Category Archives: Stem Cell Doctors

Scots Football hosting "Be the Match" registry event – WQKT

The College of Wooster is among the latest college football teams to join forces with Be The Match and get in the game with a blood stem cell registry drive. Woosters drive will take place on Friday, April 28 from 10 a.m. 3 p.m. inside the Lowry Student Center at the student tabling tables.

Hundreds of college athletic teams have registered thousands of their team members, peers, and local community members for the Be The Match Registry. Wooster football players will run tables to assist students, faculty, staff, and local community members with their Be The Match process, which includes a registration, filling out a health history form, and providing a swab inside your cheek. The registry drive is open to people ages 18 to 40 years old, and the event is open to the local community.

More young people of diverse racial and ethnic heritage are needed to help patients searching for a match. People between the ages of 18 and 35 are most urgently needed since they are requested by transplant doctors most often, and research shows that these donors provide the greatest chance for transplant success.

Every year, 12,000 patients are diagnosed with life-threatening blood cancers or other diseases like sickle cell, for which a blood stem cell transplant from an unrelated donor may be their best or only hope for a cure. Be The Match connects patients with a matching donor for a life-saving blood stem cell transplant. A blood stem cell transplant can cure or treat more than 75 difference diseases, including leukemia and lymphoma, aplastic anemia, and sickle cell and immune-deficiency disorders. Be The Match has facilitated more than 120,000 transplants since 1987 and continues to impact more lives every year. Be The Match is a global leader in bone marrow transplantation and conducts research to improve transplant outcomes, provides support and resources for patients, and partners with a global network.

Football teams, especially small college teams within Ohio, can help effectively communicate signing up for Be The Match, added junior defensive back Andrew Armile, who is helping spearhead Woosters registry event. Through community involvement and with the large number of football programs in the country, we can help by spreading the important message of registering for blood and marrow donations and hopefully save lives.

Those unable to make Woosters football teams registry drive can join the Be The Match donor registry online, order a free cheek swab kit from Be The Match, and return it to the organization.

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Scots Football hosting "Be the Match" registry event - WQKT

Unsure About Why Your Hair Is Going Grey? Scientists Might Have Found The Answer | HealthBeat – Times Now

Hair usually starts to slowly lose colour from 35 years of age while this can occur earlier as well. Colour produced at the hair follicle, pores around the root of hair, does not change the colour once hair starts to grow. With age, these follicles fail to produce enough pigment, as a result, once hair dies and regrows, it does not change the colour.

Updated Apr 20, 2023 | 03:45 PM IST

Published in the Nature journal, the study looked at how stem cells can affect follicles ability to produce colour.

Photo : iStock

Why does hair start to go grey?

Hair usually starts to slowly lose colour from 35 years of age while this can occur earlier as well. Colour produced at the hair follicle, pores around the root of hair, does not change the colour once hair starts to grow. With age, these follicles fail to produce enough pigment, as a result, once hair dies and regrows, it does not change the colour.

During normal growth of hair, cells continuously move back and forth during transition between compartments of developing hair follicles. But as hair ages and grows back, the number of melanocyte stem cells gets stuck in the stem cell compartment resulting in a bulge and preventing colouring. The loss of such function in the stem cells could take blame for loss of hair colour and greying. Findings suggest that such stem cell motility and reversible differentiation could be key to keeping hair coloured and healthy.

Disclaimer: Tips and suggestions mentioned in the article are for general information purposes only and should not be construed as professional medical advice. Always consult your doctor or a dietician before starting any fitness programme or making any changes to your diet.

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Unsure About Why Your Hair Is Going Grey? Scientists Might Have Found The Answer | HealthBeat - Times Now

Scientists achieve promising results towards restoring vision in … – Ophthalmology Times

This finding marks a first step towards potentially restoring vision in eye diseases characterized by photoreceptor loss. (Image credit: AdobeStock/Victoria Key)

A preclinical study using stem cells to produce progenitor photoreceptor cellslight-detecting cells found in the eyeand then transplanting these into experimental models of damaged retinas has resulted in significant vision recovery.

According to a Duke-NUS Medical School news release, this finding, by scientists at Duke-NUS Medical School, the Singapore Eye Research Institute and the Karolinska Institute in Sweden, marks a first step towards potentially restoring vision in eye diseases characterized by photoreceptor loss.

Our laboratory has developed a novel method that enables the production of photoreceptor progenitor cells resembling those in human embryos, Tay Hwee Goon, PhD, first author of the study from Duke-NUS Centre for Vision Research, said in the news release. Transplantation of these cells into experimental models has yielded partial restoration of the retinal function.

The degeneration of photoreceptors in the eye is a significant cause of declining vision that can eventually lead to blindness and for which there is currently no effective treatment. Photoreceptor degeneration occurs in a variety of inherited retinal diseases, such as retinitis pigmentosaa rare eye disease that breaks down cells in the retina over time and eventually causes vision lossand age-related macular degeneration, a leading cause of vision impairment worldwide.1

Asst Prof Tay and her team developed a procedure to grow human embryonic stem cells in the presence of purified laminin proteins that are involved in normal development of human retinas. In the presence of the laminins, stem cells could be directed to differentiate into photoreceptor progenitor cells responsible for converting light into signals that are sent to the brain.

When these cells were transplanted into damaged retinas, the preclinical models showed significant recovery of vision. A diagnostic test called electroretinogram also identified significant recovery in the retinas via electrical activity in the retina in response to a light stimulus. The transplanted cells established connections with surrounding retinal cells and nerves in the inner retina. They also survived and functioned for many weeks after transplantation.

Moving forward, the team said in the news release it hopes to refine their method to make it simpler and achieve more consistent results than earlier attempts to explore stem cell therapy for photoreceptor cell replacement.

It is exciting to find these results, which suggest a promising route towards using stem cells to treat those forms of visual deterioration and blindness caused by the loss of photoreceptors, Helder Andre, PhDm head of Molecular and Cellular Research from Karolinska Institutes Department of Clinical Neuroscience and a senior author of the study, said in the news release.

Enrico Petretto, PhD, director of the Centre for Computational Biology at Duke-NUS and the study's bioinformatics analysis lead, discussed the research.

Our method may also be useful for understanding the molecular and cellular pathways that drive the progression of macular degeneration, perhaps leading to the development of other therapeutic approaches, he said in the news release.

According to the release, the next challenge for the researchers is to explore the efficacy of their method in models of photoreceptor degeneration that more closely match the human condition.

If we get promising results in our future studies, we hope to move to clinical trials in patients, Karl Tryggvason, MD, PhD, from Duke-NUS Cardiovascular and Metabolic Disorders Program, and the corresponding author of the study, said in the release. That would be an important step towards for being able to reverse damage of the retina and restore vision.

The protocol underlying the procedure developed by Tay has since been licensed to Swedish biotech start-up Alder Therapeutics.

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Scientists achieve promising results towards restoring vision in ... - Ophthalmology Times

Unlocking the secrets to aging gracefully: How to keep your spine … – Kevin MD

An excerpt from The Spine Encyclopedia: Everything Youve Wanted to Know about Back and Neck Pain but Were Too Afraid to Ask.

As we age, our cells become less functional, and bodily tissues lose the ability to replenish and regenerate. The spine is not excluded from this process and undergoes predictable degeneration as we age. For some, spinal degeneration turns into serious pain and disability that can end in the need for surgery. For others, this is not the case, and they continue to have active lifestyles despite degeneration in the back and neck. What separates these groups? What can we do to make sure our backs work for us as opposed to having to work for our backs (going to the doctors, getting treatments and surgery)? While the answers to these questions remain somewhat unknown, there are many non-surgical interventions to not only extend the life span of our spines, but also of our lives. These include practices such as following a healthy, low-calorie diet, not smoking, treating osteoporosis, and practicing a balanced exercise regimen.

Case

Mr. Silver is a healthy 70-year-old male. He retired from a career as a teacher at the age of 65 and has been very busy in retirement. He pays close attention to his health and makes sure he does at least 40-50 minutes of vigorous exercise 4-5 times a week. This can consist of a brisk hike, bicycle riding, or even swimming, and he enjoys switching between these activities. He used to be an avid runner but finds hiking, biking, and swimming to be more tolerable to his bones and joints these days. He participates in yoga, and to outside viewers, his posture, gait, and flexibility reflect that of a young man, although he will tell you he feels stiff at times. He has never smoked and only occasionally drinks wine. In addition to these basic tenets of lifestyle, he is very active with his grandkids and enjoys a full circle of friends with whom he regularly socializes. Although he can drive himself to the doctors, he is never short of volunteers who want to come with him for support. He has no pain, has not had a fracture from weakened bones, and takes no medicines.

Getting older is inevitable. The turn of the century Italian philosopher Giacomo Leopardi had this to say about aging: Old age is the supreme evil because it deprives us of all pleasures, leaving us only the appetite for them, and it brings with it all sufferings. Nevertheless, we fear death, and we desire old age. We all want to continue living, but the price for continued life is getting older, including an aging skeleton. Unfortunately, aches and pains are going to be in everyones future, but as a physician, I have noticed that there seems to be a trick to aging gracefully. Looking at colleagues and patients, I have seen those who cruise into old age and those who bruise into old age. In other words, some have no issues in old age, and others have endless problems. While genetics likely play a crucial role in aging, we cannot control our genes (yet). However, we do have the power to change environmental factors and lifestyle choices that accelerate aging. In medicine, we talk about a patients genotype and phenotype. The genotype simply refers to the type of genes a person has (for example, a person has a gene for brown hair), while the phenotype refers to the actual expression of those genes (that is, a person has brown hair). Our environment plays a role in determining the phenotype as expressed with this equation:

Phenotype = Genotype + (diet and lifestyle).

The phenotype we all want is one that allows us to live a long, healthy life. We must assume we are stuck with our genotype, but this equation begs the question: what are the things we can do to age gracefully?

What is aging and why does it happen?

Aging is simply the process of becoming older. Superficially, as we age, we appear to have more wrinkles and blemishes in the skin, and perhaps grayer hair. We dont have the same strength, endurance, and even body shape as we did when we were younger. But on a molecular and cellular level in the body, what is driving these changes?

Cells are the building blocks that form all our tissues. As we age, our cells age too. Stem cells, which are cells that are capable of becoming a range of different tissues (bone, muscle, blood, etc.), lose the capacity to undergo differentiationthe ability to change from one cell type to another. This is problematic because stem cells are responsible for replenishing damaged tissue, for example, damaged cartilage in joints. So, the body cannot regenerate as effectively.

Unlike the cells in young bodies, cells in the older persons body also lose some of their metabolic capacity and start to accumulate waste proteins, resulting in malfunction. This is thought to occur because of several different reasons:

Thus, the body loses its ability to replace old or damaged cells, and those older cells start to malfunction. This disrupts the complex biological processes in the body.

Cellular aging processes affect the musculoskeletal system, and we know that three things happen:

Yoshihiro Katsuura is an orthopedic surgeon and author of The Spine Encyclopedia: Everything Youve Wanted to Know about Back and Neck Pain but Were Too Afraid to Ask.

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Unlocking the secrets to aging gracefully: How to keep your spine ... - Kevin MD

Selma Blair spent years terrified of being found out she was suffering symptoms of undiagnosed MS – Yakima Herald-Republic

Selma Blair spent years terrified of being found out she was suffering symptoms of her undiagnosed multiple sclerosis on film sets.

The Legally Blonde actress, 50, lived for decades with the physical and mental results of the incurable disease before she was finally diagnosed with it in August 2018, and said she spent time on jobs trying to hide the brutal impacts of the condition, which included bouts of vomiting and well as hair looks and rashes.

Mum-of-one Selma, who has son Arthur, 11, with her fashion designer ex Jason Bleick, 49, whose MS is now in remission partly due to the hematopoietic stem cell transplantation she received in 2019 said in a cover interview for Mays British Vogue magazine: I was worried since the beginning of time that a glaring fault would remove me from the workforce.

And usually it was my incoordination or getting stuck, too weak or sick, in my trailer or any time, really.

The vomiting or body issues were terrifying, (and the) baldness or rashes.

She added about her terror of being found out: I remember being very, very poorly on Hellboy and was diagnosed with cat scratch fever and possible leukaemia in Prague.

I couldnt tell anybody. I couldnt admit alcoholism or (access) treatment in my insurance for fear Id be deemed an insurance risk. I fell apart once I got back to LA.

After Selma filmed the US television remake of Kath and Kim in 2009, she finally pulled away from showbiz as her body was so exhausted.

She added: My autoimmune system was misfiring losing most of my hair and all of my energy.

I kinda bowed out (after the show.)

It was a French exit and everybody else stayed at the party my self-hatred was extreme.

I could not manage well and I couldnt even try to find work it was a running joke: How far was the audition? How many naps would I fit in on the side of the road before and after?

When I quit acting) I spent my days in bed, crying, sometimes binge drinking, sometimes reading and sleeping, seeing doctors and healers I gave up almost until the diagnosis. I was always terrified I would be deemed incapable. Or mentally unsound. My mother taught me that was death for a woman career-wise.

By the time Selma was seven she had lost use of her right eye, left leg and her bladder due to undiagnosed juvenile MS, and would wake up in the night laughing hysterically due to the incurable condition which then led her to uncontrollably weep as an adult.

The floods of emotion were the result of her damaging her frontal lobe and she didnt get a diagnosis for 40 years.

She said: I looked like a normal girl to them, but I was disabled this whole time.

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Selma Blair spent years terrified of being found out she was suffering symptoms of undiagnosed MS - Yakima Herald-Republic

The Beljanski Foundation Launches Annual Integrative Cancer Conference October 13-15 in Jacksonville, Florida – EIN News

The conference offers a chance to bring together people from all backgrounds to discuss cancer-related topics and research.

Sylvie Beljanski

The event will support breast cancer stem cell research funded by the Beljanski Foundation, a 501(c)(3) non-profit conducting scientific research into natural plant extracts for cancer treatment and cancer prevention. According to Nathan Crane, Conference and Strategic Solutions Director of the Beljanski Foundation, "the conference will offer cutting-edge solutions, science, and support for putting an end to cancer with top doctors and cancer conquerors from holistic, functional, and integrative medicine." Breast cancer stem cell research is crucially important because breast cancer stem cells are thought to be responsible for the recurrence and metastasis of breast cancer. Unlike other cancer cells, which can be killed by chemotherapy and radiation therapy, breast cancer stem cells have the ability to survive and become resistant to these treatments, leading to tumor regrowth and metastasis. Early research has shown very promising results with non-toxic natural compounds. However, more funding is needed to confirm the benefits on breast cancer stem cells, and this event aims to spread this awareness.

Since August, the Beljanski Foundation, Panacea Community, LLC, and Healing Life International, LLC have partnered to bring this three-day event to fruition. The conference will feature presentations by the top holistic doctors and leaders in functional medicine and provide "education, inspiration, community, networking, presentations, workshops, technology, scientific breakthroughs, entertainment, and fundraising." There will also be a Friday Night Black-Tie Gala dinner.

The Beljanski Foundation is committed to treating cancer holistically and to "study and share knowledge of effective non-toxic, natural answers that work both alone and in synergy with traditional western medicine to cure cancer and other chronic diseases the natural way." Sylvie Beljanski began the Beljanski Foundation to continue her father's work. Known as "the father of environmental medicine," Mirko Beljanski, Ph.D. worked to bring "nature and science together to improve the health and well-being of people," states Sylvie Beljanski. Through the Beljanski Foundation, Dr. Mirko Beljanski's research only continues.

"For a different outcome, let's look at cancer differently. After all, doing the same thing again and again and hoping for a different result is the definition of insanity," continues Beljanski.

Super early bird tickets are available until April 30, 2023. To register and learn more about "Winning the War on Cancer" - The Beljanski Integrative Cancer Conference, follow this link: https://integrativecancerconference.com

To learn more about the Beljanski Foundation and its impact on natural solutions to cancer, click here: https://beljanski.org.

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The Beljanski Foundation Launches Annual Integrative Cancer Conference October 13-15 in Jacksonville, Florida - EIN News

Closing the IP and innovation gender gap in Canada – WIPO

April 2023

By David Durand, founder of DURAND Lawyers and co-founder of MVIP, as well as sitting President of FORPIQ (agenda), Montral, Canada

In the world of innovation, creation and entrepreneurship, gender gaps or disparities should not exist. Science, whether undertaken by a man or a woman, is science, and should be judged solely on the merits of its findings. Yet, research reveals a number of barriers that prevent women from contributing to scientific endeavor and its resulting innovations.

According to a report by the Canadian Intellectual Property Office, Processing Artificial Intelligence: Analysis from a Canadian Perspective, At the international scale, there was one female identified for every three males involved in AI patenting. By comparison, for patented inventions containing at least one Canadian researcher, that ratio decreases to one female for every six male researchers.

Similarly, data from WIPO reveal that only 16.5 percent of inventors named in international patent applications in 2020 were women. While this share has increased by 3.8 percentage points, progress is slow. WIPO estimates that, at the current pace, gender parity among PCT-listed inventors will only be reached in 2058.

These ratios are concerning, as there is no doubt that women have and continue to be active contributors to the sciences, despite being identified in certain cases as unsung heroes". That is why it is important to encourage more women to engage with the intellectual property (IP) system so they can leverage the value of their work. When more women engage in IP, we all win because diversity in innovation means more talent, more new perspectives, and increased chances of finding solutions to the complex challenges we face.

The Forum International de la Proprit Intellectuelle - Qubec (FORPIQ) promotes the uptake of intellectual property across Canada via its conference and support from its partner network, organizing committee and membership. In honor of Word Intellectual Property Day 2023 and this years campaign theme, Women and IP: Accelerating Innovation and Creativity, FORPIQ wishes to highlight some of Canadas trailblazing women inventors, creators and entrepreneurs. These individuals exemplify the can do attitude of women and their ground-breaking work.

Improving heel-to-toe gait for improved mobility: Dr. Nancy Mayo, from the Division of Clinical Epidemiology, McGill University, became an entrepreneur in her late sixties. She founded Physio Biometrics Inc., in August 2019. Although no one was interested in her initial 2014 proposal, Dr. Mayo persisted in her biofeedback research to improve heel-to-toe gait for greater stability and improved mobility.

She has created a wearable sensor, Heel2ToeTM, which clips to the outside of a walking shoe. The device provides positive auditory feedback in real time when the wearer makes a good step - one that starts with a strong heel strike.

Today, Physio Biometrics has 135 prototypes of its sensor, all of which are on sale or being used in research projects with seniors and people with Parkinsons disease.

To ensure development of the sensor and its associated algorithms, Dr. Mayo collaborated with a colleague to secure grant funding from the Natural Sciences and Engineering Research Council of Canada (NSERC). This early funding opened up other opportunities to secure research funds from Healthy Brains for Healthy Lives (HBHL) and McGill Innovation Fund among others, to support innovation and provide employment for highly skilled people within her company. Additional revenue generated from workshops and the sale of the devices are being reinvested in the company to ensure the technology continues to evolve in response to consumers needs.

Dr. Mayo notes that becoming an entrepreneur can be difficult because once you start, you cant take your foot off the gas. The role of entrepreneur gets added on to other roles that women scientists take on: researcher, educator, inventor, family caregiver. The competitive nature of being an entrepreneur can mean letting go of other important roles. When confronted with barriers, Dr. Mayo says you can either step up or give up. Giving up is not in Dr. Mayos DNA, as seen from her achievements, including the publication of over 300 scientific papers. Dr. Mayo continues to excel in her field.

Becoming an entrepreneur can be difficult because once you start, you cant take your foot off the gas.

Dr. Mayos words of wisdom to future entrepreneurs, are learn your markets and consumers and provide them with the product that meets their needs, especially when they need a device that allows them to walk better.

Diagnosing infertility in men: Dr. Sarah Kimmins works for the research center of the Centre Hospitalier de lUniversit de Montral (CHUM), Department for Pathology and Cell Biology at the University of Montreal and the Department of Pharmacology and Therapeutics at McGill University. She is an epigeneticist, which means she studies how human behavior and the environment have an impact on the way our genes work.

Dr. Kimmins has developed a fertility diagnostic for men called HisTurn, based on biomarkers of the sperm epigenome (biochemical markers associated with DNA).

After reviewing and assessing Dr. Kimmins Report of Invention to the McGill Office of Innovation + Partnerships, the University took on the process of protecting the invention. McGill University also collaborated with Axelys to further support the development of the technology, with Axelys providing insights to support the technology transfer, implementation and commercialization of the HisTurn diagnostic.

According to Dr. Kimmins, the clinical adoption of HisTurn will fill a technology and health-need gap by accurately diagnosing infertility in men and providing clinicians with actionable information to choose the most appropriate treatment plan.

Dr. Kimmins explains that she and the McGill Office of Innovation + Partnerships worked with a patent agent to determine the best IP strategy to adopt to commercialize the diagnostic.

The support of our patent agent was invaluable, as it meant our team had access to the relevant expertise and understanding in the field of science in which I work, as well as deep knowledge of the law and patenting process, which can be tricky to navigate when including epigenomic targets, Dr. Kimmins explains.

With respect to the gender gap in science, technology, engineering and mathematics (STEM), Dr. Kimmins says, studies have shown that world-wide women are less likely to be awarded the same grant dollars as men, are allocated smaller lab space and start-up packages, and have increased demands placed on them for mentoring, teaching and service. They are also less likely to have their publications accepted in journals with a high-impact factor. Consequently, women allocate less time and resources to commercializing their science. Until equity is achieved in science, women will continue to be under-represented in patenting, she says.

Dr. Kimmins believes that more scholarships and financial programs should be awarded to underrepresented students (i.e., first generation migrants, low-income students, and others) to enable more talented people to take advantage of opportunities in STEM.

Until equity is achieved in science, women will continue to be under-represented in patenting.

Dr. Kimmins also believes that many of the skills learned as a principal investigator in the laboratory are transferable to entrepreneurial ventures. Running a lab includes securing millions of dollars for its operation and managing and inspiring a team of researchers towards a common goal. You are also constantly presenting your science to different communities, including the public, clinicians and other scientists. So having effective communication skills is essential, Dr. Kimmins explains.

Programs that promote women and their successes are key to attracting more young women to the field of innovation, Dr. Kimmins says.

Doctors Mayo and Kimmins agree that access to flexible funding to cover costs of patenting and to leverage matching funds to secure larger financial streams, is a key to translating an idea into a successful business. The two entrepreneurs applaud, McGills innovation fund (MIF), founded in Autumn 2021 to support entrepreneurial innovation by awarding grants to researchers seeking to commercialize new technologies and discoveries.

The fund seeks to help researchers bridge the valley of death, that precarious interval during which an invention emerges from the lab and makes its way to the market. Thats when the need for financial support is most acute, explains Dr. Mark Weber, Director of Innovation and Partnerships at the McGill Office of Research and Innovation.

To further support women in business, in September 2022, the Business Development Bank of Canada (BDC) launched a CAD 500 million Thrive Platform to assist trailblazing women-led companies to succeed and become tomorrows global leaders. The platform seeks to ensure that women entrepreneurs have access to everything they need to thrive and have a lasting impact on the economy. Its unique offering includes early stage venture capital investment for women-led businesses, strategic investment in women-led and focused funds, as well as emerging models working alongside ecosystem partners to provide equity investments to women-led businesses at the earliest stages of development.

The Innovation Asset Collective also offers grants for women in IP, provided that eligibility requirements are satisfied. The Government of Qubec has also invested CAD 8 million to increase the number of women in STEM, among other initiatives.

Promoting greater IP awareness among women scientists is an important step towards narrowing the IP and innovation gap.

Promoting greater IP awareness among women scientists is an important step towards narrowing the IP and innovation gap. But these efforts need to be complemented by a commitment to provide mentorship and leadership to younger generations in STEM. And that means changing perceptions and mindsets about innovation and IP well before young women begin their studies or pursue their academic careers.

Acknowledgement(s): The author would like to thank Drs. Kimmins, Mayo and Weber, as well as the BDC for their contributions to this article.

Me David Durand, B.Sc. (chem.), LL.L, lawyer and trademark agent, is the founder of DURAND Lawyers and co-founder of MVIP, the sitting president of FORPIQ, and is an advisor to the National Crowdfunding and Fintech Association of Canada (NCFA). Mr.Durand has appeared before the Canadian House of Commons Standing Committee on Finance regarding crypto-assets within its statutory review of the Proceeds of Crime (Money Laundering) and Terrorist Financing Act and was invited to submit its co-authored brief titled Dont block the blockchain: How Canada can guard against money laundering while maintaining global competitiveness. He has also participated in other consultations regarding the regulation of crypto-asset trading platforms (CSA/IIROC, IOSCO - CR02/2019 ), global stablecoin arrangements before the international Financial Stability Board (FSB), the modernization of Ontarios capital markets (jointly with NCFA) and the transfer of personal data across borders (joint submission with the Chamber of Digital commerce) before the Office of the Privacy Commissioner of Canada. He has also recently appeared before the Canadian House of Commons Standing Committee on Science and Research to talk about support for the commercialization of intellectual property (evidence).

Mr. Durand was recently accepted as a subject matter expert for the Standards Council of Canadas Canadian Mirror committee ISO/TC279 on innovation management standards, as well as the IEC SEG15 committee on the metaverse. He has also taught courses on IP law at the University of Ottawa, and was recently published in Durand, D., Mulcair, C. (2023). Whats the Big Idea? The Crossroads Between Investment and IP. In: Bader, M.A., Szerolu-Melchiors, S. (eds) Intellectual Property Management for Start-ups. Management for Professionals. Springer, Cham. https://doi.org/10.1007/978-3-031-16993-9_8.

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Closing the IP and innovation gender gap in Canada - WIPO

Bourbonnais toddler beats leukemia with stem cell transplant – Kankakee Daily Journal

While watching 3-year-old Mads Pomranky excitedly play on a Tuesday afternoon with his 1-year-old sister, Valen, one would never guess the difficult health struggles hes overcome.

At 5 months old, Mads was diagnosed with juvenile myelomonocytic leukemia, a rare cancer of the blood that affects young children. The diagnosis eventually turned to acute myeloid leukemia and was treatable only through a transplant from a stem cell donor.

For parents Jennifer and Derrick Pomranky, of Bourbonnais, they made the immediate decision to approach the challenge with positivity, designating their son Mighty Mads.

Its pretty difficult to watch your little baby go through this, Jennifer said. I feel like right away, we both had the mentality of, Hes gonna get through this, were gonna get through this.

We got through it one day at a time, added Derrick.

As an infant, Mads was often sick with congestion or runny nose. It was a pediatrician, Dr. Josefina Batista at Riverside Healthcare, that noticed his spleen was enlarged. Further testing would show his red blood cell count being low while his white cell count was high. These red flags led to the eventual leukemia diagnosis.

His pediatrician caught it so fast that we had time on our side that they could pinpoint the diagnosis and take their time with the chemo and wean him into it a little bit, said Jennifer while flipping through a book the family made for Mads donor. The book details Mads journey with cancer and treatment.

The book documents that Mads had six rounds of chemo, 83 doses of chemo, 31 blood transfusions, 31 platelet transfusions, 11 bone marrow biopsies, five spinal taps with chemo, two skin biopsies and one cryo transfusion.

His parents noted they were lucky in the search for a donor, as Mads health care team found a 10 out of 10 match through the stem cell/bone marrow transplant registry, DKMS.

The donation was from a young woman, Kaelynn Speed, out of Cincinnati.

Weve been an advocate for [DKMS], Jennifer said, noting that the DKMS shirts her kids were wearing were given to the family when they first met Speed through a donor meeting facilitated by the donor registry.

By the time doctors were able to begin providing transplant care to Mads then 13 months old the world was in the throes of COVID-19. As a result, Speeds cell donation had to be frozen for two weeks before being administered to Mads.

Mom Jennifer said that the process took about an hour and was similar to a blood transfusion.

Now, Mads has to have bloodwork done every three months to make sure everything is on the up and up. Additionally, he does a survivorship follow up at Comer Childrens Hospital, where he had his treatments.

Hes doing great. Hes very rambunctious and a normal toddler, said Jennifer.

Born May 16, 2019, Mads now has double the annual celebrations first, his birthday, and second, what his parents have dubbed his rebirthday on June 17, which is when he had the transplant.

Before and after transplant, he was really sick, Derrick said. So that was a bad time.

When he was going through all of it, he missed a lot of his milestones. He was basically reborn again, added Jennifer.

LIFE AND DEATH

The family still keeps in touch with Speed and her family; they received her information on the one-year anniversary of Mads transplant and set up a Zoom meeting. The families met in person last summer.

Shes the nicest person, she was only 19 when she signed up [to donate], Jennifer said. Derrick added that shes studying nursing.

Between work and two toddlers, the Pomranky parents certainly have their hands full, but they always make time to encourage people to sign up to be stem cell and/or bone marrow donors.

You could potentially save a life, Jennifer said. Its a matter of life and death, literally.

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Bourbonnais toddler beats leukemia with stem cell transplant - Kankakee Daily Journal

Invasive aspergillosis: Symptoms and more – Medical News Today

Aspergillosis is an infectious disease that occurs due to a common type of fungus, or mold, called Aspergillus. A type of aspergillosis called invasive aspergillosis particularly affects people with weakened immune systems.

Most individuals breathe Aspergillus spores daily and do not develop any health effects.

However, people with compromised immune systems, such as those who have had an organ transplant or are undergoing chemotherapy treatment, may be at greater risk of developing aspergillosis.

The disease usually affects the lungs but can spread to other areas of the body.

This article looks at invasive aspergillosis and its symptoms, diagnosis, outlook, and more.

Aspergillus mold is common indoors and outdoors and can cause infection in the sinuses and lungs of immunocompromised people.

If the infection spreads to the rest of the body, outcomes are very unfavorable and include death.

Experts do not know the extent of aspergillosis in the United States, as it is not a reportable infection. However, according to a database of insurance claims, there were almost 15,000 hospitalizations for this diagnosis in the U.S. in 2014.

That said, the number of people with aspergillosis has likely increased since then.

Invasive aspergillosis is less common than the milder, allergic forms of the disease. It is the most common fungal infection in people who have had stem cell treatment. It is also the second most common in those who have received solid organ transplants.

Invasive aspergillosis usually occurs in people with weakened immune systems who often already have other medical conditions. Therefore, it can be difficult to differentiate between the symptoms of the infection and those of the underlying illness.

The symptoms of invasive aspergillosis may include:

Types of invasive aspergillosis include:

Other types of aspergillosis include:

A person can develop aspergillosis by breathing in Aspergillus spores, which are common in indoor and outdoor environments.

Most people will not get sick from breathing the spores, but those with weakened immune systems are at greater risk of infection.

People at risk of invasive aspergillosis include individuals with weakened immune systems, such as those who have received:

Additionally, hospitalized patients with severe influenza and those with HIV are at risk of invasive aspergillosis.

To diagnose aspergillosis, a doctor may examine a persons medical history and risk factors and ask questions about their symptoms.

They may perform a physical examination and several laboratory tests. These may include:

Doctors may treat invasive aspergillosis with several different antifungal medications.

These may include:

Where possible, doctors may also decrease or discontinue immunosuppressive medications to help treat invasive aspergillosis.

Because Aspergillus spores are common in the environment, it is difficult for people to avoid breathing them in.

Experts recommend those with weakened immune systems take certain measures to protect against the fungus. However, these actions may not prevent aspergillosis.

Preventive measures may include:

The outlook for invasive aspergillosis is generally unfavorable.

The mortality rate of invasive pulmonary aspergillosis is about 20% six weeks after diagnosis, despite treatment with antifungal medications.

The mortality rate reaches close to 100% once the infection has spread to the central nervous system.

Most people safely breathe Aspergillus spores every day, as these are common in indoor and outdoor environments.

However, those with weakened immune systems may be at risk of developing health problems from breathing microscopic amounts of the fungus.

In immunocompromised people, such as those undergoing chemotherapy or those who have had stem cell or organ transplants, invasive aspergillosis may affect the lungs and sinuses. This can cause symptoms such as shortness of breath and coughing up blood.

The disease may spread to other areas of the body and is often fatal once it reaches the central nervous system.

Treatment for invasive aspergillosis typically includes the use of antifungal medication.

Doctors may advise high risk individuals who are immunocompromised to take measures that may help prevent aspergillosis. These approaches include wearing protective equipment and clothing, testing, and taking antifungal drugs.

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Invasive aspergillosis: Symptoms and more - Medical News Today

Woman diagnosed with incurable condition after eyes turned completely white – Yahoo News

Kerrys partner plans to walk the equivalent of a half marathon with Kerrys weight on his back to raise money for treatment abroad (Collect/PA Real Life)

A woman who lost her father to suicide and was diagnosed with a brain tumour in the space of six months, having seizures up to three times a month, has taught her 10-year-old son how to call 999 and says shes only still alive for (her) kids sake.

Kerry Warburton, 35, who lives in Gainsborough, Lincolnshire, with her partner, Craig Kirkham, 36, their son, Ethan, 10, and their daughter, Ellana, 10 months, landed her dream job as a teaching assistant in December 2019,but in April 2020 she began having seizures where her eyes would turn completely white and she could no longer work.

On top of this, in July 2020 Kerrys dad died by suicide, and in January 2021 doctors found a tumour in her brain, which was causing her seizures.

One month later, doctors tried to remove her tumour by performing an open craniotomy, which made her lose her speech, and while in hospital she contracted Covid and was quarantined for 12 days partnerCraig thought she was on deaths door and doctors wereseconds away from turning off her life support, but she recovered.

Things were beginning to look up Kerry fell pregnant with her second child, Ellana, but after resuming treatment, a follow-up MRI scan revealed that her brain tumour was at stage four.

Now, Craig is planning to walk the equivalent of a half marathon to raise money for stem cell therapy which could prolong Kerrys life by three to five years.

I was at an all-time low when receiving treatment, especially after losing my dad Im only still alive now for my kids sake, Kerry said.

In December 2019, Kerry finally landed her dream job, as a teaching assistant, after going back to college as a mature student.

But in April 2020, Kerry began to have seizures, which was the first warning sign for her terminal brain tumour.

Her partner Craig said: She was shaking like mad, and her eyes rolled back in her head, and I saw foam and blood come out of her mouth.

I didnt know what the hell was going on. I was so scared, and I thought she was dying.

Story continues

The whole bed was shaking, and I thought we were having an earthquake or something.

(PA Real Life)

I had no clue what to do I was trying to push her head back into the pillow to stop her shaking, and her eyes were completely white.

Craig quickly called an ambulance, and Kerry was taken into Lincoln Hospital for tests and an MRI scan.

But Kerry was not diagnosed with anything and continued to have seizures up to three times a week, while her father died by suicide in July 2020.

Kerry said: I hit rock bottom, they took me off my seizure meds because it can cause low moods, and my seizures got worse I was having them twice a week.

In January 2021, she received more devastating news she had a five-by-five-by-five centimetre tumour in her brain.

Just a few weeks later, in February, Kerry had an open craniotomy, and was told she had stage two brain cancer,which caused her to have aphasia when a person has difficulty with their language or speech.

She explained: I lost my speech completely, it was horrible.

It was so hard for me because I wanted to speak I could speak clearly in my mind, but I couldnt get it out.

(PA Real Life)

When in hospital, she contracted Covid-19 and was quarantined for 12 days.

Craig said: I thought she was on deaths door. It was so scary they were seconds away from putting her to sleep.

It was terrifying because you couldnt go and see her.

I didnt sleep at all Id message her and check her WhatsApp constantly just to check she was alive.

Once out of hospital, Kerry found out she was pregnant and in June 2022 she gave birth to her second child, Ellana.

Just two months later, she had another MRI scan which concluded the brain tumour was terminal and stage four.

Craig said: It was scary as hell we were all happy, we had the baby, and then we were thrown back into the deep end again.

We had to travel for 55 miles for treatment again, for six weeks every single day.

Since October 2022, Kerry has been receiving radiotherapy and chemotherapy, which has caused her to lose her hair and put on over two stone.

She said: It affects my confidence I dont want to leave the house.

Kerry continues to have seizures, but they have gone down to three per month, and has even had to teach her 10-year-old son Ethan how to call an ambulance.

She said: Were scared to death that I might have a seizure when Craig is at work, so weve taught him how to call an ambulance.

Weve had to give him counselling at school to cope with me being so ill.

It was hard to teach him how to do it,I was petrified, and his school have helped.

I know it must be horrible for my son, I blame myself for him getting upset about it.

To raise money for stem cell therapy, which could extend Kerrys life by three to five years,Craig has set up a GoFundMe and plans to walk from Lincoln Castle to his house, which is the equivalent of a half marathon, with Kerrys weight, 12 stone, on his back.

Craig said: Gravity will be trying to pull me into the ground just like this tumour is trying to put her in the ground, but we are going to defy both.

Kerry added: It would just be wonderful to have the treatment, and to not worry my son anymore.

To find out more about Craigs fundraising, visit http://www.gofundme.com/f/kerry-the-white-knight.

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Woman diagnosed with incurable condition after eyes turned completely white - Yahoo News