Overview Our program brings together basic scientists and clinicians studying stem cells in a variety of adult and developing organ systems. The goal is to understand and exploit their remarkable capacity to maintain healthy tissues and to replace cells lost by disease or injury. Program highlights include:

Faculty Search Cell Biology is hiring a tenure-track Assistant or Associate Professor with a strong record of creativity and productivity in developmental and/or regenerative biology. Applicants should submit a curriculum vitae, a 3-page summary of accomplishments and research plans, a teaching statement, and at least 3 letters of recommendation by November 15, 2015. Applications should be submitted via Academic Jobs Online. Questions may be directed to Ken Poss or Brigid Hogan.

Executive Director Search The new tissueregenerationinitiative at Duke is hiring an Executive Director, an Associate in Research position at Duke University, to work closely with the Director, Co-Directors, and faculty members to promote and integrate discovery research, training, and applications in the broad field of tissue regeneration.We invite applications from candidates who have a Ph.D. and postdoctoral research experience in the relevant areas of developmental biology, stem cell biology, or tissue regeneration tosubmit a cover letter, curriculum vitae, summary of research accomplishments and any administrative leadership experience, and a list of at least three references to Academic Jobs Online. Questions may be directed toKen Poss.

Niche regulation of new neurons production in the adult brain Robust production of new neurons continues in the adult rodent brain, but how this is sustained remains unknown. Researchers in Dr. Chay T. Kuos laboratory found that self-assembly of radial glia into support structures for adult stem cells is critical for continued neurogenesis. More...

Zebrafish heart regeneration During heart regeneration in zebrafish, retinoic production in endocardial and epicardial cells localizes to areas of tissue damage, where it promotes cardiomyocyte proliferation. More...

Intestinal Crypt Proliferation Stem cell/transit amplifying compartments (green) reside in the base of each mouse intestinal crypt. These cells give rise to the multiple lineages of the intestinal epithelium (Lechler lab). More...

Lung epithelial stem cell regulationThe airways of the lung are lined by an epithelium that contains large numbers of cells specialized for making and secreting glycoproteins and mucus, as well as multiciliated cells that remove the mucus and the particles trapped in it. More...

Role of immune cells in the spermatogonial stem cell niche In addition to their roles in immune and inflammatory responses, macrophages have diverse functions in development. In reproductive biology, macrophages have been implicated in ovarian follicular growth and in Leydig cell function, but their role in spermatogonial differentiation has not been examined. More...

Drosophila hindgut repairThe fruit fly Drosophila has long been a leading genetic model for stem cell research. However, until recently no Drosophila models existed for study of mechanisms by which adult organs lacking active stem cells repair damaged tissue. More...

Indispensible pre-mitotic endocycles promote aneuploidy in the Drosophila rectum

Time lapse imaging of a tripolar division during developmental organ regeneration in the Drosophila hindgut. These divisions occur in cells with extra copies of the genome (polyploid cells) and produce an adult organ in which many of the cells have variable, imbalanced chromosome numbers (aneuploid cells). DNA is in purple, and centrosomes and cell membranes are in green.

Fox Lab. Schoenfelder et al. (2014) Development 141:3551-3560

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Duke Stem Cell and Regenerative Medicine Program