SEOUL, South Korea, Aug. 31, 2012 /PRNewswire/ -- In a landmark    clinical study, scientists of the RNL Stem Cell Technology    Institute have demonstrated that the transplant of patients'    own ("autologous") stem cells can dramatically improve the    ability of plastic surgeons to repair diseases. In the    September 2012 issue of the prestigious international plastic    surgery journal Annals of Plastic Surgery (69:3),    researchers published their controlled study of the power of    stem cells, describing a breakthrough with patients who have    Parry-Romberg Syndrome. More than 200,000 have this tragic and    debilitating disease in the U.S. alone. Their prognosis without    treatment is the slow loss of control, then paralysis of the    face and in some cases the mouth and even eyes. Most patients    with Parry-Romberg begin to experience these symptoms between    the age of five (5) and fifteen (15) years of age. There is,    says the National Institute of Neurological Disorders and    Stroke of the U.S. National Institutes of Health, "no cure." To    date, treatments have involved waiting until the disease slows    and then transplanting fat into patients' faces, strengthening    bones in their faces, and using microvascular surgery to    "install" a free flap of skin.  
    However the only solution for patients with this disorder, and    those with similar disorders, the grafting of fat, is at best a    temporary solution, which alleviates none of the pain felt by    these patients, and can in fact result in an increase in pain    when fat grafts fail. So, plastic surgeons, engineers and    others have searched for years for a solution with longer term    effects, or even a way to fight the disease's symptoms in a    sustained way.  
    Dr. Kyeung-Suk Ko and Dr. Jong-Woo Choi led a research team    under Dr. Jeong-chan Ra of RNL Stem Cell Technology Institute    that may have uncovered, for the first time, just such a tool    for plastic surgeons: patients' own stem cells. In their    controlled study, the team painlessly removed a few ounces of    fat from one group Parry-Romberg Syndrome patients, harvesting    stem cells from these patients' fat, cells that are genetically    identical to the patient's cells throughout their body and that    have well documented abilities to "home in" on inflammation and    disease and have dramatic effects on patients' symptoms and    even disease itself. In this study, those patients in the    "treated" group received stem cells magnified into the millions    (using the team's patented technology whose safety has been    well published). These patients' outcomes, adding stem cells to    standard-of-care therapies, were measured against traditional    microfat grafts in the control group receiving no stem cells.  
    In what many have described as a revolutionary finding, the    team found that those patients who received their own "adult"    mesenchymal stem cells saw unprecedented improvement in the    effectiveness of therapies. Fat grafts that are often    "resorbed" into patients' skin shortly after they are placed    were 50% less likely to disappear when provided alongside stem    cells (20.59% vs 46.81%).  
    This study was approved by the Korea Food and Drug    Administration, the institutional IRB of the Asan Medical    Center, and peer-reviewed prior to acceptance in the renowned    plastic surgery publication under the title: "Clinical    application of human adipose tissue-derived mesenchymal stem    cells in progressive hemifacial atrophy (Parry-Romberg Disease)    with microfat grafting techniques using three-dimensional    computed tomography and three-dimensional camera." Authors and    investigators included: Koh KS, Oh TS, Kim H, Chung IW, Lee KW,    Lee HB, Park EJ, Chung JS, Shin IS, Ra JC, Choi JW. Media    and others may access the article at http://journals.lww.com/annalsplasticsurgery/Abstract/2012/09000/Clinical_Application_of_Human_Adipose.22.aspx.    Its National Library of Medicine ID is PMID:22878516.  
    Dr. Ra, senior author, said, "We believe that this is a big    step for Parry-Romberg Syndrome patients and expect to see    autologous stem cell transplantation as standard of care for    their treatment. The next step is to test the efficacy of the    many ways in which stem cells from adults' own bodies will    expand the quality of life and even identify cures for many    rare diseases."  
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Stem Cells Bring New Hope for Parry-Romberg Syndrome Patients