Archive for the ‘Stem Cell Medicine’ Category

10 talks on the future of stem cell medicine | TED Blog

Stem Cell Medicine | Posted by admin
Mar 23 2019

Health TED Talks

Will the next generation think about diseases like Alzheimers and diabetes the way we think about polio and the whooping cough? Susan Solomon, the co-founder of the New York Stem Cell Foundation (NYSCF), certainly hopes so. In this fascinating talk from TEDGlobal 2012, Solomon delves into the foundations work on research with stem cells, which she calls the black boxes for diseases.

[Stem cells] are our bodies own repair kits. They are pluripotent, which means they can morph into all of the cells in our bodies, says Solomon. Right now there are some really extraordinary things that we are doing with stem cells that are completely changing the way we model disease, our ability to understand why we get sick and even develop drugs. But this field has been under siege, politically and financially.

While much of the fray is about embryonic stem cells still the gold standard when it comes to cells Solomon explains that another type of pluripotent stem cell (called iPS cells) can now be created by, essentially, reprogramming skin cells. These cells hold great promise for allowing researchers to see how diseases develop in humans, rather than in rodents.

Currently, developing a drug takes an average of 13 years, costs $4 billion, and has a 99% failure rate. And because its impossible to test a new drug on a large and representative sample of the human population, even a drug that tests well with many people will have side-effects for others, based on their genetic makeup. This is a problem thats sometimes not apparent until the drug is on the market and being prescribed to patients like in the tragic case of Vioxx.

Thats a terrible business model, but also is a horrible social model,she says. The way weve been developing drugs is essentially like going into a shoe store and no one asking what size you are They just say, Well, you have feet. Here are shoes.

From the TEDGlobal stage, Solomon outlined an exciting new approachher team at NYSCF has developed a machine that creates stem cell lines that, until now, had to be crafted by hand. NYSCF expects to produce 2,500 stem cell lines by the end of the year. The idea is to eventually produce a comprehensive array of 25,000 stem cell lines which act like avatars for a wide sample of people that researchers would have access to as they test new drugs.This could help avoid disasters and also let people know ahead of time of what side-effects they, specifically, can expect with a given medicine.

Two months after her talk, Solomon tells the TED Blog that interest in NYSCF work is growing. Pointing to a recent article in The New York Times about how future lung cancer treatments could be tailored to individuals, Solomon said, Its really the leading edge of where this field is going.

But Solomon stressed that it will be extremely difficult to change the current systems of drug development.

All the established companies have been using mouse-and-rodent testing forever, she said. A lot of peoples careers are staked to a method that is outdated. Its like the tech sector; this is really the high-tech sector for biomedical research.

To hear more about the NYSCF, watch Solomons talk. Below, watch 9 more talks about the incredible promise of stem cells.

Susan Lim: Transplant cells, not organsAs a woman, surgeon Susan Lim had to fight for the right to perform the first liver transplant in Asia. But she began to question the morality of such work given that with donor organs in such short supply many are coerced or forced to donate. Lim began looking at another approach: transplanting cells, rather than organs. In this talk, given at the INK Conference, she describes her work with adult stem cells derived from fat.

Daniel Kraft invents a better way to harvest bone marrowPediatrician and stem cell researcher Daniel Kraft has created a device to collect bone marrow in a way that is far less painful for both the patient and the doctor. In this talk from TED2009, Kraft shows how the stem cells found in this marrow could be used to treat heart disease and Parkinsons.

Eva Vertes: Do stem cells cause cancer?Microbiology prodigy Eva Vertes was 19 years old when she spoke at TED2005 about a theory that cancer might be a repair response to damaged stem cells in the lungs, liver, bones, etc. The implication she is testing? Its possible, although far-fetched, that in the future we could think of cancer being used as a therapy.

Alan Russell: The potential of regenerative medicineNot for the squeamish, in this talk from TED2006, medical futurist Alan Russell shows a video of stem cells being removed from a patients hip and injected directly into their heart and how this procedure has gotten much more precise over a short time. Such cell regeneration therapies will keep improving, Russell says.

Noel Bairey Merz: The single biggest health threat women faceWhile heart disease is often thought of as a male disease, Noel Bairey Merz explains that it is actually the biggest killer of women. In this talk from TEDxWomen 2011, Merz gives a call to arms for women to think of heart disease in the same way we do breast cancer, and talks about some exciting possibilities for treatment, including stem cell therapy.

Daniel Kraft: Medicines future? Theres an app for thatKraft, chair of the FutureMed program at Singularity University, talks about some of the big innovations coming down the pipeline in medicine. Near the end of this talk given at TEDxMaastricht, Kraft talks about cancer stem cells and how understanding them could lead to an era of personalized oncology the ability to leverage all of this data together, analyze the tumor and come up with a real, specific cocktail for the individual patient.

Juan Enriquez: The next species of humanFuturist Juan Enriquez believes that some big changes are coming, and that the next generation of humans could potentially be considered a different species. Why? In this talk from TED2009, he looks at the ability to engineer both cells and tissue, and describes some shocking ways researchers are using stem cells.

Kevin Stone: The bio-future of joint replacementArthritis affects more adults than cancer, says Kevin Stone in this talk from TED2010. While therapies using human tissue have been very promising in helping joint damage, there simply isnt enough donor tissue to go around. Stone explains a process which uses cartilage from a pig, loaded with a persons own stem cells, to ease pain and immobility.

Iain Hutchison: Saving facesIn this talk from TEDGlobal 2010 which contains some images of badly injured and disfigured faces that may be disturbing facial surgeon Iain Hutchison gives a look at his groundbreaking work. Towards the end of the talk, he describes an promising area of research tissue engineering which uses a patients own stem cells, taken from their hip, to help heal facial damage.

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10 talks on the future of stem cell medicine | TED Blog

Ansary Stem Cell Institute | Department of Medicine

Stem Cell Medicine | Posted by admin
Mar 10 2019

Directed by Division Chief Dr. Shahin Rafii, the Ansary Stem Cell Institute is home to landmark advances in regenerative medicine.Dr. Shahin is nationally and internationally recognized for having pioneered the transformative paradigm demonstrating that tissue-specific adult endothelial cells (ECs) are unique instructive vascular niche cells that produce paracrine angiocrine factors to directly induce organ regeneration. This concept has revealed the remarkable heterogeneity of the adult vasculature that is underscored by production of tissue-specific angiocrine factors necessary for orchestrating organ regeneration. Under Dr. Rafiis direction, his laboratory has ushered in a new era in state-of-the-art models for the study of tissue-specific induction of angiocrine factors in ECs. His laboratory has driven many breakthroughs, including the identification of physiologically relevant tissue-specific stimulatory and anti-fibrotic angiocrine factors.The team utilizes in vivo genetic models to determine the role of angiocrine factors in organ regeneration and has played a major role in illuminating the intrinsic and microenvironmental determinants of vascular heterogeneity.

The Division of Regenerative Medicine also focuses on stem cell biology and their niches using mouse and human genetic models, tissue culture approaches and molecular biology to model the complex interactions between stem cells and their micro-environment. Multi-omics, molecular and cell biological techniques are combined to achieve a systems level understanding of these complex processes.

Our three investigators are engaging cutting edge technologies and concepts to decipher these interactions:

Shahin Rafiis Laboratory

Currently, Rafii's work is focused on identifying the molecular and cellular pathways involved in organ regeneration and tumor growth. He has established the concept that vascular endothelial cells are not just inert plumbing to deliver oxygen and nutrients, but also by production of tissue-specific growth factors, defined as angiocrine factors, support organ regeneration and tumor proliferation. He has shown that bone marrow endothelial cells by elaboration of angiocrine factors, such as Notch ligands, support stem cell self-renewal and differentiation into lymphoid and myeloid progenitors. He has recently demonstrated that liver and lung endothelial cells are endowed with unique phenotypic and functional attributes and by production of unique instructive growth factors contribute to the hepatic and alveolar regeneration.

He employed this knowledge to induce differentiation of the murine and human pluripotent embryonic stem cells into functional and engraftable vascular and hematopoietic derivatives. He developed screening approaches to exploit endothelial cells as a vascular niche platform to identify as yet unrecognized novel angiocrine factors that instruct organ morphogenesis as well as orchestrating stem cell self-renewal and differentiation.

Qiao Zhous Laboratory

The Zhou lab studies how specific cell types are created during development and uses this knowledge to regenerate or rejuvenate vital cells by in vivo reprogramming in adult organs. These adult cells demonstrate remarkable stability, maintaining their unique identity despite constantly changing physiological conditions. If this stability is undermined, diseases of metaplasia and cancer can arise. On the other hand, controlled manipulation of cell identity (converting a cell from one specialized type into another) is a key step towards tissue regeneration. Our laboratory investigates the molecular machinery that safeguards normal cell identity and seeks to control this process to regenerate tissues that are lost due to disease or injury.

Currently, two major model systems are employed. The first is revolved upon beta cells, the sole provider of insulin for the body. The goal is to regenerate beta cells in adults as a way to treat Type I diabetes, a disease marked by a lack of beta cells due to autoimmune attacks. In development is a novel approach to regenerate beta cells by converting cells of various internal organs, such as pancreatic exocrine cells, liver cells, and intestine cells, into beta cells by cellular reprogramming. The promise of this approach was recently demonstrated in animal models.

In process is the building of beta cells and spinal glial cells into platforms to understand the broad principles and molecular machinery that control cell identity. An array of molecular, cellular, and genetic techniques are employed in pursuit of this goal. These basic research efforts provide a firm foundation in our search for new treatments for degenerative diseases.

Raphael Liss Laboratory

Development and maintenance of the haematopoietic system relies on a scant number of self-renewing haematopoietic stem cells (HSCs) residing in the adult bone marrow and representing the top of a complex cellular hierarchy. Transplantation of HSCs, harvested from either bone marrow, mobilized peripheral blood or umbilical cord blood (UCB), has become the standard of care for numerous hereditary and malignant blood diseases. However, the limited availability of optimally human leukocyte antigen (HLA)- matched donor HSCs remains a challenge, especially for individuals of non-Caucasian background or mixed ethnicity. While the immunologic navet of UCB enables transplantation despite antigen mismatch, the relatively low HSC dose slows engraftment and raises the threat of graft failure.

In vitro expansion of UCB HSCs has been vigorously investigated, but despite substantial progress, current protocols are not yet clinically approved. Consequently, and because considerable interest in illuminating fundamental aspects of blood development, de novo generation of HSCs from non haematopoietic sources has become a major objective for the field, a holy grail, with wide-ranging implications for HSC biology and transplantation medicine.

This research has converted endothelial cells to engraftable HSC-like cells through direct conversion by expression of FOSB, GFI1, RUNX1, SPI1 (FGRS). Propagation of these cells onto a vascular-niche-like environment has substantially enhanced reprogramming efficiency, emphasizing the importance of inductive cues from the physiological micro-environment in the orchestration of haematopoietic specification. The converted cells acquired colony-forming potential and were successfully engrafted in recipient mice, after primary and secondary transplantation, producing long-term myeloid and B lymphoid progeny. This innovative approach constitute a landmark advance towards engineered autologous bone marrow transplant and hematological disease modeling.

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Ansary Stem Cell Institute | Department of Medicine

PRP vs. Stem Cell Therapy in Medicine | NSI Stem Cell

Stem Cell Medicine | Posted by admin
Mar 09 2019

We get it. Its confusing. So much is online, on TV, and in print about platelet rich plasma (PRP) and stem cell therapy in todays medical fields. How can the average person separate, to paraphrase author Nate Silver, the signal from the noise? Fact from hype? Which is better: platelet rich plasma treatments or therapies that are stem cell based? The short answer is: both! But there is a lot more to the story of PRP and stem cell therapy in regenerative medicine. NSI Stem Cell Centers in Florida use both types of therapy, because both have unique, remarkable qualities. Sometimes, only PRP treatment is used, as in certain physical injuries. Various types of knee pain, for example. Sometimes, only stem cell therapy is used, as in certain types of neurological conditions. But PRP and stem cell therapies are far from rivals. Often, they join forces to treat a wide array of diseases, injuries, and acute disorders. So, what are the differences between platelet rich plasma treatment and stem cell therapy in todays medicine? To answer that, lets take a closer look at each, and how the development of these regenerative techniques is revolutionizing medical practices across the board. Stem Cell Therapy In Practical Medicine Mesenchymal stem cells (MSCs) are known for their ability to self-renew and to differentiate into multiple lineage pathways. What does that mean? It means that MSCs are packets of potential. They remain in our bodies throughout life, waiting for chemical signals to alert them to the needs of both brain and body. In this service they can become whatever type of cell is needed for repair, re-growth, replacement, and regeneration. This includes cells of skin, bone, cartilage, blood, organs, and brain. It doesnt matter if the reason is disease, a wound, neurologically based, or even a combination of causes. Stem cell therapy in regenerative medicine is used to address and heal the underlying causes of illness and injury. There are various types of MSCs, classified according to where the body stores them. But the type that is responsible for the remarkable growth of stem cell therapy in todays practical medicine is the adipose-derived MSC. Also known as adipose stem cells, they are adult stem cells, meaning that they are among the types of MSCs that remain with us throughout life. The body stores adipose stem cells in the fatty tissue layer that lies just beneath the skin. This fatty tissue is called adipose fat. But why are adipose-derived MCSs in particular the driving force behind the explosive development of stem cell therapy in medicine? Adipose fat holds a particular abundance of MSCs. So, adipose-derived stem cells are easy to harvest. But they are also an exceptionally potent type of MSC. That means a smaller sample can be taken at harvest. Harvesting the sample is minimally invasive. This means that the procedure is far easier on the patient. The ease of the harvest and the potency of the adipose MSCs taken together have given rise to a golden age of stem cell therapy in regenerative medicine. Already over twenty treatments have been developed and are in practice as FDA guidelines-compliant procedures. They are available today across the United States at advanced medical clinics like NSI Stem Cell. As research and clinical trials continue to expand, more therapies come online regularly. Platelet Rich Plasma (PRP) In Practical Medicine Platelet rich plasma made its popular debut largely through professional sports. When well known athletes like basketball pro Brandon Roy, Masters champion golfer Tiger Woods, baseball star Alex Rodriguez, and tennis champion Rafael Nadal began using PRP to treat their career-related injuries, both the public and the wider medical community at large took note. Much of the present attention that PRP therapy has received from both the public and the medical community stems from pro athletes being treated for acute injuries related to their sports. These include ligament and muscle injuries. Prior to the development of PRP therapy, the treatment of such injuries relied on medication, physical therapy, or invasive surgery. But as more and more pro athletes began crediting platelet rich plasma with a quicker return to the game, PRP therapy began to be seen as a viable alternative to more invasive procedures. Whereas the source for stem cell therapy in todays fastest growing regenerative medicine procedures is adipose fat, platelet rich plasma is derived from the blood. As with adipose-derived MSC therapies, the blood sample does not have to be particularly large. After the sample is drawn, a portion of it undergoes a process call centrifugation. At the end of the process, the blood has been broken down into its three main components: platelet poor plasma (PPP), platelet rich plasma, and red blood cells. It is the platelet rich plasma that is the basis of all PRP therapies. The centrifugation separates the platelets from the other blood cells and increases their concentration. Then the increased concentration of platelets is combined with the remaining blood that was drawn. The platelets in PRP play a primary part in the clotting of blood. They are also a rich resource of growth factors. Growth factors play an essential role in wound healing and the process of regeneration. But PRP also releases an abundance of other substances critical in the healing of wounds. PRP augments the creation of blood vessels, improves healing of soft tissues, and enhances the regeneration of bone. Platelet rich plasma holds a concentration of platelets that is five to ten times the amount of platelets found in blood. Specifically, a platelet is a cell that is disk shaped. Along with red and white blood cells, platelets circulate through the bloodstream. A platelet contains natural growth factors. Among them are proteins and cytokines. When bones or soft tissue -such as tendons or ligaments- are damaged, the growth factors in platelets stimulate healing of bone and soft tissues. These proteins, cytokines and other growth factors in the PRP provide a number of ways to assist in the repairing of cell damage. They decrease inflammation, improve cell growth, and provide signaling to the immune system. In addition, particular types of cytokines focus on the creation of metabolic pathways that support cell recovery. PRP treatments are highly effective for relieving acute pain. The success of platelet rich plasma therapy is confirmed by both ultrasound and MRI images, which have shown definitive tissue repair after PRP therapy. PRP therapy is commonly used to address acute pain without resorting to invasive surgical techniques. In the FDA guidelines-compliant procedures practiced at NSI Stem Cell Centers, neither general anesthesia nor overnight hospital stays are necessary. There is also no prolonged recovery time. In general, most people return to their jobs or usual activities right after the procedure. As with FDA guidelines-compliant stem cell therapy in regenerative procedures, there is no risk of the patients immune system rejecting the therapy or any risk of disease transmission. This is because the PRP is made from the patients own blood. In both the case of PRP treatment and stem cell therapy in FDA guidelines-compliant procedures as practiced at NSI Stem Cell Centers, all are done on an out-patient basis. This is largely possible because of the ease of sample harvesting. With no need for highly invasive surgery or general anesthesia, overnight hospital stays are unnecessary. Neither is there any long, post-procedure recovery time involved. Patients can return to their usual, daily activities immediately. Examples of PRP and Stem Cell Therapies The list of illnesses, injuries, and conditions that are safely and effectively treated through PRP and/or stem cell therapy in regenerative medicine is already extensive. It includes: In addition, PRP and stem cells are often used as important enhancement aids in the traditional treatment of heart disease, liver disease, stroke, and traumatic brain injury. And great optimism grows among doctors regarding future stem cell therapy in the treatment of some of humankinds most pressing medical challenges, such as ALS and Alzheimers disease. What to Look for in a Stem Cell Medical Clinic When searching for a qualified stem cell therapy center its important to remember that not all of them are created equal. Stem cells, when used properly, are your bodys most powerful means for healing that can repair everything from ligaments, tendons, and cartilage to organs including your liver, pancreas and lungs and even neurological tissue like your brain, nerves and spinal cord. Unfortunately, the majority of so-called regenerative medicine clinics in the world arent trained in the latest, most technologically advanced procedures and will, therefore, provide poor results if any. The good news is the National Stem Cell Institute (NSI) has established the most advanced stem cell and platelet rich plasma procedures on the planet which has drawn patients from all over the world as well as professional athletes and celebrities because they are recognized as the best in the world at stem cell therapy. What makes NSI Stem Cell the top stem cell clinic in the world is demonstrated in 5 key areas: 1. Highly trained and experienced, board-certified doctors and team members who have performed stem cell procedures on thousands of patients with incredible results. 2. Cutting edge procedures utilizing all that regenerative medicine has to offer for many chronic degenerative conditions. 3. Leading scientific researchers who follow the advanced guidelines to maximize the healing potential of your stem cells and to maintain compliance and ethics 4. Use of only the most potent and viable resource of living, viable stem cells and harvested on the same day. No vial that you can purchase will contain living stem cells. If there is no harvest then there are no stem cells. 5. Post-operative guidance for supporting stem-cell growth including rehabilitation, diet and supplement protocols. NSI is a full-service healthcare center focused on patient outcomes. Stem cell therapy is only one tool used to help improve patients lives. Patients have raved about their experience at NSI Stem Cell Clinics testifying that it was their unique cutting-edge procedures that helped them experience a breakthrough when nothing else worked. If you want to learn more about NSI Stem Cell Clinics, you can set up a complimentary consultation today to see if you are a candidate. You can contact the National Stem Cell Institute at (877) 278-3623.

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PRP vs. Stem Cell Therapy in Medicine | NSI Stem Cell

Top Stem Cell Conferences | Stem Cell Research 2019 …

Stem Cell Medicine | Posted by admin
Mar 08 2019

Session and Tracks Track 1: Stem Cells Biology

Stem cells are defined as precursor cells that have the capability to self-renew and to come up with multiple mature cell types. Stem cells are an ongoing source of the differentiated cells that make up the tissues and organs of plants and animals. After collecting and culturing tissues is it possible to classify cells as per their operational concept. There are 2 major types of stem cells: Embryonic Stem Cells and Adult Stem Cells that is also known as tissue stem cells. This difficulty in characteristic stem cells in situ, without any manipulation, limits the understanding of their true nature. There is great interest in stem cells as a result of they have potential in the development of therapies for replacing defective or damaged cells ensuing from a variety of disorders and injuries, like Parkinson disease, heart disease, and diabetes.

Related Conferences:

25thGlobal Meet on Cancer Research & Oncology, May 20-21, 2019, Rome, Italy; 2ndWorld Congress on Advanced Cancer Science & Therapy, January 28-29, 2019, Dubai, UAE; 3rdAdvances in Cell & Stem Cell Research Congress, September 25-26, 2019, Rome, Italy; 3rdInternational Conference on Nanostructures, Nanomaterials and Nanoengineering, October 21-22, 2019, Las Vegas, USA; 3rdWorld Congress on Advanced Biomaterials and Tissue Engineering, August 26-27, 2019, Madrid, Spain;

Hematopoietic Stem Cells are the immature cell that is developed into all types of blood cells, including red blood cells, white blood cells, and platelets which are found in the peripheral blood and the bone marrow. These stem cells are also called blood stem cell. Studies have described two populations of Hematopoietic Stem Cells that are Long Term and Short Term. Long-Term Hematopoietic stem cells which are capable of self-renewal, while Short Term Hematopoietic stem cells do not have this capacity.

Related Conferences:

4thWorld Biotechnology Congress, May 20-21, 2019, London, UK; 6thWorld Congress on Microbial Biotechnology, June 17-18, 2019, Paris, France; Annual Congress on Advanced Tissue Science and Regenerative Medicine, April 15-16, 2019, Amsterdam, Netherlands; World Congress on Cell & Gene Therapy, September 25-26, 2019, Rome, Italy; World Congress on Novel Trends and Advances in Biotechnology, September 25-26, 2019, Rome, Italy;

Embryonic Stem Cells are developed when embryos formed during the blastocyst phase of embryological development. They can grow in all derivatives of the 3 primary germ layers i.e. ectoderm, endoderm and mesoderm. These include each of the more than 220 cell varieties within the adult body. Pluripotency distinguishes embryonic stem cells from adult stem cells found in adults; whereas embryonic stem cells can generate all cell types within the body, adult stem cells are multipotent and can produce only a restricted number of cell types. Embryonic stem cells are capable of propagating themselves indefinitely. This allows embryonic stem cells to be employed as useful tools for both research and regenerative medicine, because they can produce limitless numbers of themselves for continued research or clinical use.

Related Conferences:

25thGlobal Meet on Cancer Research & Oncology, May 20-21, 2019, Rome, Italy; 2ndWorld Congress on Advanced Cancer Science & Therapy, January 28-29, 2019, Dubai, UAE; 3rdAdvances in Cell & Stem Cell Research Congress, September 25-26, 2019, Rome, Italy; 3rdInternational Conference on Nanostructures, Nanomaterials and Nanoengineering, October 21-22, 2019, Las Vegas, USA; 3rdWorld Congress on Advanced Biomaterials and Tissue Engineering, August 26-27, 2019, Madrid, Spain;

Induced Pluripotent Stem Cells (iPSCs) are the adult stem cells derived from skin or blood cells which are reprogrammed to an embryonic stem cell maintaining the essential properties of introducing important genes and also to enables the development of an unlimited source of any type of human cell needed for the therapeutic purpose. Researchers have rapidly developed the techniques for generating iPSCs and by creating a new and powerful way to "de-differentiate" cells whose developmental fates.

Related Conferences:

4thWorld Biotechnology Congress, May 20-21, 2019, London, UK; 6thWorld Congress on Microbial Biotechnology, June 17-18, 2019, Paris, France; Annual Congress on Advanced Tissue Science and Regenerative Medicine, April 15-16, 2019, Amsterdam, Netherlands; World Congress on Cell & Gene Therapy, September 25-26, 2019, Rome, Italy; World Congress on Novel Trends and Advances in Biotechnology, September 25-26, 2019, Rome, Italy;

Though the concept of stem cell niche was prevailing in vertebrates, the first characterization of stem cell niche in vivo was figured out in drosophila germinal development. A stem-cell niche is an area of a tissue that provides a specific microenvironment, in which stem cells are present in an undifferentiated and self-renewable state. Cells of the stem-cell niche interact with the stem cells to take care of them or promote their differentiation. Characterization of these stem cell niches depends on the ability to identify stem cells in vivo in their normal setting. Through comparison of different stem cell systems, some themes emerge that indicate possible general characteristics of the relationship between stem cells and their supporting niche.

Related Conferences:

4thWorld Biotechnology Congress, May 20-21, 2019, London, UK; 6thWorld Congress on Microbial Biotechnology, June 17-18, 2019, Paris, France; Annual Congress on Advanced Tissue Science and Regenerative Medicine, April 15-16, 2019, Amsterdam, Netherlands; World Congress on Cell & Gene Therapy, September 25-26, 2019, Rome, Italy; World Congress on Novel Trends and Advances in Biotechnology, September 25-26, 2019, Rome, Italy;

Stem cell banking is the extraction, processing and storage of stem cells which can used for treatment when required. Stem cells have the amazing power to transform into any tissue or organ in the body. It is due to this unique characteristic that they have the potential to treat over 80 life threatening diseases, and provide numerous benefits to the baby, its siblings and the family. There are variety of sources from where stem cells can be banked, with the most common amongst them being the umbilical cord. Cord blood banking is that the extraction of stem cells from the umbilical cord. This is done during childbirth and is a fast, hassle free and painless procedure. While, the umbilical cord and cord blood are the foremost common sources of stem cells - the Placenta, amniotic sac and amniotic fluid are by far the richest sources, in terms of both - quantity and quality. Some other rich sources of stem cells are Placenta, Umbilical Cord, Amniotic Fluid, Dental Stem Cells, Menstrual Fluid, Adipose Tissue and Bone Marrow.

Related Conferences:

25thGlobal Meet on Cancer Research & Oncology, May 20-21, 2019, Rome, Italy; 2ndWorld Congress on Advanced Cancer Science & Therapy, January 28-29, 2019, Dubai, UAE; 3rdAdvances in Cell & Stem Cell Research Congress, September 25-26, 2019, Rome, Italy; 3rdInternational Conference on Nanostructures, Nanomaterials and Nanoengineering, October 21-22, 2019, Las Vegas, USA; 3rdWorld Congress on Advanced Biomaterials and Tissue Engineering, August 26-27, 2019, Madrid, Spain;

A procedure in which a patient receives healthy blood-forming cells (stem cells) to replace their own, when stem cells or bone marrow are damaged or destroyed by disease, as well as some types of cancer, or by high doses of chemotherapy or radiation therapy used to treat cancer. The healthy stem cells may come from the blood or from a donors bone marrow or from the umbilical cord blood of a newborn baby. A stem cell transplant may be autologous (use of stem cells from your own bone marrow or blood), allogeneic use of stem cells from someone else, the donor could also be a relative or somebody who isn't associated with you) or syngeneic (use of stem cells from an identical twin). The stem cells within the bone marrow transform into red blood cells, white blood cells and platelets. when these blood cells mature, they go into the peripheral blood (the blood that flows through the body). If the bone marrow is damaged or destroyed, it cant create normal blood cells. in a stem cell transplant, healthy stem cells are placed in your body to assist your bone marrow start to work properly. The new stem cells make healthy blood cells.

Related Conferences:

4thWorld Biotechnology Congress, May 20-21, 2019, London, UK; 6thWorld Congress on Microbial Biotechnology, June 17-18, 2019, Paris, France; Annual Congress on Advanced Tissue Science and Regenerative Medicine, April 15-16, 2019, Amsterdam, Netherlands; World Congress on Cell & Gene Therapy, September 25-26, 2019, Rome, Italy; World Congress on Novel Trends and Advances in Biotechnology, September 25-26, 2019, Rome, Italy;

Stem Cell Therapy is the treatment for various disorders which non-seriously life-threatening by using stem cells. These stem cells can be obtained from a lot of different sources and used to potentially treat more than 80 disorders which include neuromuscular, organ, chronic and degenerative disorders. Chronic disorders arise from degeneration or wear and tear of cartilage, muscle, bone, fat or the opposite organ, tissue or cell. This may occur owing to a spread of reasons, but it's usually the tactic spoken as aging, or 'getting old' that is the largest cause. Stem cell therapy is currently being researched for the treatment of various diseases. While research and clinical trials are in process with varying degrees of success, stem cell therapy holds the potential to offer a successful cure for these conditions.

Related Conferences:

4thWorld Biotechnology Congress, May 20-21, 2019, London, UK; 6thWorld Congress on Microbial Biotechnology, June 17-18, 2019, Paris, France; Annual Congress on Advanced Tissue Science and Regenerative Medicine, April 15-16, 2019, Amsterdam, Netherlands; World Congress on Cell & Gene Therapy, September 25-26, 2019, Rome, Italy; World Congress on Novel Trends and Advances in Biotechnology, September 25-26, 2019, Rome, Italy;

Cancer is defined as the abnormal growth of cells that possesses the ability to spread to other cells and tissues. Cancer is one of the major illness which it seemed to be more prevalent all over the world. Even though the death rate and peoples suffering from these diseases are in greater number in recent years. There are over 200 variety of types of cancer across the globe. The death rate increasing year-by-year due to this disease even in developed countries. Cancer Stem Cells (CSCs) are a small population of cells inside tumors with capabilities of self-renewal, differentiation, and tumorigenicity once transplanted into an animal host. The CSC hypothesis thus doesn't imply that cancer is always caused by stem cells or that the potential application of stem cells to treat conditions like cardiovascular disease or diabetes which is able to result in tumor formation. Rather, tumor-initiating cells possess stem-like characteristics to a degree sufficient to warrant the comparison with stem cells along with the observed experimental and clinical behaviors of metastatic cancer cells are extremely resembling the classical properties of stem cells

Related Conferences:

25thGlobal Meet on Cancer Research & Oncology, May 20-21, 2019, Rome, Italy; 2ndWorld Congress on Advanced Cancer Science & Therapy, January 28-29, 2019, Dubai, UAE; 3rdAdvances in Cell & Stem Cell Research Congress, September 25-26, 2019, Rome, Italy; 3rdInternational Conference on Nanostructures, Nanomaterials and Nanoengineering, October 21-22, 2019, Las Vegas, USA; 3rdWorld Congress on Advanced Biomaterials and Tissue Engineering, August 26-27, 2019, Madrid, Spain;

As an organism grows and develops, carefully orchestrated chemical reactions activate and deactivate components of the genome at strategic times and in specific locations. Epigenetics is that the study of these chemical reactions and the factors that influence them. It is strongly believed that there are some signals at the epigenetic level that regulate the fate of the stem cells. Though all of the cells in our body contain the same genetic makeup. These genes are not necessarily active at all times, rather they are expressed at times when needed in a highly controlled fashion.

Related Conferences:

25thGlobal Meet on Cancer Research & Oncology, May 20-21, 2019, Rome, Italy; 2ndWorld Congress on Advanced Cancer Science & Therapy, January 28-29, 2019, Dubai, UAE; 3rdAdvances in Cell & Stem Cell Research Congress, September 25-26, 2019, Rome, Italy; 3rdInternational Conference on Nanostructures, Nanomaterials and Nanoengineering, October 21-22, 2019, Las Vegas, USA; 3rdWorld Congress on Advanced Biomaterials and Tissue Engineering, August 26-27, 2019, Madrid, Spain;

Tissue Engineering is a scientific field centered on the advance of Tissue and Organ Substitutes by controlling their environment, biomechanical and biophysical parameters which include the utilization of a different or same scaffold for the arrangement of new tissue. These frameworks empower the In-vitro investigation of human physiology and physiopathology, while giving a rendezvous of biomedical instruments with potential materialness in toxicology, medicinal gadgets, tissue substitution, repair and Regenerative Medicine. Regeneration is that the progression of renewal, regeneration, and growth that makes it cells, organ regeneration to natural changes or events that cause damage or disturbance. This study is carried out as craniofacial tissue engineering, in-situ tissue regeneration, adipose-derived stem cells for tissue science which is also a breakthrough in cell culture technology. The study isn't stopped with the regeneration of tissue wherever it is further carried out in relation to cell signaling, morphogenetic proteins. Most of the neurological disorders occurred accidentally having a scope of recovery by replacement or repair of intervertebral discs repair, spinal fusion and plenty of more advancement.

Related Conferences:

4thWorld Biotechnology Congress, May 20-21, 2019, London, UK; 6thWorld Congress on Microbial Biotechnology, June 17-18, 2019, Paris, France; Annual Congress on Advanced Tissue Science and Regenerative Medicine, April 15-16, 2019, Amsterdam, Netherlands; World Congress on Cell & Gene Therapy, September 25-26, 2019, Rome, Italy; World Congress on Novel Trends and Advances in Biotechnology, September 25-26, 2019, Rome, Italy;

Regeneration Medicine is that the Survival of any living body essentially relying upon its capability to repair and recover injured or harmed tissues or potential organs amid its lifespan following injury, illness, or maturing. This will shape the system for recognizing novel clinical medicines which will enhance the mending and regenerative limit of individuals. The Regeneration process involves Cell Proliferation where most of the medical disorders occurred accidentally includes a scope of recovery by replacement or repair of intervertebral discs repair, spinal fusion and plenty of more advancements.

Related Conferences:

25thGlobal Meet on Cancer Research & Oncology, May 20-21, 2019, Rome, Italy; 2ndWorld Congress on Advanced Cancer Science & Therapy, January 28-29, 2019, Dubai, UAE; 3rdAdvances in Cell & Stem Cell Research Congress, September 25-26, 2019, Rome, Italy; 3rdInternational Conference on Nanostructures, Nanomaterials and Nanoengineering, October 21-22, 2019, Las Vegas, USA; 3rdWorld Congress on Advanced Biomaterials and Tissue Engineering, August 26-27, 2019, Madrid, Spain;

Cell reprogramming is the process of reverting mature, specialized cells into induced pluripotent stem cells. Reprogramming also refers to the erasure and re-establishment of epigenetic marks during mammalian germ cell development. The discovery of Induced pluripotent stem cells emphasizes on reprograming of any adult differentiated cells into stem cells by genetic modification under precisely controlled laboratory conditions. Reprograming of cells is supposed to presage revolution in both, medical and biological research and allows modeling and analysis of human diseases and cell cytotoxicity by drugs. The technique is still in its growing phase and requires a great deal of extensive research and approval from authorities for further trials.

Related Conferences:

25thGlobal Meet on Cancer Research & Oncology, May 20-21, 2019, Rome, Italy; 2ndWorld Congress on Advanced Cancer Science & Therapy, January 28-29, 2019, Dubai, UAE; 3rdAdvances in Cell & Stem Cell Research Congress, September 25-26, 2019, Rome, Italy; 3rdInternational Conference on Nanostructures, Nanomaterials and Nanoengineering, October 21-22, 2019, Las Vegas, USA; 3rdWorld Congress on Advanced Biomaterials and Tissue Engineering, August 26-27, 2019, Madrid, Spain;

Stem cell nanotechnology has emerged as a brand-new exciting field. Experimental and theoretical studies of interaction between nanostructures or nanomaterials and stem cells have made great advances. The importance of nanomaterials, nanostructures, and nanotechnology to the basic developments in stem cells-based therapies for injuries and degenerative diseases has been recognized. Apart from tracking the localization of stem cells, nanotechnology has improved targetability, half-life, and stability of stem cells by providing a suitable microenvironment. In particular nanomaterials have played a significant role in the isolation and proliferation or differentiation of stem cells and intracellular delivery of small and macromolecules within stem cells. In this field over the past few years, explore the application prospects, and discuss the issues, approaches and challenges, with the aim of rising application of nanotechnology in the stem cells research and development.

Related Conferences:

4thWorld Biotechnology Congress, May 20-21, 2019, London, UK; 6thWorld Congress on Microbial Biotechnology, June 17-18, 2019, Paris, France; Annual Congress on Advanced Tissue Science and Regenerative Medicine, April 15-16, 2019, Amsterdam, Netherlands; World Congress on Cell & Gene Therapy, September 25-26, 2019, Rome, Italy; World Congress on Novel Trends and Advances in Biotechnology, September 25-26, 2019, Rome, Italy;

Stem Cell Technologies will become a global biotechnology that manufactures, develops and sells product by providing the services to support academic and industrial scientists. Stem cells analysis and development team typically collaborates with educational institutes and industrial partners to manufacture, develop and distribute a specific product for a given analysis. A stem cell has helped several scientific communities and industries to develop technologies to achieving the world biotechnology market. The corporate makes a specialist in developing cell culture media, cell separation product, instruments and completely different reagents to be utilized in the cell, immunology, cancer, Regenerative medicine and cellular treatment analysis.

Related Conferences:

25thGlobal Meet on Cancer Research & Oncology, May 20-21, 2019, Rome, Italy; 2ndWorld Congress on Advanced Cancer Science & Therapy, January 28-29, 2019, Dubai, UAE; 3rdAdvances in Cell & Stem Cell Research Congress, September 25-26, 2019, Rome, Italy; 3rdInternational Conference on Nanostructures, Nanomaterials and Nanoengineering, October 21-22, 2019, Las Vegas, USA; 3rdWorld Congress on Advanced Biomaterials and Tissue Engineering, August 26-27, 2019, Madrid, Spain;

There are many research advancements and applications and of Stem Cells. Stem cell research that can be applied to develop new therapies includes cell replacement therapy, development of drugs, using iPSC technology to generate stem cells from the patients skin or blood, using trans differentiation technology to convert a specialized cell type to a progenitor cell and many more. It also carries the immense potential for treating a number of human diseases such as to repair or regenerate blood vessels, treatment of eyesight, Diabetes, Neurodegenerative Disorders and Wound Healing etc.

Related Conferences:

4thWorld Biotechnology Congress, May 20-21, 2019, London, UK; 6thWorld Congress on Microbial Biotechnology, June 17-18, 2019, Paris, France; Annual Congress on Advanced Tissue Science and Regenerative Medicine, April 15-16, 2019, Amsterdam, Netherlands; World Congress on Cell & Gene Therapy, September 25-26, 2019, Rome, Italy; World Congress on Novel Trends and Advances in Biotechnology, September 25-26, 2019, Rome, Italy;

Carefully planned and ethically approved clinical trials resulting from a robust preclinical pathway are necessary to advance the field. This will require a programmatic approach that involves partnerships of clinicians, academics, industry, and regulatory authorities with a focus on understanding basic biology that informs a tight linkage between preclinical and clinical studies. Rather than suggesting that clinical trials are premature, such trials should be encouraged as part of multidisciplinary programs in regenerative medicine.

Related Conferences:

25thGlobal Meet on Cancer Research & Oncology, May 20-21, 2019, Rome, Italy; 2ndWorld Congress on Advanced Cancer Science & Therapy, January 28-29, 2019, Dubai, UAE; 3rdAdvances in Cell & Stem Cell Research Congress, September 25-26, 2019, Rome, Italy; 3rdInternational Conference on Nanostructures, Nanomaterials and Nanoengineering, October 21-22, 2019, Las Vegas, USA; 3rdWorld Congress on Advanced Biomaterials and Tissue Engineering, August 26-27, 2019, Madrid, Spain;

The field of bioethics has addressed a broad swathe of human inquiry, ranging from debates over the boundaries of life, surrogacy, and the allocation of scarce health care resources to the right to refuse medical care for religious or cultural reasons. StemGen is a research database of international, regional and national normative instruments concerning the socio-ethical and legal aspects of stem cell research and related therapies. The regulation of stem cell research is an issue that has drawn much comment, criticism and even judicial arbitration in recent years along with the marketing status of Stem Cells, Cell therapy, Regenerative Medicine, Tissue Engineering and many more worldwide.

Related Conferences:

4thWorld Biotechnology Congress, May 20-21, 2019, London, UK; 6thWorld Congress on Microbial Biotechnology, June 17-18, 2019, Paris, France; Annual Congress on Advanced Tissue Science and Regenerative Medicine, April 15-16, 2019, Amsterdam, Netherlands; World Congress on Cell & Gene Therapy, September 25-26, 2019, Rome, Italy; World Congress on Novel Trends and Advances in Biotechnology, September 25-26, 2019, Rome, Italy;

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Top Stem Cell Conferences | Stem Cell Research 2019 ...

Bone Marrow & Stem Cell Transplant | Weill Cornell Medicine

Stem Cell Medicine | Posted by admin
Mar 07 2019

Bone Marrow & Stem Cell Transplant

The Bone Marrow and Stem Cell Transplant Program at Weill Cornell Medicine was established with the mission of providing the best care and most innovative research in a compassionate and comfortable environment.

We take a multidisciplinary approach to care for patients with cancer and blood diseases who need stem cell transplants, providing world-class clinical care in collaboration with experts in leukemia, lymphoma, myeloma and other blood disorders. Based at NewYork-Presbyterian/Weill Cornell Medical Center, one of the top ten general hospitals in the nation, the expertise of our consulting team is unsurpassed.

Our patients and families cope with life-threatening illness; as such, sensitivity and compassion are a priority for our team. We view each patient as an individual, and our approach ensures that each treatment regimen is narrowly tailored to meet the unique, changing needs of our patients and their families before, during and after transplant.

As New Yorks premier healthcare institution, Weill Cornell Medicine is at the forefront of scientific research and clinical trials, enabling us to provide a full range of diagnostic and treatment protocols, including the latest breakthroughs in medicine.

Our Team

Our team of internationally-recognized bone marrow transplant and stem cell surgery specialists is known for advanced work and published research in:

Treating patients with aggressive leukemia and myelodysplastic syndromes

Bridge protocols for patients with refractory lymphoma and leukemia

Novel strategies to mobilize stem cells and improve transplantation for patients with multiple myeloma, leukemia and lymphoma

Transplants for solid tumors, severe auto-immune disorders, and AIDS

Treatment

We pride ourselves on exceptional outcomes and offer patients the most advanced diagnostic methods and treatment therapies to improve quality of life, including:

Umbilical cord blood transplant

Outpatient transplant

Autologous stem cell transplant; uses stem cells extracted from the bone marrow or peripheral blood of the patients own blood

Allogeneic stem cell transplant; uses stem cells extracted from the bone marrow or peripheral blood of a matching donor

Hematopoietic stem cell transplant; used to treat certain cancers of the blood/bone marrow, including leukemia and myeloma

Matched unrelated donor stem cell transplantation through the National Donor Matching Program

Non-ablative "mini" transplants

Haplo-Cord Transplant, allowing us to find donors for all patients, regardless of age or ethnic background

Bendamustine, a therapy that is well-tolerated and has excellent response rates in patients with myeloma

Novel forms of transplant, offering hope and success to older patients with leukemia

Clinical Trials

Clinical trials are important to improve outcomes and offer new treatment options. At Weill Cornell Medicine, we conduct more studies in blood cancers than any of our regional peers, allowing us to provide our patients with access to many multi-phase clinical trials. As active members of the international cancer research community, our oncologists also collaborate with other research centers to offer patients the most promising treatments available.

Second Opinions

In concert with your referring physician, we are always available to offer a second opinion in the form of a consultation with one of our specialists.

Why Choose Us?

Our collaborative approach means our patients receive supportive, comprehensive care and the most cutting-edge stem cell therapy and treatments. This enables patients to receive the best possible transplant outcomes. Additionally, we offer more allogeneic stem cell transplants for older adults than any other center in New York City and the entire tri-state area.

For more information or to schedule an appointment, call us at 212-746-2119 or 212-746-2646.

Located in New York City, Weill Cornell Medical College is ranked among the nations best by U.S. News & World Report year after year.

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Bone Marrow & Stem Cell Transplant | Weill Cornell Medicine

Stem Cell | Regenerative medicine | 2019 | Conference …

Stem Cell Medicine | Posted by admin
Jan 29 2019

Responsibility

The organizers holds no responsibilities or liabilities of the personal articles of attendees at the venue against any kind of theft, lost, damage, due to any reason whatsoever. Delegates are entirely responsible for the safety of their own belongings.

Insurance

No insurance, of any kind, is included along with the registration in any of the events of the organization.

Transportation

Please note that transportation and parking is the responsibility of the registrant, Allied Academies will not be liable for any actions howsoever related to transportation and parking.

Press/Media

Press permission must be obtained from Allied Academies Conference Organizing Committee prior to the event. The press will not quote speakers or delegates unless they have obtained their approval in writing. The Allied Academies is an objective third-party nonprofit organization and this conference is not associated with any commercial meeting company.

Requesting an Invitation Letter

For security purposes, letter of invitation will be sent only to those individuals who had registered for the conference after payment of complete registration fee. Once registration is complete, please contactstemcell@alliedevents.org

Cancellation Policy

All cancellations or modifications of registration must be made in writing to finance@alliedacademies.com

If, due to any reason, Allied academies postpone an event on the scheduled date, the participant is eligible for a credit of 100% of the registration fee paid. This credit shall only be used for another event organized by Allied academies within period of one year from the date of rescheduling.

Postponement of event

If, due to any reason, Allied academies postpone an event and the participant is unable or unwilling to attend the conference on rescheduled dates, he/she is eligible for a credit of 100% of the registration fee paid. This credit shall only be used for another event organized by Allied academies within period of one year from the date of rescheduling.

Transfer of registration

All registrations, after payment of complete registration fee, are transferable to other persons from the same organization, if in case the person is unable to attend the event. Request for transfer of registration must be made by the registered person in writing to contacts@alliedacademies.com Details must include the full name of replaced new registrant, their title, contact phone number and email address. All other registration details will be assigned to the new person unless otherwise specified. Registration can be transferred to one conference to another conference of Allied academies if the person is unable to attend one of conferences.

However, Registration cannot be transferred if intimated within 14 days of respective conference.

The transferred registrations will not be eligible for Refund.

This cancellation policy was last updated on April 04, 2015.

Visa Information

Keeping in view of increased security measures, we would like to request all the participants to apply for Visa as soon as possible.

Allied academies will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues are not covered under the cancellation policy of Allied academies, including the inability to obtain a visa.

Refund Policy.

If the registrant is unable to attend, and is not in a position to transfer his/her participation to another person or event, then the following refund policies apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overhead charges, following Refund Policy

Orders are available:

Accommodation Cancellation Policy

Accommodation Service Providers (Hotels) have their own cancellation policies which are applicable when cancellations are made less than 30 days prior to arrival. If in case the registrant wishes to cancel or amend the accommodation, he/ she is expected to inform the organizing authorities on a prior basis. Allied academies will advise the registrant to ensure complete awareness about the cancellation policy of your accommodation provider, prior to cancellation or modification of their booking.

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Stem Cell | Regenerative medicine | 2019 | Conference ...

Original Medicine Wellness Center – Functional Medicine …

Stem Cell Medicine | Posted by admin
Jan 28 2019

Stem Cell Therapy

Today we are seeing incredible results with stem cells in treating heart disease, brain disease, diabetes, cancer, arthritis, spinal cord injuries, burns, macular degeneration, and much more.

Optimize Brain Health

Having brain fog or difficulty focusing can be the result of many factors including hormonal imbalance, gut health, and neurotransmitter imbalance.

Educational Classes

We'll provide you with education and resources to better support your health as an individual as well as for your family.

Hormone Solutions

Our goal is to balance hormones through fixing the underlying problems that exist in the organs and glands. Rather than giving the body a hormone, why not get the body to produce its own?

Original Medicine

We approach health with the idea that the body is a self-healing, self-regulating and self-developing organism.

CONTACT USOriginal Medicine Wellness Center

1500 Lomas Blvd NW, Suite B

Albuquerque, NM 87104

(505) 503-6490

info@OriginalMedicineABQ.com

AcupunctureMaintain health and balance in your bodys systems, restore function and promote healing with acupuncture. Learn more.

Chinese HerbsChinese herbal medicine is part of our integrated system of health care that has been around for thousands of years.

Lifestyle & Wellness Programs

Wellness is more than being free from illness it is a dynamic process of change and growth. We customize programs for your individual needs.

Our purpose is to provide the highest level of care so that people may lead happy, productive, pain-free and healthy lives naturally.

At Original Medicine, our licensed professionals have been helping people in and around Albuquerque stay healthy and feel better naturally since 2004. Our Functional Medicine approach combines Chinese medicine with modern testing to get a full picture of the body's health.

Through compassionate healthcare and wellness education, we inspire our patients to better understand their health and wellbeing while effectively treating their mind, body and spirit.

Some of the many services we offer include:

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Original Medicine Wellness Center - Functional Medicine ...

Stem Cell Medicine Licenses Exosome Technology for …

Stem Cell Medicine | Posted by admin
Jan 11 2019

JERUSALEM Israel, January 2nd, 2019 Stem Cell Medicine Ltd. (SCM), a biotechnology company developing new therapies for neurological indications, including mesenchymal stem cells and anti-BMP molecules for the treatment of Multiple Sclerosis, and gene therapy for the treatment of neuropathic pain, has licensed an innovative exosomes based technology for the treatment of neurodegenerative and neuropsychiatric indications, specifically, autism spectrum disorder (ASD). The treatment is based on vesicles, exosomes, derived from adult stem cells (MSC-exo) that are administered intranasally. The technology was developed by Professor Dani Offen, Sackler School of Medicine, Sagol School of Neurosciences Tel Aviv University and was licensed from Ramot, the Business Engagement Center at Tel Aviv University.

The first indication to be developed with the exosome technology is ASD, which is a group of neurodevelopmental disorders characterized by three core symptoms: severe impairment of social interactions and communication skills, increased repetitive behaviors and cognitive inflexibility. The prevalence of ASD has been steadily increasing in children over the past several years, with no effective treatment, hence, it represents a growing unmet medical need. More than 3.5 million Americans live with ASD. According to the US Department of Health and Human Services (CDC) the prevalence of autism in US children in 2018 is estimated to be 1 in 59 children and has increased from 1 in 110 children in 2010, making it the fastest-growing developmental disability with currently no FDA approved drug. Given the size of the patient population and lack of treatments, the market opportunity is compelling. SCM projects that a regulatory approved therapeutic based on the exosome technology would have blockbuster potential within five years following market launch.

In efficacy studies conducted in preclinical models, intranasal treatment with MSC-exo was associated with a significant improvement in the several autistic behavioral phenotypes. Social interaction and ultrasonic vocalizations increased, repetitive behaviors were reduced and there was a significant improvement in maternal behaviors of pup retrieval. No negative symptoms were observed.

Prof. Ditza A. Zachor, Head, The Autism Center/ALUT, Assaf Harofeh Medical Center said: The MSC derived exosomes are a novel promising technology that presented strong efficacy in the pre-clinical studies conducted by the Company, providing a clinical development direction for the treatment of autism in pediatric and adult populations, a growing major unmet medical need in this field.

Ehud Marom, SCMs Chairman, said, Intranasal administration is especially suitable for pediatric ASD patients and, based on the encouraging results we have seen to date with the MSC-exo technology, we are committed to investing in this treatment. This is an important part of SCMs focus and this program is consistent with our goal to bring novel treatments for neurological conditions, including autism, to market. SCM is rapidly progressing from pre-clinical activities to the clinical development. We plan to fund the program by raising $30 million through partnerships and investment.

About Stem Cell Medicine Ltd. (SCM)

SCM is a biotechnology company that develops second generation cell therapy products as stand-alone treatments or in combination with pharmaceuticals, with a focus on neurological indications, including MS, pain and neuromuscular injuries, and manages the production, registration and marketing of such products. The company, headquartered in Jerusalem, was founded in 2010 by an experienced team of entrepreneurs from the life science & pharmaceutical industries. SCMs facilities include state-of-the-art R&D laboratories and GMP production cleanrooms that enable an optimal environment for the development of products up to and including clinical trials. For more information, please visit: http://www.stemcell-medicine.com

Contacts: Alex Mogle Vice President, Corporate Development Stem Cell Medicine +972 52 6080297 alex@stemcell-medicine.com

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Stem Cell Medicine Licenses Exosome Technology for ...

Stem Cell Medicine | Murdoch Children’s Research Institute

Stem Cell Medicine | Posted by admin
Nov 30 2018

Stem Cell Medicine is the Murdoch Children's Research Institute's (MCRI)world-class research program in stem cells.We havea vision to prepare Australia for the transition from fundamental stem cell research in the lab towardtranslation outcomes using stem cells, with the delivery of human stem cell-based products and clinical practices.

Our research includes stem cell-based disease modelling and drug screening and the development of stem cell therapies and bioengineered tissues (explained in detail below). Embedded in the Royal Children's Hospital, and located in Melbourne's biomedical precinct, MCRI Stem Cell Medicine ensures that we workclosely and collaboratively with key experts in the field, including clinicians, biomedical scientists, engineers, ethicists, as well asthe local and international biotech sector. We also engage closely with key stem cell research networks and bodies including Stem Cells Australia, the Australasian Society for Stem Cell Research, the National Stem Cell Foundation of Australia, and look forward to participating in the International Society for Stem Cell Research annual meeting scheduled in Melbourne 2018.

By consolidating our research talent, fostering collaboration, strategically investing resources, and expanding our infrastructureplatforms, MCRI is now one of the worlds leading institutes in pluripotent stem cell research.

A stem cell is a cell that can generate more stem cells but can also form other specialised types of cells.

The early embryo is formed from embryonic stem cells. These stem cells are pluripotent, which means they are able to divide and program themselves into any other type of cell. Pluripotent cells are no longer present after birth, and while some specialised adult stem cells remain throughout the body in places like the skin, liver, blood and intestine, most adult cells are fully differentiated.

In the lab, we reprogram these adult cell types back into pluripotent stem cells and then differentiate them again into the type of cell we wish to study. These are called induced pluripotent stem cells (iPSCs).

At MCRI, we turn iPSCs into different types of committed cells that the human body is unable to regenerate itself, such as the cells of the kidney and heart. Our researchers are world leaders in both generating iPSCs and generating specific cell types from them.

Using Stem Cell Medicine to Transform Clinical Care and Patient Outcomes

Our vision is to be an Australian and international leader in navigating the transition forthe use of human iPSCs from the lab towardclinical use and practice.The use of iPSCs enables cutting-edgeopportunities to conductpatient-specific disease modelling, personalised drug screening, cell therapy and bioengineered organs built from stem cells.

Our location within the Royal Childrens Hospital and our participation in theMelbourne ChildrensCampusmakes us ideally placed to discover and deliver stem cell medical breakthroughs.

Stem Cell Medicine Expertise

MCRI Stem Cell Medicinehas established a Stem Cell Derivation Facility for generating patient stem cells, and has pioneered protocols for turning these stem cells into heart, blood, cartilage, pancreas, nerves and kidney cells. In early 2017 we also introduced a Gene Editing Facility, currently servicing internally only.

We also have expertise in gene editing, which allows us to correct or create specific gene changes in normal or patient stem cells. Our Translational Genomics Unit is being used to examine tissues made from patient stem cells to monitor the effect of the gene changes on every other gene. This information can be used to validate the link between novel gene changes and disease, and find potential pathways to target with drugs.

Our expertise lies in the generation of stem cells from patients and the differentiation of those stem cells into different specialised tissues. This provides the potential for both patient-based disease modelling and the development of treatments for:

It is now possible to take any cell from a patient and turn this back into a stem cell, which we then have the ability to transform into any other cell type in our labs. This means we can make a stem cell from a patient with a disease and study any gene changes that may have caused the disease. This stem cell can then be differentiated into the cell type that is damaged, such as a nerve, kidney or muscle cell for a 'disease in a dish' approach.

In this way, we can study whether a gene is at fault, and then understand why this change is affecting cell function. Put simply, we make a tissue from the patient to understand their disease.

This provides the possibility of testing new drugs or new therapies to specifically treat that patient.

Human tissue formed using stem cells provides a new approach for the pharmaceutical industry to test drugs before clinical trial, providing an early opportunity to identify drug toxicity and a platform for testing drug efficacy.

Such drug screening has the potential to reduce the use of animals in drug development and enable substantial cost savings in the pharmaceutical industry. Using patient-derived stem cells, it may also be possible to develop personalised treatments by testing these on patient stem cell-derived tissues.

By improving our methods for turning a human stem cell into the many types of tissues present in the body, it will eventually be possible to deliver cells back into patients to treat disease.

Around the world, the first clinical trials using stem cell-derived tissues are being performed to treat blindness, neurological disease and diabetes.

Together with new approaches for making the right cell type, MCRI Stem Cell Medicine is ideally located within a hospital precinct, allowing research into how to deliver the right cells into the right patients and access to the Melbourne Childrens Trial Centre to test safety and patient outcome.

Our research will focus on the treatment of childhood cancer, blood disorders, heart disease and kidney disease.

In some cases, delivering a cell may not be enough. MCRI Stem Cell Medicine also conducts research into approaches for the bioengineering of replacement organs using human cell types generated from stem cells.

The hope is that this will ultimately provide treatments for many conditions, including heart disease, bone disease and kidney disease.

Delivering a cell or bioengineered organ into a patient will face the same challenges seen in conventional organ donation.

Without a good DNA match, the patient will reject their stem cell treatment. To address this, we aim to generate a bank of human stem cells matched to the genetically diverse Australian population. These stem cells, generated from banked cord blood, can be turned into the required cell type for treatment ensuring a good match for the patient being treated.

As the home of the Bone Marrow Donor Institute (BMDI) Cord Blood Bank, MCRI is ideally positioned to establish the first bank of human stem cells (known as a Haplobank) matched for the Australian population.

Tailored to the ethnic diversity present in Australia, we will generate human stem cell lines designed to provide a transplantation match for more than 95 per cent of the Australian population.

Stem cell research has attracted considerable public interest and ethical debate. We engage actively with the public to discuss this new area of research, listening to the feedback from the community on any potential concerns and ensuring there is accurate information available for those seeking advice.

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Stem Cell Medicine | Murdoch Children's Research Institute

FAQs – Ocean Springs, MS – Gulf Coast Stem Cell …

Stem Cell Medicine | Posted by admin
Nov 14 2018

Our Technology

Gulf Coast Stem Cell & Regenerative Medicine Center (GCSC&RMC) uses adipose-derived stem cells for deployment & clinical research. Early stem cell research has traditionally been associated with the controversial use of embryonic stem cells. The new focus is on non-embryonic adult mesenchymal stem cells which are found in a persons own blood, bone marrow, and fat. Most stem cell therapy centers in the world are currently using stem cells derived from bone marrow.

A recent technological breakthrough enables us to now use adipose (fat) derived stem cells. Autologous stem cells from a persons own fat are easy to harvest safely under local anesthesia and are abundant in quantities up to 2500 times those seen in bone marrow.

Clinical success and favorable outcomes appear to be related directly to the quantity of stem cells deployed. Once these adipose-derived stem cells are administered back into the patient, they have the potential to repair human tissue by forming new cells of mesenchymal origin, such as cartilage, bone, ligaments, tendons, nerve, fat, muscle, blood vessels, and certain internal organs. Stem cells ability to form cartilage and bone makes them potentially highly effective therapy for degenerative orthopedic conditions. Their ability to form new blood vessels and smooth muscle makes them potentially very useful in treating Peyronies disease and impotence. Stem cells are used extensively in Europe and Asia to treat these conditions.

We have anecdotal and experimental evidence that stem cell therapy is effective in healing and regeneration. Stem cells seek out damaged tissues in order to repair the body naturally. The literature and internet are full of successful testimonials but we are still awaiting definitive studies demonstrating the efficacy of stem cell therapy. Such data may take five or ten years to accumulate. In an effort to provide relief for patients suffering from certain degenerative diseases that have been resistant to common modalities of medical care, we are initiating pilot studies as experimental tests of therapy effectiveness with very high numbers of adipose-derived stem cells obtained from fat. Adipose fat is an abundant and reliable source of stem cells.

GCSC&RMCs cell harvesting and isolation techniques are based on technology from Korea. This new technological breakthrough allows patients to safely receive their own autologous stem cells in extremely large quantities. Our therapy and research are patient funded and we have endeavored successfully to make it affordable. All of our sterile procedures are non-invasive and done under local anesthesia. Patients who are looking for non-surgical alternatives to their degenerative disorders can participate in our trials by filling out our application to determine if they are candidates.GCSC&RMC is proud to be state of the art in the new field of Regenerative Medicine. RETURN TO TOP

We are currently in the process of setting up FDA approved protocols for stem cell banking in collaboration with a reputable cryo-technology company. This enables a person to receive autologous stem cells at any time in the future without having to undergo liposuction which may be inconvenient or contraindicated. Having your own stem cells available for medical immediate use is a valuable medical asset.

Provisions are nearly in place for this option and storage of your own stem cells obtained by liposuction at GCSC&RMC or from fat obtained from cosmetic procedures performed elsewhere should be possible in the near future. RETURN TO TOP

Adult (NonEmbryonic) Mesenchymal Stem Cells are undifferentiated cells that have the ability to replace dying cells and regenerate damaged tissue. These special cells seek out areas of injury, disease, and destruction where they are capable of regenerating healthy cells and enabling a persons natural healing processes to be accelerated. As we gain a deeper understanding of their medical function and apply this knowledge, we are realizing their enormous therapeutic potential to help the body heal itself. Adult stem cells have been used for a variety of medicaltherapies to repair and regenerate acute and chronically damaged tissues in humans and animals. The use of stem cells is not FDA approved for treating any specific disease in the United States at this time and their use is therefore investigational. Many reputable international centers have been using stem cell therapy to treat various chronic degenerative conditions as diverse as severe neurologic diseases, renal failure, erectile dysfunction, degenerative orthopedic problems, and even cardiac and pulmonary diseases to name a few. Adult stem cells appear to be particularly effective at repairing cartilage in degenerated joints. RETURN TO TOP

Regenerative Medicine is the process of creating living, functional tissues to repair or replace tissue or organ function lost due to damage, or congenital defects. This field holds the promise of regenerating damaged tissues and organs in the body by stimulating previously irreparable organs to heal themselves. (Wikipedia) RETURN TO TOP

Traditionally, we have used various medications and hormones to limit disease and help the body repair itself. For example, hormone replacement therapy has, in many cases, shown the ability to more optimally help the immune system and thus help us repair diseased or injured tissues. Genetic research is an evolving area where we will eventually learn and utilize more ways of specifically dealing with gene defects causing degenerative disease. Stem cell therapy is another rapidly evolving and exciting area that has already shown considerable promise in treating many degenerative conditions. RETURN TO TOP

A stem cell is basically any cell that can replicate and differentiate. This means the cell can not only multiply, it can turn into different types of tissues. There are different kinds of stem cells. Most people are familiar with or have heard the term embryonic stem cell. These are cells from the embryonic stage that have yet to differentiate as such, they can change into any body part at all. These are then called pluripotential cells. Because they are taken from unborn or unwanted embryos, there has been considerable controversy surrounding their use. Also, while they have been used in some areas of medicine particularly, outside the United States they have also been associated with occasional tumor (teratoma) formations. There is work being conducted by several companies to isolate particular lines of embryonic stem cells for future use.

Another kind of stem cell is the adult stem cell. This is a stem cell that already resides in ones body within different tissues. In recent times, much work has been done isolating bone-marrow derived stem cells. These are also known as mesenchymal stem cells because they come from the mesodermal section of your body. They can differentiate into bone and cartilage, and probably all other mesodermal elements, such as fat, connective tissue, blood vessels, muscle and nerve tissue. Bone marrow stem cells can be extracted and because they are low in numbers, they are usually cultured in order to multiply their numbers for future use. As it turns out, fat is also loaded with mesenchymal stem cells. In fact, it has hundreds if not thousands of times more stem cells compared to bone marrow. Today, we actually have tools that allow us to separate the stem cells from fat. Because most people have adequate fat supplies and the numbers of stem cells are so great, there is no need to culture the cells over a period of days and they can be used right away. RETURN TO TOP

These adult stem cells are known as progenitor cells. This means they remain dormant (do nothing) unless they witness some level of tissue injury. Its the tissue injury that turns them on. So, when a person has a degenerative type problem, the stem cells tend to go to that area of need and stimulate the healing process. Were still not sure if they simply change into the type of injured tissue needed for repair or if they send out signals that induce the repair by some other mechanism. Suffice it to say that there are multiple animal models and a plethora of human evidence that indicates these are significant reparative cells. RETURN TO TOP

This will depend on the type of degenerative condition you have. A specialist will evaluate you and discuss whether youre a potential candidate for stem cell therapy. If after youve been recommended for therapy, had an opportunity to understand the potential risks and benefits, and decided on your own that you would like to explore this avenue, then you can be considered for stem cell therapy. Of course, even though its a minimally invasive procedure, you will still need to be medically cleared for the procedure. RETURN TO TOP

NO. However, GCSC&RMCs procedures fall under the category of physicians practice of medicine, wherein the physician and patient are free to consider their chosen course for medical care. The FDA does have guidelines about therapy and manipulation of a patients own tissues. At GCSC&RMC we meet these guidelines by providing same day deployment with the patients own cells that undergo very minimal manipulation and are inserted during the same procedure. RETURN TO TOP

No. Only adult mesenchymal stem cells are used. These cells are capable of forming bone, cartilage, fat, muscle, ligaments, blood vessels, and certain organs. Embryonic stem cells are associated with ethical considerations and limitations. RETURN TO TOP

Patients suffer from many varieties of degenerative illnesses. There may be conditions associated with nearly all aspects of the body. Board-certified specialists are ideal to evaluate, recommend and/or treat, and subsequently, follow your progress. Together, through the GCSC&RMC, we work to coordinate and provide therapy mainly with your own stem cells, but also through other avenues of regenerative medicine. This could include hormone replacement therapy or other appropriate recommendations.

For example, if you have a knee problem, you would see GCSC&RMCs Board Certified orthopedic surgeon rather than a generic clinic director. Also, you might be recommended for evaluation for hormone replacement therapy or an exercise program should such be considered optimal. Nonetheless, we believe stem cell therapy to be the likely foundation for regenerative medicine. It should also be noted, that all therapies are currently in the investigational stage. While we recognize our patients are seeking improvement in their condition through stem cell therapy, each deployment is part of an ongoing investigation to establish optimal parameters for future therapies, to evaluate for effectiveness and for any adverse effects. It is essential that patients understand they are participating in these investigational (research) analyses. Once sufficient information is appropriately documented and statistically significant, then data (validated by an Institutional Review Board) may be presented to the FDA for consideration of making an actual claim. RETURN TO TOP

Urology, cosmetic surgery, ear, nose, & throat, orthopedics, internal medicine, and cardiology are represented. Plans are currently being made for a number of other specialties. GCSC&RMC is the first multi-specialty stem cell center in the United States. RETURN TO TOP

Many have been told that they require surgery or other risky procedures for their ailments and are looking for non-invasive options. Some have heard about the compelling testimonials about stem cells in the literature and on various websites. Many have read about the results of stem cell therapy in animal models and in humans. GCSC&RMC gives a choice to those informed patients who seek modern regenerative therapy but desire convenience, quality, and affordability. GCSC&RMC fills a need for those patients who have been told that they have to travel to different countries and pay as much as twenty to one hundred thousand dollars for stem cell therapy offshore. (See stem cell tourism). RETURN TO TOP

Stem cells are harvested and deployed during the same procedure. Our patients undergo a minimally-invasive liposuction type of harvesting procedure by a qualified surgeon in our facility in Ocean Springs, Mississippi. The harvesting procedure generally lasts a few minutes and can be done under local anesthesia. Cells are then processed and are ready for deployment within 90 minutes or less. RETURN TO TOP

Bone marrow sampling (a somewhat uncomfortable procedure) yields approximately 5,000 60,000 cells that are then cultured over several days to perhaps a few million cells prior to deployment (injection into the patient). Recent advances in stem cell science have made it possible to obtain high numbers of very excellent quality multi-potent (able to form numerous other tissues) cells from a persons own liposuction fat. GCSC&RMC uses technology acquired from Asia to process this fat to yield approximately five hundred thousand to one million stem cells per cc of fat, and therefore, it is possible to obtain as many as 10 to 40 million cells from a single procedure. These adipose-derived stem cells can form many different types of cells when deployed properly including bone, cartilage, tendon (connective tissue), muscle, blood vessels, nerve tissue and others. RETURN TO TOP

GCSC&RMC patients have their fat (usually abdominal) harvested in our special sterile facility under a local anesthetic. The fat removal procedure lasts approximately twenty minutes. Specially designed equipment is used to harvest the fat cells and less than 100cc of fat is required. Postoperative discomfort is minimal and there is minimal restriction on activity. RETURN TO TOP

Stem cells are harvested under sterile conditions using a special closed system technology so that the cells never come into contact with the environment throughout the entire process from removal to deployment. Sterile technique and antibiotics are also used to prevent infection. RETURN TO TOP

No. Only a persons own adult autologous cells are used. These are harvested from each individual and deployed back into their own body. There is no risk of contamination or risk of introduction of mammalian DNA. RETURN TO TOP

These facilities are obtaining stem cells from bone marrow or blood in relatively small quantities and they are then culturing (growing) the cells to create adequate quantities. Research seems to indicate that the success of stem cell therapy is directly related to the quantity of cells injected. GCSC&RMC uses adipose-derived stem cells that are abundant naturally at approximately 2,500 times levels found in bone marrow (the most common source of mesenchymal stem cells). GCSC&RMC uses technology that isolates adipose stem cells in vast numbers in a short time span so that prolonged culturing is unnecessary and cells can be deployed into a patient within 90 minutes of harvesting. RETURN TO TOP

GCSC&RMC is doing pioneer research for treating many diseases. All investigational data is being collected so that results will be published in peer review literature and ultimately used to promote the advancement of cellular based regenerative medicine. FDA regulations mandate that no advertising medical claims be made and that even website testimonials are prohibited. RETURN TO TOP

No. Many are confused by this because they have heard of cancer patients receiving stem cell transplants. These patients had ablative bone marrow therapy and need stem cells to re-populate their blood and marrow. This is different from the stem cells we deploy to treat noncancerous human diseases at GCSC&RMC. RETURN TO TOP

Adult mesenchymal stem cells are not known to cause cancer. Some patients have heard of stories of cancer caused by stem cells, but these are probably related to the use of embryonic cells (Not Adult Mesenchymal Cells). These embryonic tumors known as teratomas are rare but possible occurrences when embryonic cells are used. RETURN TO TOP

Stem cell therapy is thought to be safe and not affect dormant cancers. If someone has had cancer that was treated and responded sucessfully, there is know reason to withhold stem cell deployment. In most cases, stem cells should not be used in patients with known active cancer. RETURN TO TOP

We know of no documented cases personally or in the literature where serious harm has resulted. All of our patients will be entered into a database to follow and report any adverse reactions. This information is vital to the development of stem cell science. There have been a few reports of serious complications from overseas and these are being thoroughly evaluated by epidemiologists to ascertain the facts. The International Stem Cell Society registry has over 1,000 cases currently registered and only 2% were associated with any complications, none of which were considered serious adverse events. RETURN TO TOP

None. Our aim is to make cell based medicine available to patients who are interested and to provide ongoing research data under approved Institutional Review Board (IRB) validated studies. We will follow our stem cell therapy patients over their lifetimes. This will enable us to accumulate significant data about the various degenerative diseases we treat. Instead of providing simply anecdotal or testimonial information, our goal is to categorize the various conditions and follow the patients progress through various objective (e.g. x-ray evidence or video displays) and subjective (e.g. patient and/or doctor surveys) criteria. We are aware of a lot of stories about marked improvement of a variety of conditions, but we make no claims about the intended therapy. At some point, once adequate amounts of data are accumulated, it might be appropriate to submit the information to the FDA at which point an actual claim may be substantiated and recognized by the Agency. Still, these are your own cells and not medicines for sale. They are only being used in your own body. Most likely, no claim needs to be made; rather a statistical analysis of our findings would suffice to suggest whether therapy is truly and significantly effective. We also hope to submit our patients data to an approved International Registry (See ICMS Stem Cell Registry) further fostering large collections of data to help identify both positive and negative trends. RETURN TO TOP

Our adipose derived stem cell harvesting and isolation technique yields extremely high numbers of stem cells. In reviewing outcomes data, therapy cell numbers appear to correlate with therapy success. Our cells are actually in a type of soup called Stromal Vascular Fraction SVF which is stem cells bathed in a rich mixture of natural growth factors (Not the same as human growth factor hormone which is only one type of growth factor). Some types of orthopedic and urologic diseases appear to respond better to stem cells that are super enriched with growth factors created by administering Platelet Rich Plasma to the patient. Autologous Platelet Rich Plasma is derived from a patients own blood drawn at the time of deployment. At GCSC&RMC we do not add any foreign substances or medications to the stem cells. RETURN TO TOP

Depending on the type of therapy required, stem cells can be injected through veins, arteries, into spinal fluid, subcutaneously, or directly into joints or organs. All of these are considered minimally invasive methods of introducing the stem cells. Stem cells injected intravenously are known to seek out and find (see photo) areas of tissue damage and migrate to that location thus potentially providing regenerative healing. Intravenously injected stem cells have been shown to have the capability of crossing the blood-brain barrier to enter the central nervous system and they can be identified in the patients body many months after deployment. Note yellow arrow showing the stem cells concentrated in the patients hand where he had a Dupytrens contracture (Dupuytrens contracture is a hand deformity that causes the tissue beneath the surface of the hand to thicken and contract). RETURN TO TOP

Different conditions are treated in different ways and there are different degrees of success. If the goal is regeneration of joint cartilage, one may not see expected results until several months. Some patients may not experience significant improvement and others may see dramatic regeneration of damaged tissue or resolution of disease. Many of the disorders and problems that the physicians at GCSC&RMC are treating represent pioneering work and there is a lack of data. FDA regulations prevent GCSC&RMC from making any claims about expectations for success, however, if you are chosen for therapy, it will be explained that we believe stem cell therapy may be beneficial or in some cases that we are unsure and therapy would be considered investigational. RETURN TO TOP

Stem cell therapy relies on the bodys own regenerative healing to occur. The regenerative process may take time, particularly with orthopedic patients, who may not see results for several months. In some diseases, more immediate responses are possible. RETURN TO TOP

No. Only certain medical problems are currently being treated at GCSC&RMC. Check our list or fill out a candidate application form on the website. All patients need to be medically stable enough to have the stem cell deployment in our facility. There may be some exceptional conditions that may eventually be treated in hospitalized patients, but that remains for the future. Some patients may be declined due to the severity of their problem. Other patients may not have conditions appropriate to treat or may not be covered by our specialists or our protocols. A waiting list or outside referral (if we know of someone else treating such a problem) might be applicable in such cases. RETURN TO TOP

Yes. Patients with uncontrolled cancer are excluded. If you have an active infection anywhere in your body you must be treated first. Severely ill patients may require special consideration. Also, anyone with a bleeding disorder or who takes blood thinning medications requires special evaluation before consideration for stem cells. RETURN TO TOP

The specialist seeing you at GCSC&RMC will make a determination based on your history and exam, studies, and current research findings. Any complex cases may be reviewed by our ethics advisory committee. Occasionally, we may seek opinions from thought leaders around the world. RETURN TO TOP

No. Participation in any of our protocols is not mandatory and there are no incentives, financial or otherwise, to induce patients to enroll in our studies. However, GCSC&RMC is dedicated to clinical research for the development of stem cell science. GCSC&RMC is taking an active role in cutting edge clinical research in the new field of regenerative medicine. Research studies will be explained and privacy will be maintained. Formal future research studies will be regulated by an Institutional Review Board which is an authorized agency that promotes validity, transparency and protection of human study enrollees. RETURN TO TOP

At this time, we are not treating spinal cord injuries and some advanced diseases. See list of problems currently being studied at GCSC&RMC. RETURN TO TOP

Patients who are considered to be candidates based on information provided in the candidate application form will be invited for a consultation with one of our panel physicians. $250 is charged for this consultation which includes office evaluation (but may also include physicians evaluation of X-Rays, records, or telephonic consultations). Unfortunately, insurance generally will not cover the actual cost of stem cell therapy in most cases since stem cell therapy is still considered experimental. The cost varies depending on the disease state being treated and which type of stem cell deployment is required. RETURN TO TOP

Because of recent innovations in technology, GCSC&RMC is able to provide outpatient stem cell therapy at a fraction of the cost of that seen in many overseas clinics. The fee covers fat cell harvesting, cell preparation, and stem cell deployment which may include the use of advanced interventional radiology and fluoroscopy techniques. Financing is available through a credit vendor. RETURN TO TOP

Stem cells can be cryopreserved in the form of liposuction fat for prolonged periods of time. Currently, this service is outsourced to an outside provider known to have excellent quality control. Many patients have been inquiring about banking cells while they are still young since stem cell numbers drop naturally with each decade of life and some advocate obtaining and saving cells to be used later in life as needed. (see chart). RETURN TO TOP

Most patients, especially those with orthopedic conditions, require only one deployment. Certain types of degenerative conditions, particularly auto-immune disease, may respond best to a series of stem cell deployments. The number and necessity of any additional procedures would be decided on a case by case basis. Financial consideration is given in these instances. RETURN TO TOP

A good resource is the International Cellular Medicine Society (ICMS). Stem Cells 101

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FAQs - Ocean Springs, MS - Gulf Coast Stem Cell ...