10 Things You Should Know About Dermal Fillers Before Getting Them Our Interview With Dr Nicholas Toscano On Juvederm – CelebMix

Dermal fillers are a popular choice for obtaining perfect lips or smoother skin, and we find out everything you need to know about them.

By Vicky Sidler

If youre looking for smoother skin, fuller cheeks, or plumper lips, youve likely read about dermal fillers quick, injectable treatments that can restore lost volume to your lips and cheeks. These minimally invasive procedures are designed to be long-lasting while looking completely natural, and they can have a rejuvenating effect on your appearance.

The procedure is also very low-risk, provided you go to a reputable doctor. As such, we spoke to Dr. Nicholas Toscano to find out everything you need to know about dermal fillers, from what to expect during the procedure to how to choose someone reliable to administer the fillers.

Dr. Toscano is responsible for some of the most beautiful lips in the modeling world, which he creates utilizing Juvderm lip fillers and platelet-rich plasma/platelet-rich fibrin know as the Dracula injection. He is currently the official dentist for roughly 20 modeling agencies in New York City, including The Lions, Wilhelmina, One Model Management, Heroes, Muse, Marilyn, Storm, Major models, Fusion, System, State, and others.

Juvderm fillers differ from Botox in that its not a neurotoxin. Instead, dermal fillers use hyaluronic acid, which is naturally found in the skin and gives you a radiant, hydrated appearance. Hyaluronic acid production decreases as you age, so these injections work well to restore lost volume to key parts of your face, such as your lips.

The procedure shouldnt be painful if it is carried out by a skilled doctor. The fillers contain a local anesthetic, and so no additional anesthetic is required during a basic dermal filler procedure. The simple, straight-forward takes between 15 and 30 minutes and involves only a few tiny injections directly into the skin. Youre able to apply makeup straight after the procedure and go back to work right away.

Youll be able to see the results of the procedure immediately. For best results, though, you will need to maintain your fillers over time through regular, repeated treatments.

A single treatment can make your lips plumper and your skin smoother for up to six months. Typically, results last between three to six months before a touch up is needed so you can expect to visit your doctor two or three times a year to maintain your look. If youre only looking to try fillers out once or twice, you can skip the maintenance without experiencing any long-term risks. The effects will fade away entirely and safely.

Fillers dont only need to be used to treat existing lines. They offer protection against developing lines as well, so dermal fillers can be used as a preventative measure against wrinkles. Research suggests that injectable hyaluronic acid-based dermal fillers can stimulate your skins collagen production, helping you to look younger for longer.

While the procedure is safe, its not a good idea to have the injections if you are pregnant or breastfeeding. Nor should you go if you have a sinus infection or are about to undergo a dental treatment since the pressure and stretching of the face could cause the fillers to become misplaced. Instead, wait a week or so before undergoing the procedure.

If you dont like the way your filler looks or if you want them adjusted, in most cases, it wont be a problem at all. Your doctor may inject additional filler to achieve the desired effect, or theres an enzyme for hyaluronic acid fillers that can be used to dissolve the filler completely and safely.

The last thing you want is to look like you had work done. Dermal fillers should look completely natural they should emphasize your beauty in a way thats impossible to pinpoint. The goal is for it to be imperceptible. Imagine that your face is a canvas and that you are looking for an artist whose work you like. Be sure to ask for before-and-after photos of real patients to get a good idea of the doctors style. Also, be sure to ask about their techniques, levels of experience, and your specific needs.

One of the biggest mistakes you can make is to get lured in by a price that seems too good to be true because it probably is. Treatments range between $650 to $2,000 depending on the amount of filler needed. Anything under that should cause you to ask questions. A syringe of filler costs doctors between $250 and $350, so no treatment should ever be priced at around that mark or lower. Counterfeit and diluted fillers are also a problem in the industry, so its essential that you find a reputable doctor (as explained in the point above). If you have any concerns at all, it might be a good idea to ask to see the box and ensure that it has a safety seal intact.

Dr. Nicholas Toscano is an extremely accomplished and highly respected dental surgeon with a rich career of experience. He spent 13 years with the United States Navy, where he completed a 4-year surgical residency at the prestigious Walter Reed National Military Medical Center, The Presidents Hospital in Bethesda, MD.

During his time in the Navy, he received two Navy and Marine Corps Commendation Medals, three Navy and Marine Corps Achievement Medals, a National Defense Service Medal, and Global War on Terrorism Medal. He acquired one of his Navy and Marine Corps Commendation Medal for definitive life-saving treatment of a patient.

He is also a diplomate of the American Board of Periodontology and the International Congress of Implantologists, and he has written over 30 papers published in peer-reviewed scientific journals on the subject of surgical therapy, cosmetic, and reconstruction of the mouth.

His long and established career, along with his glamorous list of happy customers, makes him the dentist of choice in New York City. His client list display the kinds of smiles that will have you doing a double-take, including the gorgeous Victorias Secret models, such as Candice Swanepoel, Helena Christensen, Jasmine Tookes, Romee Strijd, Josephine Skriver, Georgia Fowler, Frida Aasen, Vittoria Ceretti, Megan Williams, Lais Ribeiro, Daniela Braga, and Blanca Padilla. To make an appointment with Dr. Nicholas Toscano to discuss the option of dental implants or any other services, visit Instagram @drtoscanodds or his website http://www.manhattanperiodontist.com.

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10 Things You Should Know About Dermal Fillers Before Getting Them Our Interview With Dr Nicholas Toscano On Juvederm - CelebMix

EdiGene and Immunochina Announce Research and Development Collaboration to Develop Allogeneic CAR-T Therapy for Cancer – Business Wire

BEIJING, China & CAMBRIDGE, Mass.--(BUSINESS WIRE)--EdiGene, Inc., which develops genome editing technologies to accelerate drug discovery and develop novel therapeutics for a broad range of diseases, and Immunochinaa company dedicated to innovative gene and cellular technology today announced that they have formed a research and development collaboration to develop allogeneic CAR-T therapy for cancer.

Under this partnership, both companies will combine EdiGenes expertise in genome editing and allogeneic T-cell process with Immunochinas expertise in innovative CAR-T technology to develop potentially best-in-class allogeneic CAR-T therapeutics. Terms are not disclosed.

"EdiGene is a leading gene-editing company with cutting edge technology platform. It is our great pleasure to work with this team," said Ting He, Ph.D.founder and CEO of Immunochina, "Make the Incurable Curable, which is Immunochinas vision. We have accumulated considerable experience in late-stage hematological malignancies, with two IND approvals. Although a number of break throughs have been made by autologous T cells lately, allogeneic T cells could also play an important role in the future. The cooperation is a big step for both teams, and I believe we will make exciting discoveries together."

We are excited to collaborate with Immunochina, one of the leading clinical-stage CAR-T companies, said Dong Wei, Ph.D.CEO of EdiGene, We believe that allogeneic T-cell therapeutics has tremendous potential, by offering innovative T-cell therapies off the shelf with more effective quality control and lower cost. By combining the expertise of EdiGene and Immunochina, we will be well positioned to develop such therapeutics and advance to clinics, one step closer to help the cancer patients in need.

About EdiGene, Inc

EdiGene is a biotechnology company focused on leveraging the cutting-edge genome editing technologies to accelerate drug discovery and develop novel therapeutics for a broad range of genetic diseases and cancer. The company has established its proprietary ex vivo genome-editing platforms for hematopoietic stem cells and T cells, in vivo therapeutic platform based on RNA base editing, and high-throughput genome-editing screening to discover novel targeted therapies. Founded in 2015, EdiGene is headquartered in Beijing, with subsidiaries in Guangzhou, China and Cambridge, Massachusetts, USA. More information can be found at http://www.edigene.com.

About Immunochina

Immunochina is committed to the application of innovative gene and cellular technology for treatment of lethal diseases. The company owns integrated CAR-T platform, including core technologies such as large-scale viral vector production and primary immune cell processing. The pipeline includes several CAR-T candidates for treatment of advanced cancer, with two IND approvals. Founded in 2015, Immunochina is headquartered in Beijing. More information can be found at http://www.immunochina.com

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EdiGene and Immunochina Announce Research and Development Collaboration to Develop Allogeneic CAR-T Therapy for Cancer - Business Wire

Precision Medicine Market 2020: Industry Analysis and Detailed Profiles of Top Industry Players are Neon Therapeutics, Moderna, Inc, Merck & Co.,…

Global Precision Medicine market report provides an in-depth overview of Product Specification, technology, product type and production analysis considering major factors such as Revenue, Cost, Gross and Gross Margin. The company profiles of all the key players and brands that are dominating the Precision Medicine market with moves like product launches, joint ventures, merges and accusations which in turn is affecting the sales, import, export, revenue and CAGR values are mentioned in the report. The report is generated based on the market type, size of the organization, availability on-premises and the end-users organization type, and the availability in areas such as North America, South America, Europe, Asia-Pacific and Middle East & Africa.

Global Precision Medicine Marketto grow with a substantial CAGR in the forecast period of 2019-2026. Growing prevalence of cancer worldwide and accelerating demand of novel therapies to prevent of cancer related disorders are the key factors for lucrative growth of market

Key Market Players:

Few of the major competitors currently working in the global precision medicine market are Neon Therapeutics, Moderna, Inc, Merck & Co., Inc, Bayer AG, PERSONALIS INC, GENOCEA BIOSCIENCES, INC., F. Hoffmann-La Roche Ltd, CureVac AG, CELLDEX THERAPEUTICS, BIONTECH SE, Advaxis, Inc, GlaxoSmithKline plc, Bioven International Sdn Bhd, Agenus Inc., Immatics Biotechnologies GmbH, Immunovative Therapies, Bristol-Myers Squibb Company, Gritstone Oncology, NantKwest, Inc among others.

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Global Precision Medicine MarketBy Application (Diagnostics, Therapeutics and Others), Technologies (Pharmacogenomics, Point-of-Care Testing, Stem Cell Therapy, Pharmacoproteomics and Others), Indication (Oncology, Central Nervous System (CNS) Disorders, Immunology Disorders, Respiratory Disorders, Others), Drugs (Alectinib, Osimertinib, Mepolizumab,Aripiprazole lauroxil and Others), Route of Administration (Oral,Injectable), End- Users (Hospitals, Homecare, Specialty Clinics, Others), Geography (North America, South America, Europe, Asia-Pacific, Middle East and Africa) Industry Trends and Forecast to 2026

Competitive Analysis:

The precision medicine market is highly fragmented and is based on new product launches and clinical results of products. Hence the major players have used various strategies such as new product launches, clinical trials, market initiatives, high expense on research and development, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of mass spectrometry market for global, Europe, North America, Asia Pacific and South America.

Market Drivers

Market Restraints

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Market Definition:

Precision medicines is also known as personalized medicines is an innovative approach to the patient care for disease treatment, diagnosis and prevention base on the persons individual genes. It allows doctors or physicians to select treatment option based on the patients genetic understanding of their disease.

According to the data published in PerMedCoalition, it was estimated that the USFDA has approved 25 novels personalized medicines in the year of 2018. These growing approvals annually by the regulatory authorities and rise in oncology and CNS disorders worldwide are the key factors for market growth.

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Key Developments in the Market:

Competitive Analysis:

Global precision medicine market is highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of global precision medicine market for Global, Europe, North America, Asia-Pacific, South America and Middle East & Africa.

Market Segmentation:

By technology:-big data analytics, bioinformatics, gene sequencing, drug discovery, companion diagnostics, and others.

By application:- oncology, hematology, infectious diseases, cardiology, neurology, endocrinology, pulmonary diseases, ophthalmology, metabolic diseases, pharmagenomics, and others.

On the basis of end-users:- pharmaceuticals, biotechnology, diagnostic companies, laboratories, and healthcare it specialist.

On the basis of geography:- North America & South America, Europe, Asia-Pacific, and Middle East & Africa. U.S., Canada, Germany, France, U.K., Netherlands, Switzerland, Turkey, Russia, China, India, South Korea, Japan, Australia, Singapore, Saudi Arabia, South Africa, and Brazil among others.

In 2017, North America is expected to dominate the market.

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Precision Medicine Market 2020: Industry Analysis and Detailed Profiles of Top Industry Players are Neon Therapeutics, Moderna, Inc, Merck & Co.,...

Vegan diet, intense cardio and stem cell therapy How Mike Tyson managed to get ripped at 53 as boxing c – talkSPORT.com

Mike Tyson has attributed his incredible body transformation to stem cell therapy and a rigid vegan diet.

The youngest world heavyweight champion in history ballooned to more than 300lbs in weight at his heaviest almost a decade ago.

However, after drastically changing his diet and implementing revolutionary reparative medication, Iron Mike is looking more streamlined and more devastating than ever.

Tyson is reportedly considering making a return to the squared circle at the age of 53, with an announcement on his opponent expected this week.

Whilst training with UFC legends Vitor Belfort and Henry Cejudo, the former undisputed heavyweight champion displayed a significantly more shredded physique.

Prior to officially announcing his desire to return, Tyson was asked by rapper LL Cool J how he would get fighting fit in just six to eight weeks.

He told Rock the Bells Radio show on SiriusXM: Really I would just change my diet and just do cardio work. Cardio has to start, you have to have your endurance to go and do the process of training.

Mike Tyson

So something to do is get in cardio, I would try and get two hours of cardio a day, make sure you get that stuff in. Youre gonna make sure youre eating the right food.

For me its almost like slave food. Doing what you hate to do but doing it like its nothing. Getting up when you dont want to get up. Thats what it is. Its becoming a slave to life.

People think a slave to life is just enjoying drugs and living your life. Being a slave to life means being the best person you can be, being the best you can possibly be, and when you are at the best you can possibly be is when you no longer exist and nobody talks about you. Thats when youre at your best.

Tyson continued: My mind wouldnt belong to me. My mind would belong to somebody that disliked me enough to break my soul, and I would give them my mind for that period of time.

Six weeks of this and Id be in the best shape Ive ever dreamed of being in. As a matter of fact, Im going through that process right now. And you know what else I did, I did stem-cell research.

Stem-cell research (also known as regenerative medicine) promotes the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives.

It is the latest advancement in organ transplantation and uses cells instead of donor organs, which are limited in supply.

After LL Cool J asked if that meant Tysons white blood cells had been spun and then put back in, Tyson continued: Yes. As they took the blood it was red and when it came back it was almost transfluid [sic], I could almost see through the blood, and then they injected it in me. And Ive been weird ever since, Ive got to get balanced now.

Getty Images - Getty

The necessity to repair the former heavyweight champion was caused by the excessive weight gain following his retirement in 2005 and his hedonistic lifestyle.

Excessive cocaine abuse left the heavyweight in a serious state of bother and led him to adopt a vegan lifestyle.

He told Totally Vegan Buzz: I was so congested from all the drugs and bad cocaine, I could hardly breathe. Tyson also revealed in the interview, I had high blood pressure, was almost dying, and had arthritis.

During aninterviewwith Oprah Winfrey in 2013, Tysoncredits his plant-based diet for saving his life.

Getty Images

He said: Well, my life is different today because I have stability in my life. Im not on drugs.

Im not out on the streets or in clubs and everything in my life that I do now is structured around the development of my life and my family. I lost weight.

I dropped over 100lbs and I just felt like changing my life, doing something different and I became a vegan.

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Vegan diet, intense cardio and stem cell therapy How Mike Tyson managed to get ripped at 53 as boxing c - talkSPORT.com

Hair regeneration using stem cells to treat baldness – BioNews

26 May 2020

Stem cells derived from fat can lead to hair regrowth for people with a common type of baldness, according to a new study.

The South Korean researchersconducted a clinical trial into androgenetic alopecia (AGA), the most common cause of hair loss. The trial showed that the use of extracts of fat tissue termed adipose-derived stem cell constituent extract (ADSC-CE) increasedboth hair thickness and density in patients.

'Recent studies have shown that ADSCs promote hair growth in both men and women with alopecia. However, no randomised, placebo-controlled trial in humans has explored the effects and safety of ADSC-CE in AGA. We aimed to assess the efficacy and tolerability of ADSC-CE in middle-aged patients with AGA in our study, hypothesising that it is an effective and safe treatment agent,' said corresponding author Dr Sang Lee from Pusan National University Yangsan Hospital.

To make their solution, the team disrupted the membrane of stem cells found in fat tissues using a low-frequency ultrasound wave and enriched the secreted stem cell with protein. They recruited 38 patients 29 men and nine women with AGA for the clinical trial. One half applied the ADSC-CE lotion to their scalp with their fingers, and the other applied a placebo solution.

A dot was tattooed on the participants'scalps in order to compare the same spot over time. After 16 weeks, the group that used the ADSC-CE lotion presented a significant increase in hair density with 28.1 percent in comparison to 7.1 percent in the control group, and also hair thickness with 14.2 percent in comparison to 6.3 percent in the control group.

The results from this clinical trial, published in the journal Stem Cells Translational Medicine, presented no side-effects, and provide an alternative to current hair therapeutic strategies that have been associated with loss of libido and erectile disfunction.

Further research is required to understand the molecular mechanisms by which ADSC-CE can affect hair growth in humans. 'The next step should be to conduct similar studies with large and diverse populations in order to confirm the beneficial effects of ADSC-CE on hair growth and elucidate the mechanisms responsible for the action of ADSC-CE in humans,' said Dr Lee.

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Hair regeneration using stem cells to treat baldness - BioNews

Human Embryonic Stem Cell Market Analysis with Key Players, Applications, Trends and Forecast to 2027 – Jewish Life News

The Covid-19 (coronavirus) pandemic is impacting society and the overall economy across the world. The impact of this pandemic is growing day by day as well as affecting the supply chain. The COVID-19 crisis is creating uncertainty in the stock market, massive slowing of supply chain, falling business confidence, and increasing panic among the customer segments. The overall effect of the pandemic is impacting the production process of several industries including Life Science, and many more. Trade barriers are further restraining the demand- supply outlook.

The human embryonic stem cells are obtained from the undifferentiated inner mass cell of the human embryo and human fetal tissue. The human embryonic stem cell can replicate indefinitely and produce non-regenerative tissue such as myocardial and neural cells. This potential of human embryonic stem cell allows them to provide an unlimited amount of tissue for transplantation therapies to treat a wide range of degenerative diseases. Hence, human embryonic stem cells are used in the treatment of various diseases such as Alzheimers disease, cancer, blood and genetic disorders related to the immune system and others.

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The global human embryonic stem cell market is expected to grow in upcoming years, factors driving the growth of market are rise in incidences of neurological disorders, increase in investment by government and other organization for research activities, awareness among people about stem cell therapeutic potency for disease treatment. On the other hand emerging stem cell banking services is expected to offer lucrative opportunities in growth of human embryonic stem cell market.

Key Players Influencing the Market:

1. BD

2. Takara Bio Inc.

3. Geron

4. Thermo Fisher Scientific Inc.

5. ViaCyte, Inc.

6. R&D Systems, Inc.


8. CellGenix GmbH

9. Vitrolife

10. Lonza

Market Segmentation :

The global human embryonic stem cell market is segmented on the basis of product type, application and end user. Based on product type, the market is segmented as totipotent stem cell, pluripotent stem cell and unipotent stem cell. On the basis of application, the global human embryonic stem cell market is segmented into regenerative medicine, stem cell biology research, tissue engineering and toxicology testing. Based on end users, the market is segmented as therapeutics companies, cell & tissue banks, tools & reagents companies and others.

The report provides a detailed overview of the industry including both qualitative and quantitative information. It provides overview and forecast of the global human embryonic stem cell market based on various segments. It also provides market size and forecast estimates from year 2017 to 2027 with respect to five major regions, namely; North America, Europe, Asia-Pacific (APAC), Middle East and Africa (MEA) and South & Central America. The human embryonic stem cell market by each region is later sub-segmented by respective countries and segments. The report covers analysis and forecast of 18 countries globally along with current trend and opportunities prevailing in the region.

The report analyzes factors affecting human embryonic stem cell market from both demand and supply side and further evaluates market dynamics effecting the market during the forecast period i.e., drivers, restraints, opportunities and future trend. The report also provides exhaustive PEST analysis for all five regions namely; North America, Europe, APAC, MEA and South & Central America after evaluating political, economic, social and technological factors effecting the human embryonic stem cell market in these regions.

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Human Embryonic Stem Cell Market Analysis with Key Players, Applications, Trends and Forecast to 2027 - Jewish Life News

Biobanks Market – Rising need for replacement organs and the steady advancement in the replacement drive growth of market – BioSpace

Biobanks are essentially repositories for storing biological substances derived from humans, which may include organs, bio-specimens, plasma, saliva, and blood. With a vast rise in the number of organ replacement surgeries globally and significant advancements made in the fields of transfusion and replacement technologies, the role of the biobanks market has become more concrete in the healthcare sector in recent years.

The global biobanks market has witnessed expansion at a significant pace in the recent years owing to the vast rise in prevalence of a number of chronic diseases and the increased demand for personal medicine. The massive rise in incidence rate of conditions such as diabetes, cancer, neurovascular diseases, cardiovascular diseases, and respiratory diseases has compelled government bodies to take stronger actions in terms of investments in biobanks and increasing awareness about them. The global market for biobanks works in coherence with these efforts by adding pace to the process of drug discovery and the treatment of chronic diseases that are caused by activities such as smoking, consumption of alcohol, obesity, and unhealthy lifestyles.

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Heavy investment by a proactive government has boosted the North America biobanks market to the leading position in the global biobanks market, followed closely by Europe. Both regions are home to several bioscience companies and host a large number of drug discovery and research activities. Asia Pacific still remains the region with the most promising growth potential as the region shown high promise owing to an increase in investments from both government and non-government organizations, along with a large and increasingly affluent population base that is gaining awareness about the market.

Global Biobanks Market: Overview

The global biobanks market owes its conception to the rising need for replacement organs and the steady advancement in the replacement and transfusion technologies regarding a number of bodily substances. Though the technology and need to store organs and other bio-entities had been available for a long time, the global biobanks market took on a more important role in the healthcare sector following the increasing research in genomics. In the new millennium, the development of the personalized medicine field has been the vital driver for the global biobanks market. The likely advancement of the latter, thanks to helpful government regulations, is likely to make the crucial difference for the global biobanks market in the near future.

The steady technological advancement in the healthcare sector in the last few decades has now led to a scenario where the full potential of biobanks can be harnessed. As a result, the global biobanks market is projected to exhibit steady growth over the coming years.

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Global Biobanks Market: Key Trends

The rising interest in personalized medicine is the prime driver for the global biobanks market. Personalized medicine has only become a viable branch of modern medicine after steady research in genomics and the way various patients react to various medicines. The biobanks market has thus come into the spotlight thanks to their role as a steady supplier of human biomaterials for research as well as direct application. The increasing research in genomics following the findings of the Human Genome Project is thus likely to remain a key driver for the global biobanks market in the coming years.

The utilization of biobanks in stem cell research has been hampered in several regions by ethical concerns regarding the origin of stem cells. Nevertheless, the potential of stem cells in the healthcare sector is immense, and is likely to have a decisive impact on the trajectory of the global biobanks market in the coming years. Many countries have, in recent years, adopted a supportive stance towards stem cell research, aiding the growth of the biobanks market. Continued government support is thus likely to remain vital for the global biobanks market in the coming years.

Global Biobanks Market: Market Potential

The leading role of the U.S. in the global biobanks market is unlikely to change in the coming years. The easy availability of government-supported healthcare infrastructure and the presence of several industry giants in the region has driven the biobanks market in the U.S.

Northwell Health, the largest healthcare provider in New York State, earlier in 2017 initiated a new biobank aimed at creating precision therapies against various types of cancer. Launched in collaboration with Indivumed, the biobank will provide catalogued biomaterials for research into lung, colorectal, breast, and pancreatic cancer. This would enable targeted, gene-specific studies of a variety of cancer samples, leading to a more comprehensive understanding of cancer. Such well-funded collaboration efforts are crucial for the developing biobanks market.

Global Biobanks Market: Geographical Dynamics

Led by the fertile healthcare research scenario in the U.S., North America is likely to retain a dominant share in the global biobanks market in the coming years. Steady support from institutes such as the NIH is likely to be vital for the North America biobanks market.

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Emerging Asia Pacific economies such as India and China could emerge with a significant share in the global biobanks market in the coming years. The healthcare sector in both countries has received steady public or private funding in the last few years. India is also a global leader in medical tourism and is likely to receive an increasing number of patients in the coming years, leading to promising prospects for the global biobanks market in the region.

Global Biobanks Market: Competitive Dynamics

Due to the dynamic nature of the global biobanks market, with advancements in diagnostic fields often determining the direction of the market, the market is heavily fragmented. It is likely to retain a significant degree of fragmentation in the coming years thanks to the diversity in the application segments of the biobanks market. The leading players in the global biobanks market include BioCision, Tecan Group, VWR, Beckman Coulter Inc., and Thermo Fisher Scientific.

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Biobanks Market - Rising need for replacement organs and the steady advancement in the replacement drive growth of market - BioSpace

Novel Therapies Needed: Poor Prognosis of Patients With TP53-Mutated Myeloid Malignancies – Cancer Therapy Advisor

Poorprognosis and limited efficacy of intensive chemotherapy approaches forpatients with TP53-mutated myeloidmalignancies were confirmed in study results published in Leukemia &Lymphoma.

Jan Philipp Bewersdorf, MD, of the department of internal medicine, section of hematology at the Yale School of Medicine in New Haven, Connecticut, and colleagues conducted the single-center retrospective cohort study from September 1, 2015, to May 31, 2019 (follow-up ended on July 4, 2019). The aims of the study were to describe the clinical, cytogenetic, and molecular characteristics of patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) with TP53 mutations and to analyze patient responses and outcomes with different treatment modalities.

Ofthe 83 participants in the study, the majority were Caucasian (88%); 51.8% werewomen and the median age was 69 years. Most patients had complex karyotypes(90%), and nearly 40% of patients developed therapy-related malignancies.

Frontline treatment included intensive chemotherapy (24.1%), low-intensity treatment (42.2%), best supportive care or hydroxyurea only (22.9%), targeted therapy (3.6%), or other treatments (8.4%).

Themedian follow up was 6.4 months. The median overall survival (OS) and 1-year OSrate were 7.6 months and 22.6%, respectively. Among patients with AML, the medianOS was 6.7 months and 1-year OS rate was 16%. Among patients with MDS, themedian OS was 10 months and the 1-year OS rate was 31.1%.

Forpatients with AML, intensive chemotherapy did not improve median OS compared withlow-intensity treatment (8.8 months vs 9.4 months, respectively; hazard ratio[HR], 0.63). The 1-year OS rates for intensive chemotherapy and low-intensitytherapy were 25.0% and 14.3%, respectively (P =.46); complete response rates were 45.0% and 14.3%, respectively.

Amongparticipents with MDS, no patients received induction chemotherapy as frontlinetreatment. For the 19 patients with MDS who received hypomethylating agent-basedtherapies, the median OS was 12.1 months. For patients who received hydroxyureaor best supportive care only, the median OS was 0.8 months.

Notably,the 11 patients who underwent allogeneic hematopoietic stem cell transplant (alloHSCT)had a significantly longer median OS than those who did not (HR, 0.08; P =.002).Therefore, the authors suggested the alloHSCT should be considered for eligiblepatients with TP53-mutated myeloidneoplasms.

Limitationsof the study included the retrospective design, small sample size, and shortfollow-up durations.

Inconclusion, our data confirm the limited efficacy of intensive chemotherapyapproaches for TP53-mutated patientswith myeloid neoplasms and suggest that a minority of patients achievelong-term survival with alloHSCT, wrote the authors.


Bewersdorf JP, Shallis RM, Gowda L, et al. Clinical outcomes and characteristics of patients with TP53-mutated acute myeloid leukemia or myelodysplastic syndromes: a single center experience [published online May 2, 2020]. Leuk Lymphoma. doi: 10.1080/10428194.2020.1759051

This article originally appeared on Hematology Advisor

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Novel Therapies Needed: Poor Prognosis of Patients With TP53-Mutated Myeloid Malignancies - Cancer Therapy Advisor

Clinical Outcomes Using RYONCIL(TM) (remestemcel-L) in Children and Adults With Severe Inflammatory Graft Versus Host Disease Published in Three…

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NEW YORK, May 25, 2020 (GLOBE NEWSWIRE) -- Mesoblast Limited (Nasdaq:MESO; ASX:MSB), global leader in cellular medicines for inflammatory diseases, today announced that clinical outcomes of its allogeneic mesenchymal stem cell (MSC) medicine RYONCIL (remestemcel-L) in children and adults with steroid-refractory acute graft versus host disease (GVHD) have been published in three peer-reviewed articles and an accompanying editorial in the May issue of Biology of Blood and Marrow Transplantation, the official publication of the American Society for Transplantation and Cellular Therapy.

Mesoblast Chief Medical Officer Dr Fred Grossman said: Results from these three trials show a consistent pattern of safety and efficacy for RYONCIL (remestemcel-L) in patients with the greatest levels of inflammation and the most severe grades of acute GVHD. These clinical outcomes provide a compelling rationale for use of remestemcel-L in children and adults with other conditions associated with severe inflammation and cytokine release, including acute respiratory distress syndrome (ARDS) and systemic vascular manifestations of COVID-19 infection.”

In the accompanying editorial, Dr Jacques Galipeau, Professor and Assistant Dean of Medicine at the Stem Cell & Regenerative Medicine Center at the University of WisconsinMadison and Chair of the International Society of Cell and Gene Therapy (ISCT) MSC Committee, concluded that after more than a decade of clinical study involving three distinct advanced trials, it appears that remestemcel-L might well have finally met the regulatory requirements for marketing approval in the United States for steroid refractory acute GVHD in children, and it is to be determined whether this industrial MSC product will find utility for adults afflicted by acute GVHD or other indications.

The trials highlighted in the three articles all evaluated the same treatment regimen of RYONCIL, with patients receiving twice weekly intravenous infusions of 2 million cells per kg body weight over a four-week period. RYONCIL was well-tolerated in all studies with no identified safety concerns. The three trials were:

1. Study 275: An Expanded Access Program in 241 children across 50 centers in eight countries where RYONCIL was used as salvage therapy for steroid-refractory acute GVHD in patients who failed to respond to steroid therapy as well as multiple other agents.

2. Study GVHD001/002: A Phase 3 single-arm trial in 55 children across 20 centers in the United States where RYONCIL was used as the first line of treatment for children who failed to respond to steroids for acute GVHD.

3. Study 280: A Phase 3 randomized placebo-controlled trial in 260 patients, including 28 children, across 72 centers in seven countries where RYONCIL or placebo were added to second line therapy in patients with steroid-refractory acute GVHD who failed to respond to steroid treatment.

About Acute Graft Versus Host Disease Acute GVHD occurs in approximately 50% of patients who receive an allogeneic bone marrow transplant (BMT). Over 30,000 patients worldwide undergo an allogeneic BMT annually, primarily during treatment for blood cancers, and these numbers are increasing.1 In patients with the most severe form of acute GVHD (Grade C/D or III/IV) mortality is as high as 90% despite optimal institutional standard of care.2,3 There are currently no FDA-approved treatments in the United States for children under 12 with steroid-refractory acute GVHD.

About RYONCILTM Mesoblast’s lead product candidate, RYONCIL (remestemcel-L), is an investigational therapy comprising culture-expanded mesenchymal stem cells derived from the bone marrow of an unrelated donor. It is administered to patients in a series of intravenous infusions. RYONCIL is believed to have immunomodulatory properties to counteract the inflammatory processes that are implicated in SR-aGVHD by down-regulating the production of pro-inflammatory cytokines, increasing production of anti-inflammatory cytokines, and enabling recruitment of naturally occurring anti-inflammatory cells to involved tissues.

References 1. Niederwieser D, Baldomero H, Szer J. Hematopoietic stem cell transplantation activity worldwide in 2012 and a SWOT analysis of the Worldwide Network for Blood and Marrow Transplantation Group including the global survey. Bone Marrow Transplant 2016; 51(6):778-85. 2. Westin, J., Saliba, RM., Lima, M. (2011) Steroid-refractory acute GVHD: predictors and outcomes. Advances in Hematology 2011;2011:601953. 3. Axt L, Naumann A, Toennies J (2019) Retrospective single center analysis of outcome, risk factors and therapy in steroid refractory graft-versus-host disease after allogeneic hematopoietic cell transplantation. Bone Marrow Transplantation 2019;54(11):1805-1814.

About Mesoblast Mesoblast Limited (Nasdaq:MESO; ASX:MSB) is a world leader in developing allogeneic (off-the-shelf) cellular medicines. The Company has leveraged its proprietary mesenchymal lineage cell therapy technology platform to establish a broad portfolio of commercial products and late-stage product candidates. The Company’s proprietary manufacturing processes yield industrial-scale, cryopreserved, off-the-shelf, cellular medicines. These cell therapies, with defined pharmaceutical release criteria, are planned to be readily available to patients worldwide.

Mesoblast’s Biologics License Application to seek approval of its product candidate RYONCIL (remestemcel-L) for pediatric steroid-refractory acute graft versus host disease (acute GVHD) has been accepted for priority review by the United States Food and Drug Administration (FDA), and if approved, product launch in the United States is expected in 2020. Remestemcel-L is also being developed for other inflammatory diseases in children and adults including moderate to severe acute respiratory distress syndrome. Mesoblast is completing Phase 3 trials for its product candidates for advanced heart failure and chronic low back pain. Two products have been commercialized in Japan and Europe by Mesoblast’s licensees, and the Company has established commercial partnerships in Europe and China for certain Phase 3 assets.

Mesoblast has a strong and extensive global intellectual property (IP) portfolio with protection extending through to at least 2040 in all major markets. This IP position is expected to provide the Company with substantial commercial advantages as it develops its product candidates for these conditions.

Mesoblast has locations in Australia, the United States and Singapore and is listed on the Australian Securities Exchange (MSB) and on the Nasdaq (MESO). For more information, please see http://www.mesoblast.com, LinkedIn: Mesoblast Limited and Twitter: @Mesoblast

Forward-Looking Statements This announcement includes forward-looking statements that relate to future events or our future financial performance and involve known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance or achievements to differ materially from any future results, levels of activity, performance or achievements expressed or implied by these forward-looking statements. We make such forward-looking statements pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995 and other federal securities laws. Forward-looking statements include, but are not limited to, statements about the initiation, timing, progress and results of Mesoblast and its collaborators’ clinical studies; Mesoblast and its collaborators’ ability to advance product candidates into, enroll and successfully complete, clinical studies; the timing or likelihood of regulatory filings and approvals; and the pricing and reimbursement of Mesoblast’s product candidates, if approved; the potential benefits of strategic collaboration agreements and Mesoblast’s ability to maintain established strategic collaborations; Mesoblast’s ability to establish and maintain intellectual property on its product candidates and Mesoblast’s ability to successfully defend these in cases of alleged infringement; the scope of protection Mesoblast is able to establish and maintain for intellectual property rights covering its product candidates and technology. You should read this press release together with our risk factors, in our most recently filed reports with the SEC or on our website. Uncertainties and risks that may cause Mesoblast’s actual results, performance or achievements to be materially different from those which may be expressed or implied by such statements, and accordingly, you should not place undue reliance on these forward-looking statements. We do not undertake any obligations to publicly update or revise any forward-looking statements, whether as a result of new information, future developments or otherwise.

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Clinical Outcomes Using RYONCIL(TM) (remestemcel-L) in Children and Adults With Severe Inflammatory Graft Versus Host Disease Published in Three...

Kyle Larson’s First Payday After His NASCAR Suspension is Smaller Than You Might Think – Sportscasting

Kyle Larson may not be allowed to compete in NASCAR events any time soon, but that isnt stopping him from winning races in the meantime. Larson won the World of Outlaws sprint car race on Saturday at Federated Auto Parts Raceway in St. Louis. It was his first race since he was suspended indefinitely by NASCAR for using a racial slur during a virtual iRacing event. Even though he won the race, the check wasnt as lucrative as Larson is used to.

RELATED: Jimmie Johnsons Historic NASCAR Career Is Ending in Frustrating Fashion

If youre wondering why Kyle Larson is racing in sprint car events instead of NASCAR races, it all stems from an iRacing incident from last month.

During a virtual NASCAR race on April 12, Larson uttered a racial slur while streaming on Twitch. Larson thought no one could hear him through his microphone, but the entire group of drivers and the thousands of viewers picked up the slur.

The next day, NASCAR suspended Larson indefinitely. Larson was fired by Chip Ganassi Racing after the incident, and he also lost all of his primary sponsorships.

Larson might not be able to compete on the NASCAR stage for now, but hes still able to race in other leagues while he serves his suspension. On Saturday, he returned to the track for the third time since the racial slur incident, and he even won the race.

Larson competed in the World of Outlaws sprint car race during Memorial Day Weekend. Unlike NASCAR, the race was held on a dirt track with smaller, slower cars and quicker turns. The difference didnt phase Larson in the slightest, as he went on to win the race.

Larson said he was happy for everyone who has stuck behind us after my mistake there. It means a lot. Im having a blast. Trying to have as much fun as I can anyways. Trying to keep my mind off things.

It might not get NASCAR fans to like him again, but Larsons win proved he can still race at a high level despite the controversy swirling around him.

In NASCAR, the purses can range from around $1 million to over $20 million. The winner of a certain race can walk away an instant millionaire, but thats not the case in sprint car races.

Sprint car races are far less popular than NASCAR races, so the television coverage and overall purses are much lower. Larson took home just $20,000 for his win on Saturday. If he was still racing in NASCAR, the payday wouldve been much larger.

Maybe his less than stellar prize will serve as a wake-up call for Larson. He undoubtedly wants to return to NASCAR soon because of the stronger competition and larger purses, but hell have to serve time in lower racing leagues for a while for what he said last month.

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Kyle Larson's First Payday After His NASCAR Suspension is Smaller Than You Might Think - Sportscasting