report has also enlisted key mergers & acquisitions encompassing the global biologics safety testing market, underlining the strategic undertakings of market players towards product development and long-term remunerative gains. The scope of the report is to enable companies boost their presence in the overall biologics safety testing market by taking informed decisions. Research findings and market forecasts availed in this report can be used as guidelines for developing strategic goals in future market direction.

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About Us

XploreMR, a leading market research firm, headquartered in San Jose, USA, XploreMR has, in a short span of time, served the market research needs of some of the biggest Fortune 500 companies. XploreMR also has highly personalized market research offerings for SMEs, and we pride ourselves on being uniquely positioned to have worked with colossal multinational firms and small, boutique firms. Our experience of working with such a diverse set from all over the world has given us invaluable perspectives on objectives, outlooks, goals, and eventually, the collective, symbiotic growth that stakeholders across the value chain aspire for. We keep these perspectives and aspirations in mind every time we work on a project, and this motivates us to exceed client expectations on a consistent basis.

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Biologics Safety Testing Market 10-Year Market Forecast and Trends Analysis Research Report 2019-2029 - Jewish Life News

Stem Cell Therapy for Osteoarthritis Market: Global Growth Manufacturers, Regions, Product Types, Major Application Analysis & Forecast to 2026 -…

The Global Stem Cell Therapy for Osteoarthritis market report offers key information about the industry, helpful and important facts and figures, expert opinions, and the latest developments across the world. The research report represents a comprehensive presumption of the market and encloses imperative future estimations, industry-authenticated figures, and facts of the global market. It predicts inclinations and augmentation statistics with emphasis on abilities & technologies, markets & industries along with the variable market trends. The Stem Cell Therapy for Osteoarthritis market report analyses and notifies the industry statistics at the global as well as regional and country levels to acquire a thorough perspective of the entire Stem Cell Therapy for Osteoarthritis market.

The Stem Cell Therapy for Osteoarthritis market report intends to offer significant information of this business space while elaborating on the key global trends. The document emphasizes on the growth opportunities as well as the drivers that will influence the profitability graph of this business vertical over the estimated timeframe. It also measures the challenges & restraints that may inhibit the expansion of the market.

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The research repot delivers a comparative statement regarding the existing and predicted market scenario to derive the growth rate of this industry vertical over the study duration. Additionally, it measures the effect of COVID-19 outbreak on the regional as well as overall market to denote the methodologies that can help in decision making.

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Major details from Table of Contents:

Product landscape

Application scope

Regional Analysis

Competitive arena

In short, the Stem Cell Therapy for Osteoarthritis market provides a granular assessment through numerous segmentations, while evaluating the other aspects including sales channel and supply chain processes which consist of downstream buyers, upstream suppliers, and distributors of this business space.

Key Answers Captured in Study Objectives are

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Stem Cell Therapy for Osteoarthritis Market: Global Growth Manufacturers, Regions, Product Types, Major Application Analysis & Forecast to 2026 -...

Hunter Syndrome Treatment Market 2020 Recent Industry Developments and Growth Strategies Adopted by Top Key Players Worldwide and Assessment to 2024 -…

The newly added market research report by Report Ocean on Hunter Syndrome Treatment Market helps in understanding Hunter Syndrome Treatment Market dynamics, structure by identifying and analyzing the market segments and project the global market size. Further, the report also focuses on the competitive analysis of key players by product, price, financial position, product portfolio, growth strategies, and regional presence.

The objective of the report is to present a comprehensive assessment of the market and contains thoughtful insights, facts, historical data, industry-validated market data and projections with a suitable set of assumptions and methodology. The report also provides PEST analysis, PORTERs analysis, SWOT analysis to address questions of shareholders to prioritizing the efforts and investment in the near future to the emerging segment in the Hunter Syndrome Treatment Market.

COVID- 19 Impact on Hunter Syndrome Treatment Market

As companies move from reacting to mitigating the impact of the COVID-19 outbreak, they are keenly focusing on strategies that may result in emerging as strong market player. This market research report included the detailed study related to impact of COVID-19 on the supply chain based on both downstream and upstream markets. The report also includes the future development in the Hunter Syndrome Treatment Market in relation with the impact of COVID-19 on the market.

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Competitive Landscape:

This section of the report has mainly focused on Key Strategies adopted by leading players in Hunter Syndrome Treatment Market. These companies are selected based on revenue, innovations, strength of product portfolio, regional presence, investment capacity and similar other factors.

Takeda GC Pharma. JCR Pharmaceuticals Co Ltd. RegenxBio Inc. Sangamo Therapeutics, Inc. ArmaGen Inc. Inventiva S.A. Denali Therapeutics Inc. Bioasis Technologies Inc. Esteve

Market Segmentation:

The segmentation is used to decide the target market into smaller sections or segments like product type, application, and geographical regions to optimize marketing strategies, advertising technique and global as well as regional sales efforts of Hunter Syndrome Treatment Market.

Product Type Segmentation Enzyme Replacement Therapy (ERT) Hematopoietic Stem Cell Transplant (HSCT)

Industry Segmentation Life Science Companies Research Institutes Hospital

Channel (Direct Sales, Distributor) Segmentation

Region Segmentation:

Each region is exhaustively researched about so that players can use the analysis to tap into unexplored markets and plan powerful strategies to gain a foothold in Hunter Syndrome Treatment Market. The regional analysis section of the report offers an extensive analysis of the Hunter Syndrome Treatment Market based on region. The Hunter Syndrome Treatment Market will showcase a steady CAGR in the forecast year.

North America Country (United States, Canada)

South America

Asia Country (China, Japan, India, Korea)

Europe Country (Germany, UK, France, Italy)

Other Country (Middle East, Africa, GCC)

Table of Contents of Hunter Syndrome Treatment Market

Report Overview: This section of report includes major players of the Hunter Syndrome Treatment Market covered in the research study, research scope, and Market segments by type, market segments by application, years considered for the research study, and objectives of the report.

Global Growth Trends: This section focuses on industry trends where market drivers and top market trends are shed light upon. It also provides growth rates of key producers operating in the Hunter Syndrome Treatment Market Furthermore, it offers production and capacity analysis where marketing pricing trends, capacity, production, and production value of the Hunter Syndrome Treatment Market are discussed.

Market Share by Manufacturers: Here, the report provides details about revenue by manufacturers, production and capacity by manufacturers, price by manufacturers, expansion plans, mergers and acquisitions, and products, market entry dates, distribution, and market areas of key manufacturers.

Market Size by Type: This section concentrates on product type segments where production value market share, price, and production market share by product type are discussed.

Market Size by Application: Besides an overview of the Hunter Syndrome Treatment Market by application, it gives a study on the consumption in the Hunter Syndrome Treatment Market by application.

Production by Region: Here, the production value growth rate, production growth rate, import and export, and key players of each regional market are provided.

Consumption by Region: This section provides information on the consumption in each regional market studied in the report. The consumption is discussed based on country, application, and product type.

Company Profiles: Almost all leading players of the Hunter Syndrome Treatment Market are profiled in this section. The analysts have provided information about their recent developments in the Hunter Syndrome Treatment Market, products, revenue, production, business, and company.

Market Forecast by Production: The production and production value forecasts included in this section are for the Hunter Syndrome Treatment Market as well as for key regional markets.

Market Forecast by Consumption: The consumption and consumption value forecasts included in this section are for the Hunter Syndrome Treatment Market as well as for key regional markets.

Value Chain and Sales Analysis: It deeply analyzes customers, distributors, sales channels, and value chain of the Hunter Syndrome Treatment Market.

Key Findings: This section gives a quick look at important findings of the research study.

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Study finds the real reason you get goosebumps – Big Think

Everybody gets goosebumps, but have you ever wondered why? Until now, the leading hypothesis was that by elevating hair-follicles on the skin, goosebumps helped keep the body warm by providing more space for warm air to be collect near the body. However, many scientists have puzzled over this explanation, as the lack of body hair on modern humans leaves us with the ability to have goose skin but without the ability to benefit from it.

Evolutionarily, that makes little sense, if it really was that useless we'd expect more than a few people to not have the ability to get them by now.

A new study published in Cell suggests a different reason for this reaction. Its authors argue that the same cells that cause goosebumps might be responsible for helping hair growth in the first place, giving a reason for evolution to retain this familiar phenomenon.

In animals, many organs are made of three kinds of tissue: epithelium, mesenchyme, and nerve. In the skin, which is an organ, a nerve connects to muscle in the mesenchyme. This nerve is part of the sympathetic nervous system and helps maintain homeostasis. The muscle itself is connected to stem cells in the epithelium that heal wounds and regenerate hair follicles.

The researchers focused on mice, as is typical in these studies, but suggest that the findings are also applicable to humans given the similarity between our skin and hair cells.

The researchers examined the behavior and structure of the nerve under an electron microscope. To their surprise, the nerve was not only attached to the previously mentioned muscle tissue but also wrapped around hair follicle stem cells.

In normal conditions, the sympathetic nervous system is always operating at a low level. This keeps the body functioning normally. When the researchers observed this behavior, they noticed signals being sent by the nervous system to the stem cells in the hair follicles. These signals seem to keep the stem cells at the ready for potential use.

However, when the researchers exposed the tissues to the cold, the activity ramped up. A flood of neurotransmitters was released, and the stem cells activated. This prompted new hair growth to begin.

Another experiment dove into how the nerve reached the stem cells in the first place. Co-Author Yulia Shwartz explained the findings in a press release:

"We discovered that the signal comes from the developing hair follicle itself. It secretes a protein that regulates the formation of the smooth muscle, which then attracts the sympathetic nerve. Then in the adult, the interaction turns around, with the nerve and muscle together regulating the hair follicle stem cells to regenerate the new hair follicle. It's closing the whole circle -- the developing hair follicle is establishing its own niche."

Putting this together, it appears that goosebumps are part of a two-phased response to cold. In the first, the muscle below the skin is stimulated to form goosebumps. If this stimulation lasts long enough, the second phase kicks in, with the sympathetic nervous system calling for new hair growth and repairs for the old ones to be made in response to the cold.

In their press release, the authors suggest that further research can focus on how the body repairs itself in response to environmental stimuli in various situations. The findings also imply that other currently unsuspected connections between the sympathetic nervous system and other parts of the body exist. These potential interactions will undoubtedly be searched for and examined.

Everybody gets goosebumps now and then. We've always assumed we knew why we still get them, even though the hypothesis had some holes. This study's findings show that the benefits of getting goosebumps are more complex than initially thought. It just goes to remind us that we still have much to learn about even the most mundane things.

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The Global Apoptosis Assays Market is expected to grow from USD 3,753.69 Million in 2019 to USD 6,153.93 Million by the end of 2025 at a Compound…

Market Segmentation & Coverage: This research report categorizes the Apoptosis Assays to forecast the revenues and analyze the trends in each of the following sub-markets:

New York, July 24, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Apoptosis Assays Market Research Report by Product, by Detection Technology, by Application, by End User - Global Forecast to 2025 - Cumulative Impact of COVID-19" - https://www.reportlinker.com/p05913231/?utm_source=GNW On the basis of Product, the Apoptosis Assays Market is studied across Assay Kits, Instruments, Microplates, and Reagents. The Assay Kits further studied across Annexin V and Cell Permeability Assays, Caspase assays, DNA Fragmentation Assays, and Mitochondrial Assays.

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The Global Apoptosis Assays Market is expected to grow from USD 3,753.69 Million in 2019 to USD 6,153.93 Million by the end of 2025 at a Compound...