Mike Tyson, 53, reveals he had stem cell research therapy and hadnt hit bags for 15 YEARS before returning t – The Sun

MIKE TYSON revealed how he has started training again having not thrown a punch for a staggering 15 years - and is being aided by stem-cell research therapy.

The Baddest Man on the Planet, who hung up his gloves in 2005 following defeat by Kevin McBride, wouldn't elaborate on why he was having the treatment but added that it was 'really wild what scientists can do'.

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Tyson was having an Instagram chat with basketball legend Shaquille O'Neal when he revealed that he had been training for the previous three days after 15 years away - and his new health regime.

Iron Mike said: "You know what I had done? I had stem-cell research therapy.

"I feel like a different person but I can't comprehend why I feel this way. It's really wild what scientists can do."

Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition that usually takes the form of a bone marrow transplantation.

He did not reveal what the exact condition was that was being treated.

Despite letting the gloves gather dust in the corner, it didn't take long for Iron Mike to show off that lethal punching power.

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The 53-year-old delighted fans in lockdown by uploading a viral video of him laying into a punchbag with his trademark speed and power.

Tyson's weight ballooned after retiring following battles with drug addiction and depression.

But he has since partnered with a new trainer, MMA coach Rafael Cordeiro, to kick-start his training after sensationally revealing his 15-year break.

During their chat, basketball legend O'Neal revealed how he ached for three days after playing with his sons.

Tyson responded: "That's just because you haven't done it for a while.

WHAT IS STEM CELL TREATMENT USED FOR?

Stem cell transplants are carried out when bone marrow is damaged or isnt able to produce healthy blood cells.

It can also be used to replace damaged blood cells as the result of intensive cancer treatment.

Here are conditions that stem cell transplants can be used to treat:

"If you continue to do it consistently you'll be back to normal.

"It's just like me, I haven't boxed or hit the bag for 15 years - it has been three days so far and I feel incredible."

Tyson, who has a 50-6 record, is reportedly gearing up for a sensational return amid plans to compete in exhibition bouts for charity later this year.

He told rapper T.I. last month: "I've been hitting the mitts for the last week.

"That's been tough, my body is really jacked up and really sore from hitting the mitts.

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NEED FOR SPEEDMike Tyson, 53, shows off speed as heavyweight legend gears up for return

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DO OR TYMike Tyson's trainer 'saw life flash before his eyes' in scary training clip

"I've been working out, I've been trying to get in the ring, I think I'm going to box some exhibitions and get in shape.

"I want to go to the gym and get in shape to be able to box three or four-round exhibitions for some charities and stuff.

"Some charity exhibitions, make some money, help some homeless and drug-affected motherf****er like me."

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Mike Tyson, 53, reveals he had stem cell research therapy and hadnt hit bags for 15 YEARS before returning t - The Sun

Century Therapeutics Announces Formation of Scientific Advisory Board – Business Wire

PHILADELPHIA--(BUSINESS WIRE)--Century Therapeutics, developer of induced pluripotent stem cell (iPSC)-derived allogeneic cell therapies for cancer, today announced the formation of its Scientific Advisory Board (SAB) to include several renowned experts in the fields of developmental and stem cell biology, genetics, and immuno-oncology. The SAB will work closely with Century as it develops off-the-shelf iPSC-derived adaptive and innate immune effector cell therapies to treat hematologic and solid malignancies.

We are privileged to welcome these distinguished scientists as inaugural members of our Scientific Advisory Board, said Lalo Flores, PhD, CEO at Century Therapeutics. Their expertise in disciplines central to the control of cellular differentiation and lymphocyte function as applied to the field of immuno-oncology will bring external scientific and clinical-translational perspectives to help guide Century in the development and expansion of our allogeneic cell therapy technology.

Centurys President of R&D, Hy Levitsky, M.D., said, Were looking forward to leveraging the deep scientific expertise and insights this elite group brings to bear on the design and development of both iPSC-derived CAR-NK and CAR-T cell products.

Centurys Scientific Advisory Board members are:

In addition to the creation of the science-focused SAB, Century will also convene a disease-focused clinical advisory board to be chaired by Dr. Marcela Maus who is a scientific co-founder of Century Therapeutics.

About Century Therapeutics

Century Therapeutics is harnessing the power of stem cells to develop curative cell therapy products for cancer that overcome the limitations of first-generation cell therapies. Our genetically engineered, universal iPSC-derived immune effector cell products (NK, T, DC and macrophage) are designed to specifically target hematologic and solid tumor cancers. Our commitment to developing off-the-shelf cell therapies will expand patient access and provides an unparalleled opportunity to advance the course of cancer care. Century was launched in 2019 by founding investor Versant Ventures in partnership with Fujifilm and Leaps by Bayer. For more information, please visit http://www.centurytx.com.

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Century Therapeutics Announces Formation of Scientific Advisory Board - Business Wire

Liberal MP Jim Carr to receive stem-cell transplant to treat blood cancer – The Globe and Mail

Jim Carr speaks to the Calgary Chamber of Commerce, on Jan. 14, 2020.

Jeff McIntosh/The Canadian Press

Liberal MP and former cabinet minister Jim Carr is returning to hospital for a stem-cell transplant, a treatment that had been twice delayed due to the COVID-19 pandemic.

The Winnipeg MP shared the news on social media Tuesday morning, saying that he and his family remain grateful for all the support they have received since his cancer was discovered last fall.

He said he expects to be recovering in hospital for the next few weeks.

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The past few months have been a challenging and unprecedented time for everyone but I know that we will get through this and emerge stronger than ever, he wrote in a message posted to Twitter.

Carr had been diagnosed with multiple myeloma after experiencing flu-like symptoms during the 2019 federal election campaign.

In his own social-media post Tuesday, Carrs son Ben said life has not been the same for the family since the diagnosis, but the fact his father had been campaigning with failing kidneys and cancer running through his blood spoke to his character.

Anyone who was with us during the campaign can tell you just how tough he is, he wrote.

Carr had headed into that campaign as the Liberals international trade diversification minister, and was one of only a handful of Liberals re-elected in the Prairie provinces in the October vote.

He stepped back from cabinet following his diagnosis to undergo treatment, though Prime Minister Justin Trudeau appointed him as a special representative for the region.

Less than a year ago he was Canadas trade minister, travelling around the world to make the country a better place, Ben Carr wrote.

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Lately, hes been resigned to his living room. A pretty tough reality to confront, no question.

His son said the stem cell transplant had been cancelled twice because of COVID-19, and the pandemic is also forcing the family apart during an exceptionally difficult time.

For me personally, one of the worst parts of whats been happening is the loss of connection with my dad. Although we speak every day by video call, it isnt the same. No hugs, no shared meals, no sitting beside each other watching sports, he wrote.

He said normally hed go visit his father during his recovery, but this time wont be allowed in the hospital.

I love you, dad. See you on the other side.

Last fall, Carrs colleague Dominic Leblanc also underwent a stem-cell transplant, this one to treat non-Hodgkins lymphoma.

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The New Brunswick MP had been diagnosed with that cancer in the spring of 2019.

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Liberal MP Jim Carr to receive stem-cell transplant to treat blood cancer - The Globe and Mail

BioCardia Announces Positive Preclinical Results Supporting Investigational New Drug Application for Anti-Inflammatory Cell Therapy in Heart Failure -…

SAN CARLOS, Calif., May 05, 2020 (GLOBE NEWSWIRE) -- BioCardia, Inc.[Nasdaq: BCDA], a leader in the development of comprehensive solutions for cardiovascular regenerative therapies, today announced data from a recent animal study performed by the Company that demonstrate meaningful improvements in heart function for subjects treated with its allogenic (from another donor, or off the shelf) neurokinin 1 receptor positive mesenchymal stem cell (NK1R+ MSC) program for heart failure, known as CardiALLO. In addition, the Company is planning further exploration and discussion with the U.S. Food and Drug Administration (FDA) on the use of its allogenic cells for COVID-19 related Acute Respiratory Distress Syndrome (ARDS).

In the 26 animals treated with both low dose and high dose NK1R+ MSC, echocardiographic measures of cardiac ejection fraction, fractional shortening and cardiac outflow were meaningfully improved, with all three measures being statistically significant for both dosage levels over control animals.

The CardiALLO cell therapy is being developed initially to treat heart failure patients whose cells do not qualify for its lead autologous cell therapy, CardiAMP (BCDA-01).

BioCardia Chief Scientific Officer Ian McNiece, PhD, said, In light of these positive data on our allogenic NK1R+ MSC therapy, we expect to meet our internal timeline to complete our submission to the FDA for our first indication for CardiALLO, and potentially receive IND acceptance by the end of the second quarter. The MSCs that were studied are subtypes of MSC that we have delivered previously in our co-sponsored trials, which we believe have enhanced potency over MSC generated from unselected bone marrow cells. We look forward to seeing additional data from this animal study that are currently being analyzed, including histology and pathology of the heart and lungs.

COVID-19 Induced Acute Respiratory Distress Syndrome (ARDS) Exploration

The Company also intends to submit an IND for the use of its NK1R+ MSC delivered via intravenous (IV) infusion for Acute Respiratory Distress Syndrome (ARDS) caused by COVID-19.

Based on preliminary clinical reports on COVID-19, respiratory failure complicated by ARDs is the leading cause of death for COVID-19 patients.1 ARDS is a type of respiratory failure characterized by the rapid onset of widespread inflammation in the lungs.

The anti-inflammatory effects of MSC have been well-documented and MSC have been shown to reduce inflammation and injury in models of lung disease.2 The specific MSCs used in BioCardias allogenic cell therapy are expanded from cells selected for the presence of the NK1 receptor, which is known to bind to substance P, an important neuropeptide associated with inflammation throughout the body and a primary mediator of inflammation in the airways.3,4

Our NK1R+ allogenic MSC may have more potential than other MSC approaches being advanced today due to their interaction with Substance P, said BioCardia CEO Peter Altman, PhD. This COVID-19 related work will be the Companys first clinical investigation outside of the cardiac space and our first exploring therapy for the lung. A recent patent publication (US 2020/0101113 A1) shows that BioCardia has long intended for these remarkable reparative cells to be targeted for respiratory disorders, in addition to cardiovascular disease. Addressing inflammation in the lungs is an important contribution we may be able to make using our NK1R+ allogenic MSC therapy.

The Companys allogenic cells are expected to be manufactured at BioCardias clinical stage cell manufacturing facility in San Carlos, California.

About BioCardiaBioCardia, Inc., headquartered in San Carlos, California, is developing regenerative biologic therapies to treat cardiovascular disease. CardiAMP and CardiALLO cell therapies are the Companys biotherapeutic product candidates in clinical development. The Company's approved products include the Helix transendocardial delivery system and its steerable guide and sheath catheter portfolio. BioCardia also partners with other biotherapeutic companies to provide its Helix System and clinical support to their programs studying therapies for the treatment of heart failure, chronic myocardial ischemia and acute myocardial infarction.

Forward Looking Statements This press release contains forward-looking statements that are subject to many risks and uncertainties. Forward-looking statements include, among other things, references to the development of NK1R+ cells for the treatment of heart failure and ARDS secondary to COVID-19, potential FDA IND acceptances, and potential FDA filings, statements regarding our intentions, beliefs, projections, outlook, analyses or current expectations. Such risks and uncertainties include, among others, the inherent uncertainties associated with developing new products or technologies. These forward-looking statements are made as of the date of this press release, and BioCardia assumes no obligation to update the forward-looking statements.

We may use terms such as believes, estimates, anticipates, expects, plans, intends, may, could, might, will, should, approximately or other words that convey the uncertainty of future events or outcomes to identify these forward-looking statements. Although we believe that we have a reasonable basis for each forward-looking statement contained herein, we caution you that forward-looking statements are not guarantees of future performance and that our actual results may differ materially from the forward-looking statements contained in this press release. As a result of these factors, we cannot assure you that the forward-looking statements in this press release will prove to be accurate. Additional factors that could materially affect actual results can be found in BioCardias Form 10-K filed with the Securities and Exchange Commission on April 9, 2020, under the caption titled Risk Factors. BioCardia expressly disclaims any intent or obligation to update these forward-looking statements, except as required by law.

Media Contact: Michelle McAdam, Chronic Communications, Inc.michelle@chronic-comm.com(310) 902-1274

Investor Contact: David McClung, Chief Financial Officerinvestors@BioCardia.com(650) 226-0120

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Canine Stem Cell Therapy Market To Extend An Assessed Value Of US$ 218.2 Mn By 2026 – Cole of Duty

Persistence Market Research (PMR) has published a new research report on canine stem cell therapy. The report has been titled, Canine Stem Cell Therapy Market: Global Industry Analysis 2016 and Forecast 20172026.Veterinary research has been used in regenerative and adult stem cell therapy andhas gained significant traction over the last decade.

Canine stem cell therapy products are identified to have gained prominence over the past five years, and according to the aforementioned research report, the market for canine stem cell therapy will expand at a moderate pace over the next few years.

Regions Covered In Report

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Company Profiles

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Though all animal stem cells are not approved by FDA, veterinary stem-cell manufacturers and university researchers have been adopting various strategies in order to meet regulatory approvals, and streamline and expedite the review-and-approval process. The vendors in the market are incessantly concentrating on research and development to come up with advanced therapy, in addition to acquiring patents.

In September 2017, VetStem Biopharma, Inc. received European patent granted to the University of Pittsburgh and VetStem received full license of the patent then. This patent will eventually provide the coverage for the ongoing commercial and product development programs of VetStem and might be also available for licensing to other companies who are rather interested in this field.

The other companies operating in the global market for canine stem cell therapy are VETherapy Corporation, Aratana Therapeutics, Inc., Regeneus Ltd, Magellan Stem Cells, Animal Cell Therapies, Inc., and Medrego, among others.

According to the Persistence Market Research report, the globalcanine stem cell therapy marketis expected to witness a CAGR of 4.2% during the forecast period 2017-2026. In 2017, the market was valued at US$ 151.4 Mn and is expected to rise to a valuation of US$ 218.2 Mn by the end of 2026.

Burgeoning Prevalence of Chronic Diseases in Dogs to Benefit Market

Adipose Stem Cells (ASCs) are the most prevalent and in-demand adult stem cells owing to their safety profile, ease of harvest, and use and the ability to distinguish into multiple cell lineages. Most early clinical research is focused on adipose stem cells to treat various chronic diseases such as arthritis, tendonitis, lameness, and atopic dermatitis in dogs.

A large area of focus in veterinary medicine is treatment of osteoarthritis in dogs, which becomes more prevalent with age. Globally, more than 20% dogs are suffering from arthritis, which is a common form of canine joint and musculoskeletal disease. Out of those 20%, merely 5% seem to receive the treatment.

However, elbow dysplasia in canine registered a prevalence rate of 64%, converting it into an alarming disease condition to be treated on priority. Thereby, with the growing chronic disorders in canine, the demand for stem cell therapy is increasing at a significant pace.

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Expensive Nature of Therapy to Obstruct Growth Trajectory

Expensive nature and limited access to canine stem cell therapy has demonstrated to be a chief hindrance forestalling its widespread adoption. The average tier II and tier III veterinary hospitals lack the facilities and expertise to perform stem cell procedures, which necessitates the referral to a specialty vet hospital with expertise veterinarians.

A trained veterinary physician charges high treatment cost associated with stem cell therapy for dogs. Generally, dog owners have pet insurance that typically covers maximum cost associated with steam cell therapy to treat the initial injury but for the succeeding measures in case of retreatment, the costs are not covered under the pet insurance. The stem cell therapy is thus cost-prohibitive for a large number of pet owners, which highlights a major restraint to the market growth. Stem cell therapy is still in its developmental stage and a positive growth outcome for the market cannot be confirmed yet.

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Canine Stem Cell Therapy Market To Extend An Assessed Value Of US$ 218.2 Mn By 2026 - Cole of Duty

Canine Stem Cell Therapy Market Analysis Of Growth, Trends Progress And Challenges Till Upcoming Year – Jewish Life News

The Canine Stem Cell Therapy market study offers an in-depth analysis of the current market trends influencing this business vertical. The study also includes market valuation, market size, revenue forecasts, geographical spectrum and SWOT Analysis of the industry. In addition, the report depicts key challenges and growth opportunities faced by the industry bigwigs, in consort with their product offerings and business strategies.

A collective analysis of Canine Stem Cell Therapy market offering an exhaustive study based on current trends influencing this vertical across various geographies has been provided in the report. Also, this research study estimates this space to accrue considerable income during the projected period, with the help of a plethora of driving forces that will boost the industry trends during the forecast duration. Snippets of these influences, in tandem with countless other dynamics relating to the Canine Stem Cell Therapy market, like the risks that are predominant across this industry along with the growth prospects existing in Canine Stem Cell Therapy market, have also been charted out in the report.

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One of the most dynamic points that makes the Canine Stem Cell Therapy market report worth a purchase is the widespread synopsis of the competitive range of the vertical. The study proficiently separates the Canine Stem Cell Therapy market into

Market Taxonomy

The global canine stem cell therapy market has been segmented into:

Product Type:

Application:

End User:

Region:

, according to the competitive hierarchy. These firms have been competing with one another to gain a near-dominant status in the industry.

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The report provides extensive data concerning the market share that each one of these companies presently gather throughout this business, followed by the market share that they are anticipated to acquire by the end of the predicted timeframe. Also, the report expounds on details relating to the goods manufactured by these firms, that would help new industry participants and major stakeholders work on their competition and portfolio strategies. In addition, their policymaking process is likely to get easier since the Canine Stem Cell Therapy market report also enumerates an idea of the trends in product prices and the revenue margins of all the major companies partaking in the industry share.

Queries that the Canine Stem Cell Therapy market report answers in respect of the regional landscape of the business domain:

The geographical landscape, according to the report, is divided into North America, Europe, Asia-Pacific, South America & Middle East and Africa. Which among these regions is more likely to amass maximum market share over the forecast duration

How much is the sales evaluations of each market player in question Also, how are the revenue statistics regarding the present market scenario

How much profit does each geography hold at present

How many proceeds will every zone including North America, Europe, Asia-Pacific, South America & Middle East and Africa account for, over the projected timeframe

How much growth rate is each region estimated to exhibit by the end of the estimated timeline

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Significant takeaways from the study:

The Canine Stem Cell Therapy market report hosts excess deliverables that may be highly advantageous. Say for instance, the report emphasizes information regarding market competition trends extremely essential data subject to contender intelligence and the current industry drifts that would enable shareholders to compete and take advantage of the biggest growth opportunities in the Canine Stem Cell Therapy market.

Another vital takeaway from the report can be accredited to the industry concentration rate that could help stakeholders to speculate on the existing sales dominance and the probable trends of the forthcoming years.

Additional deliverables mentioned in the report include details pertaining to the sales channels deployed by prominent sellers in order to retail their status in the industry, including direct and indirect marketing.

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Canine Stem Cell Therapy Market Analysis Of Growth, Trends Progress And Challenges Till Upcoming Year - Jewish Life News

Global Cell Therapy Technologies Market : Industry Analysis and Forecast (2019-2026) – MR Invasion

Global Cell Therapy Technologies Market was valued US$ 12 billion in 2018 and is expected to reach US$ 35 billion by 2026, at CAGR of 12.14 %during forecast period.

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The objective of the report is to present comprehensive assessment projections with a suitable set of assumptions and methodology. The report helps in understanding Global Cell Therapy Technologies Market dynamics, structure by identifying and analyzing the market segments and projecting the global market size. Further, the report also focuses on the competitive analysis of key players by product, price, financial position, growth strategies, and regional presence. To understand the market dynamics and by region, the report has covered the PEST analysis by region and key economies across the globe, which are supposed to have an impact on market in forecast period. PORTERs analysis, and SVOR analysis of the market as well as detailed SWOT analysis of key players has been done to analyze their strategies. The report will to address all questions of shareholders to prioritize the efforts and investment in the near future to the emerging segment in the Global Cell Therapy Technologies Market.

The report study has analyzed revenue impact of covid-19 pandemic on the sales revenue of market leaders, market followers and disrupters in the report and same is reflected in our analysis.

Global Cell Therapy Technologies Market: Overview

Cell therapy is a transplantation of live human cells to replace or repair damaged tissue and/or cells. With the help of new technologies, limitless imagination, and innovative products, many different types of cells may be used as part of a therapy or treatment for different types of diseases and conditions. Celltherapy technologies plays key role in the practice of medicine such as old fashioned bone marrow transplants is replaced by Hematopoietic stem cell transplantation, capacity of cells in drug discovery. Cell therapy overlap with different therapies like, gene therapy, tissue engineering, cancer vaccines, regenerative medicine, and drug delivery. Establishment of cell banking facilities and production, storage, and characterization of cells are increasing volumetric capabilities of the cell therapy market globally. Initiation of constructive guidelines for cell therapy manufacturing and proven effectiveness of products, these are primary growth stimulants of the market.

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Global Cell Therapy Technologies Market: Drivers and Restraints

The growth of cell therapy technologies market is highly driven by, increasing demand for clinical trials on oncology-oriented cell-based therapy, demand for advanced cell therapy instruments is increasing, owing to its affordability and sustainability, government and private organization , investing more funds in cell-based research therapy for life-style diseases such as diabetes, decrease in prices of stem cell therapies are leading to increased tendency of buyers towards cell therapy, existing companies are collaborating with research institute in order to best fit into regulatory model for cell therapies.Moreover, Healthcare practitioners uses stem cells obtained from bone marrow or blood for treatment of patients with cancer, blood disorders, and immune-related disorders and Development in cell banking facilities and resultant expansion of production, storage, and characterization of cells, these factors will drive the market of cell therapy technologies during forecast period.

On the other hand, the high cost of cell-based research and some ethical issue & legally controversial, are expected to hamper market growth of Cell Therapy Technologies during the forecast period

AJune 2016, there were around 351 companies across the U.S. that were engaged in advertising unauthorized stem cell treatments at their clinics. Such clinics boosted the revenue in this market.in August 2017, the U.S. FDA announced increased enforcement of regulations and oversight of clinics involved in practicing unapproved stem cell therapies. This might hamper the revenue generation during the forecast period; nevertheless, it will allow safe and effective use of stem cell therapies.

Global Cell Therapy Technologies Market: Segmentation Analysis

On the basis of product, the consumables segment had largest market share in 2018 and is expected to drive the cell therapy instruments market during forecast period at XX % CAGR owing to the huge demand for consumables in cell-based experiments and cancer research and increasing number of new product launches and consumables are essential for every step of cell processing. This is further expected to drive their adoption in the market. These factors will boost the market of Cell Therapy Technologies Market in upcoming years.

On the basis of process, the cell processing had largest market share in 2018 and is expected to grow at the highest CAGR during the forecast period owing to in cell processing stage,a use of cell therapy instruments and media at highest rate, mainly in culture media processing. This is a major factor will drive the market share during forecast period.

Global Cell Therapy Technologies Market: Regional Analysis

North America to held largest market share of the cell therapy technologies in 2018 and expected to grow at highest CAGR during forecast period owing to increasing R&D programs in the pharmaceutical and biotechnology industries. North America followed by Europe, Asia Pacific and Rest of the world (Row).Scope of Global Cell Therapy Technologies Market

Global Cell Therapy Technologies Market, by Product

Consumables Equipment Systems & SoftwareGlobal Cell Therapy Technologies Market, by Cell Type

Human Cells Animal CellsGlobal Cell Therapy Technologies Market, by Process Stages

Cell Processing Cell Preservation, Distribution, and Handling Process Monitoring and Quality ControlGlobal Cell Therapy Technologies Market, by End Users

Life Science Research Companies Research InstitutesGlobal Cell Therapy Technologies Market, by Region

North America Europe Asia Pacific Middle East & Africa South AmericaKey players operating in the Global Cell Therapy Technologies Market

Beckman Coulter, Inc. Becton Dickinson and Company GE Healthcare Lonza Merck KGaA MiltenyiBiotec STEMCELL Technologies, Inc. Terumo BCT, Inc. Thermo Fisher Scientific, Inc. Sartorius AG

MAJOR TOC OF THE REPORT

Chapter One: Cell Therapy Technologies Market Overview

Chapter Two: Manufacturers Profiles

Chapter Three: Global Cell Therapy Technologies Market Competition, by Players

Chapter Four: Global Cell Therapy Technologies Market Size by Regions

Chapter Five: North America Cell Therapy Technologies Revenue by Countries

Chapter Six: Europe Cell Therapy Technologies Revenue by Countries

Chapter Seven: Asia-Pacific Cell Therapy Technologies Revenue by Countries

Chapter Eight: South America Cell Therapy Technologies Revenue by Countries

Chapter Nine: Middle East and Africa Revenue Cell Therapy Technologies by Countries

Chapter Ten: Global Cell Therapy Technologies Market Segment by Type

Chapter Eleven: Global Cell Therapy Technologies Market Segment by Application

Chapter Twelve: Global Cell Therapy Technologies Market Size Forecast (2019-2026)

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Inside the twisted world of ‘rapist’ designer Peter Nygard: book – The Loppy

Peter Nygard, the flamboyant Canadian fashion mogul, built a nearly billion-dollar fortune hawking slacks and blouses at Sears, Walmart and his own store in Times Square. Known as a hard-partying Peter Pan, the man Forbes dubbed The Polyester Phenom was often surrounded by young women and threw legendary parties at his homes in the Bahamas and Los Angeles.

But it all came to a halt in February when the FBI raided Nygards Manhattan office. The bust came just a week after 10 unidentified women filed a federal lawsuit accusing the 78-year-old of a decades-long sex-trafficking scheme in which he recruited, lured, and enticed young, impressionable and often impoverished children and women, with cash payments and false promises of lucrative modeling opportunities only to, allegedly, sexually assault and rape them. On April 22, 36 more women joined a class-action complaint against Nygard.

The new book Predator King: Peter Nygards Dark Life of Rape, Drugs and Blackmail (Hot Books) by Melissa Cronin tells this dark story. (Nygards lawyer, who has sent a cease-and-desist letter to the books publisher, told The Post: Predator King recklessly presents a one-sided, unreliable, and wholly misleading portrayal of the allegations against Mr. Nygard.) Here, an adapted excerpt chronicles how Nygard allegedly used his power and privilege to take advantage of people.

Much of the alleged illegal activity is said to have taken place in and around Nygards 150,000-square-foot estate in Lyford Cay, Bahamas, which featured fake volcanos spouting dry ice, a gym on the beach, statues of nudes supposedly modeled on Nygards exes, a disco hut with cameras under the floors, an underground Mayan-themed cave housing 30 cars and an indoor swimming pool with glass through the middle, which allegedly had dolphins on one side and sharks on the other.

Massive cauldrons come to life, blazing with flames. The eyes of concrete Mayan-style gargoyles and snakes glow like embers. Angry organ chords in a minor key shoot out across the ocean, the beach and the surrounding properties: the foreboding first notes of the theme to Andrew Lloyd Webbers Phantom of the Opera.

When Peter Nygard was in residence at Nygard Cay, neighbors say, that was the nightly soundtrack. In the booming early 2000s, Nygard Cay was a playground for lingerie and bikini models flown in from Las Vegas and other major US cities.

According to Nygards [house manager], Richette Ross, his staffers used Facebook posts and messages to promote upcoming parties, which offered free dinners, massages, pedicures, and boat rides to guestsmainly females, said Ross. Mr. Nygard didnt like the competition.

Once the party began, though, Nygard would kick off a twisted competition of his own, she claimed. As guests arrived, they would be photographed and entered into Nygards personal database. He even rated them upon entry, Ross claimed: A, B, C or D, with A being the most beautiful. Ross claimed [those] women had to have what Nygard called a nice toilet a nice ass. It had to be big and round.

Ross claimed, Throughout the day, hed ask a particular girl if shed like to stay the night. If she said no? Ross alleged, Then theres always drugging.

Ross said that she personally witnessed one of Nygards bartenders drop a pill into a girls drink.

Around 10:00, we were almost ready to shut down, Ross claimed, when she spotted the girl again. She was crying naked in the office. Disorientated.

Tragically, according to Ross, this wasnt an unusual occurrence. She claimed, It happened often. She even said that at least once, she saw a girl escape from the property, only to be brought back by Bahamian police, apparently against her will.

When the New York Times covered the sexual assault accusations against Nygard earlier this year, it revealed that two accusers interviewed had then recanted and said they had been paid to lie by Ross. (Nygard has also claimed that his billionaire neighbor, Louis Bacon, with whom hes feuded for years, has paid people to make false statements about him.) However, Ross denied having paid anyone to lie and passed a polygraph test supporting her denial. In the book, Ross alleges that she herself even fell prey to her boss wicked scheme

Nygards girlfriend offered [Ross] a glass of wine. It seemed unusual, and she declined the offer to focus on her work. Still, Ross said, She stopped me and insisted I have that glass of wine. As I was going up the stairs I felt a warmness coming over my body. I turned to tell [Nygard] I wasnt feeling good. I remember going down.

When I came to, Ross alleged, he was penetrating me. I could see from the mirror (on the ceiling). I knew he was on top of me. I remember trying to ease my way to the edge of the bed He raped me.

Ross finally quit working for Nygard in 2014. She found support in a local nonprofit organization founded to help sexual violence victims. Ross even became a sort of leader in the community, introducing other alleged victims to the organization in the hopes of getting them therapy and the community support theyd never had.

She even has alleged that Nygard went so far as to kill her family dog. The New York Times found that Nygard actually wired her $10,000 at one point, emailing Ross: I sent you money to buy a new dog. (He blamed the dogs death on a political rival.)Before long, though, Ross had made herself a target. At one point, I was basically in hiding, she alleged, describing threats that were issued all the time.

According to the book, Nygard had almost unlimited power to do what he wanted in the Bahamas after bribing officials from the governments Progressive Liberal Party.

Former Nygard employee Richette Ross said she was personally tasked with putting together payoffs for high-ranking [Progressive Liberal Party] members.

[She claimed to have seen] stacks of $10,000 bundles from the bank stuffed into bags for delivery. For some, Ross said even that method of handoff was too risky. She claimed that Nygard got creative in his efforts to pay off politicos.

Mr. Nygard had required that I order some very large fish, she said. He had about $100,000 in $10,000 bundles. He told me he wanted me to break them up, roll them, and put them in this fish.

According to records obtained by the Bahamas Tribune, Shane Gibson [a member of the PLP] received $94,131.10 deposited into his Miami bank account from the Nygard Companies in 2012 and 2013. The donations were usually $5,000 or more, and were deposited on a semi-regular basis, marked services or travel.

When confronted with the records, Gibson, the Minister of Immigration and Labor at the time, told the Tribune that they were campaign donations, as well as financial contributions to community programs he was spearheading, like scholarships for local students. Gibson would later be photographed at one of Nygards pamper parties in 2014. (Gibson did not respond to The Posts requests for comment.) With Nygards support, the PLP rolled to victory in 2012 and the designer was quick to claim credit.

According to court documents obtained by the Tribune newspaper shortly [after the election] the government determined that appropriate acreage should be leased to Mr. Peter Nygard so he could develop a stem cell facility as a part of what was termed a touristic development.

Nygard admitted to having [met with government officials], but his attorneys later claimed that the minutes of that meeting had been fabricated, and that he had no desire to curry preferential treatment by the Bahamian government. The campaign to get his stem cell mecca built, though, would consume him for the next several years.

Nygard, obsessed with staying young, ended up establishing his stem cell research company in nearby St. Kitts. The alleged purpose: to use aborted fetuses from his pregnant girlfriends to provide him with fresh stem cells.

Nygard seemed to suggest that something like that could be afoot when he talked about the technology behind his treatments publicly. I may be the only person in the world, he bragged, who has my own embryos growing in a petri dish.

When I came to he was on top of me. I remember trying to ease my way to the edge of the bed.

Peter Nygards former house manager Richette Ross, claiming in Predator King that he drugged and raped her

One of his girlfriends, Suelyn Medeiros, wrote in her 2014 memoir about a trip she took with Nygard to Ukraine, where he was having stem cell research done.

He asked, Suelyn, do you know what the best stem cells are? she writes.

She did: Embryos.

Correct! she says Nygard responded. If you got pregnant and had an abortion, we could use those embryonic cells and have a lifes supply for all of us: you, your mother and me. A lot of people are doing it.

Medeiros says she was beyond stunned.

This was the sickest thing Id ever heard Peter say, she writes. I couldnt speak for a moment Finally, catching my breath, I said, Peter, I do not believe in abortion.

On Feb. 13, 2020, a class-action complaint on behalf of several Jane Does was filed in the US District Court for the Southern District of New York and revealed Nygards depravation.

On so many nights, it was alleged, the same story would unfold: Nygard lures the victims to his bedroom or has them ushered there by groomers, under the false pretense of discussing a potential modeling contract in private, where he uses physical force or coercion or knowing the victim has not attained the age of 18 years, to engage in commercial sex acts and coerce and force them to engage in unwanted sexual acts

The amounts of money provided to the victims is more than most of [them] have seen at one time in their entire lifetimes He promises many victims that he will contact them about future modeling contracts. However, in the vast majority of cases, Nygard never intends to follow through with the modeling contracts and tells his victims this for the sole purpose of maintaining control over them.

[He] also threatens the victims with implied or express threats of retribution if they tell anyone about what happened, often implying or expressly threatening to have his victims killed if they do not cooperate.

Today, Nygards Lyford Cay estate is quiet no more Phantom of the Opera melodies after it was seized by local authorities in 2018 because of illegal dredging, according to Canadas National Post. The moguls company filed for Chapter 15 bankruptcy in New York last week, and Nygard is reportedly in Winnipeg, Manitoba, awaiting the outcome of the FBI investigation.

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Inside the twisted world of 'rapist' designer Peter Nygard: book - The Loppy

Induced Pluripotent Stem Cells Market Latest Trends and Analysis Future Growth Study by 2029 Cole Reports – Cole of Duty

Induced pluripotent stem cells (iPSCs) hold profound potential in replacing the use of embryonic stem cells (ESCs) as important tool for drug discovery and development, disease modeling, and transplantation medicine. Advent of new approaches in reprogramming of somatic cells to produce iPSCs have considerably advanced stem cell research, and hence the induced pluripotent stem cells market. The iPSC technology has shown potential for disease modeling and gene therapy in various areas of regenerative medicine. Notable candidates are Parkinsons disease, spinal cord trauma, myocardial infarction, diabetes, leukemia, and heart ailments.

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Over the past few years, researchers have come out with several clinically important changes in reprogramming process; a case in point is silencing retroviruses in the human genome. Molecular mechanisms that underlie reprogramming have gained better understanding. However, the tools based on this growing understanding are still in nascent stage. Several factors affect the efficiency of reprogramming, most notably chromosomal instability and tumor expression. These have hindered researchers to utilize the full therapeutic potential of iPSCs, reflecting an unmet need, and hence, a vast potential in the induced pluripotent stemcellsmarket.

The growing application of induced pluripotent stem cells in generating patient-specific stem cells for drug development and human disease models is a key dynamic shaping their demands. Growing focus on personalized regenerative cell therapies among medical researchers and healthcare proponents in various countries have catalyzed their scope of induced pluripotent stem cells market. Advent of new methods to induce safe reprogramming of cells have helped biotechnology companies improve the clinical safety and efficacy of the prevailing stem cells therapies. The relentless pursuit of alternative source of cell types for regenerative therapies has led industry players and the research fraternity to pin hopes on iPSCs to generate potentially a wide range of human cell types with therapeutic potential.

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Advances pertaining to better utilizing of retrovirus and lentivirus as reprogramming transcription factors in recent years have expanded the avenue for players in the induced pluripotent stem cells market. Increasing focus on decreasing the clinical difference between ESCs and iPSCs in all its entirety has shaped current research in iPSC technologies, thus unlocking new, exciting potential for biotechnology and pharmaceutical industries.

Over the past few years, fast emerging markets in the global induced pluripotent stem cells are seeing the advent of patents that unveil new techniques for reprogramming of adult cells to reach embryonic stage. Particularly, the idea that these pluripotent stem cells can be made to form any cells in the body has galvanized companies to test their potential in human cell lines. Also, a few biotech companies have intensified their research efforts to improve the safety of and reduce the risk of genetic aberrations in their approved human cell lines. Recently, this has seen the form of collaborative efforts among them.

Lineage Cell Therapeutics and AgeX Therapeutics have in December 2019 announced that they have applied for a patent for a new method for generating iPSCs. These are based on NIH-approved human cell lines, and have been undergoing clinical-stage programs in the treatment of dry macular degeneration and spinal cord injuries. The companies claim to include multiple techniques for reprogramming of animal somatic cells.

Such initiatives by biotech companies are expected to impart a solid push to the evolution of the induced pluripotent stem cells.

North America is one of the regions attracting colossal research funding and industry investments in induced pluripotent stem cells technologies. Continuous efforts of players to generate immune-matched supply of pluripotent cells to be used in disease modelling has been a key accelerator for growth. Meanwhile, Asia Pacific has also been showing a promising potential in the expansion of the prospects of the market. The rising number of programs for expanding stem cell-based therapy is opening new avenues in the market.

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Induced Pluripotent Stem Cells Market Latest Trends and Analysis Future Growth Study by 2029 Cole Reports - Cole of Duty

Global Zinc Finger Nuclease Technology Market to Generate Lucrative Revenue Prospects for Manufacturers After the End of COVID-19 Crisis and Forecast…

Nucleases are the enzyme, used to cleave DNA into smaller units. Zinc-finger (ZFN) nucleases are artificial restriction enzyme used to cleave DNA into smaller fragments. It is the class of engineered DNA-binding proteins that creates double standard break at specified locations. It consist of two functional domain, a DNA-binding domain, and a DNA-cleaving domain. DNA binding domain recognizes the unique hexamer sequence of DNA and DNA-cleaving domain consisting nuclease domain of Fok I. The fusion between the DNA-binding domain, and a DNA-cleaving domain creates artificial restriction enzyme known as molecular scissor that cleaves the desired DNA sequence. ZFN is based on the DNA repair machinery and is becoming a prominent tool in the field of genome editing.

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Zinc finger nucleases are useful for various biotechnological and life science applications. It is used to manipulate plants and animals for research purpose and is used in the clinical trial of CD4+ human T-cells for the treatment of AIDS. It is also used in the generation of disease model known as isogenic human disease model. The therapeutic approach involving ZFNs is associated with the problems related to viral gene delivery, ex vivo therapy involving own stem cells. Some of the disadvantages of the zinc finger nuclease technology is that sometimes cannot target the specific site, within the gene of interest and creates many double standard break and yield chromosomal rearrangements, which can lead to cell death and risk of immunological response against the therapeutic agent.

The rise in the incidence of chronic diseases such as cardiovascular diseases, cancer, blood pressure, obesity and others due to sedentary lifestyle has led to the excessive research and development for the development of new therapeutic agent to treat various disease condition. Benefits of Zinc Finger Nuclease (ZFN) includes permanent and heritable mutations, are effective for the variety of mammalian somatic cell types, single transfection is enough to induce editing in gene, antibiotic screening is not required for selection. These benefits has helped researched to carry out their research process easily with limited accessories.

Zinc finger nuclease will be the core technology for biotechnology companies in coming years due to its wide applications such as cell screening, cell based optimization, target validation, functional genome editing to produce higher yield of target proteins, antibodies and others. Well- established, robust protocol using zinc finger nuclease technology will deliver accurate results and boost the market of zinc finger nuclease technology in the near future.

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The global market zinc finger nuclease technology is segmented on basis of application, end user and geography:

Segment by Application

Segment by End User

The global market for zinc finger nuclease technology is segmented into application type and end user. Based on the application type, the zinc finger nuclease market is segmented into cell line engineering, animal genetic engineering, plant genetic engineering, Based on the end user, the market is segmented into biotechnology industry, pharmaceutical company, hospital and diagnostic laboratory, academic and research institutes. Due to technological advantage of ZFN technology over other genome editing technologies, high precision, specificity, and efficacy of the zinc finger technology has projected to the growth of the zinc finger technology market in the near future

By regional presence, the global zinc finger nuclease technology market is segmented into five broad regions viz. North America, Latin America, Europe, Asia-Pacific, and the Middle East & Africa. North America is estimated to account for major share followed by European countries. Mainly the U.S. & European markets, owing to its innate nature of developed healthcare infrastructure, adopts advanced technology at early stage as compared to developing economies, high pricing of drugs/medical devices/technology, increase in incidence of lifestyle diseases, that follows large patient pool etc. is estimated to maintain its leadership geographically . Significant economic development has led to an increase in healthcare availability in Asia Pacific region, growing number of research institutes, laboratories, investment in research and development and penetration of global players in Asia is expected to fuel demand for gene editing technologies such as zinc finger nuclease technology for research and development, advancement in the diagnostic and treatment process.

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Some of the major players in zinc finger nuclease technology are ,

Sigma-Aldrich Co. LLC is a part of Merck Inc. and operated life science business and has reached various geographies to fulfill customer needs. Sangamo Therapeutics, Inc. has developed range of gene editing technologies with therapeutic approach. Many life sciences company and large pharmaceutical company are collaborating to develop and commercialize gene editing technologies to introduce advanced life science products.

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Global Zinc Finger Nuclease Technology Market to Generate Lucrative Revenue Prospects for Manufacturers After the End of COVID-19 Crisis and Forecast...